{"id":"https://openalex.org/W2087490934","doi":"https://doi.org/10.3109/03630268808991649","title":"Selection of Hydroxypyridin-4-Ones for the Treatment of Iron Overload Using In Vitro and In Vivo Models","display_name":"Selection of Hydroxypyridin-4-Ones for the Treatment of Iron Overload Using In Vitro and In Vivo Models","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W2087490934","doi":"https://doi.org/10.3109/03630268808991649","mag":"2087490934","pmid":"https://pubmed.ncbi.nlm.nih.gov/3209401"},"language":"en","primary_location":{"id":"doi:10.3109/03630268808991649","doi":"https://doi.org/10.3109/03630268808991649","is_oa":false,"landing_page_url":"https://doi.org/10.3109/03630268808991649","pdf_url":null,"source":{"id":"https://openalex.org/S81929299","display_name":"Hemoglobin","issn_l":"0363-0269","issn":["0363-0269","1532-432X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hemoglobin","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111536609","display_name":"E. R. Huehns","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E. R. Huehns","raw_affiliation_strings":["University College London","University College London 98 affnies Mews, London, WCIE 6HX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"University College London 98 affnies Mews, London, WCIE 6HX","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049244658","display_name":"John B. Porter","orcid":"https://orcid.org/0000-0003-3000-9359","observed_orcids":["https://orcid.org/0000-0003-3000-9359"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. B. Porter","raw_affiliation_strings":["University College London 98 affnies Mews, London, WCIE 6HX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London 98 affnies Mews, London, WCIE 6HX","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020843793","display_name":"Robert C. Hider","orcid":"https://orcid.org/0000-0003-1330-5797","observed_orcids":["https://orcid.org/0000-0003-1330-5797"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. C. Hider","raw_affiliation_strings":["King's College, Manresa Road, London, SW3 6LX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King's College, Manresa Road, London, SW3 6LX","institution_ids":["https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5447,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.93097323,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"12","issue":"5-6","first_page":"593","last_page":"600"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iron-chelators","display_name":"iron chelators","score":0.9359999895095825},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.9869999885559082},{"id":"https://openalex.org/keywords/oral-iron-chelation","display_name":"oral iron chelation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/lipid-solubility","display_name":"lipid solubility","score":0.8939999938011169},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.7979999780654907},{"id":"https://openalex.org/keywords/iron-excretion","display_name":"iron excretion","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7924214005470276},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7619322538375854},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.599808394908905},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5130871534347534},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4880887269973755},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.4441296458244324},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.4433196187019348},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.4105038046836853},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3547663688659668},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.32920995354652405},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2768940329551697},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.09831959009170532},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09194651246070862}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007502","descriptor_name":"Iron Chelating Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007502","descriptor_name":"Iron Chelating Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3109/03630268808991649","doi":"https://doi.org/10.3109/03630268808991649","is_oa":false,"landing_page_url":"https://doi.org/10.3109/03630268808991649","pdf_url":null,"source":{"id":"https://openalex.org/S81929299","display_name":"Hemoglobin","issn_l":"0363-0269","issn":["0363-0269","1532-432X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hemoglobin","raw_type":"journal-article"},{"id":"pmid:3209401","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3209401","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hemoglobin","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:91648","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/91648/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HEMOGLOBIN , 12 (5-6) 593 - 600. (1988)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1972825203","https://openalex.org/W2029249102","https://openalex.org/W2031683173","https://openalex.org/W2046771337","https://openalex.org/W2047867103","https://openalex.org/W2051260674","https://openalex.org/W2095490030","https://openalex.org/W2370463439","https://openalex.org/W2409616927","https://openalex.org/W4393818646"],"related_works":["https://openalex.org/W2269760103","https://openalex.org/W2095490030","https://openalex.org/W3103147217","https://openalex.org/W2313216429","https://openalex.org/W3092001251","https://openalex.org/W2046962611","https://openalex.org/W30168135","https://openalex.org/W2140924749","https://openalex.org/W2047363862","https://openalex.org/W2214504204"],"abstract_inverted_index":{"The":[0,91,130],"hydroxypyridin-&one":[1],"group":[2,195],"of":[3,14,48,58,74,93,96,112,118,139,142,153,193,196,204,214,226,241],"iron":[4,15,49,144,161,176,180,207],"chelators":[5,113],"show":[6],"promise":[7],"as":[8,120,122,147,149],"potential":[9,56],"compounds":[10,26,99,197],"for":[11,24,29,82,115,238],"the":[12,18,22,25,41,45,51,55,66,75,78,102,110,137,140,150,172,190,202,205,227,239,248,250,265,269,276,283],"treatment":[13,240],"overload":[16],"by":[17,218,232,281],"oral":[19],"route.":[20],"In":[21,61,286],"search":[23],"best":[27,80,277],"suited":[28,81],"long":[30],"term":[31],"clinical":[32,87,305],"use,":[33],"a":[34,94,211],"balance":[35],"has":[36,135,256,275,289],"to":[37,43,53,71,86,108,127,158,201,234,304],"be":[38,235],"struck":[39],"between":[40],"desire":[42],"mobilise":[44],"maximum":[46],"amount":[47],"and":[50,163,274],"wish":[52],"minimise":[54],"toxicity":[57,192,292,301],"such":[59],"compounds.":[60],"this":[62,194],"article":[63],"we":[64,68,186,222],"review":[65],"approach":[67,213],"have":[69,77,105,169,187,223,244],"used":[70],"evaluate":[72],"which":[73,124,225],"hydroxypyridinones":[76,228],"properties":[79,111],"further":[83],"development":[84],"prior":[85,303],"trials":[88,306],"in":[89,167,182,215,219,262,307],"man.":[90,308],"diversity":[92],"number":[95],"closely":[97,199],"related":[98],"substituted":[100],"on":[101,247],"ring":[103],"nitrogen":[104],"allowed":[106],"us":[107],"study":[109],"responsible":[114],"cellular":[116,160,175],"mobilisation":[117,162],"iron(III),":[119],"well":[121,148],"those":[123],"may":[125],"contribute":[126],"their":[128,143,154],"toxicity.":[129,164],"primary":[131],"hepatocyte":[132],"culture":[133],"model":[134],"facilitated":[136],"investigation":[138],"contribution":[141],"binding":[145],"constant,":[146],"critical":[151],"importance":[152],"relative":[155],"lipid":[156],"solubility":[157],"both":[159],"Similarly":[165],"studies":[166,302],"mice":[168],"confirmed":[170],"that":[171,189],"factors":[173],"affecting":[174],"release":[177],"also":[178],"control":[179],"excretion":[181],"whole":[183],"animals.":[184],"Further":[185],"demonstrated":[188],"acute":[191],"is":[198,268],"linked":[200],"size":[203],"available":[206],"pool.":[208],"By":[209],"using":[210],"combined":[212],"vitro":[216],"followed":[217,280],"vivo":[220],"screening":[221],"determined":[224],"are":[229],"sufficiently":[230],"active":[231,271],"mouth":[233],"useful":[236],"clinically":[237],"ironoverload.":[242],"We":[243],"stopped":[245],"working":[246],"CP20,":[249],"N-methyl":[251],"derivative,":[252],"mainly":[253],"because":[254],"it":[255],"an":[257],"unexplained":[258],"synergism":[259],"with":[260],"barbiturates":[261],"rats.":[263],"CP51,":[264],"ether":[266],"derivative":[267],"most":[270],"compound":[272,288],"tested":[273],"toxicity/activity":[278],"ratio,":[279],"CP21,":[282],"ethyl":[284],"derivative.":[285],"neither":[287],"any":[290],"overt":[291],"been":[293],"observed.":[294],"These":[295],"two":[296],"compounds,":[297],"therefore,":[298],"warrant":[299],"detailed":[300]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
