{"id":"https://openalex.org/W2087963974","doi":"https://doi.org/10.1002/ijc.11379","title":"Granulocyte/macrophage\u2010colony stimulating factor and interleukin\u20104 expand and activate type\u20101 dendritic cells (DC1) when administered in vivo to cancer patients","display_name":"Granulocyte/macrophage\u2010colony stimulating factor and interleukin\u20104 expand and activate type\u20101 dendritic cells (DC1) when administered in vivo to cancer patients","publication_year":2003,"publication_date":"2003-08-06","ids":{"openalex":"https://openalex.org/W2087963974","doi":"https://doi.org/10.1002/ijc.11379","mag":"2087963974","pmid":"https://pubmed.ncbi.nlm.nih.gov/12949803"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.11379","doi":"https://doi.org/10.1002/ijc.11379","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.11379","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.11379","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.11379","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048933993","display_name":"Sylvia M. Kiertscher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sylvia M. Kiertscher","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1690, USA. skiertscher@mednet.ucla.edu","Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA, USA","Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1690, USA. skiertscher@mednet.ucla.edu","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044795397","display_name":"Barbara Jennifer Gitlitz","orcid":"https://orcid.org/0009-0001-0107-3135","observed_orcids":["https://orcid.org/0009-0001-0107-3135"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara J. Gitlitz","raw_affiliation_strings":["Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, CA, USA","Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050649350","display_name":"Robert A. Figlin","orcid":"https://orcid.org/0000-0002-6323-6075","observed_orcids":["https://orcid.org/0000-0002-6323-6075"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Figlin","raw_affiliation_strings":["Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, CA, USA","Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006314383","display_name":"Michael D. Roth","orcid":"https://orcid.org/0000-0003-2194-6578","observed_orcids":["https://orcid.org/0000-0003-2194-6578"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Roth","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048933993"],"corresponding_institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":0.974,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.74247628,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"107","issue":"2","first_page":"256","last_page":"261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.8859999775886536},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":1.0},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.7310000061988831},{"id":"https://openalex.org/keywords/dendritic-cell-precursors","display_name":"dendritic cell precursors","score":0.8809999823570251},{"id":"https://openalex.org/keywords/th1-response","display_name":"Th1 response","score":0.6069999933242798},{"id":"https://openalex.org/keywords/th2-response","display_name":"Th2 immune response","score":0.968999981880188},{"id":"https://openalex.org/keywords/hla-dr","display_name":"HLA-DR","score":0.7630000114440918},{"id":"https://openalex.org/keywords/cd11c","display_name":"CD11c","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cd123","display_name":"CD123","score":0.8640000224113464},{"id":"https://openalex.org/keywords/mixed-lymphocyte-reaction","display_name":"mixed lymphocyte reaction","score":0.6919999718666077},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8360000252723694},{"id":"https://openalex.org/keywords/metastatic-cancer","display_name":"metastatic cancer","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cytokine-therapy","display_name":"cytokine therapy","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C2777478134","wikidata":"https://www.wikidata.org/wiki/Q423660","display_name":"Granulocyte macrophage colony-stimulating factor","level":3,"score":0.6080741882324219},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5640029907226562},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5432636737823486},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.521704375743866},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5191394686698914},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4835076630115509},{"id":"https://openalex.org/C880424","wikidata":"https://www.wikidata.org/wiki/Q416030","display_name":"Colony-stimulating factor","level":4,"score":0.4827822744846344},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4789370000362396},{"id":"https://openalex.org/C2779919695","wikidata":"https://www.wikidata.org/wiki/Q4201963","display_name":"CD11c","level":4,"score":0.4194737672805786},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3364015519618988},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3300221264362335},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.30548807978630066},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.2439548671245575},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.12416061758995056},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11520138382911682},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0903560221195221},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009360","descriptor_name":"Neoplastic Cells, Circulating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.11379","doi":"https://doi.org/10.1002/ijc.11379","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.11379","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.11379","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:12949803","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12949803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1002/ijc.11379","doi":"https://doi.org/10.1002/ijc.11379","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.11379","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.11379","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G6049791153","display_name":"IN VIVO GENERATED DENDRITIC CELL BASED IMMUNOTHERAPY","funder_award_id":"5k23rr016361-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7109068497","display_name":null,"funder_award_id":"K23-RR16361-01","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2087963974.pdf"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W181906590","https://openalex.org/W1486301687","https://openalex.org/W1503066288","https://openalex.org/W1503844819","https://openalex.org/W1550301398","https://openalex.org/W1552227471","https://openalex.org/W1558372199","https://openalex.org/W1571546772","https://openalex.org/W1585754595","https://openalex.org/W1858218633","https://openalex.org/W1948375327","https://openalex.org/W1982636859","https://openalex.org/W1983268059","https://openalex.org/W2003269304","https://openalex.org/W2003402522","https://openalex.org/W2012148175","https://openalex.org/W2028092080","https://openalex.org/W2029528862","https://openalex.org/W2045985250","https://openalex.org/W2059059131","https://openalex.org/W2078450673","https://openalex.org/W2097738077","https://openalex.org/W2103748070","https://openalex.org/W2104904748","https://openalex.org/W2107954314","https://openalex.org/W2110101961","https://openalex.org/W2115674896","https://openalex.org/W2116716017","https://openalex.org/W2124376809","https://openalex.org/W2127803059","https://openalex.org/W2131761283","https://openalex.org/W2142721824","https://openalex.org/W2152467957","https://openalex.org/W2156467383","https://openalex.org/W2156564635","https://openalex.org/W2157278565","https://openalex.org/W2161503027","https://openalex.org/W2166876123","https://openalex.org/W2168048025","https://openalex.org/W2169539795","https://openalex.org/W2170933182","https://openalex.org/W2171807963","https://openalex.org/W2180137130"],"related_works":["https://openalex.org/W2097738077","https://openalex.org/W2321022755","https://openalex.org/W2003402522","https://openalex.org/W1969639414","https://openalex.org/W2418250453","https://openalex.org/W2079664601","https://openalex.org/W2098844082","https://openalex.org/W2004644095","https://openalex.org/W2417392431","https://openalex.org/W2020152683"],"abstract_inverted_index":{"Two":[0],"rare":[1],"populations":[2],"of":[3,8,29,51,66,117,143,157,168,188],"cells":[4,23,38],"with":[5,72,78,204],"the":[6,62,94,154,175,196],"features":[7],"dendritic":[9],"cell":[10],"precursors":[11,129],"(preDC)":[12],"can":[13],"be":[14],"identified":[15,130],"in":[16,69,103,110,113,132,172,199,220],"human":[17],"peripheral":[18,155],"blood.":[19],"PreDC1":[20],"are":[21,36],"HLA-DR+/CD11c+":[22],"which":[24,211],"mature":[25],"into":[26,45],"DC1":[27,68,128,151],"capable":[28],"stimulating":[30],"Th1":[31],"responses.":[32],"In":[33],"contrast,":[34],"preDC2":[35,104],"HLA-DR+/CD11c-/CD123+":[37],"that":[39,49,167,185],"promote":[40],"Th2":[41],"responses":[42],"when":[43],"matured":[44],"DC2.":[46],"We":[47,183],"hypothesized":[48],"administration":[50,92,187],"GM-CSF":[52,79,180,189,213],"and":[53,64,82,139,146,181,190,194,214],"IL-4,":[54],"growth":[55],"factors":[56],"for":[57,88],"DC1,":[58],"would":[59],"specifically":[60],"augment":[61],"number":[63],"function":[65],"circulating":[67,118],"vivo.":[70,200,221],"Patients":[71],"advanced":[73],"metastatic":[74],"cancer":[75],"were":[76,135],"treated":[77],"(2.5":[80],"microg/kg/day)":[81,87],"IL-4":[83,96,191,215],"(4":[84],"or":[85],"6":[86],"7":[89],"days.":[90],"Cytokine":[91],"at":[93],"highest":[95],"dose":[97],"produced":[98],"an":[99,114],"average":[100],"2.3-fold":[101],"increase":[102,109],"number,":[105],"but":[106],"a":[107,208],"6.5-fold":[108],"preDC1,":[111],"resulting":[112],"increased":[115],"ratio":[116],"preDC1:preDC2":[119],"from":[120,153,174],"1.4:1":[121],"pre-treatment":[122,149,177],"to":[123,166],"4.3:1":[124],"after":[125,131],"cytokine":[126],"therapy.":[127],"vivo":[133],"therapy":[134,161],"larger,":[136],"more":[137],"complex":[138],"expressed":[140],"higher":[141],"levels":[142],"HLA-DR,":[144],"CD11c":[145],"CD80":[147],"than":[148],"cells.":[150],"isolated":[152],"blood":[156,178],"patients":[158],"receiving":[159],"GM-CSF/IL-4":[160],"demonstrated":[162],"MLR":[163],"activity":[164],"comparable":[165],"monocyte-derived":[169],"DC":[170],"generated":[171],"vitro":[173],"patients'":[176],"using":[179],"IL-4.":[182],"conclude":[184],"systemic":[186,212],"preferentially":[192],"expands":[193],"matures":[195],"preDC1":[197],"population":[198],"These":[201],"effects":[202],"correlate":[203],"antigen-presenting":[205],"activity,":[206],"providing":[207],"mechanism":[209],"by":[210],"might":[216],"stimulate":[217],"anti-tumor":[218],"immunity":[219]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}