{"id":"https://openalex.org/W2087906992","doi":"https://doi.org/10.1210/en.2011-1273","title":"Proprotein Convertase 5/6 Is Critical for Embryo Implantation in Women: Regulating Receptivity by Cleaving EBP50, Modulating Ezrin Binding, and Membrane-Cytoskeletal Interactions","display_name":"Proprotein Convertase 5/6 Is Critical for Embryo Implantation in Women: Regulating Receptivity by Cleaving EBP50, Modulating Ezrin Binding, and Membrane-Cytoskeletal Interactions","publication_year":2011,"publication_date":"2011-10-04","ids":{"openalex":"https://openalex.org/W2087906992","doi":"https://doi.org/10.1210/en.2011-1273","mag":"2087906992","pmid":"https://pubmed.ncbi.nlm.nih.gov/21971156"},"language":"en","primary_location":{"id":"doi:10.1210/en.2011-1273","doi":"https://doi.org/10.1210/en.2011-1273","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.2011-1273","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3266359","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001059672","display_name":"Sophea Heng","orcid":"https://orcid.org/0000-0001-9570-8746","observed_orcids":["https://orcid.org/0000-0001-9570-8746"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]},{"id":"https://openalex.org/I60733029","display_name":"Monash Institute of Medical Research","ror":"https://ror.org/05p96ba03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802600346","https://openalex.org/I60733029"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sophea Heng","raw_affiliation_strings":["Prince Henry's Institute of Medical Research (S.H., A.N.S., Y.L., J.Z., S.P., A.R., H.S., L.S., G.N.), Monash University, Clayton, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince Henry's Institute of Medical Research (S.H., A.N.S., Y.L., J.Z., S.P., A.R., H.S., L.S., G.N.), Monash University, Clayton, Victoria 3168, Australia","institution_ids":["https://openalex.org/I56590836","https://openalex.org/I60733029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034659728","display_name":"Ana Cerver\u00f3","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]},{"id":"https://openalex.org/I4210099458","display_name":"Valencian Infertility Institute","ror":"https://ror.org/00gs35582","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210099458"]},{"id":"https://openalex.org/I4405277315","display_name":"Fundaci\u00f3n IVI","ror":"https://ror.org/0288f4f61","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4405277315"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Cervero","raw_affiliation_strings":["Fundaci\u00f3n IVI (A.C., C.S., A.Q.), Instituto Universitario IVI, Universidad de Valencia, 46015 Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundaci\u00f3n IVI (A.C., C.S., A.Q.), Instituto Universitario IVI, Universidad de Valencia, 46015 Valencia, Spain","institution_ids":["https://openalex.org/I16097986","https://openalex.org/I4210099458","https://openalex.org/I4405277315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090345459","display_name":"Carlos Sim\u00f3n","orcid":"https://orcid.org/0000-0003-0902-9531","observed_orcids":["https://orcid.org/0000-0003-0902-9531"]},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]},{"id":"https://openalex.org/I4210099458","display_name":"Valencian Infertility Institute","ror":"https://ror.org/00gs35582","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210099458"]},{"id":"https://openalex.org/I4405277315","display_name":"Fundaci\u00f3n IVI","ror":"https://ror.org/0288f4f61","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4405277315"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Simon","raw_affiliation_strings":["Fundaci\u00f3n IVI (A.C., C.S., A.Q.), Instituto Universitario IVI, Universidad de Valencia, 46015 Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundaci\u00f3n IVI (A.C., C.S., A.Q.), Instituto Universitario IVI, Universidad de Valencia, 46015 Valencia, Spain","institution_ids":["https://openalex.org/I16097986","https://openalex.org/I4210099458","https://openalex.org/I4405277315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111759385","display_name":"Andrew N. Stephens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]},{"id":"https://openalex.org/I60733029","display_name":"Monash Institute of Medical Research","ror":"https://ror.org/05p96ba03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802600346","https://openalex.org/I60733029"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andrew N. Stephens","raw_affiliation_strings":["Prince Henry's Institute of Medical Research (S.H., A.N.S., Y.L., J.Z., S.P., A.R., H.S., L.S., G.N.), Monash University, Clayton, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince Henry's Institute of Medical Research (S.H., A.N.S., Y.L., J.Z., S.P., A.R., H.S., L.S., G.N.), Monash University, Clayton, Victoria 3168, Australia","institution_ids":["https://openalex.org/I56590836","https://openalex.org/I60733029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100462701","display_name":"Ying Li","orcid":"https://orcid.org/0000-0002-6050-6869","observed_orcids":["https://orcid.org/0000-0002-6050-6869","https://orcid.org/0009-0009-8767-1678"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]},{"id":"https://openalex.org/I60733029","display_name":"Monash Institute of Medical Research","ror":"https://ror.org/05p96ba03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802600346","https://openalex.org/I60733029"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ying Li","raw_affiliation_strings":["Prince Henry's Institute of Medical Research (S.H., A.N.S., Y.L., J.Z., S.P., A.R., H.S., L.S., G.N.), Monash University, Clayton, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince Henry's Institute of Medical Research (S.H., A.N.S., Y.L., J.Z., S.P., A.R., H.S., L.S., G.N.), Monash University, Clayton, Victoria 3168, Australia","institution_ids":["https://openalex.org/I56590836","https://openalex.org/I60733029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100405896","display_name":"Jin Chi Zhang","orcid":"https://orcid.org/0000-0001-5416-0964","observed_orcids":["https://orcid.org/0000-0001-5416-0964"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]},{"id":"https://openalex.org/I60733029","display_name":"Monash Institute of Medical Research","ror":"https://ror.org/05p96ba03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802600346","https://openalex.org/I60733029"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jin Zhang","raw_affiliation_strings":["Prince Henry's Institute of Medical Research (S.H., A.N.S., Y.L., J.Z., S.P., A.R., H.S., L.S., G.N.), Monash University, Clayton, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince Henry's Institute of Medical Research (S.H., A.N.S., Y.L., J.Z., S.P., A.R., H.S., L.S., G.N.), Monash University, Clayton, Victoria 3168, Australia","institution_ids":["https://openalex.org/I56590836","https://openalex.org/I60733029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103573390","display_name":"Sarah G. Paule","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]},{"id":"https://openalex.org/I60733029","display_name":"Monash Institute of Medical Research","ror":"https://ror.org/05p96ba03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802600346","https://openalex.org/I60733029"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sarah Paule","raw_affiliation_strings":["Prince Henry's Institute of Medical Research (S.H., A.N.S., Y.L., J.Z., S.P., A.R., H.S., L.S., G.N.), Monash University, Clayton, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince Henry's Institute of Medical Research (S.H., A.N.S., Y.L., J.Z., S.P., A.R., H.S., L.S., G.N.), Monash University, Clayton, Victoria 3168, Australia","institution_ids":["https://openalex.org/I56590836","https://openalex.org/I60733029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076798321","display_name":"Adam Rainczuk","orcid":"https://orcid.org/0000-0002-0813-1107","observed_orcids":["https://orcid.org/0000-0002-0813-1107"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]},{"id":"https://openalex.org/I60733029","display_name":"Monash Institute of Medical Research","ror":"https://ror.org/05p96ba03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802600346","https://openalex.org/I60733029"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Adam Rainczuk","raw_affiliation_strings":["Prince Henry's Institute of Medical Research (S.H., A.N.S., Y.L., J.Z., S.P., A.R., H.S., L.S., G.N.), Monash University, Clayton, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince Henry's Institute of Medical Research (S.H., A.N.S., Y.L., J.Z., S.P., A.R., H.S., L.S., G.N.), Monash University, Clayton, Victoria 3168, Australia","institution_ids":["https://openalex.org/I56590836","https://openalex.org/I60733029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000414353","display_name":"Harmeet Singh","orcid":"https://orcid.org/0000-0002-1989-9066","observed_orcids":["https://orcid.org/0000-0002-1989-9066"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]},{"id":"https://openalex.org/I60733029","display_name":"Monash Institute of Medical Research","ror":"https://ror.org/05p96ba03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802600346","https://openalex.org/I60733029"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Harmeet Singh","raw_affiliation_strings":["Prince Henry's Institute of Medical Research (S.H., A.N.S., Y.L., J.Z., S.P., A.R., H.S., L.S., G.N.), Monash University, Clayton, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince Henry's Institute of Medical Research (S.H., A.N.S., Y.L., J.Z., S.P., A.R., H.S., L.S., G.N.), Monash University, Clayton, Victoria 3168, Australia","institution_ids":["https://openalex.org/I56590836","https://openalex.org/I60733029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059778233","display_name":"Alicia Qui\u00f1onero","orcid":"https://orcid.org/0009-0000-7286-5757","observed_orcids":["https://orcid.org/0009-0000-7286-5757"]},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]},{"id":"https://openalex.org/I4210099458","display_name":"Valencian Infertility Institute","ror":"https://ror.org/00gs35582","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210099458"]},{"id":"https://openalex.org/I4405277315","display_name":"Fundaci\u00f3n IVI","ror":"https://ror.org/0288f4f61","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4405277315"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alicia Quinonero","raw_affiliation_strings":["Fundaci\u00f3n IVI (A.C., C.S., A.Q.), Instituto Universitario IVI, Universidad de Valencia, 46015 Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundaci\u00f3n IVI (A.C., C.S., A.Q.), Instituto Universitario IVI, Universidad de Valencia, 46015 Valencia, Spain","institution_ids":["https://openalex.org/I16097986","https://openalex.org/I4210099458","https://openalex.org/I4405277315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038925826","display_name":"Alejandro Tapia-Pizarro","orcid":"https://orcid.org/0000-0003-0742-8395","observed_orcids":["https://orcid.org/0000-0003-0742-8395"]},"institutions":[{"id":"https://openalex.org/I10457146","display_name":"Universidad de Santiago de Chile","ror":"https://ror.org/02ma57s91","country_code":"CL","type":"education","lineage":["https://openalex.org/I10457146"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Alejandro Tapia","raw_affiliation_strings":["Laboratorio de Inmunolog\u00eda de la Reproducci\u00f3n (A.T., L.V.), Facultad de Qu\u00edmica y Biolog\u00eda, Universidad de Santiago de Chile, Santiago 9170022, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Inmunolog\u00eda de la Reproducci\u00f3n (A.T., L.V.), Facultad de Qu\u00edmica y Biolog\u00eda, Universidad de Santiago de Chile, Santiago 9170022, Chile","institution_ids":["https://openalex.org/I10457146"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065807808","display_name":"Lu\u00eds Vel\u00e1squez","orcid":"https://orcid.org/0000-0002-9479-1792","observed_orcids":["https://orcid.org/0000-0002-9479-1792"]},"institutions":[{"id":"https://openalex.org/I10457146","display_name":"Universidad de Santiago de Chile","ror":"https://ror.org/02ma57s91","country_code":"CL","type":"education","lineage":["https://openalex.org/I10457146"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Luis Velasquez","raw_affiliation_strings":["Laboratorio de Inmunolog\u00eda de la Reproducci\u00f3n (A.T., L.V.), Facultad de Qu\u00edmica y Biolog\u00eda, Universidad de Santiago de Chile, Santiago 9170022, Chile","Medicine School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Inmunolog\u00eda de la Reproducci\u00f3n (A.T., L.V.), Facultad de Qu\u00edmica y Biolog\u00eda, Universidad de Santiago de Chile, Santiago 9170022, Chile","institution_ids":["https://openalex.org/I10457146"]},{"raw_affiliation_string":"Medicine School","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047753337","display_name":"Lois A. Salamonsen","orcid":"https://orcid.org/0000-0003-0558-7325","observed_orcids":["https://orcid.org/0000-0003-0558-7325","https://orcid.org/0000-0002-8083-9740"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]},{"id":"https://openalex.org/I60733029","display_name":"Monash Institute of Medical Research","ror":"https://ror.org/05p96ba03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802600346","https://openalex.org/I60733029"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Lois Salamonsen","raw_affiliation_strings":["Prince Henry's Institute of Medical Research (S.H., A.N.S., Y.L., J.Z., S.P., A.R., H.S., L.S., G.N.), Monash University, Clayton, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince Henry's Institute of Medical Research (S.H., A.N.S., Y.L., J.Z., S.P., A.R., H.S., L.S., G.N.), Monash University, Clayton, Victoria 3168, Australia","institution_ids":["https://openalex.org/I56590836","https://openalex.org/I60733029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044684679","display_name":"Luk J. F. Rombauts","orcid":"https://orcid.org/0000-0003-2656-2792","observed_orcids":["https://orcid.org/0000-0003-2656-2792"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Luk J. F. Rombauts","raw_affiliation_strings":["Department of Obstetrics and Gynecology (L.J.F.R.), Monash University, Clayton, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (L.J.F.R.), Monash University, Clayton, Victoria 3168, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006391071","display_name":"Guiying Nie","orcid":"https://orcid.org/0000-0001-9641-087X","observed_orcids":["https://orcid.org/0000-0001-9641-087X"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]},{"id":"https://openalex.org/I60733029","display_name":"Monash Institute of Medical Research","ror":"https://ror.org/05p96ba03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802600346","https://openalex.org/I60733029"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Guiying Nie","raw_affiliation_strings":["Prince Henry's Institute of Medical Research (S.H., A.N.S., Y.L., J.Z., S.P., A.R., H.S., L.S., G.N.), Monash University, Clayton, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince Henry's Institute of Medical Research (S.H., A.N.S., Y.L., J.Z., S.P., A.R., H.S., L.S., G.N.), Monash University, Clayton, Victoria 3168, Australia","institution_ids":["https://openalex.org/I56590836","https://openalex.org/I60733029"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5006391071"],"corresponding_institution_ids":["https://openalex.org/I56590836","https://openalex.org/I60733029"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.5786,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.81907193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"152","issue":"12","first_page":"5041","last_page":"5052"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neiguan-pc6","display_name":"Neiguan (PC6)","score":0.7279999852180481},{"id":"https://openalex.org/keywords/embryo-implantation","display_name":"embryo implantation","score":0.925000011920929},{"id":"https://openalex.org/keywords/endometrial-receptivity","display_name":"endometrial receptivity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ebp50","display_name":"EBP50","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ezrin","display_name":"ezrin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/membrane-cytoskeleton-interactions","display_name":"membrane-cytoskeleton interactions","score":0.8510000109672546},{"id":"https://openalex.org/keywords/endometrial-epithelium","display_name":"endometrial epithelium","score":0.8320000171661377},{"id":"https://openalex.org/keywords/infertility","display_name":"infertility","score":0.47999998927116394},{"id":"https://openalex.org/keywords/plasma-membrane-remodeling","display_name":"plasma membrane remodeling","score":0.6800000071525574},{"id":"https://openalex.org/keywords/cytoskeletal-rearrangement","display_name":"cytoskeletal rearrangement","score":0.5699999928474426},{"id":"https://openalex.org/keywords/blastocyst-attachment","display_name":"blastocyst attachment","score":0.6299999952316284},{"id":"https://openalex.org/keywords/proteolytic-cleavage","display_name":"proteolytic cleavage","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C2780246058","wikidata":"https://www.wikidata.org/wiki/Q18032329","display_name":"Ezrin","level":4,"score":0.7393512725830078},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7086219191551208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5815026760101318},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.5143450498580933},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.4481111466884613},{"id":"https://openalex.org/C2776292417","wikidata":"https://www.wikidata.org/wiki/Q18029442","display_name":"Moesin","level":5,"score":0.4409191906452179},{"id":"https://openalex.org/C196509110","wikidata":"https://www.wikidata.org/wiki/Q18031082","display_name":"Radixin","level":5,"score":0.43940481543540955},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.4338870644569397},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32647019624710083},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.278298556804657},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.22375434637069702},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12178662419319153},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09008443355560303}],"mesh":[{"descriptor_ui":"D000099149","descriptor_name":"Ezrin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004717","descriptor_name":"Endometrium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010064","descriptor_name":"Embryo Implantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045702","descriptor_name":"Proprotein Convertase 5","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1210/en.2011-1273","doi":"https://doi.org/10.1210/en.2011-1273","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.2011-1273","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:21971156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21971156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:americanae.aecid.es:3266359","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3266359","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ENDOCRINOLOGY","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:localhost:10533/138036","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10533/138036","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ENDOCRINOLOGY","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:3266359","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3266359","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ENDOCRINOLOGY","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1968207046","https://openalex.org/W1968859295","https://openalex.org/W1969370001","https://openalex.org/W1984338129","https://openalex.org/W1984849627","https://openalex.org/W1989886417","https://openalex.org/W1991241006","https://openalex.org/W1993866784","https://openalex.org/W2006562777","https://openalex.org/W2007039255","https://openalex.org/W2007652054","https://openalex.org/W2009730891","https://openalex.org/W2032435199","https://openalex.org/W2042015318","https://openalex.org/W2047007560","https://openalex.org/W2050063286","https://openalex.org/W2050655852","https://openalex.org/W2060700635","https://openalex.org/W2062808764","https://openalex.org/W2063444559","https://openalex.org/W2069725875","https://openalex.org/W2076430025","https://openalex.org/W2081634385","https://openalex.org/W2085226735","https://openalex.org/W2095342573","https://openalex.org/W2097350573","https://openalex.org/W2099844899","https://openalex.org/W2101723989","https://openalex.org/W2107490653","https://openalex.org/W2111642864","https://openalex.org/W2118661243","https://openalex.org/W2118976848","https://openalex.org/W2121093397","https://openalex.org/W2124101330","https://openalex.org/W2130522400","https://openalex.org/W2142415017","https://openalex.org/W2150086479","https://openalex.org/W2153653822","https://openalex.org/W2156589304","https://openalex.org/W2157223292","https://openalex.org/W2158621470","https://openalex.org/W2163842198","https://openalex.org/W2167896519","https://openalex.org/W2188536013","https://openalex.org/W2189363641","https://openalex.org/W2322561651","https://openalex.org/W2481029853","https://openalex.org/W4211232189"],"related_works":["https://openalex.org/W2056121733","https://openalex.org/W2047217323","https://openalex.org/W2134999659","https://openalex.org/W2133885587","https://openalex.org/W2025696923","https://openalex.org/W7099714404","https://openalex.org/W2150086479","https://openalex.org/W2595631239","https://openalex.org/W2059002722","https://openalex.org/W2147958605"],"abstract_inverted_index":{"Establishment":[0],"of":[1,34,50,76,94,99,119,179,218,234,246],"endometrial":[2,89,120],"receptivity":[3,15,52,81,108,180],"is":[4,40,58],"vital":[5],"for":[6],"successful":[7],"embryo":[8],"implantation;":[9],"its":[10,151],"failure":[11],"causes":[12],"infertility.":[13],"Epithelial":[14],"acquisition":[16],"involves":[17],"dramatic":[18],"structural":[19],"changes":[20],"in":[21,42,65,79,82,87,96,107,115,181,184,186,201],"the":[22,35,43,48,59,72,88,92,139,231,244],"plasma":[23,164,209],"membrane":[24,210],"and":[25,53,74,163,169,212,237,251],"cytoskeleton.":[26],"Proprotein":[27],"convertase":[28,37],"5/6":[29],"(PC6),":[30],"a":[31,112,131,198,219],"serine":[32],"protease":[33],"proprotein":[36],"(PC)":[38],"family,":[39],"up-regulated":[41],"human":[44,182],"endometrium":[45,183],"specifically":[46],"at":[47],"time":[49],"epithelial":[51,121],"stromal":[54],"cell":[55],"decidualization.":[56],"PC6":[57,77,84,124,137,177,196,216],"only":[60],"PC":[61,235,252],"member":[62],"tightly":[63],"regulated":[64],"this":[66,175],"manner.":[67],"The":[68],"current":[69,232],"study":[70],"addressed":[71],"importance":[73],"mechanisms":[75],"action":[78],"regulating":[80,202,226],"women.":[83],"was":[85,109],"dysregulated":[86],"epithelium":[90],"during":[91],"window":[93],"implantation":[95],"infertile":[97,189],"women":[98],"three":[100],"demographically":[101],"different":[102],"cohorts.":[103],"Its":[104],"critical":[105],"role":[106,200],"evidenced":[110],"by":[111,126],"significant":[113],"reduction":[114],"mouse":[116],"blastocyst":[117],"attachment":[118],"cells":[122],"after":[123],"knockdown":[125],"small":[127],"interfering":[128],"RNA.":[129],"Using":[130],"proteomic":[132],"approach,":[133],"we":[134],"discovered":[135],"that":[136,195],"cleaved":[138],"key":[140,158,199],"scaffolding":[141,221],"protein,":[142],"ezrin-radixin-moesin":[143],"binding":[144,154],"phosphoprotein":[145],"50":[146],"(EBP50),":[147],"thereby":[148,224],"profoundly":[149,225],"affecting":[150],"interaction":[152],"with":[153],"protein":[155,159,222],"ezrin":[156],"(a":[157],"bridging":[160],"actin":[161],"filaments":[162],"membrane),":[165],"EBP50/ezrin":[166],"cellular":[167,204,249],"localization,":[168],"cytoskeleton-membrane":[170],"connections.":[171],"We":[172],"further":[173],"validated":[174],"novel":[176],"regulation":[178],"vivo":[185],"fertile":[187],"vs.":[188],"patients.":[190],"These":[191],"results":[192],"strongly":[193],"indicate":[194],"plays":[197],"fundamental":[203],"remodeling":[205],"processes,":[206],"such":[207],"as":[208],"transformation":[211],"membrane-cytoskeletal":[213,227],"interface":[214],"reorganization.":[215],"cleavage":[217],"crucial":[220],"EBP50,":[223],"reorganization,":[228],"greatly":[229],"extends":[230],"knowledge":[233],"biology":[236],"provides":[238],"substantial":[239],"new":[240],"mechanistic":[241],"insight":[242],"into":[243],"fields":[245],"reproduction,":[247],"basic":[248],"biology,":[250],"biochemistry.":[253]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}