{"id":"https://openalex.org/W2087613091","doi":"https://doi.org/10.1038/bcj.2015.36","title":"A novel MYD88 mutation, L265RPP, in Waldenstr\u00f6m macroglobulinemia activates the NF-\u03baB pathway to upregulate Bcl-xL expression and enhances cell survival","display_name":"A novel MYD88 mutation, L265RPP, in Waldenstr\u00f6m macroglobulinemia activates the NF-\u03baB pathway to upregulate Bcl-xL expression and enhances cell survival","publication_year":2015,"publication_date":"2015-05-15","ids":{"openalex":"https://openalex.org/W2087613091","doi":"https://doi.org/10.1038/bcj.2015.36","mag":"2087613091","pmid":"https://pubmed.ncbi.nlm.nih.gov/25978434","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4476015"},"language":"en","primary_location":{"id":"doi:10.1038/bcj.2015.36","doi":"https://doi.org/10.1038/bcj.2015.36","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bcj.2015.36","pdf_url":"https://www.nature.com/articles/bcj201536.pdf","source":{"id":"https://openalex.org/S2496263508","display_name":"Blood Cancer Journal","issn_l":"2044-5385","issn":["2044-5385"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/bcj201536.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071276592","display_name":"Toshikage Nagao","orcid":"https://orcid.org/0000-0002-1766-3842","observed_orcids":["https://orcid.org/0000-0002-1766-3842"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Nagao","raw_affiliation_strings":["Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032874540","display_name":"Gaku Oshikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"G Oshikawa","raw_affiliation_strings":["Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Ishida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Ishida","raw_affiliation_strings":["Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004981982","display_name":"Hiroki Akiyama","orcid":"https://orcid.org/0000-0003-2627-1055","observed_orcids":["https://orcid.org/0000-0003-2627-1055"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Akiyama","raw_affiliation_strings":["Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002230786","display_name":"Yoshihiro Umezawa","orcid":"https://orcid.org/0000-0003-1027-1552","observed_orcids":["https://orcid.org/0000-0003-1027-1552"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Umezawa","raw_affiliation_strings":["Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002326282","display_name":"Akihiko Nogami","orcid":"https://orcid.org/0000-0003-0359-4601","observed_orcids":["https://orcid.org/0000-0003-0359-4601"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A Nogami","raw_affiliation_strings":["Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024750099","display_name":"Tetsuya Kurosu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Kurosu","raw_affiliation_strings":["Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074139458","display_name":"Osamu Miura","orcid":"https://orcid.org/0000-0002-0981-3054","observed_orcids":["https://orcid.org/0000-0002-0981-3054"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"O Miura","raw_affiliation_strings":["Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5074139458"],"corresponding_institution_ids":["https://openalex.org/I125602781"],"apc_list":{"value":5290,"currency":"USD","value_usd":5290},"apc_paid":{"value":5290,"currency":"USD","value_usd":5290},"fwci":2.0864,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.877112,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"5","issue":"5","first_page":"e314","last_page":"e314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/waldenstrom-macroglobulinemia","display_name":"Waldenstr\u00f6m macroglobulinemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/myd88-mutation","display_name":"MYD88 mutation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/myd88-l265p","display_name":"MYD88 L265P","score":0.9679999947547913},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.9139999747276306},{"id":"https://openalex.org/keywords/monoclonal-igm","display_name":"monoclonal IgM","score":0.6690000295639038},{"id":"https://openalex.org/keywords/splenic-marginal-zone-lymphoma","display_name":"splenic marginal zone lymphoma","score":0.8259999752044678},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.8830000162124634},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/allele-specific-pcr","display_name":"allele-specific PCR","score":0.9649999737739563}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.8374776840209961},{"id":"https://openalex.org/C2781038049","wikidata":"https://www.wikidata.org/wiki/Q1778287","display_name":"Waldenstrom macroglobulinemia","level":3,"score":0.7105786800384521},{"id":"https://openalex.org/C2776391228","wikidata":"https://www.wikidata.org/wiki/Q4118092","display_name":"Macroglobulinemia","level":3,"score":0.6515235304832458},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6067635416984558},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5525811910629272},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.4745258390903473},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.41291525959968567},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3772684335708618},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3085814118385315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3004670739173889},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2783728837966919},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.18473589420318604},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1544525921344757},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.13775885105133057},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1376883089542389},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07651612162590027},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.05991742014884949}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008258","descriptor_name":"Waldenstrom Macroglobulinemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008258","descriptor_name":"Waldenstrom Macroglobulinemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053594","descriptor_name":"Myeloid Differentiation Factor 88","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053594","descriptor_name":"Myeloid Differentiation Factor 88","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/bcj.2015.36","doi":"https://doi.org/10.1038/bcj.2015.36","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bcj.2015.36","pdf_url":"https://www.nature.com/articles/bcj201536.pdf","source":{"id":"https://openalex.org/S2496263508","display_name":"Blood Cancer Journal","issn_l":"2044-5385","issn":["2044-5385"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4476015","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4476015","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer J","raw_type":"Text"},{"id":"pmid:25978434","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25978434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood cancer journal","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1038/bcj.2015.36","doi":"https://doi.org/10.1038/bcj.2015.36","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bcj.2015.36","pdf_url":"https://www.nature.com/articles/bcj201536.pdf","source":{"id":"https://openalex.org/S2496263508","display_name":"Blood Cancer Journal","issn_l":"2044-5385","issn":["2044-5385"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1730165007","display_name":"Development of novel therapeutic strategy against chemotherapy-resistant hematological malignancies by targeting cell cycle checkpoint mechanisms","funder_award_id":"26461416","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4657651685","display_name":null,"funder_award_id":"26461416","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G6326430391","display_name":null,"funder_award_id":"24591384","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G6892416975","display_name":"Development of therapeutic strategies targeting molecular mechanisms underlying the therapy resistance endowed by activated tyrosine kinase mutants in hematological malignancies","funder_award_id":"15K09467","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320324799","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2087613091.pdf","grobid_xml":"https://content.openalex.org/works/W2087613091.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1950448919","https://openalex.org/W1989634457","https://openalex.org/W2006422013","https://openalex.org/W2007851220","https://openalex.org/W2019712119","https://openalex.org/W2039945582","https://openalex.org/W2052855201","https://openalex.org/W2059048035","https://openalex.org/W2061321423","https://openalex.org/W2067907405","https://openalex.org/W2116382435","https://openalex.org/W2120866805","https://openalex.org/W2140380015","https://openalex.org/W2160940401"],"related_works":["https://openalex.org/W2059048035","https://openalex.org/W2108120512","https://openalex.org/W2007851220","https://openalex.org/W2574746636","https://openalex.org/W7100327521","https://openalex.org/W2341157074","https://openalex.org/W4250372004","https://openalex.org/W2082287210","https://openalex.org/W2009550376","https://openalex.org/W2018830398"],"abstract_inverted_index":{"Waldenstr\u00f6m":[0],"macroglobulinemia":[1],"(WM)":[2],"is":[3,158],"a":[4,10,22,31,136],"distinct":[5,32],"clinicopathological":[6],"entity":[7],"defined":[8],"by":[9],"low-grade":[11,128,168],"B-cell":[12,69,129,169],"lymphoma,":[13,15,145],"lymphoplasmacytic":[14],"infiltrating":[16],"the":[17,26,50,86,101,161,173,185],"bone":[18],"marrow":[19],"and":[20,95,134,149],"producing":[21,135],"monoclonal":[23,103,137],"immunoglobulin":[24],"of":[25,44,62,77,98,105,124,155,164,175],"IgM":[27,138],"class.":[28],"1":[29,112,189],"Recently,":[30],"mutation":[33,89,118,157],"in":[34,40,59,93,96,122],"MYD88,":[35],"L265P,":[36],"has":[37,119],"been":[38,57,120],"found":[39,58,121],"more":[41],"than":[42],"90%":[43],"patients":[45,99,125],"with":[46,64,72,100,126],"WM.":[47,111],"2":[48,114],"On":[49],"other":[51,127],"hand,":[52],"various":[53],"MYD88":[54,73,82,88,186],"mutations":[55],"have":[56],"about":[60],"40%":[61],"cases":[63],"activated":[65],"B-cell-like":[66],"diffuse":[67],"large":[68],"lymphoma":[70],"(ABC-DLBCL),":[71],"L265P":[74,83,187],"constituting":[75],"75\u201380%":[76],"these":[78,167],"mutations.":[79],"3":[80],"However,":[81],"represents":[84],"almost":[85],"sole":[87],"reported":[90],"so":[91],"far":[92],"WM":[94,165],"50\u201360%":[97],"IgM-type":[102],"gammopathy":[104],"undetermined":[106],"significance,":[107],"which":[108],"may":[109],"precede":[110],",":[113,115,190,192,194,196],"4":[116],"This":[117],"<10%":[123],"neoplasms":[130],"showing":[131],"plasmacytic":[132],"differentiation":[133],"protein,":[139],"such":[140],"as":[141],"splenic":[142],"marginal":[143],"zone":[144],"chronic":[146],"lymphocytic":[147],"leukemia":[148],"IgM-secreting":[150],"multiple":[151],"myeloma.":[152],"Thus,":[153],"detection":[154],"this":[156],"valuable":[159],"for":[160],"differential":[162],"diagnosis":[163],"from":[166],"neoplasms,":[170],"leading":[171],"to":[172,182],"development":[174],"highly":[176],"sensitive":[177],"allele-specific":[178],"PCR":[179],"(AS-PCR)":[180],"methods":[181],"detect":[183],"specifically":[184],"mutation.":[188],"5":[191],"6":[193],"7":[195],"8":[197]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}