{"id":"https://openalex.org/W2087945271","doi":"https://doi.org/10.1016/j.cub.2009.08.016","title":"Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain","display_name":"Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain","publication_year":2009,"publication_date":"2009-09-11","ids":{"openalex":"https://openalex.org/W2087945271","doi":"https://doi.org/10.1016/j.cub.2009.08.016","mag":"2087945271","pmid":"https://pubmed.ncbi.nlm.nih.gov/19747824"},"language":"en","primary_location":{"id":"doi:10.1016/j.cub.2009.08.016","doi":"https://doi.org/10.1016/j.cub.2009.08.016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2009.08.016","pdf_url":"http://www.cell.com/article/S0960982209015863/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0960982209015863/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078450407","display_name":"Jeffrey M. Copeland","orcid":"https://orcid.org/0000-0001-5432-3524","observed_orcids":["https://orcid.org/0000-0001-5432-3524"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey M. Copeland","raw_affiliation_strings":["Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA. davidwalker@ucla.edu","Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA. davidwalker@ucla.edu","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101946202","display_name":"Jaehyoung Cho","orcid":"https://orcid.org/0000-0002-6534-116X","observed_orcids":["https://orcid.org/0000-0002-6534-116X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaehyoung Cho","raw_affiliation_strings":["Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069979181","display_name":"Thomas Lo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Lo","raw_affiliation_strings":["Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029734171","display_name":"Jae H. Hur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jae H. Hur","raw_affiliation_strings":["Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073592036","display_name":"Sepehr Bahadorani","orcid":"https://orcid.org/0000-0003-2287-1432","observed_orcids":["https://orcid.org/0000-0003-2287-1432"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sepehr Bahadorani","raw_affiliation_strings":["Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063827464","display_name":"Tagui Arabyan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tagui Arabyan","raw_affiliation_strings":["Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016674692","display_name":"Jason Rabie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Rabie","raw_affiliation_strings":["Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jennifer Soh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Soh","raw_affiliation_strings":["Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020966831","display_name":"David W. Walker","orcid":"https://orcid.org/0000-0002-9422-2178","observed_orcids":["https://orcid.org/0000-0002-9422-2178"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David W. Walker","raw_affiliation_strings":["Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020966831"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":6.865,"has_fulltext":false,"cited_by_count":419,"citation_normalized_percentile":{"value":0.98190955,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"19","issue":"19","first_page":"1591","last_page":"1598"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.8820000290870667},{"id":"https://openalex.org/keywords/lifespan-extension","display_name":"lifespan extension","score":0.8119999766349792},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7559999823570251},{"id":"https://openalex.org/keywords/mitochondrial-electron-transport-chain","display_name":"mitochondrial electron transport chain","score":0.8640000224113464},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.7630000114440918},{"id":"https://openalex.org/keywords/respiratory-chain-complexes","display_name":"respiratory chain complexes","score":0.7440000176429749},{"id":"https://openalex.org/keywords/complex-i","display_name":"complex I","score":0.7839999794960022},{"id":"https://openalex.org/keywords/cytochrome-bc1-complex","display_name":"cytochrome bc1 complex","score":0.593999981880188},{"id":"https://openalex.org/keywords/cytochrome-c-oxidase","display_name":"cytochrome c oxidase","score":0.9860000014305115},{"id":"https://openalex.org/keywords/atp-synthase","display_name":"ATP synthase","score":0.996999979019165},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.47699999809265137},{"id":"https://openalex.org/keywords/paraquat-resistance","display_name":"paraquat resistance","score":0.6869999766349792},{"id":"https://openalex.org/keywords/fertility","display_name":"fertility","score":0.7229999899864197},{"id":"https://openalex.org/keywords/energy-production","display_name":"energy production","score":0.41499999165534973},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.4020000100135803}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9575587511062622},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.718267560005188},{"id":"https://openalex.org/C2988516024","wikidata":"https://www.wikidata.org/wiki/Q441195","display_name":"Life span","level":2,"score":0.5553144216537476},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.522031307220459},{"id":"https://openalex.org/C3020377403","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Respiratory chain","level":3,"score":0.5168212056159973},{"id":"https://openalex.org/C2778029271","wikidata":"https://www.wikidata.org/wiki/Q5421931","display_name":"Extension (predicate logic)","level":2,"score":0.5016605854034424},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.45813846588134766},{"id":"https://openalex.org/C3020761558","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Mitochondrial respiratory chain","level":3,"score":0.4535475969314575},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.42042461037635803},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.4185425639152527},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3868136703968048},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34755271673202515},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.33866214752197266},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.1777389645576477},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1676928997039795},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045222","descriptor_name":"Electron Transport Chain Complex Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045222","descriptor_name":"Electron Transport Chain Complex Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cub.2009.08.016","doi":"https://doi.org/10.1016/j.cub.2009.08.016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2009.08.016","pdf_url":"http://www.cell.com/article/S0960982209015863/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},{"id":"pmid:19747824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19747824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current biology : CB","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.cub.2009.08.016","doi":"https://doi.org/10.1016/j.cub.2009.08.016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2009.08.016","pdf_url":"http://www.cell.com/article/S0960982209015863/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306135","display_name":"Ellison Medical Foundation","ror":"https://ror.org/01pqy3846"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2087945271.pdf"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1276475939","https://openalex.org/W1488265246","https://openalex.org/W1548851567","https://openalex.org/W1879890282","https://openalex.org/W1991210531","https://openalex.org/W2035678345","https://openalex.org/W2048967691","https://openalex.org/W2053133117","https://openalex.org/W2054950766","https://openalex.org/W2055486023","https://openalex.org/W2055893161","https://openalex.org/W2056388945","https://openalex.org/W2056558785","https://openalex.org/W2063014525","https://openalex.org/W2065646103","https://openalex.org/W2066027084","https://openalex.org/W2066541482","https://openalex.org/W2072712477","https://openalex.org/W2079167667","https://openalex.org/W2086324577","https://openalex.org/W2090373595","https://openalex.org/W2104431515","https://openalex.org/W2108244474","https://openalex.org/W2110643873","https://openalex.org/W2120317882","https://openalex.org/W2121966499","https://openalex.org/W2122267356","https://openalex.org/W2130605000","https://openalex.org/W2130906350","https://openalex.org/W2142353558","https://openalex.org/W2150972545","https://openalex.org/W2155265427"],"related_works":["https://openalex.org/W2156211385","https://openalex.org/W2080346572","https://openalex.org/W7101191121","https://openalex.org/W2053133117","https://openalex.org/W2008332742","https://openalex.org/W2913856667","https://openalex.org/W2155265427","https://openalex.org/W183700014","https://openalex.org/W2050229842","https://openalex.org/W2767476039"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":22},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":30},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":35},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":31},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":42},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":24}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
