{"id":"https://openalex.org/W2087985294","doi":"https://doi.org/10.1161/01.cir.100.suppl_2.ii-187","title":"Impaired Glucose Transporter Activity in Pressure-Overload Hypertrophy Is an Early Indicator of Progression to Failure","display_name":"Impaired Glucose Transporter Activity in Pressure-Overload Hypertrophy Is an Early Indicator of Progression to Failure","publication_year":1999,"publication_date":"1999-11-09","ids":{"openalex":"https://openalex.org/W2087985294","doi":"https://doi.org/10.1161/01.cir.100.suppl_2.ii-187","mag":"2087985294","pmid":"https://pubmed.ncbi.nlm.nih.gov/10567302"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.100.suppl_2.ii-187","doi":"https://doi.org/10.1161/01.cir.100.suppl_2.ii-187","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.100.suppl_2.ii-187","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022775023","display_name":"Ingeborg Friehs","orcid":"https://orcid.org/0000-0002-2631-2972","observed_orcids":["https://orcid.org/0000-0002-2631-2972"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. Friehs","raw_affiliation_strings":["Department of Cardiac Surgery, The Children's Hospital, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, The Children's Hospital, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075779327","display_name":"Adrian M. Moran","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. M. Moran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072408501","display_name":"Christof Stamm","orcid":"https://orcid.org/0000-0003-3035-2106","observed_orcids":["https://orcid.org/0000-0003-3035-2106"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Stamm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000020632","display_name":"Steven D. Colan","orcid":"https://orcid.org/0000-0002-7941-0947","observed_orcids":["https://orcid.org/0000-0002-7941-0947"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. D. Colan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021174309","display_name":"Koh Takeuchi","orcid":"https://orcid.org/0000-0002-6227-4627","observed_orcids":["https://orcid.org/0000-0002-6227-4627"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Takeuchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085544309","display_name":"Hung Cao-Danh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Cao-Danh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074062561","display_name":"Christine M. Rader","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. M. Rader","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044364350","display_name":"Francis X. Jr McGowan","orcid":"https://orcid.org/0000-0002-1892-8806","observed_orcids":["https://orcid.org/0000-0002-1892-8806"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. X. McGowan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001927963","display_name":"Pedro J. del Nido","orcid":"https://orcid.org/0000-0003-4252-8789","observed_orcids":["https://orcid.org/0000-0003-4252-8789"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. J. del Nido","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4549,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.83661852,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"100","issue":"Supplement 2","first_page":"II","last_page":"187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.7792999744415283,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.7792999744415283,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.14149999618530273,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.03009999915957451,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pressure-overload-hypertrophy","display_name":"pressure overload hypertrophy","score":0.9169999957084656},{"id":"https://openalex.org/keywords/glucose-uptake","display_name":"glucose uptake","score":0.6990000009536743},{"id":"https://openalex.org/keywords/glucose-transporters","display_name":"glucose transporters","score":0.7570000290870667},{"id":"https://openalex.org/keywords/heart-failure-progression","display_name":"heart failure progression","score":0.6830000281333923},{"id":"https://openalex.org/keywords/ventricular-dilation","display_name":"ventriculomegaly","score":0.9409999847412109},{"id":"https://openalex.org/keywords/compensatory-hypertrophy","display_name":"compensatory hypertrophy","score":0.7400000095367432},{"id":"https://openalex.org/keywords/myocardial-energy-metabolism","display_name":"myocardial energy metabolism","score":0.7739999890327454},{"id":"https://openalex.org/keywords/aortic-banding","display_name":"aortic banding","score":0.7480000257492065},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.6320000290870667},{"id":"https://openalex.org/keywords/31p-nuclear-magnetic-resonance-spectroscopy","display_name":"31P nuclear magnetic resonance spectroscopy","score":0.6589999794960022},{"id":"https://openalex.org/keywords/2-deoxy-d-glucose","display_name":"2-deoxyglucose","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8332722783088684},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.776408314704895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6663932800292969},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6646752953529358},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.6332660913467407},{"id":"https://openalex.org/C2776002628","wikidata":"https://www.wikidata.org/wiki/Q1628627","display_name":"Left ventricular hypertrophy","level":3,"score":0.6165431141853333},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.5810363292694092},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5290557146072388},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.5257595181465149},{"id":"https://openalex.org/C2778271984","wikidata":"https://www.wikidata.org/wiki/Q17126794","display_name":"Pressure overload","level":4,"score":0.48978161811828613},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.37810179591178894},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2635873854160309},{"id":"https://openalex.org/C3018791406","wikidata":"https://www.wikidata.org/wiki/Q945225","display_name":"Cardiac hypertrophy","level":3,"score":0.23605385422706604},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.19756236672401428}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004106","descriptor_name":"Dilatation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006348","descriptor_name":"Cardiac Surgical Procedures","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D009004","descriptor_name":"Monosaccharide Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.cir.100.suppl_2.ii-187","doi":"https://doi.org/10.1161/01.cir.100.suppl_2.ii-187","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.100.suppl_2.ii-187","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:10567302","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10567302","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3540068832","display_name":null,"funder_award_id":"HL46207","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G35769386","display_name":"Myocardial Endotoxin Signaling in Surgery","funder_award_id":"R01HL052589","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4686955971","display_name":null,"funder_award_id":"HL 52589","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W132224581","https://openalex.org/W140527398","https://openalex.org/W1821324646","https://openalex.org/W1948436988","https://openalex.org/W1963840316","https://openalex.org/W1965482152","https://openalex.org/W1972246579","https://openalex.org/W1974890922","https://openalex.org/W1980839560","https://openalex.org/W1986409524","https://openalex.org/W1997862023","https://openalex.org/W1998826582","https://openalex.org/W2001342018","https://openalex.org/W2012847250","https://openalex.org/W2016088813","https://openalex.org/W2018364757","https://openalex.org/W2019332275","https://openalex.org/W2022938773","https://openalex.org/W2028761750","https://openalex.org/W2029651486","https://openalex.org/W2036637373","https://openalex.org/W2036973081","https://openalex.org/W2043090124","https://openalex.org/W2043498565","https://openalex.org/W2059424055","https://openalex.org/W2060616628","https://openalex.org/W2061088776","https://openalex.org/W2070892520","https://openalex.org/W2072185207","https://openalex.org/W2080929370","https://openalex.org/W2093041672","https://openalex.org/W2094909991","https://openalex.org/W2095173006","https://openalex.org/W2095359498","https://openalex.org/W2098221150","https://openalex.org/W2100837269","https://openalex.org/W2100943227","https://openalex.org/W2112225791","https://openalex.org/W2124328401","https://openalex.org/W2151418836","https://openalex.org/W2165743173","https://openalex.org/W2278537666","https://openalex.org/W2344156160","https://openalex.org/W2395325033","https://openalex.org/W2500434365"],"related_works":["https://openalex.org/W2109762329","https://openalex.org/W2128481603","https://openalex.org/W2275713104","https://openalex.org/W2344156160","https://openalex.org/W634590065","https://openalex.org/W1989214434","https://openalex.org/W2274498814","https://openalex.org/W4409090669","https://openalex.org/W2914175519","https://openalex.org/W2167702011"],"abstract_inverted_index":{"BACKGROUND:":[0],"Severe":[1],"hypertrophy":[2,17,44,66,88],"and":[3,26,48,67,136,239],"heart":[4],"failure":[5,49],"are":[6,50],"important":[7],"risk":[8],"factors":[9],"in":[10,16,39,62,117,219,271],"cardiac":[11],"surgery.":[12],"Early":[13],"adaptive":[14],"changes":[15],"include":[18],"increased":[19,27,129,192,252],"ventricular":[20,46,73,97,237],"mass-to-cavity":[21],"volume":[22],"ratio":[23,127,168],"(M/V":[24],"ratio)":[25],"dependence":[28,253],"on":[29,258],"glucose":[30,35,56,150,170,196,240,244,259],"for":[31],"energy":[32],"metabolism.":[33],"However,":[34,231],"uptake":[36,57,101,151,171,197,224,245],"is":[37,226,246],"decreased":[38],"the":[40,63,70,83,147,217,251,255,272],"late":[41],"stages":[42],"of":[43,65,72,82,87,149,157,181,205,250,254],"when":[45,125],"dilatation":[47],"present.":[51],"We":[52],"hypothesized":[53],"that":[54,263],"impaired":[55],"would":[58],"be":[59,267],"evident":[60],"early":[61],"progression":[64,273],"associated":[68],"with":[69,188,190,233],"onset":[71],"dilatation.":[74],"METHODS":[75],"AND":[76],"RESULTS:":[77],"Ten-day-old":[78],"rabbits":[79,124],"underwent":[80],"banding":[81],"descending":[84],"aorta.":[85],"Development":[86],"was":[89,115,152,198,216],"followed":[90],"by":[91,105,130,137],"transthoracic":[92],"echocardiography":[93],"to":[94,113,274],"measure":[95],"left":[96],"M/V":[98,126,167,193],"ratio.":[99],"Glucose":[100,212,223],"rate,":[102],"as":[103],"determined":[104],"(31)P-nuclear":[106],"magnetic":[107],"resonance":[108],"spectroscopy":[109],"measuring":[110],"2-deoxyglucose":[111],"conversion":[112],"2-deoxyglucose-6-phosphate,":[114],"measured":[116],"isolated":[118],"perfused":[119],"hearts":[120,189,257],"obtained":[121],"from":[122,132,139],"banded":[123],"had":[128],"15%":[131,166],"baseline":[133,140],"(compensated":[134],"hypertrophy)":[135],"30%":[138,191],"(early-decompensated":[141],"hypertrophy).":[142],"In":[143],"age-matched":[144],"control":[145,175],"animals,":[146],"rate":[148,172,225],"0.61+/-0.08":[153],"micromol":[154,178,202],"x":[155,160,179,184,203,208],"g":[156,180,204],"wet":[158,182,206],"weight(-1)":[159,183,207],"30":[161,185,209],"min(-1)":[162],"(mean+/-SEM).":[163],"With":[164],"a":[165,268],"increase,":[169],"remained":[173],"at":[174],"levels":[176],"(0.6+/-0.05":[177],"min(-1)),":[186],"compared":[187],"ratios,":[194],"where":[195],"significantly":[199,247],"lower":[200],"(0.42+/-0.05":[201],"min(-1);":[210],"P</=0.05).":[211],"transporter":[213,241],"protein":[214,242],"expression":[215],"same":[218],"all":[220],"groups.":[221],"CONCLUSIONS:":[222],"maintained":[227],"during":[228],"compensated":[229],"hypertrophy.":[230],"coinciding":[232],"severe":[234],"hypertrophy,":[235],"preceding":[236],"dilatation,":[238],"downregulation,":[243],"decreased.":[248],"Because":[249],"hypertrophied":[256],"use,":[260],"we":[261],"speculate":[262],"this":[264],"impairment":[265],"may":[266],"contributing":[269],"factor":[270],"failure.":[275]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}