{"id":"https://openalex.org/W2087568826","doi":"https://doi.org/10.1002/ajmg.b.32190","title":"Genetic predictors of risk and resilience in psychiatric disorders: A cross\u2010disorder genome\u2010wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia","display_name":"Genetic predictors of risk and resilience in psychiatric disorders: A cross\u2010disorder genome\u2010wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia","publication_year":2013,"publication_date":"2013-09-13","ids":{"openalex":"https://openalex.org/W2087568826","doi":"https://doi.org/10.1002/ajmg.b.32190","mag":"2087568826","pmid":"https://pubmed.ncbi.nlm.nih.gov/24039173","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4019336"},"language":"en","primary_location":{"id":"doi:10.1002/ajmg.b.32190","doi":"https://doi.org/10.1002/ajmg.b.32190","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ajmg.b.32190","pdf_url":null,"source":{"id":"https://openalex.org/S2764647521","display_name":"American Journal of Medical Genetics Part B Neuropsychiatric Genetics","issn_l":"1552-4841","issn":["1552-4841","1552-485X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4019336","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079667945","display_name":"Lauren M. McGrath","orcid":"https://orcid.org/0000-0001-6928-9656","observed_orcids":["https://orcid.org/0000-0001-6928-9656"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lauren M. McGrath","raw_affiliation_strings":["Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020046115","display_name":"Marilyn C. Cornelis","orcid":"https://orcid.org/0000-0002-0699-1664","observed_orcids":["https://orcid.org/0000-0002-0699-1664"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marilyn C. Cornelis","raw_affiliation_strings":["Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028441784","display_name":"Phil Hyoun Lee","orcid":"https://orcid.org/0000-0003-1770-3100","observed_orcids":["https://orcid.org/0000-0003-1770-3100"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phil H. Lee","raw_affiliation_strings":["Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002303468","display_name":"Elise Robinson","orcid":"https://orcid.org/0000-0003-2314-2792","observed_orcids":["https://orcid.org/0000-0003-2314-2792","https://orcid.org/0000-0002-6527-901X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elise B. Robinson","raw_affiliation_strings":["Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024497692","display_name":"Laramie E. Duncan","orcid":"https://orcid.org/0000-0003-1131-661X","observed_orcids":["https://orcid.org/0000-0003-1131-661X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laramie E. Duncan","raw_affiliation_strings":["Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts","Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008089065","display_name":"Jennifer H. Barnett","orcid":"https://orcid.org/0000-0002-4851-5949","observed_orcids":["https://orcid.org/0000-0002-4851-5949"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jennifer H. Barnett","raw_affiliation_strings":["Department of Psychiatry, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031988329","display_name":"Jie Huang","orcid":"https://orcid.org/0000-0002-9036-4304","observed_orcids":["https://orcid.org/0000-0002-9036-4304","https://orcid.org/0000-0002-9441-4698","https://orcid.org/0000-0001-6191-4912"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jie Huang","raw_affiliation_strings":["Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016155997","display_name":"Gloria Frances Gerber","orcid":"https://orcid.org/0000-0001-9855-0075","observed_orcids":["https://orcid.org/0000-0001-9855-0075"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gloria Gerber","raw_affiliation_strings":["Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062214008","display_name":"Pamela B. Sklar","orcid":"https://orcid.org/0000-0001-9715-4943","observed_orcids":["https://orcid.org/0000-0001-9715-4943"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela Sklar","raw_affiliation_strings":["Division of Psychiatric Genomics, Mount Sinai School of Medicine, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Psychiatric Genomics, Mount Sinai School of Medicine, New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061802355","display_name":"Patrick F. Sullivan","orcid":"https://orcid.org/0000-0002-6619-873X","observed_orcids":["https://orcid.org/0000-0002-6619-873X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Sullivan","raw_affiliation_strings":["Department of Genetics, University of North Carolina, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of North Carolina, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064278484","display_name":"Roy H. Perlis","orcid":"https://orcid.org/0000-0002-5862-6757","observed_orcids":["https://orcid.org/0000-0002-5862-6757"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy H. Perlis","raw_affiliation_strings":["Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044998046","display_name":"Jordan W. Smoller","orcid":"https://orcid.org/0000-0002-0381-6334","observed_orcids":["https://orcid.org/0000-0002-0381-6334"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan W. Smoller","raw_affiliation_strings":["Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5079667945"],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":{"value":3920,"currency":"USD","value_usd":3920},"apc_paid":null,"fwci":2.5297,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.89854807,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"162","issue":"8","first_page":"779","last_page":"788"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8622999787330627,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8622999787330627,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.06610000133514404,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.045099999755620956,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/functional-disability","display_name":"functional disability","score":0.9950000047683716},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.878000020980835},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.875},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":1.0},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":1.0},{"id":"https://openalex.org/keywords/mental-disorders","display_name":"mental illness","score":0.574999988079071},{"id":"https://openalex.org/keywords/genetic-risk","display_name":"genetic risk","score":0.4830000102519989},{"id":"https://openalex.org/keywords/resilience","display_name":"resilience","score":0.8149999976158142},{"id":"https://openalex.org/keywords/adamts16","display_name":"ADAMTS16","score":0.9200000166893005},{"id":"https://openalex.org/keywords/physical-functioning","display_name":"physical function","score":0.9580000042915344},{"id":"https://openalex.org/keywords/symptom-severity","display_name":"symptom severity","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.8054848909378052},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.7668344378471375},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.6719626784324646},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5853661894798279},{"id":"https://openalex.org/C3018432486","wikidata":"https://www.wikidata.org/wiki/Q7575316","display_name":"Schizophrenia spectrum","level":3,"score":0.5444719195365906},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5286878943443298},{"id":"https://openalex.org/C2993918154","wikidata":"https://www.wikidata.org/wiki/Q12131","display_name":"Functional impairment","level":2,"score":0.4718187749385834},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4498825669288635},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.4332418143749237},{"id":"https://openalex.org/C145734003","wikidata":"https://www.wikidata.org/wiki/Q7242342","display_name":"Prevalence of mental disorders","level":3,"score":0.43033507466316223},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.41991183161735535},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37721845507621765},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.2935029864311218},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.20528125762939453},{"id":"https://openalex.org/C134362201","wikidata":"https://www.wikidata.org/wiki/Q317309","display_name":"Mental health","level":2,"score":0.1456109583377838},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12831416726112366},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.10517680644989014},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08075344562530518},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.07903435826301575},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.0658809244632721},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06057789921760559}],"mesh":[{"descriptor_ui":"D000071096","descriptor_name":"ADAMTS Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055500","descriptor_name":"Resilience, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/ajmg.b.32190","doi":"https://doi.org/10.1002/ajmg.b.32190","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ajmg.b.32190","pdf_url":null,"source":{"id":"https://openalex.org/S2764647521","display_name":"American Journal of Medical Genetics Part B Neuropsychiatric Genetics","issn_l":"1552-4841","issn":["1552-4841","1552-485X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","raw_type":"journal-article"},{"id":"pmid:24039173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24039173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4019336","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4019336","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Am J Med Genet B Neuropsychiatr Genet","raw_type":"Text"},{"id":"pmh:cdr.lib.unc.edu:7s75dk21k","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/edm5-vw64","pdf_url":"https://cdr.lib.unc.edu/downloads/2f75rf855","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Medical Genetics. Part B. Neuropsychiatric Genetics, 162(8)","raw_type":"Article"},{"id":"doi:10.17615/edm5-vw64","doi":"https://doi.org/10.17615/edm5-vw64","is_oa":true,"landing_page_url":"https://doi.org/10.17615/edm5-vw64","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4019336","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4019336","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Am J Med Genet B Neuropsychiatr Genet","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1811832139","display_name":"Using Genetics to Dissect Schizhoprenia, Bipolar Disorder, and Depression","funder_award_id":"R01MH079799","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8757928469","display_name":"Research and Mentoring on Integrating Psychiatric Genetics and Neuroscience","funder_award_id":"K24MH094614","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000882768","display_name":"Stuart T. Hauser Research Training Program in Biological and Social Psychiatry","funder_award_id":"T32MH016259","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320311440","display_name":"National Alliance for Research on Schizophrenia and Depression","ror":"https://ror.org/03a63f080"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2087568826.pdf","grobid_xml":"https://content.openalex.org/works/W2087568826.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W31622913","https://openalex.org/W329953669","https://openalex.org/W1605375568","https://openalex.org/W1616286551","https://openalex.org/W1958344535","https://openalex.org/W1970019957","https://openalex.org/W1977465442","https://openalex.org/W1988763037","https://openalex.org/W1993185259","https://openalex.org/W1993322814","https://openalex.org/W1998207473","https://openalex.org/W2002265699","https://openalex.org/W2006286710","https://openalex.org/W2013757355","https://openalex.org/W2014972070","https://openalex.org/W2015652405","https://openalex.org/W2023634568","https://openalex.org/W2024341419","https://openalex.org/W2030038103","https://openalex.org/W2030246164","https://openalex.org/W2033262590","https://openalex.org/W2037377025","https://openalex.org/W2043643721","https://openalex.org/W2052114798","https://openalex.org/W2052521084","https://openalex.org/W2059483509","https://openalex.org/W2059742736","https://openalex.org/W2061378977","https://openalex.org/W2065020285","https://openalex.org/W2082832014","https://openalex.org/W2085459418","https://openalex.org/W2087949243","https://openalex.org/W2089843122","https://openalex.org/W2092323433","https://openalex.org/W2098597355","https://openalex.org/W2101605059","https://openalex.org/W2105980866","https://openalex.org/W2110341150","https://openalex.org/W2110361971","https://openalex.org/W2113463873","https://openalex.org/W2114613490","https://openalex.org/W2116451813","https://openalex.org/W2122796918","https://openalex.org/W2130309831","https://openalex.org/W2143427837","https://openalex.org/W2146170358","https://openalex.org/W2149375666","https://openalex.org/W2159155203","https://openalex.org/W2160070901","https://openalex.org/W2161633633","https://openalex.org/W2162557372","https://openalex.org/W2162993517","https://openalex.org/W2163013660","https://openalex.org/W2163184920","https://openalex.org/W2163805611","https://openalex.org/W2165930296","https://openalex.org/W2167806431","https://openalex.org/W2168909456","https://openalex.org/W2169205386","https://openalex.org/W2171577507","https://openalex.org/W2172151487","https://openalex.org/W2182897588","https://openalex.org/W2314449892","https://openalex.org/W2327785829","https://openalex.org/W2902614660","https://openalex.org/W3004292749","https://openalex.org/W4285719527","https://openalex.org/W4292806894"],"related_works":["https://openalex.org/W4410846129","https://openalex.org/W4387521162","https://openalex.org/W2116451813","https://openalex.org/W2110361971","https://openalex.org/W2126508046","https://openalex.org/W2033346358","https://openalex.org/W2130964553","https://openalex.org/W7009853836","https://openalex.org/W2935769777","https://openalex.org/W3184422061"],"abstract_inverted_index":{"Functional":[0],"impairment":[1,27,45,210],"is":[2,14],"one":[3],"of":[4,10,31,43,49,54,67,98,101,110,116,119,140,150,166],"the":[5,37,47,92,111,151,163],"most":[6],"enduring,":[7],"intractable":[8],"consequences":[9],"psychiatric":[11,130,212],"disorders":[12],"and":[13,17,81,107,113,160,174,195],"both":[15],"familial":[16],"heritable.":[18],"Previous":[19],"studies":[20,66],"have":[21],"suggested":[22],"that":[23],"variation":[24],"in":[25,46,172],"functional":[26,44,141,209],"can":[28],"be":[29],"independent":[30],"symptom":[32,131,134,161],"severity.":[33,132],"Here":[34],"we":[35],"report":[36],"first":[38],"genome-wide":[39],"association":[40,168],"study":[41,88,199],"(GWAS)":[42],"context":[48],"major":[50,74],"mental":[51,112],"illness.":[52],"Participants":[53],"European-American":[55],"descent":[56],"(N":[57,71,78,84],"=":[58,72,79,85,178],"2,246)":[59],"were":[60],"included":[61],"from":[62],"three":[63],"large":[64],"treatment":[65],"bipolar":[68],"disorder":[69,76],"(STEP-BD)":[70],"765),":[73],"depressive":[75],"(STAR*D)":[77],"1091),":[80],"schizophrenia":[82],"(CATIE)":[83],"390).":[86],"At":[87],"entry,":[89],"participants":[90],"completed":[91],"SF-12,":[93],"a":[94,105,137,201],"widely":[95],"used":[96],"measure":[97],"health-related":[99,117],"quality":[100,118],"life.":[102],"We":[103],"performed":[104],"GWAS":[106],"pathway":[108],"analysis":[109,184],"physical":[114,175],"components":[115],"life":[120],"across":[121,153,211],"diagnosis":[122],"(\u223c1.6":[123],"million":[124],"single":[125],"nucleotide":[126],"polymorphisms),":[127],"adjusting":[128],"for":[129,146,157,192,204],"Psychiatric":[133],"severity":[135],"was":[136,169],"significant":[138,188],"predictor":[139],"impairment,":[142],"but":[143],"it":[144],"accounted":[145],"less":[147],"than":[148],"one-third":[149],"variance":[152],"disorders.":[154,213],"After":[155],"controlling":[156],"diagnostic":[158],"category":[159],"severity,":[162],"strongest":[164],"evidence":[165],"genetic":[167,206],"between":[170],"variants":[171],"ADAMTS16":[173],"functioning":[176],"(P":[177],"5.87":[179],"\u00d7":[180],"10(-8)":[181],").":[182],"Pathway":[183],"did":[185],"not":[186],"indicate":[187],"enrichment":[189],"after":[190],"correction":[191],"gene":[193],"clustering":[194],"multiple":[196],"testing.":[197],"This":[198],"illustrates":[200],"phenotypic":[202],"framework":[203],"examining":[205],"contributions":[207],"to":[208]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
