{"id":"https://openalex.org/W2087838522","doi":"https://doi.org/10.1158/1538-7445.am2012-3433","title":"Abstract 3433: Molecular regulation of RKIP, a tumor metastasis suppressor in breast cancer","display_name":"Abstract 3433: Molecular regulation of RKIP, a tumor metastasis suppressor in breast cancer","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2087838522","doi":"https://doi.org/10.1158/1538-7445.am2012-3433","mag":"2087838522"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-3433","doi":"https://doi.org/10.1158/1538-7445.am2012-3433","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-3433","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100447434","display_name":"Jiyoung Lee","orcid":"https://orcid.org/0000-0001-8503-4805","observed_orcids":["https://orcid.org/0000-0001-8503-4805"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiyoung Lee","raw_affiliation_strings":["1The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009903231","display_name":"Jieun Yun","orcid":"https://orcid.org/0000-0002-4241-4274","observed_orcids":["https://orcid.org/0000-0002-4241-4274"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jieun Yun","raw_affiliation_strings":["1The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015648467","display_name":"Kam C. Yeung","orcid":"https://orcid.org/0000-0002-1415-484X","observed_orcids":["https://orcid.org/0000-0002-1415-484X"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kam C. Yeung","raw_affiliation_strings":["2The University of Toledo, Ohio, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2The University of Toledo, Ohio, OH","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035583989","display_name":"Marsha Rich Rosner","orcid":"https://orcid.org/0000-0001-6586-8335","observed_orcids":["https://orcid.org/0000-0001-6586-8335"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marsha R. Rosner","raw_affiliation_strings":["1The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"3433","last_page":"3433"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rkip","display_name":"RKIP","score":0.9810000061988831},{"id":"https://openalex.org/keywords/metastasis-suppressor","display_name":"metastasis suppressor","score":0.8669999837875366},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8650000095367432},{"id":"https://openalex.org/keywords/bach1","display_name":"BACH1","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hmga2","display_name":"HMGA2","score":1.0},{"id":"https://openalex.org/keywords/let-7-microrna","display_name":"let-7 microRNA","score":0.8669999837875366},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.7110000252723694},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.5889999866485596},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.515999972820282},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/metastasis-biomarkers","display_name":"metastasis biomarkers","score":0.7020000219345093},{"id":"https://openalex.org/keywords/chromatin-binding","display_name":"chromatin binding","score":0.6359999775886536},{"id":"https://openalex.org/keywords/mouse-xenograft-model","display_name":"xenograft mouse model","score":0.7459999918937683},{"id":"https://openalex.org/keywords/metastasis-free-survival","display_name":"metastasis-free survival","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.799858808517456},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7199125289916992},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6059625148773193},{"id":"https://openalex.org/C2778025950","wikidata":"https://www.wikidata.org/wiki/Q6823243","display_name":"Metastasis suppressor","level":4,"score":0.5995064377784729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5755358338356018},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.563938558101654},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.49784421920776367},{"id":"https://openalex.org/C118646709","wikidata":"https://www.wikidata.org/wiki/Q1657620","display_name":"CA15-3","level":4,"score":0.4973297417163849},{"id":"https://openalex.org/C2909960190","wikidata":"https://www.wikidata.org/wiki/Q6823243","display_name":"Metastasis Suppressor Gene","level":4,"score":0.46695858240127563},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.450400710105896},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4459479749202728},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.42899248003959656},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4218537211418152},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32099151611328125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31005221605300903}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-3433","doi":"https://doi.org/10.1158/1538-7445.am2012-3433","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-3433","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4383067023","https://openalex.org/W2106435751","https://openalex.org/W2061040732","https://openalex.org/W3004509924","https://openalex.org/W2132619290","https://openalex.org/W1898564425","https://openalex.org/W3004623544","https://openalex.org/W2885863161","https://openalex.org/W2132974858","https://openalex.org/W1983784090"],"abstract_inverted_index":{"Abstract":[0],"Breast":[1],"cancer":[2,95,121,144,169,226,262,291,306],"mortality":[3],"is":[4,91,96,164,193,201],"primarily":[5],"due":[6],"to":[7,9,33,150,177,185,194,205,308],"metastasis":[8,18,21,51,179,227],"organs":[10],"including":[11,58],"bone,":[12],"lungs,":[13],"liver":[14],"and":[15,64,72,80,104,157,184,221,238,255,270,281,293],"brain.":[16],"Tumor":[17],"suppressors":[19],"are":[20,159,175,240,276,283],"inhibitors":[22],"but":[23],"do":[24],"not":[25],"affect":[26],"the":[27,30,38,147,167,196,304,338,343],"ability":[28],"of":[29,56,180,244,296,303,337,342],"transformed":[31],"cells":[32,149,183,188,292,307],"produce":[34],"a":[35,50,54,229],"tumor":[36,148,182,187],"at":[37],"primary":[39],"sites.":[40],"Raf":[41],"kinase":[42],"inhibitory":[43],"protein":[44],"(RKIP)":[45],"has":[46],"been":[47,135],"identified":[48],"as":[49,320,322],"suppressor":[52],"for":[53,189,316,325,346],"number":[55],"cancers":[57],"breast,":[59],"prostate,":[60],"liver,":[61],"colon,":[62],"skin,":[63],"nasopharyngeal":[65],"carcinoma.":[66],"RKIP":[67,89,100,115,131,163,173,200,258,298],"overexpression":[68],"in":[69,82,93,118,127,141,166,203,228,260,287],"hepatoma,":[70],"melanoma,":[71],"prostate":[73,120],"metastatic":[74,168,289,326],"cell":[75,263],"lines":[76,264],"diminished":[77],"their":[78],"invasiveness":[79],"motility":[81],"vitro.":[83],"The":[84],"molecular":[85,250],"mechanism":[86,197],"by":[87,198,252,285],"which":[88,199,253],"transcription":[90],"regulated":[92,202],"breast":[94,143,181,225,261,290,305,327],"largely":[97],"unknown.":[98],"Interestingly,":[99],"expression":[101,132,259],"was":[102,116,125],"highly":[103,288],"positively":[105],"correlated":[106],"with":[107],"patient's":[108],"metastasis-free":[109],"survival":[110],"after":[111],"radiotherapy.":[112],"Likewise,":[113],"when":[114,162],"reduced":[117,126],"human":[119,142],"cells,":[122,145],"radiation-induced":[123],"apoptosis":[124],"xenograft":[128,230],"tumors.":[129],"Moreover,":[130],"levels":[133,174],"have":[134,211,248],"induced":[136],"upon":[137],"chemotherapeutic":[138,318],"drug":[139],"treatment":[140],"sensitizing":[146],"apoptosis.":[151],"These":[152,310],"studies":[153,311],"indicate":[154],"that":[155,213,223,236],"chemotherapy":[156,286],"radiotherapy":[158],"more":[160],"effective":[161],"present":[165],"cells.":[170],"Therefore,":[171],"high":[172],"desirable":[176],"prevent":[178],"sensitize":[186],"chemotherapy.":[190,309],"Our":[191],"goal":[192],"understand":[195],"order":[204],"restore":[206],"its":[207],"levels.":[208],"Previously,":[209],"we":[210,234,247],"observed":[212],"let-7":[214],"negatively":[215],"regulates":[216],"two":[217],"target":[218],"genes,":[219],"BACH1":[220,237,254,280],"HMGA2":[222,239,256,282],"promote":[224],"mouse":[231],"model.":[232],"Here":[233],"demonstrate":[235],"themselves":[241],"negative":[242],"regulators":[243,299],"RKIP.":[245],"Specifically,":[246],"delineated":[249],"mechanisms":[251],"inhibit":[257],"using":[265],"both":[266],"luciferase":[267],"reporter":[268],"assays":[269],"chromatin":[271],"immunoprecipitation":[272],"(ChIP)":[273],"assays.":[274],"We":[275],"also":[277],"analyzing":[278],"whether":[279,294],"dysregulated":[284],"suppression":[295],"these":[297],"can":[300],"potentiate":[301],"sensitivity":[302,319],"provide":[312],"valuable":[313],"mechanistic":[314],"insights":[315],"potentiating":[317],"well":[321],"potential":[323],"biomarkers":[324],"cancer.":[328],"Citation":[329],"Format:":[330],"{Authors}.":[331],"{Abstract":[332],"title}":[333],"[abstract].":[334],"In:":[335],"Proceedings":[336],"103rd":[339],"Annual":[340],"Meeting":[341],"American":[344],"Association":[345],"Cancer":[347,358],"Research;":[348],"2012":[349],"Mar":[350],"31-Apr":[351],"4;":[352],"Chicago,":[353],"IL.":[354],"Philadelphia":[355],"(PA):":[356],"AACR;":[357],"Res":[359],"2012;72(8":[360],"Suppl):Abstract":[361],"nr":[362],"3433.":[363],"doi:1538-7445.AM2012-3433":[364]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2016-06-24T00:00:00"}
