{"id":"https://openalex.org/W2087734833","doi":"https://doi.org/10.1111/j.2042-7158.1990.tb07017.x","title":"Impairment of Endothelium-dependent Relaxation and Changes in Levels of cyclic GMP in Carotid Arteries from Stroke-prone Spontaneously Hypertensive Rats","display_name":"Impairment of Endothelium-dependent Relaxation and Changes in Levels of cyclic GMP in Carotid Arteries from Stroke-prone Spontaneously Hypertensive Rats","publication_year":1990,"publication_date":"1990-11-01","ids":{"openalex":"https://openalex.org/W2087734833","doi":"https://doi.org/10.1111/j.2042-7158.1990.tb07017.x","mag":"2087734833","pmid":"https://pubmed.ncbi.nlm.nih.gov/1982299"},"language":"en","primary_location":{"id":"doi:10.1111/j.2042-7158.1990.tb07017.x","doi":"https://doi.org/10.1111/j.2042-7158.1990.tb07017.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.2042-7158.1990.tb07017.x","pdf_url":null,"source":{"id":"https://openalex.org/S118304455","display_name":"Journal of Pharmacy and Pharmacology","issn_l":"0022-3573","issn":["0022-3573","2042-7158"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacy and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109253276","display_name":"Noriyuki Miyata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Noriyuki Miyata","raw_affiliation_strings":["Research Center, Taisho Pharmaceutical Co. Ltd , 1\u2013403 Yoshino-cho, Ohmiya, Saitama 330,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center, Taisho Pharmaceutical Co. Ltd , 1\u2013403 Yoshino-cho, Ohmiya, Saitama 330,","institution_ids":["https://openalex.org/I144245601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073148481","display_name":"Katsuharu Tsuchida","orcid":"https://orcid.org/0000-0002-5460-5617","observed_orcids":["https://orcid.org/0000-0002-5460-5617"]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuharu Tsuchida","raw_affiliation_strings":["Research Center, Taisho Pharmaceutical Co. Ltd , 1\u2013403 Yoshino-cho, Ohmiya, Saitama 330,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center, Taisho Pharmaceutical Co. Ltd , 1\u2013403 Yoshino-cho, Ohmiya, Saitama 330,","institution_ids":["https://openalex.org/I144245601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037866444","display_name":"Makoto Tanaka","orcid":"https://orcid.org/0000-0002-1826-3111","observed_orcids":["https://orcid.org/0000-0002-1826-3111"]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Tanaka","raw_affiliation_strings":["Research Center, Taisho Pharmaceutical Co. Ltd , 1\u2013403 Yoshino-cho, Ohmiya, Saitama 330,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center, Taisho Pharmaceutical Co. Ltd , 1\u2013403 Yoshino-cho, Ohmiya, Saitama 330,","institution_ids":["https://openalex.org/I144245601"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112817015","display_name":"Susumu Otomo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Susumu Otomo","raw_affiliation_strings":["Research Center, Taisho Pharmaceutical Co. Ltd , 1\u2013403 Yoshino-cho, Ohmiya, Saitama 330,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center, Taisho Pharmaceutical Co. Ltd , 1\u2013403 Yoshino-cho, Ohmiya, Saitama 330,","institution_ids":["https://openalex.org/I144245601"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109253276"],"corresponding_institution_ids":["https://openalex.org/I144245601"],"apc_list":{"value":2911,"currency":"GBP","value_usd":3839},"apc_paid":null,"fwci":0.4957,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.65894559,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"42","issue":"11","first_page":"763","last_page":"766"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelium-dependent-relaxation","display_name":"endothelium-dependent relaxation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.9459999799728394},{"id":"https://openalex.org/keywords/carotid-artery","display_name":"carotid artery","score":0.8619999885559082},{"id":"https://openalex.org/keywords/stroke-prone-spontaneously-hypertensive-rats","display_name":"stroke-prone spontaneously hypertensive rats","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9259999990463257},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.9459999799728394},{"id":"https://openalex.org/keywords/a23187","display_name":"A23187","score":0.777999997138977},{"id":"https://openalex.org/keywords/melittin","display_name":"melittin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/sodium-nitroprusside","display_name":"sodium nitroprusside","score":0.953000009059906},{"id":"https://openalex.org/keywords/guanylate-cyclase","display_name":"guanylate cyclase","score":0.8539999723434448},{"id":"https://openalex.org/keywords/vascular-dysfunction","display_name":"vascular dysfunction","score":0.5320000052452087},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.8920000195503235}],"concepts":[{"id":"https://openalex.org/C2779610285","wikidata":"https://www.wikidata.org/wiki/Q27108300","display_name":"Sodium nitroprusside","level":3,"score":0.7544939517974854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.706981897354126},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.6238653063774109},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.6195429563522339},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.6148554682731628},{"id":"https://openalex.org/C2987047532","wikidata":"https://www.wikidata.org/wiki/Q214275","display_name":"Carotid arteries","level":2,"score":0.5559555888175964},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.555691659450531},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5445549488067627},{"id":"https://openalex.org/C2776029896","wikidata":"https://www.wikidata.org/wiki/Q3935810","display_name":"Relaxation (psychology)","level":2,"score":0.4995307922363281},{"id":"https://openalex.org/C171614378","wikidata":"https://www.wikidata.org/wiki/Q5064093","display_name":"Cerebral arteries","level":2,"score":0.4701421856880188},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.4147634208202362},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3599798083305359},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.32054150104522705}],"mesh":[{"descriptor_ui":"D000001","descriptor_name":"Calcimycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008555","descriptor_name":"Melitten","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009126","descriptor_name":"Muscle Relaxation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009599","descriptor_name":"Nitroprusside","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011918","descriptor_name":"Rats, Inbred SHR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011921","descriptor_name":"Rats, Inbred WKY","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.2042-7158.1990.tb07017.x","doi":"https://doi.org/10.1111/j.2042-7158.1990.tb07017.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.2042-7158.1990.tb07017.x","pdf_url":null,"source":{"id":"https://openalex.org/S118304455","display_name":"Journal of Pharmacy and Pharmacology","issn_l":"0022-3573","issn":["0022-3573","2042-7158"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacy and Pharmacology","raw_type":"journal-article"},{"id":"pmid:1982299","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1982299","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pharmacy and pharmacology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W57656757","https://openalex.org/W134957533","https://openalex.org/W1765750524","https://openalex.org/W1922132784","https://openalex.org/W1949347306","https://openalex.org/W1970445852","https://openalex.org/W2012907151","https://openalex.org/W2015222002","https://openalex.org/W2023992334","https://openalex.org/W2025458248","https://openalex.org/W2033451262","https://openalex.org/W2044610799","https://openalex.org/W2048672688","https://openalex.org/W2051328736","https://openalex.org/W2069915524","https://openalex.org/W2070420553","https://openalex.org/W2077798575","https://openalex.org/W2094562301","https://openalex.org/W2113220448","https://openalex.org/W2113637522","https://openalex.org/W2127203967","https://openalex.org/W2169182236","https://openalex.org/W2258411363","https://openalex.org/W2274474673","https://openalex.org/W2430112821","https://openalex.org/W2441134372","https://openalex.org/W4407043727"],"related_works":["https://openalex.org/W57656757","https://openalex.org/W177795619","https://openalex.org/W1998384321","https://openalex.org/W2430112821","https://openalex.org/W1949347306","https://openalex.org/W7096330215","https://openalex.org/W2001753245","https://openalex.org/W2067385238","https://openalex.org/W2023255319","https://openalex.org/W2400528919"],"abstract_inverted_index":{"Endothelium-dependent":[0],"relaxation":[1,30,126],"of":[2,9,78],"carotid":[3,37,56,84,117],"arteries":[4,38,57,85],"and":[5,17,48,66],"changes":[6,104],"in":[7,36,55,72,83,105,115,121,127,134],"levels":[8],"cyclic":[10],"(c)GMP":[11],"between":[12],"stroke-prone":[13],"spontaneously":[14],"hypertensive":[15,135],"(SHRSP)":[16],"Wistar-Kyoto":[18],"(WKY)":[19],"rats":[20],"have":[21],"been":[22],"compared.":[23],"The":[24],"concentration-response":[25],"curve":[26],"for":[27,93],"acetylcholine":[28],"(ACh)-induced":[29],"was":[31,80],"shifted":[32],"to":[33,70],"the":[34,91,116],"right":[35],"from":[39,58,74,86,97],"SHRSP.":[40,59],"Relaxation":[41,60],"responses":[42,61],"produced":[43,62],"by":[44,63],"calcimycin":[45],"(A":[46],"23187)":[47],"melittin,":[49],"both":[50],"endothelium-dependent":[51,125],"agents,":[52],"were":[53,68],"depressed":[54],"sodium":[64],"nitroprusside":[65],"8-Br-cGMP":[67],"similar":[69],"those":[71],"strips":[73,96],"WKY.":[75,98],"ACh-induced":[76],"production":[77],"cGMP":[79,113],"significantly":[81],"decreased":[82],"SHRSP":[87,128],"when":[88],"compared":[89],"with":[90],"level":[92],"similarly":[94],"treated":[95],"These":[99],"results":[100],"suggest":[101],"that":[102],"functional":[103],"endothelium,":[106],"but":[107],"not":[108],"guanylate":[109],"cyclase":[110],"activity":[111],"or":[112],"sensitivity":[114],"arteries,":[118],"may":[119,129],"occur":[120],"hypertension.":[122],"Thus,":[123],"impaired":[124],"play":[130],"an":[131],"important":[132],"role":[133],"vascular":[136],"diseases":[137],"such":[138],"as":[139],"stroke.":[140]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}