{"id":"https://openalex.org/W2087660290","doi":"https://doi.org/10.1097/01.tp.0000155175.24802.73","title":"Measurement of Apoptosis of Intact Human Islets by Confocal Optical Sectioning and Stereologic Analysis of YO-PRO-1???Stained Islets","display_name":"Measurement of Apoptosis of Intact Human Islets by Confocal Optical Sectioning and Stereologic Analysis of YO-PRO-1???Stained Islets","publication_year":2005,"publication_date":"2005-03-31","ids":{"openalex":"https://openalex.org/W2087660290","doi":"https://doi.org/10.1097/01.tp.0000155175.24802.73","mag":"2087660290","pmid":"https://pubmed.ncbi.nlm.nih.gov/15818328"},"language":"en","primary_location":{"id":"doi:10.1097/01.tp.0000155175.24802.73","doi":"https://doi.org/10.1097/01.tp.0000155175.24802.73","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000155175.24802.73","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006849637","display_name":"Daniel J. Boffa","orcid":"https://orcid.org/0000-0001-5471-8833","observed_orcids":["https://orcid.org/0000-0001-5471-8833"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Boffa","raw_affiliation_strings":["Department of Surgery, The New York Presbyterian Hospital, Weill-Cornell Medical Center, New York, NY 10021, USA","Department of Surgery, The New York Presbyterian Hospital, Weill-Cornell Medical Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, The New York Presbyterian Hospital, Weill-Cornell Medical Center, New York, NY 10021, USA","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4405272987"]},{"raw_affiliation_string":"Department of Surgery, The New York Presbyterian Hospital, Weill-Cornell Medical Center, New York, New York","institution_ids":["https://openalex.org/I1340179700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030381582","display_name":"John Waka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Waka","raw_affiliation_strings":["Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074201719","display_name":"Dolca A. Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dolca Thomas","raw_affiliation_strings":["Department of Medicine, The New York Presbyterian Hospital, Weill-Cornell Medical Center, New York, New York","Department of Transplantation Medicine, The New York Presbyterian Hospital, Weill-Cornell Medical Center, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The New York Presbyterian Hospital, Weill-Cornell Medical Center, New York, New York","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4405272987"]},{"raw_affiliation_string":"Department of Transplantation Medicine, The New York Presbyterian Hospital, Weill-Cornell Medical Center, New York","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4405272987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111969223","display_name":"Sungwook Suh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sungwook Suh","raw_affiliation_strings":["Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055001531","display_name":"Kevin Joseph Curran","orcid":"https://orcid.org/0000-0002-3337-9956","observed_orcids":["https://orcid.org/0000-0002-3337-9956"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Curran","raw_affiliation_strings":["Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Vijay K. Sharma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijay K. Sharma","raw_affiliation_strings":["Department of Medicine, The New York Presbyterian Hospital, Weill-Cornell Medical Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The New York Presbyterian Hospital, Weill-Cornell Medical Center, New York, New York","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4405272987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016972079","display_name":"Melissa Besada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Besada","raw_affiliation_strings":["Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009885369","display_name":"Thangamani Muthukumar","orcid":"https://orcid.org/0000-0002-0294-6209","observed_orcids":["https://orcid.org/0000-0002-0294-6209"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thangamani Muthukumar","raw_affiliation_strings":["Department of Medicine, The New York Presbyterian Hospital, Weill-Cornell Medical Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The New York Presbyterian Hospital, Weill-Cornell Medical Center, New York, New York","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4405272987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103202991","display_name":"Hua Yang","orcid":"https://orcid.org/0000-0002-1396-5448","observed_orcids":["https://orcid.org/0000-0002-1396-5448"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Yang","raw_affiliation_strings":["Department of Medicine, The New York Presbyterian Hospital, Weill-Cornell Medical Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The New York Presbyterian Hospital, Weill-Cornell Medical Center, New York, New York","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4405272987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073533672","display_name":"Manikkam Suthanthiran","orcid":"https://orcid.org/0000-0001-6894-0486","observed_orcids":["https://orcid.org/0000-0001-6894-0486"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Manikkam Suthanthiran","raw_affiliation_strings":["Department of Medicine, The New York Presbyterian Hospital, Weill-Cornell Medical Center, New York, New York","Department of Transplantation Medicine, The New York Presbyterian Hospital, Weill-Cornell Medical Center, New York","Manikkam Suthanthiran, M.D., Weill Cornell Medical Center, 525 East 68 Street, Box 3, New York, NY, 10021. E-mail"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The New York Presbyterian Hospital, Weill-Cornell Medical Center, New York, New York","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4405272987"]},{"raw_affiliation_string":"Department of Transplantation Medicine, The New York Presbyterian Hospital, Weill-Cornell Medical Center, New York","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4405272987"]},{"raw_affiliation_string":"Manikkam Suthanthiran, M.D., Weill Cornell Medical Center, 525 East 68 Street, Box 3, New York, NY, 10021. E-mail","institution_ids":["https://openalex.org/I4405272987"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109189567","display_name":"Katia Manova","orcid":"https://orcid.org/0000-0003-0915-6696","observed_orcids":["https://orcid.org/0000-0003-0915-6696"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katia Manova","raw_affiliation_strings":["Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5073533672"],"corresponding_institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4405272987"],"apc_list":null,"apc_paid":null,"fwci":1.5121,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.83216395,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"79","issue":"7","first_page":"842","last_page":"845"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7850000262260437},{"id":"https://openalex.org/keywords/human-pancreatic-islets","display_name":"human pancreatic islets","score":0.8930000066757202},{"id":"https://openalex.org/keywords/yo-pro-1","display_name":"YO-PRO-1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/dna-intercalation","display_name":"DNA intercalation","score":0.6880000233650208},{"id":"https://openalex.org/keywords/confocal-laser-scanning-microscopy","display_name":"confocal laser scanning microscopy","score":0.7850000262260437},{"id":"https://openalex.org/keywords/stereology","display_name":"stereology","score":0.7450000047683716},{"id":"https://openalex.org/keywords/islet-cell-death","display_name":"islet cell death","score":0.6190000176429749},{"id":"https://openalex.org/keywords/apoptosis-quantification","display_name":"apoptosis quantification","score":0.828000009059906},{"id":"https://openalex.org/keywords/islet-heterogeneity","display_name":"islet heterogeneity","score":0.7490000128746033},{"id":"https://openalex.org/keywords/islet-transplantation","display_name":"islet transplantation","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.915929913520813},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7972472906112671},{"id":"https://openalex.org/C136009344","wikidata":"https://www.wikidata.org/wiki/Q336201","display_name":"Confocal","level":2,"score":0.6535425186157227},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6522751450538635},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.5960956811904907},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.5465540289878845},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5130559206008911},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4316312074661255},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42693957686424255},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42204561829566956},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40778613090515137},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14358574151992798},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.1104469895362854},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09165608882904053},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.06415608525276184},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001583","descriptor_name":"Benzoxazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D011806","descriptor_name":"Quinolinium Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.tp.0000155175.24802.73","doi":"https://doi.org/10.1097/01.tp.0000155175.24802.73","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000155175.24802.73","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:15818328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15818328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2342768883","display_name":"Gene Therapy for Islet Cell Transplantation","funder_award_id":"R21DK060186","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1607919675","https://openalex.org/W1963684624","https://openalex.org/W1964192392","https://openalex.org/W1989353069","https://openalex.org/W1998662212","https://openalex.org/W2012260175","https://openalex.org/W2013898694","https://openalex.org/W2014627762","https://openalex.org/W2058657286","https://openalex.org/W2061505769","https://openalex.org/W2075813652","https://openalex.org/W2078532650","https://openalex.org/W2087612574","https://openalex.org/W2090728938","https://openalex.org/W2131207346","https://openalex.org/W2143487734","https://openalex.org/W2160581159","https://openalex.org/W2171678230","https://openalex.org/W2328786770"],"related_works":["https://openalex.org/W1982298267","https://openalex.org/W2064753484","https://openalex.org/W7099998885","https://openalex.org/W2143487734","https://openalex.org/W4245597396","https://openalex.org/W625774573","https://openalex.org/W3047789990","https://openalex.org/W2046236577","https://openalex.org/W2320082304","https://openalex.org/W2164125230"],"abstract_inverted_index":{"Apoptosis":[0],"is":[1],"an":[2],"established":[3],"pathway":[4],"for":[5,11,72],"islet":[6,14,33,108,140,146],"cell":[7,15,42,141],"demise.":[8],"Current":[9],"protocols":[10],"assessment":[12],"of":[13,31,41,51,57,76,78,88,104,113,119,133,139,149],"apoptosis":[16,77,105,120,142],"are":[17,60],"time-consuming":[18],"(as":[19,35,44],"with":[20,36,45,93],"terminal":[21],"deoxynucleotide":[22],"transferase-mediated":[23],"dUTP":[24],"nick-end":[25],"labeling":[26],"reaction)":[27],"and":[28,85,95,110,143],"involve":[29],"disruption":[30],"the":[32,63,73,117,124],"architecture":[34,109],"flow":[37],"cytometry)":[38],"or":[39],"destruction":[40],"integrity":[43],"enzyme-linked":[46],"immunosorbent":[47],"assay).":[48],"The":[49,98],"membranes":[50],"apoptotic":[52],"cells,":[53,59],"but":[54],"not":[55],"those":[56],"live":[58],"permeant":[61],"to":[62],"DNA-intercalant":[64],"dye":[65],"YO-PRO-1.":[66],"We":[67],"report":[68],"a":[69],"novel":[70],"methodology":[71],"rapid":[74,102],"quantification":[75,103],"human":[79,90],"islets:":[80],"confocal":[81],"laser":[82,128],"optical":[83],"sectioning":[84],"stereologic":[86],"analysis":[87],"intact":[89],"islets":[91,122,135],"stained":[92],"YO-PRO-1":[94],"Hoechst":[96],"33342.":[97],"advantages":[99],"include":[100],"(1)":[101],"without":[106],"disrupting":[107],"(2)":[111],"identification":[112],"significant":[114],"heterogeneity":[115],"in":[116],"extent":[118],"among":[121],"from":[123],"same":[125],"isolate.":[126],"Confocal":[127],"scanning":[129],"microscopy":[130],"microscopic":[131],"imaging":[132],"YO-PRO-1-stained":[134],"may":[136],"advance":[137],"investigation":[138],"help":[144],"develop":[145],"parameters":[147],"predictive":[148],"posttransplant":[150],"function.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
