{"id":"https://openalex.org/W2087787271","doi":"https://doi.org/10.1074/jbc.m109.058461","title":"Lipid Droplets Are Novel Sites of N-Acylethanolamine Inactivation by Fatty Acid Amide Hydrolase-2","display_name":"Lipid Droplets Are Novel Sites of N-Acylethanolamine Inactivation by Fatty Acid Amide Hydrolase-2","publication_year":2009,"publication_date":"2009-11-20","ids":{"openalex":"https://openalex.org/W2087787271","doi":"https://doi.org/10.1074/jbc.m109.058461","mag":"2087787271","pmid":"https://pubmed.ncbi.nlm.nih.gov/19926788","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2807334"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m109.058461","doi":"https://doi.org/10.1074/jbc.m109.058461","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.058461","pdf_url":"http://www.jbc.org/article/S0021925819637713/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819637713/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072968238","display_name":"Martin Kaczocha","orcid":"https://orcid.org/0000-0002-2527-1398","observed_orcids":["https://orcid.org/0000-0002-2527-1398"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Martin Kaczocha","raw_affiliation_strings":["Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794, USA. MKaczoch@notes.sunysb.edu","Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794, USA. MKaczoch@notes.sunysb.edu","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794, USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078232191","display_name":"Sherrye T. Glaser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherrye T. Glaser","raw_affiliation_strings":["Departments of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019528095","display_name":"Janiper Chae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janiper Chae","raw_affiliation_strings":["From the Departments of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034329109","display_name":"Deborah A. Brown","orcid":"https://orcid.org/0000-0002-6249-2384","observed_orcids":["https://orcid.org/0000-0002-6249-2384"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah A. Brown","raw_affiliation_strings":["From the Departments of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074856959","display_name":"Dale G. Deutsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dale G. Deutsch","raw_affiliation_strings":["From the Departments of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794","institution_ids":["https://openalex.org/I59553526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072968238"],"corresponding_institution_ids":["https://openalex.org/I59553526"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":6.7093,"has_fulltext":true,"cited_by_count":98,"citation_normalized_percentile":{"value":0.97208671,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"285","issue":"4","first_page":"2796","last_page":"2806"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.07429999858140945,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fatty-acid-amide-hydrolase","display_name":"fatty acid amide hydrolase","score":0.6399999856948853},{"id":"https://openalex.org/keywords/n-acylethanolamines","display_name":"N-acylethanolamines","score":0.8640000224113464},{"id":"https://openalex.org/keywords/anandamide","display_name":"anandamide","score":0.9929999709129333},{"id":"https://openalex.org/keywords/palmitoylethanolamide","display_name":"palmitoylethanolamide","score":0.996999979019165},{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.9670000076293945},{"id":"https://openalex.org/keywords/enzyme-localization","display_name":"enzyme localization","score":0.6940000057220459},{"id":"https://openalex.org/keywords/substrate-supply","display_name":"substrate supply","score":0.5220000147819519},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.8159999847412109},{"id":"https://openalex.org/keywords/fusion-protein","display_name":"fusion protein","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C2781144285","wikidata":"https://www.wikidata.org/wiki/Q21113274","display_name":"Fatty acid amide hydrolase","level":5,"score":0.9808701276779175},{"id":"https://openalex.org/C2779783865","wikidata":"https://www.wikidata.org/wiki/Q410228","display_name":"Anandamide","level":5,"score":0.9633908271789551},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.7783968448638916},{"id":"https://openalex.org/C2777767828","wikidata":"https://www.wikidata.org/wiki/Q2159860","display_name":"Palmitoylethanolamide","level":5,"score":0.6660065054893494},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6396865844726562},{"id":"https://openalex.org/C46721173","wikidata":"https://www.wikidata.org/wiki/Q368952","display_name":"Endocannabinoid system","level":3,"score":0.6175932288169861},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5476842522621155},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.5093585252761841},{"id":"https://openalex.org/C65588867","wikidata":"https://www.wikidata.org/wiki/Q24775735","display_name":"Amidase","level":3,"score":0.4972069561481476},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4139583110809326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34612980484962463},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.05785810947418213},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000099252","descriptor_name":"Fatty Acid Amide Hydrolases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002451","descriptor_name":"Cell Compartmentation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002458","descriptor_name":"Cell Fractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004983","descriptor_name":"Ethanolamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053284","descriptor_name":"Polyunsaturated Alkamides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063385","descriptor_name":"Cannabinoid Receptor Modulators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063388","descriptor_name":"Endocannabinoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m109.058461","doi":"https://doi.org/10.1074/jbc.m109.058461","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.058461","pdf_url":"http://www.jbc.org/article/S0021925819637713/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2032593","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2807334","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2807334","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2807334","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:19926788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19926788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m109.058461","doi":"https://doi.org/10.1074/jbc.m109.058461","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.058461","pdf_url":"http://www.jbc.org/article/S0021925819637713/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1204090660","display_name":null,"funder_award_id":"DA9374","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G1882549651","display_name":null,"funder_award_id":"DA16419","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G4390592224","display_name":"Endocannabinoid Inactivation:Plasma Membrane Uptake and Cellular Trafficking","funder_award_id":"R01DA016419","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G5175334991","display_name":"Anandamide and the Fatty Amide Hydrolase (FAAH)","funder_award_id":"R01DA009374","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2087787271.pdf","grobid_xml":"https://content.openalex.org/works/W2087787271.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1602606610","https://openalex.org/W1966673014","https://openalex.org/W1969338731","https://openalex.org/W1977869194","https://openalex.org/W1978379381","https://openalex.org/W1982196151","https://openalex.org/W1988519309","https://openalex.org/W1988800581","https://openalex.org/W1995793646","https://openalex.org/W2001601666","https://openalex.org/W2002081608","https://openalex.org/W2003594380","https://openalex.org/W2010557865","https://openalex.org/W2016087136","https://openalex.org/W2025367112","https://openalex.org/W2038225007","https://openalex.org/W2040634905","https://openalex.org/W2041562164","https://openalex.org/W2043033522","https://openalex.org/W2043644388","https://openalex.org/W2052148515","https://openalex.org/W2052329951","https://openalex.org/W2056416370","https://openalex.org/W2056827996","https://openalex.org/W2070645541","https://openalex.org/W2071244034","https://openalex.org/W2072291193","https://openalex.org/W2082493917","https://openalex.org/W2084652074","https://openalex.org/W2094612016","https://openalex.org/W2097716239","https://openalex.org/W2100867316","https://openalex.org/W2127694087","https://openalex.org/W2129968939","https://openalex.org/W2131290128","https://openalex.org/W2144387375","https://openalex.org/W2157400187","https://openalex.org/W2182085115"],"related_works":["https://openalex.org/W2160791784","https://openalex.org/W7100105727","https://openalex.org/W2047559819","https://openalex.org/W2125609930","https://openalex.org/W2111910036","https://openalex.org/W2017965801","https://openalex.org/W2012409818","https://openalex.org/W1994099277","https://openalex.org/W2086061960","https://openalex.org/W1989867219"],"abstract_inverted_index":{"Anandamide":[0],"(AEA)":[1],"and":[2,43,59,66,78,201],"other":[3],"bioactive":[4],"N-acylethanolamines":[5],"(NAEs)":[6],"are":[7],"primarily":[8],"inactivated":[9],"by":[10],"the":[11,121],"enzyme":[12,27,200],"fatty":[13],"acid":[14],"amide":[15],"hydrolase":[16],"(FAAH).":[17],"Recently,":[18],"FAAH-2":[19,42,56,75,111,127,143,194],"was":[20,112,128,140,174],"discovered":[21],"in":[22,32,50,80,98,209],"humans,":[23],"suggesting":[24],"an":[25],"additional":[26],"can":[28],"mediate":[29],"NAE":[30,96,163,188,204],"inactivation":[31,205],"higher":[33,212],"mammals.":[34,213],"Here,":[35],"we":[36,166],"performed":[37],"a":[38,91,131,196],"biochemical":[39],"characterization":[40],"of":[41,70,88,126,162,187,211],"explored":[44],"its":[45],"capacity":[46],"to":[47,105,170,177],"hydrolyze":[48],"NAEs":[49],"cells.":[51],"In":[52,73,103],"homogenate":[53],"activity":[54,144,152],"assays,":[55],"hydrolyzed":[57,76],"AEA":[58,77,173],"palmitoylethanolamide":[60],"(PEA)":[61],"with":[62,83],"activities":[63],"approximately":[64,67,85],"6":[65],"20%":[68],"those":[69,87],"FAAH,":[71,89,108],"respectively.":[72],"contrast,":[74],"PEA":[79],"intact":[81],"cells":[82,210],"rates":[84],"30-40%":[86],"highlighting":[90],"potentially":[92],"greater":[93],"contribution":[94],"toward":[95],"catabolism":[97],"vivo":[99],"than":[100],"previously":[101],"appreciated.":[102],"contrast":[104],"endoplasmic":[106],"reticulum-localized":[107],"immunofluorescence":[109],"revealed":[110],"localized":[113],"on":[114],"lipid":[115,133,149,178,182],"droplets.":[116],"Supporting":[117],"this":[118],"distribution":[119],"pattern,":[120],"putative":[122],"N-terminal":[123],"hydrophobic":[124],"region":[125],"identified":[129],"as":[130,145,195],"functional":[132,185],"droplet":[134,138],"localization":[135,139],"sequence.":[136],"Lipid":[137,157],"essential":[141],"for":[142],"chimeras":[146],"excluded":[147],"from":[148],"droplets":[150,158,183],"lacked":[151],"and/or":[153],"were":[154],"poorly":[155],"expressed.":[156],"represent":[159],"novel":[160],"sites":[161,186],"inactivation.":[164,189],"Therefore,":[165],"examined":[167],"substrate":[168],"delivery":[169],"these":[171,191],"organelles.":[172],"readily":[175],"trafficked":[176],"droplets,":[179],"confirming":[180],"that":[181,203],"constitute":[184],"Collectively,":[190],"results":[192],"establish":[193],"bone":[197],"fide":[198],"NAE-catabolizing":[199],"suggest":[202],"is":[206],"spatially":[207],"separated":[208]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
