{"id":"https://openalex.org/W2088080997","doi":"https://doi.org/10.1161/01.cir.87.4.1328","title":"Distribution and functional significance of cardiac angiotensin converting enzyme in hypertrophied rat hearts.","display_name":"Distribution and functional significance of cardiac angiotensin converting enzyme in hypertrophied rat hearts.","publication_year":1993,"publication_date":"1993-04-01","ids":{"openalex":"https://openalex.org/W2088080997","doi":"https://doi.org/10.1161/01.cir.87.4.1328","mag":"2088080997","pmid":"https://pubmed.ncbi.nlm.nih.gov/8384939"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.87.4.1328","doi":"https://doi.org/10.1161/01.cir.87.4.1328","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.87.4.1328","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.87.4.1328","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.87.4.1328","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006952690","display_name":"Heribert Schunkert","orcid":"https://orcid.org/0000-0001-6428-3001","observed_orcids":["https://orcid.org/0000-0001-6428-3001"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Schunkert","raw_affiliation_strings":["Charles A. Dana Research Institute, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles A. Dana Research Institute, Boston","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001131889","display_name":"B J Jackson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Jackson","raw_affiliation_strings":["Charles A. Dana Research Institute, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles A. Dana Research Institute, Boston","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112265385","display_name":"Shiow\u2010Shih Tang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S S Tang","raw_affiliation_strings":["Charles A. Dana Research Institute, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles A. Dana Research Institute, Boston","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017730082","display_name":"Frederick J. Sch\u00f6en","orcid":"https://orcid.org/0000-0002-5912-7300","observed_orcids":["https://orcid.org/0000-0002-5912-7300"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F J Schoen","raw_affiliation_strings":["Charles A. Dana Research Institute, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles A. Dana Research Institute, Boston","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035889183","display_name":"Jos F.M. Smits","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J F Smits","raw_affiliation_strings":["Charles A. Dana Research Institute, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles A. Dana Research Institute, Boston","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090004654","display_name":"Carl S. Apstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C S Apstein","raw_affiliation_strings":["Charles A. Dana Research Institute, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles A. Dana Research Institute, Boston","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085665354","display_name":"Beverly H. Lorell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B H Lorell","raw_affiliation_strings":["Charles A. Dana Research Institute, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles A. Dana Research Institute, Boston","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.8229,"has_fulltext":true,"cited_by_count":191,"citation_normalized_percentile":{"value":0.99270036,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"87","issue":"4","first_page":"1328","last_page":"1339"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.968999981880188},{"id":"https://openalex.org/keywords/angiotensin-ii-generation","display_name":"angiotensin II generation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/angiotensin-i-to-angiotensin-ii-conversion","display_name":"angiotensin I to angiotensin II conversion","score":0.9330000281333923},{"id":"https://openalex.org/keywords/aortic-stenosis","display_name":"aortic stenosis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.5289999842643738},{"id":"https://openalex.org/keywords/enalaprilat","display_name":"enalaprilat","score":0.9710000157356262},{"id":"https://openalex.org/keywords/lisinopril","display_name":"lisinopril","score":0.7670000195503235},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.5559999942779541},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.3529999852180481},{"id":"https://openalex.org/keywords/ace-mrna-expression","display_name":"ACE mRNA expression","score":0.4300000071525574},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.871076226234436},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5966945886611938},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.5817978382110596},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.550212562084198},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.5238792300224304},{"id":"https://openalex.org/C3018791406","wikidata":"https://www.wikidata.org/wiki/Q945225","display_name":"Cardiac hypertrophy","level":3,"score":0.5092390775680542},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.4768284857273102},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4159039855003357},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3915833830833435},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1975060999393463},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15430691838264465},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000803","descriptor_name":"Angiotensin I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007703","descriptor_name":"Peptidyl-Dipeptidase A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015773","descriptor_name":"Enalaprilat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.cir.87.4.1328","doi":"https://doi.org/10.1161/01.cir.87.4.1328","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.87.4.1328","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.87.4.1328","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:8384939","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8384939","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1161/01.cir.87.4.1328","doi":"https://doi.org/10.1161/01.cir.87.4.1328","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.87.4.1328","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.87.4.1328","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4399999976158142,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1613082450","display_name":"DIASTOLIC RELAXATION IN ISCHEMIA/HYPERTROPHY/FAILURE","funder_award_id":"5p01hl038189-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1928030200","display_name":null,"funder_award_id":"HL 38189","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2219641279","display_name":null,"funder_award_id":"HL 43131","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3628867291","display_name":"NUCLEAR EFFECTS OF ANGIOTENSIN ON VASCULAR SMOOTH MUSCLE","funder_award_id":"5r01hl043131-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2088080997.pdf","grobid_xml":"https://content.openalex.org/works/W2088080997.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W138960260","https://openalex.org/W172952989","https://openalex.org/W1521804991","https://openalex.org/W1528895376","https://openalex.org/W1751733883","https://openalex.org/W1964522609","https://openalex.org/W1967561584","https://openalex.org/W1968898175","https://openalex.org/W1970263680","https://openalex.org/W1970888273","https://openalex.org/W1980003717","https://openalex.org/W1992351338","https://openalex.org/W1995427147","https://openalex.org/W1998503550","https://openalex.org/W2000515863","https://openalex.org/W2002260065","https://openalex.org/W2002899223","https://openalex.org/W2003563752","https://openalex.org/W2007424272","https://openalex.org/W2023017689","https://openalex.org/W2029443254","https://openalex.org/W2036110989","https://openalex.org/W2037915656","https://openalex.org/W2051010843","https://openalex.org/W2052884912","https://openalex.org/W2054301807","https://openalex.org/W2060000070","https://openalex.org/W2067165584","https://openalex.org/W2071579664","https://openalex.org/W2082702456","https://openalex.org/W2086354749","https://openalex.org/W2088515575","https://openalex.org/W2091795899","https://openalex.org/W2093222664","https://openalex.org/W2099819636","https://openalex.org/W2101076761","https://openalex.org/W2109302809","https://openalex.org/W2115787016","https://openalex.org/W2129152732","https://openalex.org/W2129925176","https://openalex.org/W2130153779","https://openalex.org/W2132161051","https://openalex.org/W2137664559","https://openalex.org/W2150341329","https://openalex.org/W2168029143","https://openalex.org/W2171083892","https://openalex.org/W2206375685","https://openalex.org/W2262482762","https://openalex.org/W2298497916","https://openalex.org/W2320384507","https://openalex.org/W2341796320","https://openalex.org/W2398570007","https://openalex.org/W2405472647","https://openalex.org/W2410988641","https://openalex.org/W2413552267","https://openalex.org/W2431469698","https://openalex.org/W2474196319","https://openalex.org/W3114912897","https://openalex.org/W4210555084","https://openalex.org/W4232078882","https://openalex.org/W4248891692"],"related_works":["https://openalex.org/W2129925176","https://openalex.org/W2040828603","https://openalex.org/W2885791462","https://openalex.org/W1992173844","https://openalex.org/W2149917489","https://openalex.org/W2091795899","https://openalex.org/W1988779201","https://openalex.org/W2121872928","https://openalex.org/W2084741098","https://openalex.org/W7047884988"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,226],"intracardiac":[2,36,232,370,647],"conversion":[3,233,256,351,374,651],"rate":[4,352,375,652],"of":[5,15,47,55,100,108,126,141,149,169,183,213,220,228,234,279,294,308,314,321,327,337,366,390,541,556,615,621,632,639,658],"angiotensin":[6,16],"(Ang)":[7],"I":[8,236,271,316,329,397,481,508,544,584,597],"to":[9,44,84,237,265,301,340,445,532,574,582],"Ang":[10,37,235,238,270,315,328,348,371,385,396,436,480,507,543,583,596,648,659],"II":[11,38,239,350,373,650,661],"and":[12,53,73,89,110,124,216,240,252,296,416,457,471,488,626,653],"the":[13,34,94,147,166,180,210,275,280,302,369,438,539,542,613,636,640,655],"expression":[14],"converting":[17],"enzyme":[18,641],"(ACE)":[19],"mRNA":[20,627],"are":[21],"amplified":[22],"in":[23,40,58,75,113,119,165,179,186,200,223,231,246,263,274,356,359,376,413,428,440,454,468,476,486,492,566,580,601,629,635],"rat":[24,60],"hearts":[25,61,76,298,361,378,415,456,470,477,591],"with":[26,81,154,343,435,479,512,593,595],"left":[27,151,187,518],"ventricular":[28,188,519],"hypertrophy":[29],"(LVH).":[30],"To":[31],"examine":[32],"whether":[33],"accelerated":[35],"generation":[39],"LVH":[41,82,109,251,295,357,377,414,455,487,516,616,634],"is":[42,610],"related":[43],"an":[45,177,198,218,643],"induction":[46],"cardiac":[48,56,229,623],"ACE,":[49],"we":[50],"studied":[51,245],"localization":[52],"function":[54,497],"ACE":[57,64,70,95,117,133,214,221,230,281,608,624,644],"hypertrophied":[59,150,224],"using":[62],"specific":[63,242],"inhibitors.":[65],"METHODS":[66],"AND":[67],"RESULTS:":[68],"Cardiac":[69],"was":[71,143,244,353,433,443,472,498,510,552,562],"localized":[72],"quantified":[74],"from":[77,90,190,524,568],"male":[78],"Wistar":[79],"rats":[80],"due":[83],"chronic":[85],"experimental":[86],"aortic":[87,191],"stenosis":[88,192],"control":[91,111,253,297,360,429,469,493,559],"rats.":[92,193],"With":[93],"inhibitor":[96,282,645],"125I-351A,":[97],"a":[98,103,162,289,344,563],"derivative":[99],"lisinopril,":[101],"as":[102,171,173,258,260],"radioligand":[104],"on":[105],"coronal":[106],"sections":[107],"hearts,":[112,494,517,560,617],"vitro":[114],"autoradiography":[115],"demonstrated":[116,161],"binding":[118],"aorta,":[120],"coronary":[121,392,399],"arteries,":[122],"atria,":[123],"ventricles":[125,152],"both":[127],"groups.":[128],"Quantitative":[129,159],"analyses":[130],"revealed":[131],"that":[132,197,607],"density":[134,215],"(counts":[135],"per":[136,138,204,394],"minute":[137],"cross-sectional":[139],"area":[140],"tissue)":[142],"twofold":[144],"higher":[145,355],"within":[146,612],"myocardium":[148,614],"compared":[153],"controls":[155],"(p":[156,362,381,408,423,463,483,546,585],"<":[157,363,382,409,424,464,484,490,547,586],"0.005).":[158],"morphometry":[160],"modest":[163],"increase":[164,178,199,439,565,600],"fractional":[167,181],"volume":[168,175,182,203],"myocytes":[170],"well":[172,259],"capillary":[174],"without":[176],"endothelial":[184,201],"cells":[185],"tissue":[189],"These":[194,604],"data":[195],"suggest":[196],"cell":[202],"se":[205],"cannot":[206],"alone":[207],"account":[208],"for":[209],"observed":[211],"doubling":[212],"support":[217],"upregulation":[219],"production":[222],"tissue.":[225],"role":[227],"its":[241],"inhibition":[243],"isolated,":[247],"isovolumic":[248],"beating,":[249],"buffer-perfused":[250],"hearts.":[254,430],"Biochemical":[255],"rates":[257],"functional":[261,656],"changes":[262,657],"response":[264,581],"3":[266,460],"x":[267,285],"10(-7)":[268],"M":[269],"were":[272,299],"examined":[273],"absence":[276],"or":[277,334],"presence":[278],"enalaprilat":[283,322,331,367,432,594],"(4":[284],"10(-6)":[286],"M).":[287],"After":[288],"brief":[290],"stabilization":[291],"period,":[292],"groups":[293],"subjected":[300],"following":[303],"infusion":[304,503,509,545,555],"protocols:":[305],"15":[306,319,575],"minutes":[307,313,320,326,336],"vehicle":[309,338],"followed":[310,323],"by":[311,324,379,402,417,501,554,642],"30":[312,325],"plus":[317,330],"vehicle,":[318],"(enal/Ang":[332],"I),":[333],"45":[335],"only":[339,482],"allow":[341],"comparison":[342],"time":[345],"control.":[346],"Intracardiac":[347],"I-to-Ang":[349,372,649,660],"fourfold":[354],"than":[358,475],"0.05).":[364],"Infusion":[365],"reduced":[368],"70%":[380],"0.05":[383,465,485,491,587],"versus":[384,411,426,452,466,549,588],"I).":[386],"At":[387],"similar":[388],"levels":[389,628],"constant":[391],"flow":[393],"gram,":[395],"increased":[398,523,611,622],"perfusion":[400,441],"pressure":[401,442,521],"23":[403],"+/-":[404,419,447,459,526,534,570,576],"5":[405,446,448],"mm":[406,421,449,461,528,536,572,578],"Hg":[407,422,450,462,529,537,573,579],"0.01":[410],"vehicle)":[412,427,453,467],"36":[418],"10":[420,525,569],"0.005":[425],"When":[431],"infused":[434,478],"I,":[437],"limited":[444],"(NS":[451],"12":[458],"significantly":[473],"lower":[474],"p":[489],"respectively).":[495],"Systolic":[496],"not":[499],"affected":[500],"either":[502],"protocol.":[504],"In":[505,515,558],"contrast,":[506],"associated":[511],"diastolic":[513],"dysfunction.":[514],"end-diastolic":[520],"(LVEDP)":[522],"1":[527,571,577],"at":[530,538],"baseline":[531],"25":[533],"2":[535],"end":[540],"0.001":[548],"vehicle),":[550],"which":[551],"inhibited":[553],"enalaprilat.":[557],"there":[561],"lesser":[564],"LVEDP":[567],"LVH).":[589],"Control":[590],"treated":[592],"displayed":[598],"no":[599],"LVEDP:":[602],"CONCLUSIONS:":[603],"observations":[605],"indicate":[606],"protein":[609],"extending":[618],"recent":[619],"findings":[620],"activity":[625],"this":[630],"model":[631],"pressure-overload":[633],"rat.":[637],"Blockade":[638],"decreases":[646],"prevents":[654],"activation":[662]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}