{"id":"https://openalex.org/W2087766074","doi":"https://doi.org/10.1016/j.jalz.2010.05.513","title":"PL\u201005\u201001: A transgenic model of the earliest stage of Alzheimer's disease","display_name":"PL\u201005\u201001: A transgenic model of the earliest stage of Alzheimer's disease","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W2087766074","doi":"https://doi.org/10.1016/j.jalz.2010.05.513","mag":"2087766074"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2010.05.513","doi":"https://doi.org/10.1016/j.jalz.2010.05.513","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2010.05.513","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068688487","display_name":"Bradley T. Hyman","orcid":"https://orcid.org/0000-0002-7959-9401","observed_orcids":["https://orcid.org/0000-0002-7959-9401"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley T. Hyman","raw_affiliation_strings":["[Massachusetts General Hospital, Charlestown, MA, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[Massachusetts General Hospital, Charlestown, MA, USA]","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015800434","display_name":"Alix de Calignon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alix de Calignon","raw_affiliation_strings":["[Massachusetts General Hospital, Charlestown, MA, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[Massachusetts General Hospital, Charlestown, MA, USA]","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085734630","display_name":"Marc Su\u00e1rez\u2010Calvet","orcid":"https://orcid.org/0000-0002-2993-569X","observed_orcids":["https://orcid.org/0000-0002-2993-569X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Suarez-Calvet","raw_affiliation_strings":["[Massachusetts General Hospital, Charlestown, MA, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[Massachusetts General Hospital, Charlestown, MA, USA]","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003038799","display_name":"Christopher M. William","orcid":"https://orcid.org/0000-0001-8933-1639","observed_orcids":["https://orcid.org/0000-0001-8933-1639"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher William","raw_affiliation_strings":["[Massachusetts General Hospital, Charlestown, MA, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[Massachusetts General Hospital, Charlestown, MA, USA]","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082333535","display_name":"Rose Pitstick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160556","display_name":"McLaughlin Research Institute","ror":"https://ror.org/05j752d14","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210160556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rose Pitstick","raw_affiliation_strings":["McLaughlin Research Institute, Great Falls, MT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McLaughlin Research Institute, Great Falls, MT, USA","institution_ids":["https://openalex.org/I4210160556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109088186","display_name":"George A. Carlson","orcid":"https://orcid.org/0000-0001-9208-0148","observed_orcids":["https://orcid.org/0000-0001-9208-0148"]},"institutions":[{"id":"https://openalex.org/I4210160556","display_name":"McLaughlin Research Institute","ror":"https://ror.org/05j752d14","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210160556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George A. Carlson","raw_affiliation_strings":["McLaughlin Research Institute, Great Falls, MT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McLaughlin Research Institute, Great Falls, MT, USA","institution_ids":["https://openalex.org/I4210160556"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088747780","display_name":"Tara L. Spires\u2010Jones","orcid":"https://orcid.org/0000-0003-2530-0598","observed_orcids":["https://orcid.org/0000-0003-2530-0598"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tara L. Spires-Jones","raw_affiliation_strings":["[Massachusetts General Hospital, Charlestown, MA, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[Massachusetts General Hospital, Charlestown, MA, USA]","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21852962,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"4S_Part_5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9340000152587891},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.9319999814033508}],"concepts":[{"id":"https://openalex.org/C2780715579","wikidata":"https://www.wikidata.org/wiki/Q2603645","display_name":"Entorhinal cortex","level":3,"score":0.8947081565856934},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7121273875236511},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6030797362327576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5206669569015503},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.4655395746231079},{"id":"https://openalex.org/C2777831001","wikidata":"https://www.wikidata.org/wiki/Q1981429","display_name":"Neuropil","level":3,"score":0.43198734521865845},{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.4174136519432068},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.4138079285621643},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.4118884801864624},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.4116182327270508},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.299426794052124},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29653847217559814},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.19190484285354614},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17848095297813416},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.16658151149749756},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2010.05.513","doi":"https://doi.org/10.1016/j.jalz.2010.05.513","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2010.05.513","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2095963715","https://openalex.org/W1990556949","https://openalex.org/W2301337095","https://openalex.org/W4234244223","https://openalex.org/W2766063076","https://openalex.org/W2070081347","https://openalex.org/W3113020355","https://openalex.org/W4231079077","https://openalex.org/W2170016760","https://openalex.org/W7097707338"],"abstract_inverted_index":{"Alzheimer":[0],"disease":[1,247],"slowly":[2,200],"develops":[3],"over":[4],"decades,":[5],"with":[6,153],"initial":[7],"neuronal":[8,16,29,93,161],"abnormalities":[9],"in":[10,19,108,116,140,168,177,192,208,240,281],"terms":[11],"of":[12,22,44,53,59,76,84,120,143,211,224,269],"neurofibrillary":[13],"tangles":[14,27,159],"and":[15,28,34,67,87,95,98,160,166,180,291,294],"loss":[17,30,52,58,94,162,239],"occurring":[18],"layer":[20,141],"II":[21,142],"the":[23,38,57,77,85,89,117,121,135,154,184,209,246,250,266,274,277,288,292],"entorhinal":[24,78,122,144],"cortex.":[25,123],"Subsequently,":[26],"progress":[31],"across":[32],"limbic":[33,97,295],"association":[35,99,293],"cortices":[36],"but":[37],"molecular":[39],"mechanisms":[40],"underlying":[41],"this":[42,126,169],"process":[43],"progression":[45,248],"are":[46,63,181],"still":[47],"not":[48],"well":[49,233,284],"understood.":[50],"This":[51,257],"neurons":[54,227],"leads":[55],"to":[56,183,204,218,264],"neural":[60],"networks":[61],"that":[62,72,133,158],"critical":[64],"for":[65,91],"memory":[66],"cognitive":[68],"functions.":[69],"We":[70,102,244],"hypothesize":[71],"NFT-related":[73],"degenerative":[74],"lesion":[75],"cortex":[79,100,145],"creates":[80],"a":[81,104,130,262],"chronic":[82],"deafferentation":[83],"hippocampus":[86],"sets":[88],"stage":[90,206],"subsequent":[92],"widespread":[96],"damage.":[101],"present":[103],"new":[105,258],"mouse":[106,131],"model":[107,260],"which":[109],"mutant":[110],"P301L":[111,155],"tau":[112,174,215],"is":[113],"only":[114,139],"expressed":[115],"outer":[118],"layers":[119],"To":[124],"obtain":[125],"model,":[127],"we":[128],"crossed":[129],"line":[132],"expresses":[134],"tet":[136],"responsive":[137],"element":[138],"(Yasuda":[146],"M,":[147],"Mayford":[148],"MR.":[149],"Neuron.":[150],"2006":[151],"50(2):309-18),":[152],"mice,":[156],"so":[157],"will":[163],"occur":[164],"uniquely":[165],"specifically":[167],"region.":[170],"1-":[171],"Early":[172],"abnormal":[173],"epitopes":[175],"appear":[176,191],"EC-II":[178,193,225,241],"neuropil":[179],"transported":[182],"perforant":[185,275],"pathway":[186],"terminal":[187],"zone":[188],"before":[189],"they":[190],"cell":[194],"bodies.":[195],"2-":[196],"Tau":[197],"pathology":[198,216],"progresses":[199],"from":[201,249],"early":[202],"phosphorylation":[203],"late":[205,255],"tangles,":[207],"area":[210,280],"expression.":[212],"3-":[213],"Later,":[214],"spreads":[217],"downstream":[219],"connected":[220],"areas.":[221],"4-":[222],"Degeneration":[223],"projection":[226],"triggers":[228],"synaptic":[229],"plasticity":[230],"events":[231,270],"as":[232,234,283,285],"microglial":[235],"activation.":[236],"5-":[237],"Neuronal":[238],"happens":[242],"last.":[243],"study":[245],"earliest":[251,278],"tangle":[252],"development":[253],"until":[254],"deafferentation.":[256],"animal":[259],"provides":[261],"tool":[263],"follow":[265],"time":[267],"course":[268],"including":[271],"alterations":[272],"affecting":[273],"pathway,":[276],"affected":[279],"AD,":[282],"connections":[286],"between":[287],"hippocampal":[289],"formation":[290],"cortices.":[296]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}