{"id":"https://openalex.org/W2087581395","doi":"https://doi.org/10.1152/japplphysiol.01021.2007","title":"WISE-2005: tibial and gastrocnemius vein and calf tissue response to LBNP after a 60-day bed rest with and without countermeasures","display_name":"WISE-2005: tibial and gastrocnemius vein and calf tissue response to LBNP after a 60-day bed rest with and without countermeasures","publication_year":2008,"publication_date":"2008-01-18","ids":{"openalex":"https://openalex.org/W2087581395","doi":"https://doi.org/10.1152/japplphysiol.01021.2007","mag":"2087581395","pmid":"https://pubmed.ncbi.nlm.nih.gov/18202168"},"language":"en","primary_location":{"id":"doi:10.1152/japplphysiol.01021.2007","doi":"https://doi.org/10.1152/japplphysiol.01021.2007","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.01021.2007","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044697840","display_name":"Philippe Arbeille","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Arbeille","raw_affiliation_strings":["EFMP-UMPS, CHU Trousseau, 37044 Tours, France. arbeille@med.univ-tours.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EFMP-UMPS, CHU Trousseau, 37044 Tours, France. arbeille@med.univ-tours.fr","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000115007","display_name":"P. Kerbeci","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Kerbeci","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. Mattar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Mattar","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086962507","display_name":"J. Kevin Shoemaker","orcid":"https://orcid.org/0000-0002-6794-5979","observed_orcids":["https://orcid.org/0000-0002-6794-5979"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. K. Shoemaker","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067797276","display_name":"Richard L. Hughson","orcid":"https://orcid.org/0000-0001-6915-2959","observed_orcids":["https://orcid.org/0000-0001-6915-2959"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. L. Hughson","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8112,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.84177124,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"104","issue":"4","first_page":"938","last_page":"943"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lower-body-negative-pressure","display_name":"lower body negative pressure","score":0.9660000205039978},{"id":"https://openalex.org/keywords/head-down-bed-rest","display_name":"head-down bed rest","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tibial-vein","display_name":"tibial vein","score":0.8920000195503235},{"id":"https://openalex.org/keywords/orthostatic-tolerance","display_name":"orthostatic tolerance","score":0.7580000162124634},{"id":"https://openalex.org/keywords/countermeasures","display_name":"countermeasures","score":0.7490000128746033},{"id":"https://openalex.org/keywords/treadmill-exercise","display_name":"treadmill exercise","score":0.48399999737739563},{"id":"https://openalex.org/keywords/protein-supplementation","display_name":"protein supplementation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/tilt-table-test","display_name":"tilt table test","score":0.6209999918937683},{"id":"https://openalex.org/keywords/microgravity-adaptation","display_name":"microgravity adaptation","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C2777854218","wikidata":"https://www.wikidata.org/wiki/Q850197","display_name":"Bed rest","level":2,"score":0.6471897959709167},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5346279144287109},{"id":"https://openalex.org/C3018708532","wikidata":"https://www.wikidata.org/wiki/Q713102","display_name":"Lower body","level":2,"score":0.4712643623352051},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.40831249952316284},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3757883310317993},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33029797673225403}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001510","descriptor_name":"Bed Rest","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001510","descriptor_name":"Bed Rest","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001510","descriptor_name":"Bed Rest","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007024","descriptor_name":"Hypotension, Orthostatic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007024","descriptor_name":"Hypotension, Orthostatic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007024","descriptor_name":"Hypotension, Orthostatic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007866","descriptor_name":"Leg","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D007866","descriptor_name":"Leg","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D007866","descriptor_name":"Leg","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D007866","descriptor_name":"Leg","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D007866","descriptor_name":"Leg","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D007866","descriptor_name":"Leg","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008150","descriptor_name":"Lower Body Negative Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008150","descriptor_name":"Lower Body Negative Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008150","descriptor_name":"Lower Body Negative Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009747","descriptor_name":"Nutritional Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009747","descriptor_name":"Nutritional Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009747","descriptor_name":"Nutritional Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010809","descriptor_name":"Physical Fitness","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010809","descriptor_name":"Physical Fitness","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010809","descriptor_name":"Physical Fitness","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018474","descriptor_name":"Weightlessness Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018474","descriptor_name":"Weightlessness Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018474","descriptor_name":"Weightlessness Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018544","descriptor_name":"Weightlessness Countermeasures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018544","descriptor_name":"Weightlessness Countermeasures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018544","descriptor_name":"Weightlessness Countermeasures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018924","descriptor_name":"Vascular Capacitance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018924","descriptor_name":"Vascular Capacitance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018924","descriptor_name":"Vascular Capacitance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/japplphysiol.01021.2007","doi":"https://doi.org/10.1152/japplphysiol.01021.2007","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.01021.2007","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:18202168","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18202168","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W27536068","https://openalex.org/W199743997","https://openalex.org/W1804963346","https://openalex.org/W1826787770","https://openalex.org/W1890030502","https://openalex.org/W1934393217","https://openalex.org/W1972789975","https://openalex.org/W1986445184","https://openalex.org/W1987270666","https://openalex.org/W1988238092","https://openalex.org/W1995210554","https://openalex.org/W2006611036","https://openalex.org/W2024422605","https://openalex.org/W2026278130","https://openalex.org/W2046645567","https://openalex.org/W2050126025","https://openalex.org/W2056370480","https://openalex.org/W2057998217","https://openalex.org/W2065601364","https://openalex.org/W2093021904","https://openalex.org/W2110451550","https://openalex.org/W2123557466","https://openalex.org/W2133924017","https://openalex.org/W2139367295","https://openalex.org/W2159539104","https://openalex.org/W2160004239","https://openalex.org/W2166645862","https://openalex.org/W2168658165","https://openalex.org/W2178269751","https://openalex.org/W2187744392","https://openalex.org/W2193574164","https://openalex.org/W2354119860","https://openalex.org/W2396687283","https://openalex.org/W2406532636","https://openalex.org/W2414226596"],"related_works":["https://openalex.org/W2181704445","https://openalex.org/W2166213280","https://openalex.org/W2073994047","https://openalex.org/W834182669","https://openalex.org/W2418992041","https://openalex.org/W2435098299","https://openalex.org/W2406383651","https://openalex.org/W2382825894","https://openalex.org/W2087716494","https://openalex.org/W2002882313"],"abstract_inverted_index":{"The":[0],"objective":[1],"of":[2,80,91,99,108,176],"this":[3],"study":[4],"was":[5,185,216],"to":[6,35,181,213],"quantify":[7],"by":[8],"echography":[9],"the":[10,13,28,109,122,128,135,189,204,221,240,244],"changes":[11],"in":[12,33,105,163,174,188,207,220],"intramuscular":[14],"[gastrocnemius":[15],"(Gast)]":[16],"and":[17,27,60,72,76,111,125,137,153,191,197,223,255,265,270],"nonintramuscular":[18],"[posterior":[19],"tibial":[20],"(Tib)]":[21],"calf":[22],"veins":[23,113,178],"cross-sectional":[24],"area":[25],"(CSA)":[26],"superficial":[29,271],"tissue":[30,272],"thickness":[31],"(STth)":[32],"response":[34],"lower":[36],"body":[37],"negative":[38],"pressure":[39],"(LBNP)":[40],"after":[41,96,146,218],"60-day":[42],"head-down":[43],"bed":[44,245],"rest":[45,142,180,212,246],"(HDBR).":[46],"Twenty-four":[47],"healthy":[48],"women":[49],"(25-40":[50],"yr)":[51],"were":[52,83,102,143,156,274],"divided":[53],"into":[54],"three":[55],"groups:":[56],"control":[57],"(Con),":[58],"treadmill-LBNP":[59],"flywheel":[61],"(Ex-Lb),":[62],"nutrition":[63],"(Nut;":[64],"protein":[65],"supplement).":[66],"All":[67],"underwent":[68],"a":[69,92],"LBNP":[70,184],"(0":[71],"-45":[73,149,182,214],"mmHg)":[74],"before":[75,161],"on":[77,114,209,248],"day":[78,116],"55":[79,117],"HDBR.":[81,100,147],"Subjects":[82],"identified":[84],"as":[85,229,231],"finisher":[86],"(F)":[87],"or":[88,127],"nonfinisher":[89],"(NF)":[90],"10-min":[93],"tilt":[94],"test":[95],"60":[97],"days":[98],"There":[101],"no":[103,263],"differences":[104],"resting":[106],"CSA":[107,140,175],"Tib":[110,136,152],"Gast":[112,138,154],"HDBR":[115,162,219],"compared":[118,194,200,226,233],"with":[119,195,201,227,234,276],"pre-HDBR":[120],"for":[121,132],"Ex-Lb,":[123,196,228],"Con":[124,190,222],"Nut,":[126,168],"F":[129],"groups;":[130],"however,":[131],"NF":[133,199,232],"both":[134,177],"vein":[139,250,269],"at":[141],"significantly":[144,158,186],"smaller":[145],"At":[148],"mmHg":[150,183,215],"LBNP,":[151,259],"CSAs":[155],"not":[157],"different":[159],"from":[160,179,211],"all":[164],"groups":[165,193,225],"(Ex-Lb,":[166],"Con,":[167],"F,":[169],"NF).":[170],"However,":[171],"percent":[172,205,253],"change":[173],"greater":[187],"Nut":[192,224,261],"also":[198],"F.":[202,235],"Similarly,":[203],"increase":[206,257],"STth":[208,256],"going":[210],"higher":[217,267],"well":[230],"These":[236],"results":[237],"showed":[238],"that":[239,266],"Ex-Lb":[241],"countermeasure":[242],"minimized":[243],"effect":[247,264],"leg":[249,268],"capacitance":[251,273],"(CSA":[252],"change)":[254],"during":[258],"whereas":[260],"had":[262],"associated":[275],"reduced":[277],"orthostatic":[278],"tolerance.":[279]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
