{"id":"https://openalex.org/W2087707939","doi":"https://doi.org/10.1172/jci115502","title":"An idiotypic marker associated with a germ-line encoded kappa light chain variable region that predominates the vaccine-induced human antibody response to the Haemophilus influenzae b polysaccharide.","display_name":"An idiotypic marker associated with a germ-line encoded kappa light chain variable region that predominates the vaccine-induced human antibody response to the Haemophilus influenzae b polysaccharide.","publication_year":1991,"publication_date":"1991-12-01","ids":{"openalex":"https://openalex.org/W2087707939","doi":"https://doi.org/10.1172/jci115502","mag":"2087707939","pmid":"https://pubmed.ncbi.nlm.nih.gov/1752943","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/295748"},"language":"en","primary_location":{"id":"doi:10.1172/jci115502","doi":"https://doi.org/10.1172/jci115502","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci115502","pdf_url":"http://www.jci.org/articles/view/115502/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/115502/files/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111791484","display_name":"Alexander H. Lucas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A H Lucas","raw_affiliation_strings":["Children's Hospital Oakland Research Institute, California 94609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Oakland Research Institute, California 94609","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038143566","display_name":"Raymond J. Langley","orcid":"https://orcid.org/0000-0001-8849-9325","observed_orcids":["https://orcid.org/0000-0001-8849-9325"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R J Langley","raw_affiliation_strings":["Children's Hospital Oakland Research Institute, Oakland, California 94609;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Oakland Research Institute, Oakland, California 94609;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006315819","display_name":"Dan M. Granoff","orcid":"https://orcid.org/0000-0002-1514-2250","observed_orcids":["https://orcid.org/0000-0002-1514-2250"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D M Granoff","raw_affiliation_strings":["Children's Hospital Oakland Research Institute, Oakland, California 94609;","Department ofPediatrics, and ODivision ofLaboratory Medicine , Department ofPathology , Washington University School ofMedicine , St. Louis , Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Oakland Research Institute, Oakland, California 94609;","institution_ids":[]},{"raw_affiliation_string":"Department ofPediatrics, and ODivision ofLaboratory Medicine , Department ofPathology , Washington University School ofMedicine , St. Louis , Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071979134","display_name":"Moon H. Nahm","orcid":"https://orcid.org/0000-0002-6922-1042","observed_orcids":["https://orcid.org/0000-0002-6922-1042"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M H Nahm","raw_affiliation_strings":["Children's Hospital Oakland Research Institute, Oakland, California 94609;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Oakland Research Institute, Oakland, California 94609;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054442009","display_name":"Marina Kitamura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Y Kitamura","raw_affiliation_strings":["Children's Hospital Oakland Research Institute, Oakland, California 94609;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Oakland Research Institute, Oakland, California 94609;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103147359","display_name":"M G Scott","orcid":"https://orcid.org/0000-0002-0142-4986","observed_orcids":["https://orcid.org/0000-0002-0142-4986"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I2608559034","display_name":"American Society for Biochemistry and Molecular Biology","ror":"https://ror.org/025mg0739","country_code":"US","type":"other","lineage":["https://openalex.org/I2608559034"]},{"id":"https://openalex.org/I4210160153","display_name":"American Association of Immunologists","ror":"https://ror.org/04q9fhm49","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210160153"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M G Scott","raw_affiliation_strings":["tDivision ofInfectious Diseases , The Edward Mallinckrodt","American Society for Biochemistry and Molecular Biology and the American Association of Immunologists,","Children's Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609","NIH/NIAID, Twinbrook II, Rock-ville, MD 20852","tDivision ofInfectious Diseases, The Edward Mallinckrodt Department ofPediatrics, and ODivision ofLaboratory Medicine, Department ofPathology, Washington University School ofMedicine, St. Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"tDivision ofInfectious Diseases , The Edward Mallinckrodt","institution_ids":[]},{"raw_affiliation_string":"American Society for Biochemistry and Molecular Biology and the American Association of Immunologists,","institution_ids":["https://openalex.org/I2608559034","https://openalex.org/I4210160153"]},{"raw_affiliation_string":"Children's Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609","institution_ids":[]},{"raw_affiliation_string":"NIH/NIAID, Twinbrook II, Rock-ville, MD 20852","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"tDivision ofInfectious Diseases, The Edward Mallinckrodt Department ofPediatrics, and ODivision ofLaboratory Medicine, Department ofPathology, Washington University School ofMedicine, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":6.1923,"has_fulltext":true,"cited_by_count":62,"citation_normalized_percentile":{"value":0.96495093,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"88","issue":"6","first_page":"1811","last_page":"1818"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8871999979019165,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8871999979019165,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.06549999862909317,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cross-reactive-idiotype","display_name":"cross-reactive idiotype","score":0.8019999861717224},{"id":"https://openalex.org/keywords/vaccine-induced-antibody-response","display_name":"vaccine-induced antibody response","score":0.7049999833106995},{"id":"https://openalex.org/keywords/b-cell-ontogeny","display_name":"B cell ontogeny","score":0.7110000252723694},{"id":"https://openalex.org/keywords/antibody-combining-site","display_name":"antibody combining site","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6750309467315674},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.6441389322280884},{"id":"https://openalex.org/C2776925733","wikidata":"https://www.wikidata.org/wiki/Q1141979","display_name":"Haemophilus influenzae","level":3,"score":0.5812940001487732},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.570044994354248},{"id":"https://openalex.org/C2778724333","wikidata":"https://www.wikidata.org/wiki/Q14401","display_name":"Kappa","level":2,"score":0.5167426466941833},{"id":"https://openalex.org/C2779592421","wikidata":"https://www.wikidata.org/wiki/Q368134","display_name":"Hib vaccine","level":5,"score":0.5156334638595581},{"id":"https://openalex.org/C74505204","wikidata":"https://www.wikidata.org/wiki/Q1047644","display_name":"Idiotype","level":4,"score":0.4798021614551544},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42031538486480713},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39725661277770996},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.38329678773880005},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3710462749004364},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.28538191318511963},{"id":"https://openalex.org/C2779583294","wikidata":"https://www.wikidata.org/wiki/Q5161160","display_name":"Conjugate vaccine","level":4,"score":0.1602623164653778},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.13809892535209656},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13410824537277222},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08838900923728943},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001428","descriptor_name":"Bacterial Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006193","descriptor_name":"Haemophilus influenzae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007130","descriptor_name":"Immunoglobulin Idiotypes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007145","descriptor_name":"Immunoglobulin kappa-Chains","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007145","descriptor_name":"Immunoglobulin kappa-Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011135","descriptor_name":"Polysaccharides, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016667","descriptor_name":"Bacterial Capsules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018073","descriptor_name":"Haemophilus Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1172/jci115502","doi":"https://doi.org/10.1172/jci115502","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci115502","pdf_url":"http://www.jci.org/articles/view/115502/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:1752943","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1752943","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci115502","doi":"https://doi.org/10.1172/jci115502","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci115502","pdf_url":"http://www.jci.org/articles/view/115502/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1708564272","display_name":null,"funder_award_id":"AI25008","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2739679489","display_name":null,"funder_award_id":"AI 17962","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G738821783","display_name":"GENETIC CONTROL OF ANTIBODY RESPONSES TO POLYSACCHARIDES","funder_award_id":"7r01ai017962-11","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2087707939.pdf","grobid_xml":"https://content.openalex.org/works/W2087707939.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W161233626","https://openalex.org/W1189774283","https://openalex.org/W1528800735","https://openalex.org/W1529828734","https://openalex.org/W1547299437","https://openalex.org/W1556273434","https://openalex.org/W1599072923","https://openalex.org/W1603027603","https://openalex.org/W1801863882","https://openalex.org/W1885130446","https://openalex.org/W1913436096","https://openalex.org/W1966411902","https://openalex.org/W1990615139","https://openalex.org/W1992889917","https://openalex.org/W1993422891","https://openalex.org/W1993887766","https://openalex.org/W2010246582","https://openalex.org/W2011632789","https://openalex.org/W2014589365","https://openalex.org/W2024208188","https://openalex.org/W2034784258","https://openalex.org/W2036050361","https://openalex.org/W2038151811","https://openalex.org/W2041992126","https://openalex.org/W2043673311","https://openalex.org/W2044632723","https://openalex.org/W2045232776","https://openalex.org/W2051823651","https://openalex.org/W2053194143","https://openalex.org/W2080575737","https://openalex.org/W2086672151","https://openalex.org/W2090410391","https://openalex.org/W2094057307","https://openalex.org/W2118107917","https://openalex.org/W2118396981","https://openalex.org/W2128056949","https://openalex.org/W2147633732","https://openalex.org/W2157645615","https://openalex.org/W2160159908","https://openalex.org/W2169253475","https://openalex.org/W2328316613","https://openalex.org/W4300872464"],"related_works":["https://openalex.org/W2014589365","https://openalex.org/W1831981047","https://openalex.org/W1953875181","https://openalex.org/W2019314826","https://openalex.org/W2050390687","https://openalex.org/W1595312837","https://openalex.org/W1575299344","https://openalex.org/W1967487152","https://openalex.org/W1599072923","https://openalex.org/W1765151782"],"abstract_inverted_index":{"Human":[0],"antibodies":[1,109,129,143,210,317],"specific":[2],"for":[3,206],"the":[4,25,28,51,96,101,104,163,187,193,239,243,289,327],"Haemophilus":[5],"influenzae":[6],"b":[7],"polysaccharide":[8],"(Hib":[9,234],"PS)":[10],"frequently":[11],"express":[12],"a":[13,20,58,280,285,323],"cross-reactive":[14],"idiotype":[15],"(CRI),":[16],"and":[17,42,125,198,236,262,283,334],"commonly":[18],"utilize":[19],"VL":[21,339],"region":[22,40],"that":[23,162,186,306,316,335],"is":[24,48,190,341],"product":[26],"of":[27,67,103,121,139,219,242,267,288,326,338],"V":[29,39,52,131,146,148,152,171,194],"kappa":[30,53,132,149,153,172,195,320],"II":[31],"gene":[32],"A2.":[33],"To":[34],"examine":[35],"further":[36],"anti-Hib":[37,68,107,127,141,169,247,269,291,328],"PS":[38,69,75,108,128,142,170,209,226,229,270,292,302,329],"expression":[41,47,250,340],"to":[43,192,231,254,300],"determine":[44],"whether":[45],"CRI":[46,86],"correlated":[49],"with":[50,63,81,95,106,167,178,203,222,273],"IIA2":[54,133,173,196,321],"chain,":[55,197],"we":[56],"isolated":[57,168],"monoclonal":[59],"antibody":[60,293],"(MAb)":[61],"reactive":[62],"an":[64],"idiotypic":[65],"determinant":[66,189],"antibodies.":[70],"This":[71],"MAb":[72,105,164],"inhibited":[73,112],"Hib":[74,97,114,225,228,274],"binding":[76],"but":[77,176],"did":[78],"not":[79,177,200,252],"react":[80],"Ig":[82],"isotypic":[83],"determinants.":[84],"The":[85],"recognized":[87],"by":[88,113,119,332],"this":[89,336],"MAb,":[90],"designated":[91],"HibId-1,":[92],"was":[93,117,251,277],"associated":[94],"PS-combining":[98],"site":[99],"since":[100],"reactivity":[102],"could":[110],"be":[111],"PS.":[115,248],"HibId-1":[116,188,212,249,276],"expressed":[118,156,278],"17":[120,122],"clonally":[123],"purified":[124],"sequence-defined":[126],"having":[130,144],"L":[134,174,183],"chains.":[135],"In":[136],"contrast,":[137],"0":[138],"10":[140],"either":[145,223],"lambda,":[147],"I,":[150],"or":[151,181,227],"III":[154],"chains":[155,175,180],"HibId-1.":[157],"Western":[158],"blot":[159],"analysis":[160],"showed":[161],"anti-CRI":[165],"reacted":[166],"H":[179,204],"other":[182],"chains,":[184],"indicating":[185],"localized":[191],"does":[199],"require":[201],"pairing":[202],"chain":[205],"expression.":[207],"Anti-Hib":[208],"bearing":[211,318],"were":[213],"present":[214],"in":[215,294,344],"at":[216,256,279],"least":[217],"85%":[218],"subjects":[220],"immunized":[221],"free":[224],"coupled":[230],"diphtheria":[232],"toxoid":[233],"PS-DT),":[235],"comprised":[237,284],"on":[238],"average":[240],"60%":[241],"total":[244,290],"vaccine-induced":[245],"serum":[246],"related":[253],"age":[255],"vaccination":[257,272],"inasmuch":[258],"as":[259,298],"infants,":[260],"children,":[261],"adults":[263],"had":[264],"similar":[265],"distributions":[266],"HibId-1-positive":[268,310],"after":[271],"PS-DT.":[275],"lower":[281],"frequency":[282],"smaller":[286],"fraction":[287],"adult":[295],"preimmunization":[296],"sera":[297],"compared":[299],"post-Hib":[301],"immunization":[303,307],"sera,":[304],"suggesting":[305],"preferentially":[308],"stimulates":[309],"B":[311],"cells.":[312],"These":[313],"data":[314],"demonstrate":[315],"HibId-1/V":[319],"comprise":[322],"predominant":[324],"component":[325],"response":[330],"induced":[331],"immunization,":[333],"pattern":[337],"established":[342],"early":[343],"ontogeny.":[345]},"counts_by_year":[{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
