{"id":"https://openalex.org/W2088056339","doi":"https://doi.org/10.1002/art.1780180211","title":"Effects of acute cartilaginous injury on serum and cartilage lysozyme levels","display_name":"Effects of acute cartilaginous injury on serum and cartilage lysozyme levels","publication_year":1975,"publication_date":"1975-03-01","ids":{"openalex":"https://openalex.org/W2088056339","doi":"https://doi.org/10.1002/art.1780180211","mag":"2088056339","pmid":"https://pubmed.ncbi.nlm.nih.gov/1131282"},"language":"en","primary_location":{"id":"doi:10.1002/art.1780180211","doi":"https://doi.org/10.1002/art.1780180211","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.1780180211","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & Rheumatism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043119427","display_name":"Robert A. Greenwald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I2800560132","display_name":"Long Island Jewish Medical Center","ror":"https://ror.org/00c8v4891","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I2800560132"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Greenwald","raw_affiliation_strings":["Physician\u2010in\u2010Charge, Division of Rheumatology, Long Island Jewish\u2010Hillside Medical Center, and Assistant Professor of Medicine, State University of New York at Stony Brook"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physician\u2010in\u2010Charge, Division of Rheumatology, Long Island Jewish\u2010Hillside Medical Center, and Assistant Professor of Medicine, State University of New York at Stony Brook","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I2800560132","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039695762","display_name":"Jerome Owen Cantor","orcid":"https://orcid.org/0000-0002-2100-5236","observed_orcids":["https://orcid.org/0000-0002-2100-5236"]},"institutions":[{"id":"https://openalex.org/I2800560132","display_name":"Long Island Jewish Medical Center","ror":"https://ror.org/00c8v4891","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I2800560132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerome O. Cantor","raw_affiliation_strings":["Research Trainee, Rheumatic Disease Research Laboratory, Long Island Jewish\u2010Hillside Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Trainee, Rheumatic Disease Research Laboratory, Long Island Jewish\u2010Hillside Medical Center","institution_ids":["https://openalex.org/I2800560132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072815495","display_name":"Charles E. Schwartz","orcid":"https://orcid.org/0000-0002-7770-1943","observed_orcids":["https://orcid.org/0000-0002-7770-1943"]},"institutions":[{"id":"https://openalex.org/I2800560132","display_name":"Long Island Jewish Medical Center","ror":"https://ror.org/00c8v4891","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I2800560132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles E. Schwartz","raw_affiliation_strings":["Research Assistant, Rheumatic Disease Research Laboratory, Long Island Jewish\u2010Hillside Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Assistant, Rheumatic Disease Research Laboratory, Long Island Jewish\u2010Hillside Medical Center","institution_ids":["https://openalex.org/I2800560132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111558086","display_name":"Alan S. Josephson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan S. Josephson","raw_affiliation_strings":["Associate Professor of Medicine, Downstate Medical Center, Brooklyn, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor of Medicine, Downstate Medical Center, Brooklyn, New York","institution_ids":["https://openalex.org/I181697535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2527,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.86788425,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"2","first_page":"139","last_page":"144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.10719999670982361,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cartilage-damage","display_name":"cartilage damage","score":0.8019999861717224},{"id":"https://openalex.org/keywords/lysozyme","display_name":"lysozyme","score":0.8360000252723694},{"id":"https://openalex.org/keywords/serum-lysozyme","display_name":"serum lysozyme","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cartilage-degeneration","display_name":"cartilage degeneration","score":0.7760000228881836},{"id":"https://openalex.org/keywords/chondroitin-sulfate","display_name":"chondroitin sulfate","score":0.9679999947547913},{"id":"https://openalex.org/keywords/auricular-cartilage","display_name":"auricular cartilage","score":0.9430000185966492},{"id":"https://openalex.org/keywords/costal-cartilage","display_name":"costal cartilage","score":0.9829999804496765}],"concepts":[{"id":"https://openalex.org/C2776966407","wikidata":"https://www.wikidata.org/wiki/Q24779410","display_name":"Lysozyme","level":2,"score":0.9712517261505127},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.8163419365882874},{"id":"https://openalex.org/C2779553658","wikidata":"https://www.wikidata.org/wiki/Q408014","display_name":"Chondroitin sulfate","level":3,"score":0.5763736367225647},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5472405552864075},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4886346459388733},{"id":"https://openalex.org/C2779832904","wikidata":"https://www.wikidata.org/wiki/Q410420","display_name":"Papain","level":3,"score":0.4254511594772339},{"id":"https://openalex.org/C2778232976","wikidata":"https://www.wikidata.org/wiki/Q15320335","display_name":"Cartilage oligomeric matrix protein","level":4,"score":0.42182114720344543},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36366787552833557},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35834211111068726},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31760483980178833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2623984217643738},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.262006938457489},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.22213226556777954},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2146455943584442},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19027546048164368},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.15961149334907532},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001168","descriptor_name":"Arthritis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002357","descriptor_name":"Cartilage Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D002357","descriptor_name":"Cartilage Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002357","descriptor_name":"Cartilage Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002807","descriptor_name":"Chondroitin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008722","descriptor_name":"Methods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010206","descriptor_name":"Papain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/art.1780180211","doi":"https://doi.org/10.1002/art.1780180211","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.1780180211","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & Rheumatism","raw_type":"journal-article"},{"id":"pmid:1131282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1131282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis and rheumatism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1506668623","https://openalex.org/W1599947302","https://openalex.org/W1965665915","https://openalex.org/W1977802642","https://openalex.org/W1979638688","https://openalex.org/W1982661128","https://openalex.org/W2039857107","https://openalex.org/W2081341857","https://openalex.org/W2082881994","https://openalex.org/W2095076478","https://openalex.org/W2106066574","https://openalex.org/W2116300457","https://openalex.org/W2131989780","https://openalex.org/W2312186519","https://openalex.org/W2324149157","https://openalex.org/W2330995524","https://openalex.org/W2418044717","https://openalex.org/W2473640722","https://openalex.org/W2476433576","https://openalex.org/W6630197361"],"related_works":["https://openalex.org/W2088895116","https://openalex.org/W2426151911","https://openalex.org/W2288677093","https://openalex.org/W2074449969","https://openalex.org/W1767518263","https://openalex.org/W1964970304","https://openalex.org/W2095076478","https://openalex.org/W1563964441","https://openalex.org/W2161871052","https://openalex.org/W2427806625"],"abstract_inverted_index":{"Acute":[0],"cartilage":[1,73,83],"degradation":[2],"was":[3],"produced":[4],"in":[5,16,20,23,33,45,51,60,78],"rabbits":[6],"by":[7],"the":[8,26,34,49,58,65,72],"intravenous":[9],"injection":[10],"of":[11,25,38,57,67],"crude":[12],"papain.":[13],"This":[14],"resulted":[15],"a":[17,31],"significant":[18],"rise":[19,44,50,59],"serum":[21,46,52],"lysozyme":[22,36,47,61,70,76],"97%":[24],"animals,":[27],"as":[28,30],"well":[29],"fall":[32],"residual":[35],"content":[37],"auricular":[39],"and":[40],"costal":[41],"cartilage.":[42],"The":[43,55],"paralleled":[48],"chondroitin":[53],"sulfate.":[54],"source":[56],"appeared":[62],"to":[63],"be":[64],"release":[66],"extracellular,":[68],"nonlysosomal":[69],"from":[71],"matrix.":[74],"Serum":[75],"elevation":[77],"arthritic":[79],"disorders":[80],"may":[81],"reflect":[82],"degradation.":[84]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}