{"id":"https://openalex.org/W2087736673","doi":"https://doi.org/10.1016/s2215-0366(14)00069-8","title":"Rehabilitative therapies for chronic fatigue syndrome: a secondary mediation analysis of the PACE trial","display_name":"Rehabilitative therapies for chronic fatigue syndrome: a secondary mediation analysis of the PACE trial","publication_year":2015,"publication_date":"2015-01-27","ids":{"openalex":"https://openalex.org/W2087736673","doi":"https://doi.org/10.1016/s2215-0366(14)00069-8","mag":"2087736673","pmid":"https://pubmed.ncbi.nlm.nih.gov/26359750"},"language":"en","primary_location":{"id":"doi:10.1016/s2215-0366(14)00069-8","doi":"https://doi.org/10.1016/s2215-0366(14)00069-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2215-0366(14)00069-8","pdf_url":"http://www.thelancet.com/article/S2215036614000698/pdf","source":{"id":"https://openalex.org/S2531556786","display_name":"The Lancet Psychiatry","issn_l":"2215-0366","issn":["2215-0366","2215-0374"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.thelancet.com/article/S2215036614000698/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053459824","display_name":"Trudie Chalder","orcid":"https://orcid.org/0000-0003-0775-1045","observed_orcids":["https://orcid.org/0000-0003-0775-1045"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Trudie Chalder","raw_affiliation_strings":["Academic Department of Psychological Medicine, King's College London, Weston Education Centre, London, UK. Electronic address: trudie.chalder@kcl.ac.uk","Academic Department of Psychological Medicine, King\u2019s College London, Weston Education Centre, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Department of Psychological Medicine, King's College London, Weston Education Centre, London, UK. Electronic address: trudie.chalder@kcl.ac.uk","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Academic Department of Psychological Medicine, King\u2019s College London, Weston Education Centre, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008628902","display_name":"Kimberley Goldsmith","orcid":"https://orcid.org/0000-0002-0620-7868","observed_orcids":["https://orcid.org/0000-0002-0620-7868"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kimberley A Goldsmith","raw_affiliation_strings":["Department of Biostatistics, King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059881864","display_name":"Peter Denton White","orcid":"https://orcid.org/0000-0002-8193-5355","observed_orcids":["https://orcid.org/0000-0002-8193-5355"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter D White","raw_affiliation_strings":["Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine, Queen Mary University, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine, Queen Mary University, London, UK","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068297606","display_name":"Michael Sharpe","orcid":"https://orcid.org/0000-0002-6474-9980","observed_orcids":["https://orcid.org/0000-0002-6474-9980"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Sharpe","raw_affiliation_strings":["Psychological Medicine Research, Department of Psychiatry, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychological Medicine Research, Department of Psychiatry, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033846900","display_name":"Andrew R. Pickles","orcid":"https://orcid.org/0000-0003-1283-0346","observed_orcids":["https://orcid.org/0000-0003-1283-0346"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew R Pickles","raw_affiliation_strings":["Department of Biostatistics, King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5053459824"],"corresponding_institution_ids":["https://openalex.org/I183935753"],"apc_list":{"value":7280,"currency":"USD","value_usd":7280},"apc_paid":null,"fwci":16.0252,"has_fulltext":true,"cited_by_count":139,"citation_normalized_percentile":{"value":0.9962106,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"2","issue":"2","first_page":"141","last_page":"152"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11368","display_name":"Long-Term Effects of COVID-19","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-fatigue-syndrome","display_name":"chronic fatigue syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cognitive-behavioral-therapy","display_name":"cognitive behavioral therapy","score":0.8759999871253967},{"id":"https://openalex.org/keywords/graded-exercise-therapy","display_name":"graded exercise therapy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/specialist-care","display_name":"specialist care","score":0.9139999747276306},{"id":"https://openalex.org/keywords/fear-avoidance-beliefs","display_name":"fear-avoidance beliefs","score":0.8500000238418579},{"id":"https://openalex.org/keywords/exercise-tolerance","display_name":"exercise tolerance","score":0.8399999737739563},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.515999972820282},{"id":"https://openalex.org/keywords/physical-functioning","display_name":"physical function","score":0.9980000257492065},{"id":"https://openalex.org/keywords/therapeutic-mechanisms","display_name":"therapeutic mechanisms","score":0.7760000228881836},{"id":"https://openalex.org/keywords/mediation-analysis","display_name":"mediation analysis","score":0.7409999966621399},{"id":"https://openalex.org/keywords/pace-trial","display_name":"PACE trial","score":0.9399999976158142},{"id":"https://openalex.org/keywords/disability","display_name":"disability","score":0.640999972820282},{"id":"https://openalex.org/keywords/6-minute-walk-test","display_name":"6-minute walk test","score":0.5040000081062317},{"id":"https://openalex.org/keywords/chalder-fatigue-scale","display_name":"Chalder Fatigue Scale","score":0.7950000166893005},{"id":"https://openalex.org/keywords/sf-36-physical-function","display_name":"SF-36 physical function","score":0.9430000185966492}],"concepts":[{"id":"https://openalex.org/C2779566273","wikidata":"https://www.wikidata.org/wiki/Q209733","display_name":"Chronic fatigue syndrome","level":2,"score":0.6485978364944458},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6217331290245056},{"id":"https://openalex.org/C179420905","wikidata":"https://www.wikidata.org/wiki/Q223871","display_name":"Mediation","level":2,"score":0.6068461537361145},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.5794687271118164},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.5207490921020508},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4753912687301636},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.33348989486694336},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2616291046142578},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012046","descriptor_name":"Rehabilitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015673","descriptor_name":"Fatigue Syndrome, Chronic","qualifier_ui":"Q000534","qualifier_name":"rehabilitation","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s2215-0366(14)00069-8","doi":"https://doi.org/10.1016/s2215-0366(14)00069-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2215-0366(14)00069-8","pdf_url":"http://www.thelancet.com/article/S2215036614000698/pdf","source":{"id":"https://openalex.org/S2531556786","display_name":"The Lancet Psychiatry","issn_l":"2215-0366","issn":["2215-0366","2215-0374"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Psychiatry","raw_type":"journal-article"},{"id":"pmid:26359750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26359750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The lancet. Psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/2981bb5e-7801-43ca-98fe-fd507f9ac868","doi":null,"is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/2981bb5e-7801-43ca-98fe-fd507f9ac868","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chalder, T, Goldsmith, K A, White, P D, Sharpe, M & Pickles, A R 2015, 'Rehabilitative therapies for chronic fatigue syndrome : A secondary mediation analysis of the PACE trial', The Lancet Psychiatry, vol. 2, no. 2, pp. 141-152. https://doi.org/10.1016/S2215-0366(14)00069-8","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/s2215-0366(14)00069-8","doi":"https://doi.org/10.1016/s2215-0366(14)00069-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2215-0366(14)00069-8","pdf_url":"http://www.thelancet.com/article/S2215036614000698/pdf","source":{"id":"https://openalex.org/S2531556786","display_name":"The Lancet Psychiatry","issn_l":"2215-0366","issn":["2215-0366","2215-0374"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1502803342","display_name":"Mediators, Moderators, Mixtures and Model Averaging","funder_award_id":"DRF-2011-04-061","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320311198","display_name":"South London and Maudsley NHS Foundation Trust","ror":"https://ror.org/015803449"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334658","display_name":"Menzies Centre for Australian Studies, King's College London, University of London","ror":"https://ror.org/0220mzb33"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2087736673.pdf","grobid_xml":"https://content.openalex.org/works/W2087736673.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W61113570","https://openalex.org/W1538919177","https://openalex.org/W1551066522","https://openalex.org/W1640894779","https://openalex.org/W1969930527","https://openalex.org/W1971440513","https://openalex.org/W1981138990","https://openalex.org/W1992654505","https://openalex.org/W1995476363","https://openalex.org/W1995945562","https://openalex.org/W1996331388","https://openalex.org/W2008925929","https://openalex.org/W2024023399","https://openalex.org/W2027451332","https://openalex.org/W2029895558","https://openalex.org/W2034388485","https://openalex.org/W2048726427","https://openalex.org/W2057459852","https://openalex.org/W2070515730","https://openalex.org/W2092884989","https://openalex.org/W2096230543","https://openalex.org/W2098336743","https://openalex.org/W2101015742","https://openalex.org/W2110124206","https://openalex.org/W2136088258","https://openalex.org/W2136415723","https://openalex.org/W2139469023","https://openalex.org/W2153739619","https://openalex.org/W2168494834","https://openalex.org/W2168646330","https://openalex.org/W2171701188","https://openalex.org/W2253364553","https://openalex.org/W2316878322","https://openalex.org/W3106889297"],"related_works":["https://openalex.org/W2111853615","https://openalex.org/W2129821788","https://openalex.org/W2136415723","https://openalex.org/W2155523469","https://openalex.org/W2144067520","https://openalex.org/W2273915763","https://openalex.org/W2076789163","https://openalex.org/W2062555864","https://openalex.org/W2076907552","https://openalex.org/W2464610688"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":24},{"year":2015,"cited_by_count":17}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}