{"id":"https://openalex.org/W2087948992","doi":"https://doi.org/10.1111/j.0022-202x.2004.23231.x","title":"17\u03b2-Estradiol Enhances the Production of Granulocyte-Macrophage Colony-Stimulating Factor in Human Keratinocytes","display_name":"17\u03b2-Estradiol Enhances the Production of Granulocyte-Macrophage Colony-Stimulating Factor in Human Keratinocytes","publication_year":2004,"publication_date":"2004-07-09","ids":{"openalex":"https://openalex.org/W2087948992","doi":"https://doi.org/10.1111/j.0022-202x.2004.23231.x","mag":"2087948992","pmid":"https://pubmed.ncbi.nlm.nih.gov/15245433"},"language":"en","primary_location":{"id":"doi:10.1111/j.0022-202x.2004.23231.x","doi":"https://doi.org/10.1111/j.0022-202x.2004.23231.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.0022-202x.2004.23231.x","pdf_url":"http://www.jidonline.org/article/S0022202X15309258/pdf","source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jidonline.org/article/S0022202X15309258/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015522451","display_name":"Naoko Kanda","orcid":"https://orcid.org/0000-0003-4389-2312","observed_orcids":["https://orcid.org/0000-0003-4389-2312"]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Naoko Kanda","raw_affiliation_strings":["Department of Dermatology, Teikyo University, School of Medicine, Kaga, Itabashi-Ku, Tokyo, Japan. nmk@med.teikyo-u.ac.jp","Department of Dermatology, Teikyo University, School of Medicine, Kaga, Itabashi-Ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Teikyo University, School of Medicine, Kaga, Itabashi-Ku, Tokyo, Japan. nmk@med.teikyo-u.ac.jp","institution_ids":["https://openalex.org/I87531838"]},{"raw_affiliation_string":"Department of Dermatology, Teikyo University, School of Medicine, Kaga, Itabashi-Ku, Tokyo, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100747348","display_name":"Shinichi Watanabe","orcid":"https://orcid.org/0000-0001-8216-9237","observed_orcids":["https://orcid.org/0000-0001-8216-9237"]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinichi Watanabe","raw_affiliation_strings":["Department of Dermatology, Teikyo University, School of Medicine, Kaga, Itabashi-Ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Teikyo University, School of Medicine, Kaga, Itabashi-Ku, Tokyo, Japan","institution_ids":["https://openalex.org/I87531838"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015522451"],"corresponding_institution_ids":["https://openalex.org/I87531838"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":1.2532,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.73543016,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"123","issue":"2","first_page":"329","last_page":"337"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.227400004863739,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.968999981880188},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9850000143051147},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9649999737739563},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7450000047683716},{"id":"https://openalex.org/keywords/estrogen-signaling","display_name":"estrogen signaling","score":0.843999981880188},{"id":"https://openalex.org/keywords/ap-1-transcription-factor","display_name":"AP-1 transcription factor","score":0.9350000023841858},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.8389999866485596},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.8069999814033508},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.7149999737739563},{"id":"https://openalex.org/keywords/mek-erk-signaling","display_name":"MEK/ERK signaling","score":0.7910000085830688},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.9129999876022339},{"id":"https://openalex.org/keywords/inositol-1-4-5-trisphosphate","display_name":"inositol 1,4,5-trisphosphate","score":0.9150000214576721},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6008220911026001},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.586819052696228},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5380781292915344},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.4557090401649475},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.42270174622535706},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3835335373878479}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016755","descriptor_name":"Proto-Oncogene Proteins c-jun","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016760","descriptor_name":"Proto-Oncogene Proteins c-fos","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051571","descriptor_name":"Protein Kinase C-alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.0022-202x.2004.23231.x","doi":"https://doi.org/10.1111/j.0022-202x.2004.23231.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.0022-202x.2004.23231.x","pdf_url":"http://www.jidonline.org/article/S0022202X15309258/pdf","source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},{"id":"pmid:15245433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15245433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of investigative dermatology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.0022-202x.2004.23231.x","doi":"https://doi.org/10.1111/j.0022-202x.2004.23231.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.0022-202x.2004.23231.x","pdf_url":"http://www.jidonline.org/article/S0022202X15309258/pdf","source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2087948992.pdf","grobid_xml":"https://content.openalex.org/works/W2087948992.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W64697629","https://openalex.org/W101870996","https://openalex.org/W195679876","https://openalex.org/W1519060218","https://openalex.org/W1651302448","https://openalex.org/W1662062786","https://openalex.org/W1673414420","https://openalex.org/W1730632510","https://openalex.org/W1758789982","https://openalex.org/W1963875990","https://openalex.org/W1965704185","https://openalex.org/W1966736624","https://openalex.org/W1966959415","https://openalex.org/W1974601413","https://openalex.org/W1975548084","https://openalex.org/W1980812648","https://openalex.org/W1985592723","https://openalex.org/W1985941840","https://openalex.org/W1987530944","https://openalex.org/W1990321113","https://openalex.org/W1990404489","https://openalex.org/W1995720047","https://openalex.org/W1995884552","https://openalex.org/W1996188229","https://openalex.org/W2000082154","https://openalex.org/W2005766913","https://openalex.org/W2021451131","https://openalex.org/W2030147852","https://openalex.org/W2032666845","https://openalex.org/W2033607304","https://openalex.org/W2037790468","https://openalex.org/W2038459913","https://openalex.org/W2040777809","https://openalex.org/W2043074327","https://openalex.org/W2046983914","https://openalex.org/W2051596977","https://openalex.org/W2056837489","https://openalex.org/W2059183932","https://openalex.org/W2060006903","https://openalex.org/W2060903877","https://openalex.org/W2065060491","https://openalex.org/W2067642579","https://openalex.org/W2072705742","https://openalex.org/W2080532845","https://openalex.org/W2082619937","https://openalex.org/W2087161138","https://openalex.org/W2089041157","https://openalex.org/W2090023666","https://openalex.org/W2098236847","https://openalex.org/W2098719212","https://openalex.org/W2103588834","https://openalex.org/W2104462420","https://openalex.org/W2106214793","https://openalex.org/W2109283410","https://openalex.org/W2109785551","https://openalex.org/W2121158501","https://openalex.org/W2126440278","https://openalex.org/W2126923765","https://openalex.org/W2132762158","https://openalex.org/W2134674714","https://openalex.org/W2137889099","https://openalex.org/W2148013529","https://openalex.org/W2148188193","https://openalex.org/W2155744736","https://openalex.org/W2159418899","https://openalex.org/W2160582900","https://openalex.org/W2162935886","https://openalex.org/W2411489956","https://openalex.org/W2471472906","https://openalex.org/W6641179007","https://openalex.org/W6672400740"],"related_works":["https://openalex.org/W2037945516","https://openalex.org/W2065060491","https://openalex.org/W7144952947","https://openalex.org/W2089041157","https://openalex.org/W1990321113","https://openalex.org/W4245131309","https://openalex.org/W2121497709","https://openalex.org/W1487590794","https://openalex.org/W2005025499","https://openalex.org/W2109785551"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}