{"id":"https://openalex.org/W2087463572","doi":"https://doi.org/10.1016/j.febslet.2008.12.043","title":"Stress induces tRNA cleavage by angiogenin in mammalian cells","display_name":"Stress induces tRNA cleavage by angiogenin in mammalian cells","publication_year":2008,"publication_date":"2008-12-27","ids":{"openalex":"https://openalex.org/W2087463572","doi":"https://doi.org/10.1016/j.febslet.2008.12.043","mag":"2087463572","pmid":"https://pubmed.ncbi.nlm.nih.gov/19114040"},"language":"en","primary_location":{"id":"doi:10.1016/j.febslet.2008.12.043","doi":"https://doi.org/10.1016/j.febslet.2008.12.043","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.febslet.2008.12.043","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2087463572"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032953597","display_name":"Hanjiang Fu","orcid":"https://orcid.org/0000-0002-4352-1178","observed_orcids":["https://orcid.org/0000-0002-4352-1178"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanjiang Fu","raw_affiliation_strings":["Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004046742","display_name":"Junjun Feng","orcid":"https://orcid.org/0000-0003-4933-9083","observed_orcids":["https://orcid.org/0000-0003-4933-9083"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junjun Feng","raw_affiliation_strings":["Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100432497","display_name":"Qin Liu","orcid":"https://orcid.org/0000-0002-5465-1189","observed_orcids":["https://orcid.org/0000-0002-5465-1189"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qin Liu","raw_affiliation_strings":["Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008626725","display_name":"Fang Yun Sun","orcid":"https://orcid.org/0000-0003-0481-125X","observed_orcids":["https://orcid.org/0000-0003-0481-125X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fang Sun","raw_affiliation_strings":["Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103871586","display_name":"Yi Tie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi Tie","raw_affiliation_strings":["Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044911914","display_name":"Jie Zhu","orcid":"https://orcid.org/0000-0002-9836-8035","observed_orcids":["https://orcid.org/0000-0002-9836-8035"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Zhu","raw_affiliation_strings":["Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112118272","display_name":"Ruiyun Xing","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruiyun Xing","raw_affiliation_strings":["Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029557558","display_name":"Zhixian Sun","orcid":"https://orcid.org/0009-0004-0624-4513","observed_orcids":["https://orcid.org/0009-0004-0624-4513"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhixian Sun","raw_affiliation_strings":["Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People's Republic of China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088559244","display_name":"Xiaofei Zheng","orcid":"https://orcid.org/0000-0001-7502-6131","observed_orcids":["https://orcid.org/0000-0001-7502-6131"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xiaofei Zheng","raw_affiliation_strings":["Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People's Republic of China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5088559244"],"corresponding_institution_ids":[],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":4.2224,"has_fulltext":false,"cited_by_count":600,"citation_normalized_percentile":{"value":0.95753311,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"583","issue":"2","first_page":"437","last_page":"442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.06589999794960022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trna-cleavage","display_name":"tRNA cleavage","score":0.9919999837875366},{"id":"https://openalex.org/keywords/angiogenin","display_name":"angiogenin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/rnase-a-superfamily","display_name":"RNase A superfamily","score":0.8610000014305115},{"id":"https://openalex.org/keywords/trna-derived-fragments","display_name":"tRNA-derived fragments","score":0.7870000004768372},{"id":"https://openalex.org/keywords/anticodon-loop","display_name":"anticodon loop","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cellular-stress-response","display_name":"cellular stress response","score":0.7210000157356262},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6019999980926514},{"id":"https://openalex.org/keywords/trna-halves","display_name":"tRNA halves","score":0.6899999976158142},{"id":"https://openalex.org/keywords/mammalian-cells","display_name":"mammalian cells","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2776719180","wikidata":"https://www.wikidata.org/wiki/Q14882120","display_name":"Angiogenin","level":3,"score":0.9799818992614746},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.8223003149032593},{"id":"https://openalex.org/C10879258","wikidata":"https://www.wikidata.org/wiki/Q76826611","display_name":"RNase P","level":4,"score":0.7525272369384766},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.6487241387367249},{"id":"https://openalex.org/C2777271071","wikidata":"https://www.wikidata.org/wiki/Q422529","display_name":"Nuclease","level":3,"score":0.6198682188987732},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5668337941169739},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.5184245109558105},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4988250732421875},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.4828236997127533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47940966486930847},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4139302968978882},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38967037200927734},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3778975307941437},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.3726802468299866},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3414251208305359},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.281260222196579},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.17854821681976318},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1728232204914093},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1236439049243927},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000926","descriptor_name":"Anticodon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012259","descriptor_name":"Ribonuclease, Pancreatic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.febslet.2008.12.043","doi":"https://doi.org/10.1016/j.febslet.2008.12.043","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.febslet.2008.12.043","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:19114040","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19114040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1562069683","https://openalex.org/W1601491244","https://openalex.org/W2002657956","https://openalex.org/W2007982521","https://openalex.org/W2009040420","https://openalex.org/W2017617041","https://openalex.org/W2021470992","https://openalex.org/W2021555827","https://openalex.org/W2032501207","https://openalex.org/W2035982269","https://openalex.org/W2057268153","https://openalex.org/W2069493167","https://openalex.org/W2073355522","https://openalex.org/W2075101961","https://openalex.org/W2114079476","https://openalex.org/W2120014697","https://openalex.org/W2128098883","https://openalex.org/W2154245736","https://openalex.org/W2162391016","https://openalex.org/W2164760302","https://openalex.org/W2167557255","https://openalex.org/W2419144104","https://openalex.org/W4236097366"],"related_works":["https://openalex.org/W2981253991","https://openalex.org/W2008255393","https://openalex.org/W3004447159","https://openalex.org/W4214576010","https://openalex.org/W2109140791","https://openalex.org/W2978006966","https://openalex.org/W2149403492","https://openalex.org/W6958409939"],"abstract_inverted_index":{"tRNAs":[0,76],"play":[1],"a":[2,63],"central":[3],"role":[4,94],"in":[5,28,37,56,80,83,95],"protein":[6],"translation,":[7],"acting":[8],"as":[9],"the":[10,29,72,101],"carrier":[11],"of":[12,65,104],"amino":[13],"acids.":[14],"By":[15],"cloning":[16],"microRNAs,":[17],"we":[18],"unexpectedly":[19],"obtained":[20],"some":[21],"tRNA":[22,26,33,53,78],"fragments":[23,34],"generated":[24],"by":[25],"cleavage":[27,54],"anticodon":[30],"loop.":[31],"These":[32,85],"are":[35],"present":[36],"many":[38],"cell":[39,96],"lines":[40],"and":[41,82],"different":[42],"mouse":[43],"tissues.":[44],"In":[45],"addition,":[46],"various":[47],"stress":[48,97],"conditions":[49],"can":[50],"induce":[51],"this":[52],"event":[55],"mammalian":[57],"cells.":[58],"More":[59],"importantly,":[60],"angiogenin":[61,89],"(ANG),":[62],"member":[64],"RNase":[66],"A":[67],"superfamily,":[68],"appears":[69],"to":[70],"be":[71],"nuclease":[73],"which":[74],"cleaves":[75],"into":[77],"halves":[79],"vitro":[81],"vivo.":[84],"results":[86],"imply":[87],"that":[88],"plays":[90],"an":[91],"important":[92],"physiological":[93],"response,":[98],"except":[99],"for":[100],"known":[102],"function":[103],"inducing":[105],"angiogenesis.":[106]},"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":36},{"year":2024,"cited_by_count":50},{"year":2023,"cited_by_count":45},{"year":2022,"cited_by_count":52},{"year":2021,"cited_by_count":49},{"year":2020,"cited_by_count":63},{"year":2019,"cited_by_count":49},{"year":2018,"cited_by_count":41},{"year":2017,"cited_by_count":25},{"year":2016,"cited_by_count":30},{"year":2015,"cited_by_count":32},{"year":2014,"cited_by_count":26},{"year":2013,"cited_by_count":26},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}