{"id":"https://openalex.org/W2087692018","doi":"https://doi.org/10.1016/s1472-6483(10)62112-8","title":"Discrepancies between the effects of glutamine in cultures of preimplantation mouse embryos","display_name":"Discrepancies between the effects of glutamine in cultures of preimplantation mouse embryos","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2087692018","doi":"https://doi.org/10.1016/s1472-6483(10)62112-8","mag":"2087692018","pmid":"https://pubmed.ncbi.nlm.nih.gov/15257823"},"language":"en","primary_location":{"id":"doi:10.1016/s1472-6483(10)62112-8","doi":"https://doi.org/10.1016/s1472-6483(10)62112-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1472-6483(10)62112-8","pdf_url":null,"source":{"id":"https://openalex.org/S206719219","display_name":"Reproductive BioMedicine Online","issn_l":"1472-6483","issn":["1472-6483","1472-6491"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive BioMedicine Online","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111939315","display_name":"John D. Biggers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John D Biggers","raw_affiliation_strings":["Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. john_biggers@hms.harvard.edu","Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue,Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. john_biggers@hms.harvard.edu","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue,Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032222331","display_name":"Lynda K. McGinnis","orcid":"https://orcid.org/0000-0001-7910-9655","observed_orcids":["https://orcid.org/0000-0001-7910-9655"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynda K McGinnis","raw_affiliation_strings":["Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue,Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue,Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058335295","display_name":"Michael C. Summers","orcid":"https://orcid.org/0000-0003-2438-0995","observed_orcids":["https://orcid.org/0000-0003-2438-0995"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael C Summers","raw_affiliation_strings":["Reproductive Science Centre, One Forbes Road, Lexington, MA, 02421 and Department of Obstetrics and Gynecology, University of Massachusetts Medical School, Worcester, MA, 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Science Centre, One Forbes Road, Lexington, MA, 02421 and Department of Obstetrics and Gynecology, University of Massachusetts Medical School, Worcester, MA, 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":null,"fwci":0.4595,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.26047904,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"1","first_page":"70","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamine","display_name":"glutamine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/preimplantation-embryo-culture","display_name":"preimplantation embryo culture","score":0.9190000295639038},{"id":"https://openalex.org/keywords/exencephaly","display_name":"exencephaly","score":0.8190000057220459},{"id":"https://openalex.org/keywords/ammonia","display_name":"ammonia","score":0.6259999871253967},{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.8289999961853027},{"id":"https://openalex.org/keywords/mouse-embryo","display_name":"mouse embryo","score":0.6299999952316284},{"id":"https://openalex.org/keywords/embryo-culture-medium","display_name":"embryo culture media","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.8979817628860474},{"id":"https://openalex.org/C2781052626","wikidata":"https://www.wikidata.org/wiki/Q1774245","display_name":"Exencephaly","level":5,"score":0.8390012979507446},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.7601730823516846},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5274807810783386},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4082765281200409},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.335979700088501},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3271441161632538},{"id":"https://openalex.org/C65290608","wikidata":"https://www.wikidata.org/wiki/Q631521","display_name":"Teratology","level":4,"score":0.18817973136901855},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1744624376296997},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.1597992479801178},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.09723255038261414},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.08064639568328857}],"mesh":[{"descriptor_ui":"D000643","descriptor_name":"Ammonium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001755","descriptor_name":"Blastocyst","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046149","descriptor_name":"Embryo Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1472-6483(10)62112-8","doi":"https://doi.org/10.1016/s1472-6483(10)62112-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1472-6483(10)62112-8","pdf_url":null,"source":{"id":"https://openalex.org/S206719219","display_name":"Reproductive BioMedicine Online","issn_l":"1472-6483","issn":["1472-6483","1472-6491"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive BioMedicine Online","raw_type":"journal-article"},{"id":"pmid:15257823","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15257823","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive biomedicine online","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W69694070","https://openalex.org/W1535301903","https://openalex.org/W1967317013","https://openalex.org/W1980813479","https://openalex.org/W1981650543","https://openalex.org/W1989455265","https://openalex.org/W2002885816","https://openalex.org/W2006872945","https://openalex.org/W2012503619","https://openalex.org/W2020943479","https://openalex.org/W2022205071","https://openalex.org/W2028331558","https://openalex.org/W2040846074","https://openalex.org/W2078826636","https://openalex.org/W2083485306","https://openalex.org/W2105719125","https://openalex.org/W2108711091","https://openalex.org/W2109086273","https://openalex.org/W2129554629","https://openalex.org/W2135776691","https://openalex.org/W2140018835","https://openalex.org/W2150662771","https://openalex.org/W2152277071","https://openalex.org/W2155436742","https://openalex.org/W2158014022","https://openalex.org/W2158377474","https://openalex.org/W2160734895","https://openalex.org/W2162480880","https://openalex.org/W2223756585","https://openalex.org/W2418378127","https://openalex.org/W2485121984","https://openalex.org/W4214727671"],"related_works":["https://openalex.org/W2291476470","https://openalex.org/W2001771960","https://openalex.org/W1974055306","https://openalex.org/W2587972587","https://openalex.org/W2011540934","https://openalex.org/W2414967978","https://openalex.org/W1980813479","https://openalex.org/W2055877967","https://openalex.org/W7220017705","https://openalex.org/W1980796885"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}