{"id":"https://openalex.org/W2087564482","doi":"https://doi.org/10.1111/jne.12085","title":"Early Histone Modifications in the Ventromedial Hypothalamus and Preoptic Area Following Oestradiol Administration","display_name":"Early Histone Modifications in the Ventromedial Hypothalamus and Preoptic Area Following Oestradiol Administration","publication_year":2013,"publication_date":"2013-08-08","ids":{"openalex":"https://openalex.org/W2087564482","doi":"https://doi.org/10.1111/jne.12085","mag":"2087564482","pmid":"https://pubmed.ncbi.nlm.nih.gov/23927378","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3896307"},"language":"en","primary_location":{"id":"doi:10.1111/jne.12085","doi":"https://doi.org/10.1111/jne.12085","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jne.12085","pdf_url":null,"source":{"id":"https://openalex.org/S100175869","display_name":"Journal of Neuroendocrinology","issn_l":"0953-8194","issn":["0953-8194","1365-2826"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroendocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3896307","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064922181","display_name":"Khatuna Gagnidze","orcid":"https://orcid.org/0000-0002-8503-7261","observed_orcids":["https://orcid.org/0000-0002-8503-7261"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K. Gagnidze","raw_affiliation_strings":["Laboratory of Neurobiology and Behaviour The Rockefeller University New York NY USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurobiology and Behaviour The Rockefeller University New York NY USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026436156","display_name":"Zachary M. Weil","orcid":"https://orcid.org/0000-0003-3758-1809","observed_orcids":["https://orcid.org/0000-0003-3758-1809"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z. M. Weil","raw_affiliation_strings":["Laboratory of Neurobiology and Behaviour The Rockefeller University New York NY USA","The Rockefeller University Laboratory of Neurobiology and Behaviour New York NY USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurobiology and Behaviour The Rockefeller University New York NY USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"The Rockefeller University Laboratory of Neurobiology and Behaviour New York NY USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088364396","display_name":"Larissa Costa Faustino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. C. Faustino","raw_affiliation_strings":["Laboratory of Neurobiology and Behaviour The Rockefeller University New York NY USA","The Rockefeller University Laboratory of Neurobiology and Behaviour New York NY USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurobiology and Behaviour The Rockefeller University New York NY USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"The Rockefeller University Laboratory of Neurobiology and Behaviour New York NY USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088100186","display_name":"Sara M. Schaafsma","orcid":"https://orcid.org/0000-0003-0476-7877","observed_orcids":["https://orcid.org/0000-0003-0476-7877"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. M. Schaafsma","raw_affiliation_strings":["Laboratory of Neurobiology and Behaviour The Rockefeller University New York NY USA","The Rockefeller University Laboratory of Neurobiology and Behaviour New York NY USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurobiology and Behaviour The Rockefeller University New York NY USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"The Rockefeller University Laboratory of Neurobiology and Behaviour New York NY USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086866710","display_name":"Donald W. Pfaff","orcid":"https://orcid.org/0000-0002-6569-8505","observed_orcids":["https://orcid.org/0000-0002-6569-8505"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. W. Pfaff","raw_affiliation_strings":["Laboratory of Neurobiology and Behaviour The Rockefeller University New York NY USA","The Rockefeller University Laboratory of Neurobiology and Behaviour New York NY USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurobiology and Behaviour The Rockefeller University New York NY USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"The Rockefeller University Laboratory of Neurobiology and Behaviour New York NY USA","institution_ids":["https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064922181"],"corresponding_institution_ids":["https://openalex.org/I83399316"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":4.1244,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.94149727,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"25","issue":"10","first_page":"939","last_page":"955"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8227999806404114,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8227999806404114,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.08229999989271164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.6740000247955322},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9810000061988831},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":0.8820000290870667},{"id":"https://openalex.org/keywords/lordosis","display_name":"lordosis","score":0.7059999704360962},{"id":"https://openalex.org/keywords/ventromedial-hypothalamic-nucleus","display_name":"ventromedial hypothalamus","score":0.9210000038146973},{"id":"https://openalex.org/keywords/preoptic-area","display_name":"preoptic area","score":0.9950000047683716},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.777999997138977},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.7329999804496765},{"id":"https://openalex.org/keywords/histone-h3k4me3","display_name":"histone H3K4me3","score":0.7860000133514404},{"id":"https://openalex.org/keywords/histone-h3k9me3","display_name":"histone H3K9me3","score":0.9610000252723694},{"id":"https://openalex.org/keywords/oxytocin-receptor","display_name":"oxytocin receptor","score":0.7739999890327454},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.7250000238418579},{"id":"https://openalex.org/keywords/female-sexual-behavior","display_name":"female sexual behavior","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C2780914512","wikidata":"https://www.wikidata.org/wiki/Q25323943","display_name":"H3K4me3","level":5,"score":0.7499852180480957},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7132863402366638},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6970561742782593},{"id":"https://openalex.org/C2776745794","wikidata":"https://www.wikidata.org/wiki/Q24777451","display_name":"Histone H3","level":4,"score":0.613977313041687},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6079566478729248},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5797329545021057},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.5199107527732849},{"id":"https://openalex.org/C2776046087","wikidata":"https://www.wikidata.org/wiki/Q7920337","display_name":"Ventromedial nucleus of the hypothalamus","level":3,"score":0.49534788727760315},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4316751956939697},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.31521186232566833},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2264864444732666},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1241464912891388},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09810513257980347}],"mesh":[{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011301","descriptor_name":"Preoptic Area","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/jne.12085","doi":"https://doi.org/10.1111/jne.12085","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jne.12085","pdf_url":null,"source":{"id":"https://openalex.org/S100175869","display_name":"Journal of Neuroendocrinology","issn_l":"0953-8194","issn":["0953-8194","1365-2826"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroendocrinology","raw_type":"journal-article"},{"id":"pmid:23927378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23927378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroendocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3896307","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3896307","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neuroendocrinol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3896307","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3896307","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neuroendocrinol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1624374029","display_name":"ENDOCRINE RESEARCH TRAINING GRANT","funder_award_id":"T32DK007313","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3654376730","display_name":"BRAIN MECHANISMS OF REPRODUCTIVE BEHAVIOR","funder_award_id":"R01HD005751","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3713766447","display_name":"Brain Mechanisms of Reproductive Behavior","funder_award_id":"R37HD005751","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4616922649","display_name":null,"funder_award_id":"HD05751-39","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1483942674","https://openalex.org/W1522531331","https://openalex.org/W1569704074","https://openalex.org/W1594452843","https://openalex.org/W1632688166","https://openalex.org/W1967769642","https://openalex.org/W1970569586","https://openalex.org/W1972385372","https://openalex.org/W1974973093","https://openalex.org/W1975497776","https://openalex.org/W1976416751","https://openalex.org/W1980333310","https://openalex.org/W1981306061","https://openalex.org/W1987528584","https://openalex.org/W1992868516","https://openalex.org/W1995428338","https://openalex.org/W1998568965","https://openalex.org/W2003758571","https://openalex.org/W2004499293","https://openalex.org/W2004988279","https://openalex.org/W2007684630","https://openalex.org/W2013181087","https://openalex.org/W2013322816","https://openalex.org/W2016024994","https://openalex.org/W2021768020","https://openalex.org/W2022243072","https://openalex.org/W2024584416","https://openalex.org/W2025901495","https://openalex.org/W2026443131","https://openalex.org/W2028470262","https://openalex.org/W2030637684","https://openalex.org/W2032903445","https://openalex.org/W2039576757","https://openalex.org/W2044809684","https://openalex.org/W2044816110","https://openalex.org/W2045389096","https://openalex.org/W2048595449","https://openalex.org/W2049868369","https://openalex.org/W2050912412","https://openalex.org/W2051357093","https://openalex.org/W2052347419","https://openalex.org/W2054621094","https://openalex.org/W2056415305","https://openalex.org/W2058756987","https://openalex.org/W2060889804","https://openalex.org/W2060959074","https://openalex.org/W2068113812","https://openalex.org/W2068194528","https://openalex.org/W2071308804","https://openalex.org/W2073340956","https://openalex.org/W2073353512","https://openalex.org/W2077881729","https://openalex.org/W2081684816","https://openalex.org/W2086479929","https://openalex.org/W2090991839","https://openalex.org/W2095595375","https://openalex.org/W2103042362","https://openalex.org/W2110297259","https://openalex.org/W2114570899","https://openalex.org/W2117326208","https://openalex.org/W2120477765","https://openalex.org/W2132619798","https://openalex.org/W2135342851","https://openalex.org/W2141920376","https://openalex.org/W2142902360","https://openalex.org/W2145799423","https://openalex.org/W2156933633","https://openalex.org/W2157609159","https://openalex.org/W2161218552","https://openalex.org/W2168463311","https://openalex.org/W2169102621","https://openalex.org/W2169318796","https://openalex.org/W2169766629","https://openalex.org/W4212766227","https://openalex.org/W4237142329","https://openalex.org/W4254205284"],"related_works":["https://openalex.org/W2954249062","https://openalex.org/W2411484624","https://openalex.org/W2058526650","https://openalex.org/W2969460066","https://openalex.org/W2062401068","https://openalex.org/W2299726268","https://openalex.org/W2594318525","https://openalex.org/W2027668562","https://openalex.org/W2067723059","https://openalex.org/W2026463002"],"abstract_inverted_index":{"Expression":[0],"of":[1,15,28,32,55,67,77,95,102,118,140,182,192,211,218,231,237,246,254,261,290,311],"the":[2,25,29,33,86,96,100,116,138,160,173,177,189,193,197,206,216,235,244,249,262,274,287,306],"primary":[3],"female":[4,103,120,238,312],"sex":[5],"behaviour,":[6],"lordosis,":[7,165],"in":[8,24,99,115,176,205,243,286,294,305,323],"laboratory":[9],"animals":[10],"depends":[11],"on":[12,327],"oestrogen-induced":[13],"expression":[14,289],"progesterone":[16],"receptor":[17,58,223],"(PgR)":[18],"within":[19,166,196],"a":[20,56,148,156,295],"defined":[21],"cell":[22,328],"group":[23],"ventrolateral":[26],"portion":[27],"ventromedial":[30],"nucleus":[31],"hypothalamus":[34,307],"(VMH).":[35],"The":[36,80],"minimal":[37],"latency":[38],"from":[39],"oestradiol":[40],"administration":[41,107,281],"to":[42,72,84,137,248,269,283,316],"lordosis":[43],"is":[44],"18":[45],"h.":[46],"During":[47],"that":[48],"time,":[49],"ligand-bound":[50],"oestrogen":[51],"receptors":[52],"(ER),":[53],"members":[54],"nuclear":[57],"superfamily,":[59],"recruit":[60],"transcriptional":[61,73,93,143,161],"coregulators,":[62],"which":[63],"induce":[64],"covalent":[65],"modifications":[66,114,213],"histone":[68,113,183,212,331],"proteins,":[69],"thus":[70],"leading":[71],"activation":[74,94],"or":[75],"repression":[76],"target":[78],"genes.":[79],"present":[81],"study":[82],"aimed":[83],"investigate":[85],"early":[87,314],"molecular":[88],"epigenetic":[89],"events":[90],"underlying":[91],"oestrogen-regulated":[92],"Pgr":[97,194,255],"gene":[98,195],"VMH":[101,117,236],"mice.":[104,121],"Oestradiol":[105],"(E\u2082)":[106],"induced":[108],"rapid":[109],"and":[110,129,179,227,308,336],"transient":[111],"global":[112],"ovariectomised":[119],"Histone":[122],"H3":[123,184],"N-terminus":[124],"phosphorylation":[125],"(H3S10phK14Ac),":[126],"acetylation":[127],"(H3Ac)":[128],"methylation":[130],"(H3K4me3)":[131],"exhibited":[132],"distinct":[133],"temporal":[134,150],"patterns":[135],"facilitative":[136],"induction":[139],"transcription.":[141],"A":[142],"repressive":[144],"(H3K9me3)":[145],"modification":[146,332],"showed":[147],"different":[149],"pattern.":[151],"Collectively,":[152],"this":[153],"should":[154],"create":[155],"permissive":[157],"environment":[158],"for":[159,164],"activity":[162],"necessary":[163],"3-6":[167],"h":[168],"after":[169],"E\u2082":[170,232,240,280,317],"treatment.":[171,233],"In":[172,234],"VMH,":[174],"changes":[175,285,322],"H3Ac":[178],"H3K4me3":[180],"levels":[181],"were":[185,203],"also":[186],"detected":[187],"at":[188],"promoter":[190,217,277],"region":[191],"same":[198],"time":[199,337],"window,":[200],"although":[201,266],"they":[202],"delayed":[204],"preoptic":[207,309],"area.":[208],"Moreover,":[209],"examination":[210],"associated":[214],"with":[215,273],"another":[219],"ER-target":[220],"gene,":[221,256,330],"oxytocin":[222],"(Oxtr),":[224],"revealed":[225],"gene-":[226],"brain-region":[228,296],"specific":[229,321],"effects":[230],"mice,":[239,313],"treatment":[241,318],"resulted":[242],"recruitment":[245],"ER\u03b1":[247,271],"oestrogen-response-elements-containing":[250],"putative":[251],"enhancer":[252],"site":[253,335],"approximately":[257],"200":[258],"kb":[259],"upstream":[260],"transcription":[263],"start":[264],"site,":[265],"it":[267],"failed":[268],"increase":[270],"association":[272],"more":[275],"proximal":[276],"region.":[278],"Finally,":[279],"led":[282],"significant":[284],"mRNA":[288],"several":[291],"ER":[292],"coregulators":[293],"dependent":[297,326],"manner.":[298],"Taken":[299],"together,":[300],"these":[301],"data":[302],"indicate":[303],"that,":[304],"area":[310],"responses":[315],"involve":[319],"highly":[320],"chromatin":[324],"structure,":[325],"group,":[329],"studied,":[333],"promoter/enhancer":[334],"following":[338],"E\u2082.":[339]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
