{"id":"https://openalex.org/W2088048435","doi":"https://doi.org/10.1515/jpm.2005.036","title":"Pregnancy outcome of euploid fetuses with increased nuchal translucency: how bad is the news?","display_name":"Pregnancy outcome of euploid fetuses with increased nuchal translucency: how bad is the news?","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2088048435","doi":"https://doi.org/10.1515/jpm.2005.036","mag":"2088048435","pmid":"https://pubmed.ncbi.nlm.nih.gov/15914340"},"language":"en","primary_location":{"id":"doi:10.1515/jpm.2005.036","doi":"https://doi.org/10.1515/jpm.2005.036","is_oa":false,"landing_page_url":"https://doi.org/10.1515/jpm.2005.036","pdf_url":null,"source":{"id":"https://openalex.org/S61009040","display_name":"Journal of Perinatal Medicine","issn_l":"0300-5577","issn":["0300-5577","1619-3997"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Perinatal Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101604265","display_name":"Ron Maymon","orcid":"https://orcid.org/0000-0002-2987-3847","observed_orcids":["https://orcid.org/0000-0002-2987-3847"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I4210114157","display_name":"Assaf Harofeh Medical Center","ror":"https://ror.org/02722hp10","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210114157"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ron Maymon","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. intposgr@post.tau.ac.il","1. Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. intposgr@post.tau.ac.il","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I4210114157"]},{"raw_affiliation_string":"1. Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I4210114157"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111585730","display_name":"Zwi Weinraub","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I4210114157","display_name":"Assaf Harofeh Medical Center","ror":"https://ror.org/02722hp10","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210114157"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Zwi Weinraub","raw_affiliation_strings":["2. Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2. Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I4210114157"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111523099","display_name":"Arie Herman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I4210114157","display_name":"Assaf Harofeh Medical Center","ror":"https://ror.org/02722hp10","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210114157"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Arie Herman","raw_affiliation_strings":["3. Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3. Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I4210114157"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"EUR","value_usd":0},"apc_paid":null,"fwci":0.2565,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.21703854,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"33","issue":"3","first_page":"191","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12716","display_name":"Congenital Anomalies and Fetal Surgery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuchal-translucency","display_name":"nuchal translucency","score":0.9340000152587891},{"id":"https://openalex.org/keywords/euploid-fetuses","display_name":"euploid fetuses","score":0.949999988079071},{"id":"https://openalex.org/keywords/pregnancy-outcomes","display_name":"pregnancy outcomes","score":0.7360000014305115},{"id":"https://openalex.org/keywords/prenatal-counselling","display_name":"prenatal counseling","score":0.6859999895095825},{"id":"https://openalex.org/keywords/first-trimester-screening","display_name":"first-trimester screening","score":0.746999979019165},{"id":"https://openalex.org/keywords/miscarriage","display_name":"miscarriage","score":0.7400000095367432},{"id":"https://openalex.org/keywords/perinatal-death","display_name":"perinatal death","score":0.9850000143051147},{"id":"https://openalex.org/keywords/neurodevelopmental-problems","display_name":"neurodevelopmental problems","score":0.8529999852180481},{"id":"https://openalex.org/keywords/congenital-malformations","display_name":"congenital malformations","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cardiac-abnormalities","display_name":"cardiac anomalies","score":0.7329999804496765},{"id":"https://openalex.org/keywords/fetal-echocardiography","display_name":"fetal echocardiography","score":0.828000009059906},{"id":"https://openalex.org/keywords/nuchal-edema","display_name":"nuchal edema","score":0.9089999794960022},{"id":"https://openalex.org/keywords/maternal-age","display_name":"maternal age","score":0.6150000095367432},{"id":"https://openalex.org/keywords/family-history-medicine","display_name":"family history (medicine)","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9041531085968018},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.7773668766021729},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.680148720741272},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.5554090738296509},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.4142017066478729},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000013","descriptor_name":"Congenital Abnormalities","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000013","descriptor_name":"Congenital Abnormalities","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D004200","descriptor_name":"Diseases in Twins","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D004200","descriptor_name":"Diseases in Twins","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005315","descriptor_name":"Fetal Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005315","descriptor_name":"Fetal Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005315","descriptor_name":"Fetal Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007232","descriptor_name":"Infant, Newborn, Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007232","descriptor_name":"Infant, Newborn, Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011251","descriptor_name":"Pregnancy Complications, Infectious","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D011251","descriptor_name":"Pregnancy Complications, Infectious","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011256","descriptor_name":"Pregnancy Outcome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011256","descriptor_name":"Pregnancy Outcome","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D011261","descriptor_name":"Pregnancy Trimester, First","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011295","descriptor_name":"Prenatal Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030342","descriptor_name":"Genetic Diseases, Inborn","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D030342","descriptor_name":"Genetic Diseases, Inborn","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D048208","descriptor_name":"Nuchal Translucency Measurement","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1515/jpm.2005.036","doi":"https://doi.org/10.1515/jpm.2005.036","is_oa":false,"landing_page_url":"https://doi.org/10.1515/jpm.2005.036","pdf_url":null,"source":{"id":"https://openalex.org/S61009040","display_name":"Journal of Perinatal Medicine","issn_l":"0300-5577","issn":["0300-5577","1619-3997"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Perinatal Medicine","raw_type":"journal-article"},{"id":"pmid:15914340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15914340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of perinatal medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1764132625","https://openalex.org/W1915452254","https://openalex.org/W1964591473","https://openalex.org/W1967944941","https://openalex.org/W1973253914","https://openalex.org/W1977416181","https://openalex.org/W1984129657","https://openalex.org/W1987502902","https://openalex.org/W1988432766","https://openalex.org/W1989854802","https://openalex.org/W1991181434","https://openalex.org/W1992299166","https://openalex.org/W1995956924","https://openalex.org/W1997317528","https://openalex.org/W2002289727","https://openalex.org/W2003867840","https://openalex.org/W2018536608","https://openalex.org/W2018860541","https://openalex.org/W2021009039","https://openalex.org/W2022377440","https://openalex.org/W2033212653","https://openalex.org/W2035810975","https://openalex.org/W2047873080","https://openalex.org/W2056701148","https://openalex.org/W2058597861","https://openalex.org/W2058995602","https://openalex.org/W2061514086","https://openalex.org/W2068281101","https://openalex.org/W2072616466","https://openalex.org/W2074100252","https://openalex.org/W2074458518","https://openalex.org/W2075954213","https://openalex.org/W2085067562","https://openalex.org/W2093604190","https://openalex.org/W2094506974","https://openalex.org/W2101733942","https://openalex.org/W2102489859","https://openalex.org/W2117588516","https://openalex.org/W2120957385","https://openalex.org/W2125435699","https://openalex.org/W2135816824","https://openalex.org/W2137887594","https://openalex.org/W2148260008","https://openalex.org/W2150192135","https://openalex.org/W2152636904","https://openalex.org/W2156954183","https://openalex.org/W2162984925","https://openalex.org/W2165662178","https://openalex.org/W2166060923","https://openalex.org/W2166621803","https://openalex.org/W2167482419","https://openalex.org/W2171787092","https://openalex.org/W2313706247","https://openalex.org/W2767916132","https://openalex.org/W4302402196"],"related_works":["https://openalex.org/W1915452254","https://openalex.org/W3151421823","https://openalex.org/W2153717004","https://openalex.org/W2344726838","https://openalex.org/W2054118336","https://openalex.org/W2315598525","https://openalex.org/W2072616466","https://openalex.org/W2039129420","https://openalex.org/W1931801672","https://openalex.org/W2898855598"],"abstract_inverted_index":{"AIMS:":[0],"The":[1,64],"number":[2],"of":[3,71,82,103,119,125,181],"fetuses":[4,85,105,140,148],"with":[5,56,61,86,149],"an":[6,57,116],"abnormal":[7],"increased":[8,58,87,150],"first":[9],"trimester":[10],"nuchal":[11,182],"translucency":[12],"(NT),":[13],"but":[14,60],"confirmed":[15],"normal":[16,142],"karyotype":[17],"and":[18,23,108,123,179,190],"anatomy":[19],"is":[20],"relatively":[21],"small":[22],"therefore":[24],"a":[25,36,160],"challenge":[26],"for":[27,35,46,188],"prenatal":[28],"counseling.":[29],"Universal":[30],"guidelines":[31],"are":[32],"still":[33],"needed":[34],"systematic":[37],"work-up,":[38],"how":[39,52],"to":[40,53,68],"decide":[41],"on":[42,78,175],"the":[43,79,104,126,132],"rewarding":[44],"cut-off":[45],"this":[47],"policy":[48],"as":[49,51,171,173],"well":[50,172],"counsel":[54],"patients":[55],"NT":[59,88,157],"euploid":[62,84,147],"fetuses.":[63],"current":[65],"review":[66],"aims":[67],"address":[69],"some":[70],"these":[72],"issues.":[73],"RESULTS:":[74],"Eleven":[75],"studies":[76],"reporting":[77],"pregnancy":[80,192],"outcome":[81],"2,128":[83],"(>or=3":[89],"mm":[90,155],"or":[91,153],">or=95":[92],"centile)":[93],"were":[94,128],"retrieved":[95],"by":[96],"our":[97],"previously":[98],"reported":[99],"literature":[100],"search.":[101],"2.2-10.6%":[102],"has":[106],"miscarried":[107],"0.5-15.8%":[109],"ended":[110],"in":[111],"perinatal":[112],"death.":[113],"There":[114],"was":[115],"overall":[117],"rate":[118],"0.5-13%":[120],"neurodevelopmental":[121],"problems,":[122],"2-8%":[124],"malformations":[127],"undiagnosed":[129],"before":[130],"birth,":[131],"most":[133],"common":[134],"being":[135],"cardiac":[136],"anomalies.":[137],"Nevertheless,":[138],"70-90%":[139],"had":[141],"outcomes.":[143],"CONCLUSION:":[144],"For":[145],"those":[146],"NT>2":[151],"MoM":[152],">or=1.5":[154],"delta":[156],"we":[158],"recommend":[159],"detailed":[161],"two-step":[162],"anomaly":[163],"scan":[164],"including":[165],"midgestation":[166],"fetal":[167],"echocardiography.":[168],"Maternal":[169],"age":[170],"data":[174],"relevant":[176,186],"family":[177],"history":[178],"persistence":[180],"edema":[183],"provides":[184],"additional":[185],"information":[187],"counseling":[189],"planning":[191],"management.":[193]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
