{"id":"https://openalex.org/W2087455409","doi":"https://doi.org/10.7705/biomedica.v27i1.229","title":"Predicci\u00f3n computacional de la estructura terciaria de la iduronato 2-sulfato sulfatasa humana","display_name":"Predicci\u00f3n computacional de la estructura terciaria de la iduronato 2-sulfato sulfatasa humana","publication_year":2007,"publication_date":"2007-08-26","ids":{"openalex":"https://openalex.org/W2087455409","doi":"https://doi.org/10.7705/biomedica.v27i1.229","mag":"2087455409","pmid":"https://pubmed.ncbi.nlm.nih.gov/17546220"},"language":"es","primary_location":{"id":"doi:10.7705/biomedica.v27i1.229","doi":"https://doi.org/10.7705/biomedica.v27i1.229","is_oa":true,"landing_page_url":"https://doi.org/10.7705/biomedica.v27i1.229","pdf_url":"https://revistabiomedica.org/index.php/biomedica/article/download/229/214","source":{"id":"https://openalex.org/S114824300","display_name":"Biom\u00e9dica","issn_l":"0120-4157","issn":["0120-4157","2590-7379"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","publindex-b","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310318852","host_organization_name":"National Institute of Health","host_organization_lineage":["https://openalex.org/P4310318852"],"host_organization_lineage_names":["National Institute of Health"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biom\u00e9dica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://revistabiomedica.org/index.php/biomedica/article/download/229/214","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017823430","display_name":"Homero S\u00e1enz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19325673","display_name":"Universidad Centroccidental Lisandro Alvarado","ror":"https://ror.org/03qgg3111","country_code":"VE","type":"education","lineage":["https://openalex.org/I19325673"]},{"id":"https://openalex.org/I233745408","display_name":"Pontificia Universidad Javeriana","ror":"https://ror.org/03etyjw28","country_code":"CO","type":"education","lineage":["https://openalex.org/I233745408"]}],"countries":["CO","VE"],"is_corresponding":false,"raw_author_name":"Homero S\u00e1enz","raw_affiliation_strings":["Instituto de Errores Innatos del Metabolismo, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogot\u00e1 D.C., Colombia. Unidad de Biolog\u00eda Celular y Microscop\u00eda, Decanato de Medicina, Universidad Centroccidental \u201cLisandro Alvarado\u201d, Barquisi","Universidad Centroccidental Lisandro #TAB##TAB##TAB##TAB##TAB##TAB#Alvarado, Barquisimeto, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Errores Innatos del Metabolismo, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogot\u00e1 D.C., Colombia. Unidad de Biolog\u00eda Celular y Microscop\u00eda, Decanato de Medicina, Universidad Centroccidental \u201cLisandro Alvarado\u201d, Barquisi","institution_ids":["https://openalex.org/I19325673","https://openalex.org/I233745408"]},{"raw_affiliation_string":"Universidad Centroccidental Lisandro #TAB##TAB##TAB##TAB##TAB##TAB#Alvarado, Barquisimeto, Venezuela","institution_ids":["https://openalex.org/I19325673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111481689","display_name":"Leonardo Lareo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I233745408","display_name":"Pontificia Universidad Javeriana","ror":"https://ror.org/03etyjw28","country_code":"CO","type":"education","lineage":["https://openalex.org/I233745408"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Leonardo Lareo","raw_affiliation_strings":["Grupo de Investigaci\u00f3n en Bioqu\u00edmica Computacional, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogot\u00e1 D.C., Colombia","Pontificia Universidad Javeriana, Bogot\u00e1 D. C, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Investigaci\u00f3n en Bioqu\u00edmica Computacional, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogot\u00e1 D.C., Colombia","institution_ids":["https://openalex.org/I233745408"]},{"raw_affiliation_string":"Pontificia Universidad Javeriana, Bogot\u00e1 D. C, Colombia","institution_ids":["https://openalex.org/I233745408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010406382","display_name":"Ra\u00fal Alberto Poutou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I233745408","display_name":"Pontificia Universidad Javeriana","ror":"https://ror.org/03etyjw28","country_code":"CO","type":"education","lineage":["https://openalex.org/I233745408"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Ra\u00fal A. Poutou","raw_affiliation_strings":["Instituto de Errores Innatos del Metabolismo, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogot\u00e1 D.C., Colombia. Grupo de Biotecnolog\u00eda Ambiental e Industrial, Facultad de Ciencias, Pontificia Universidad Javeriana. Bogot\u00e1 D.C., Colombia","Pontificia Universidad Javeriana, Bogot\u00e1 D. C, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Errores Innatos del Metabolismo, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogot\u00e1 D.C., Colombia. Grupo de Biotecnolog\u00eda Ambiental e Industrial, Facultad de Ciencias, Pontificia Universidad Javeriana. Bogot\u00e1 D.C., Colombia","institution_ids":["https://openalex.org/I233745408"]},{"raw_affiliation_string":"Pontificia Universidad Javeriana, Bogot\u00e1 D. C, Colombia","institution_ids":["https://openalex.org/I233745408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051655120","display_name":"Angela Sosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I233745408","display_name":"Pontificia Universidad Javeriana","ror":"https://ror.org/03etyjw28","country_code":"CO","type":"education","lineage":["https://openalex.org/I233745408"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"\u00c1ngela C. Sosa","raw_affiliation_strings":["Instituto de Errores Innatos del Metabolismo, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogot\u00e1 D.C., Colombia","Pontificia Universidad Javeriana, Bogot\u00e1 D. C, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Errores Innatos del Metabolismo, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogot\u00e1 D.C., Colombia","institution_ids":["https://openalex.org/I233745408"]},{"raw_affiliation_string":"Pontificia Universidad Javeriana, Bogot\u00e1 D. C, Colombia","institution_ids":["https://openalex.org/I233745408"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008057554","display_name":"Luis Alejandro Barrera","orcid":"https://orcid.org/0000-0001-8287-0197","observed_orcids":["https://orcid.org/0000-0001-8287-0197"]},"institutions":[{"id":"https://openalex.org/I233745408","display_name":"Pontificia Universidad Javeriana","ror":"https://ror.org/03etyjw28","country_code":"CO","type":"education","lineage":["https://openalex.org/I233745408"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Luis A. Barrera","raw_affiliation_strings":["Instituto de Errores Innatos del Metabolismo, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogot\u00e1 D.C., Colombia","Pontificia Universidad Javeriana, Bogot\u00e1 D. C, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Errores Innatos del Metabolismo, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogot\u00e1 D.C., Colombia","institution_ids":["https://openalex.org/I233745408"]},{"raw_affiliation_string":"Pontificia Universidad Javeriana, Bogot\u00e1 D. C, Colombia","institution_ids":["https://openalex.org/I233745408"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3264,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.53110528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"27","issue":"1","first_page":"7","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.475600004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.475600004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.3513000011444092,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.15330000221729279,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hunter-syndrome","display_name":"Hunter syndrome","score":0.9470000267028809},{"id":"https://openalex.org/keywords/protein-structure-modeling","display_name":"protein structure modeling","score":0.5080000162124634},{"id":"https://openalex.org/keywords/n-glycosylation-sites","display_name":"N-glycosylation sites","score":0.8339999914169312},{"id":"https://openalex.org/keywords/active-site","display_name":"active site","score":0.7710000276565552},{"id":"https://openalex.org/keywords/genotype-phenotype-correlation","display_name":"genotype-phenotype correlation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/mutation-severity","display_name":"mutation severity","score":0.42100000381469727},{"id":"https://openalex.org/keywords/lysosomal-storage-disorders","display_name":"lysosomal storage disease","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C2776225084","wikidata":"https://www.wikidata.org/wiki/Q1529983","display_name":"Hunter syndrome","level":2,"score":0.7378071546554565},{"id":"https://openalex.org/C2780871851","wikidata":"https://www.wikidata.org/wiki/Q7636184","display_name":"Sulfatase","level":3,"score":0.564188539981842},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5329068303108215},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44405949115753174},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2906075716018677}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007066","descriptor_name":"Iduronate Sulfatase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.7705/biomedica.v27i1.229","doi":"https://doi.org/10.7705/biomedica.v27i1.229","is_oa":true,"landing_page_url":"https://doi.org/10.7705/biomedica.v27i1.229","pdf_url":"https://revistabiomedica.org/index.php/biomedica/article/download/229/214","source":{"id":"https://openalex.org/S114824300","display_name":"Biom\u00e9dica","issn_l":"0120-4157","issn":["0120-4157","2590-7379"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","publindex-b","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310318852","host_organization_name":"National Institute of Health","host_organization_lineage":["https://openalex.org/P4310318852"],"host_organization_lineage_names":["National Institute of Health"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biom\u00e9dica","raw_type":"journal-article"},{"id":"pmid:17546220","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17546220","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedica : revista del Instituto Nacional de Salud","raw_type":"English Abstract"},{"id":"pmh:oai:www.revistabiomedica.org:article/229","doi":null,"is_oa":true,"landing_page_url":"http://www.revistabiomedica.org/index.php/biomedica/article/view/229","pdf_url":"http://www.revistabiomedica.org/index.php/biomedica/article/view/229","source":{"id":"https://openalex.org/S4306401045","display_name":"Biomedica (INSTITUTO NACIONAL DE SALUD)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210128723","host_organization_name":"Instituto Nacional de Salud P\u00fablica","host_organization_lineage":["https://openalex.org/I4210128723"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biom\u00e9dica; Vol. 27, N\u00fam. 1 (2007); 7-20","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:846325596eea4f47bba47e2c842b994e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/846325596eea4f47bba47e2c842b994e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biom\u00e9dica: revista del Instituto Nacional de Salud, Vol 27, Iss 1, Pp 7-20 (2007)","raw_type":"article"},{"id":"pmh:oai:redalyc.org:84312702","doi":null,"is_oa":false,"landing_page_url":"https://www.redalyc.org/articulo.oa?id=84312702","pdf_url":null,"source":{"id":"https://openalex.org/S4377196100","display_name":"Redalyc (Universidad Aut\u00f3noma del Estado de M\u00e9xico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179647637","host_organization_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","host_organization_lineage":["https://openalex.org/I179647637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biom\u00e9dica (Colombia) Num.1 Vol.27","raw_type":"art\u00edculo cient\u00edfico"}],"best_oa_location":{"id":"doi:10.7705/biomedica.v27i1.229","doi":"https://doi.org/10.7705/biomedica.v27i1.229","is_oa":true,"landing_page_url":"https://doi.org/10.7705/biomedica.v27i1.229","pdf_url":"https://revistabiomedica.org/index.php/biomedica/article/download/229/214","source":{"id":"https://openalex.org/S114824300","display_name":"Biom\u00e9dica","issn_l":"0120-4157","issn":["0120-4157","2590-7379"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","publindex-b","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310318852","host_organization_name":"National Institute of Health","host_organization_lineage":["https://openalex.org/P4310318852"],"host_organization_lineage_names":["National Institute of Health"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biom\u00e9dica","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2087455409.pdf","grobid_xml":"https://content.openalex.org/works/W2087455409.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W26265782","https://openalex.org/W65806145","https://openalex.org/W69236340","https://openalex.org/W145465258","https://openalex.org/W221228454","https://openalex.org/W1483242733","https://openalex.org/W1486170074","https://openalex.org/W1489222678","https://openalex.org/W1506694677","https://openalex.org/W1508885706","https://openalex.org/W1524466628","https://openalex.org/W1536886974","https://openalex.org/W1546872431","https://openalex.org/W1553001294","https://openalex.org/W1567691940","https://openalex.org/W1964213393","https://openalex.org/W1966614272","https://openalex.org/W1969007008","https://openalex.org/W1969254544","https://openalex.org/W1969382234","https://openalex.org/W1975183928","https://openalex.org/W1977739991","https://openalex.org/W1979250323","https://openalex.org/W1985565008","https://openalex.org/W1988200949","https://openalex.org/W1989345252","https://openalex.org/W1991437258","https://openalex.org/W1994993595","https://openalex.org/W2001521415","https://openalex.org/W2001683569","https://openalex.org/W2005673211","https://openalex.org/W2007414751","https://openalex.org/W2015642465","https://openalex.org/W2018679100","https://openalex.org/W2022035455","https://openalex.org/W2026258231","https://openalex.org/W2026267943","https://openalex.org/W2032653601","https://openalex.org/W2034194582","https://openalex.org/W2035066314","https://openalex.org/W2038163496","https://openalex.org/W2039104547","https://openalex.org/W2041298065","https://openalex.org/W2043671720","https://openalex.org/W2043696461","https://openalex.org/W2047931563","https://openalex.org/W2049823037","https://openalex.org/W2053418558","https://openalex.org/W2061699752","https://openalex.org/W2062194343","https://openalex.org/W2063394641","https://openalex.org/W2064653004","https://openalex.org/W2065001163","https://openalex.org/W2067731363","https://openalex.org/W2071843796","https://openalex.org/W2072849873","https://openalex.org/W2074506140","https://openalex.org/W2077335984","https://openalex.org/W2081474793","https://openalex.org/W2084337677","https://openalex.org/W2084517866","https://openalex.org/W2085082287","https://openalex.org/W2086003789","https://openalex.org/W2087794630","https://openalex.org/W2088257088","https://openalex.org/W2088356579","https://openalex.org/W2089260408","https://openalex.org/W2093383286","https://openalex.org/W2098975839","https://openalex.org/W2101969277","https://openalex.org/W2106823173","https://openalex.org/W2107768450","https://openalex.org/W2109219849","https://openalex.org/W2126362472","https://openalex.org/W2127099223","https://openalex.org/W2147314569","https://openalex.org/W2153187042","https://openalex.org/W2153726024","https://openalex.org/W2154320306","https://openalex.org/W2156798505","https://openalex.org/W2157297101","https://openalex.org/W2158714788","https://openalex.org/W2159466305","https://openalex.org/W2166720212","https://openalex.org/W2169772284","https://openalex.org/W2170471837","https://openalex.org/W2181574899","https://openalex.org/W2259178754","https://openalex.org/W2259881126","https://openalex.org/W2291887206","https://openalex.org/W2323600720","https://openalex.org/W2468695780","https://openalex.org/W2470331411","https://openalex.org/W3194165374"],"related_works":["https://openalex.org/W7066108238","https://openalex.org/W60807599","https://openalex.org/W2528517569","https://openalex.org/W1987251162","https://openalex.org/W2187789425","https://openalex.org/W2040754190","https://openalex.org/W2048107571","https://openalex.org/W2585253353","https://openalex.org/W2037636753","https://openalex.org/W2005500531"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Hunter":[1],"syndrome":[2],"(MC":[3],"KUSIK":[4],"309900)":[5],"or":[6],"mucopolysacharidosis":[7],"type":[8,158,183],"II":[9,85],"is":[10],"due":[11],"to":[12,139],"the":[13,16,32,46,62,125,140,144,148,157,162,165,178,182,187,191,197],"deficiency":[14],"of":[15,58,99,124,147,159,164,184,196],"enzyme":[17,25,60],"iduronate":[18,47],"2":[19,48],"sulfate":[20,49],"sulfatase":[21,50],"(E.C.":[22],"3.1.6.13).":[23],"This":[24],"has":[26],"not":[27,36],"been":[28],"crystallized,":[29],"and":[30,83,105,115,136,161,186],"therefore":[31],"experimental":[33],"structures":[34],"are":[35],"available.":[37],"OBJECTIVES:":[38],"A":[39,55,89,151],"computational":[40,56],"three-dimensional":[41,90],"model":[42,92,96,129,192],"was":[43,78,93,154],"proposed":[44],"for":[45],"enzyme.":[51],"MATERIALS":[52],"AND":[53],"METHODS:":[54],"analysis":[57],"this":[59],"used":[61],"following":[63],"free":[64],"internet":[65],"software":[66],"programs:":[67],"Comput":[68],"pI/MW,":[69],"JaMBW":[70],"Chapter":[71],"3.1.7,":[72],"SWISS-MODEL,":[73],"Geno3d,":[74],"ProSup.":[75],"Energy":[76],"minimization":[77],"done":[79],"with":[80,121],"Discover":[81],"3":[82],"Insight":[84],"version":[86],"2004.":[87],"RESULTS:":[88],"conformational":[91],"proposed.":[94],"The":[95,128,172],"showed":[97],"33.3%":[98],"helix":[100],"structure,":[101],"7.2%":[102],"beta":[103],"sheet,":[104],"59.5%":[106],"random":[107],"coil.":[108],"RMS":[109,173],"values":[110],"(Root":[111],"Mean":[112],"Square)":[113],"(0.78":[114],"0.86A)":[116],"were":[117],"found":[118,155],"when":[119],"compared":[120],"other":[122],"enzymes":[123,198],"same":[126],"family.":[127],"presented":[130],"5":[131],"exposed":[132],"N-glycosylation":[133],"potential":[134],"sites":[135],"an":[137],"entry":[138],"pocket":[141],"that":[142,190],"contains":[143],"amino":[145],"acids":[146],"active":[149],"site.":[150],"high":[152,179],"correlation":[153,180],"between":[156,181],"mutations":[160],"severity":[163],"phenotype":[166],"in":[167],"twenty":[168],"patients":[169],"analyzed.":[170],"CONCLUSION:":[171],"values,":[174],"as":[175,177],"well":[176],"mutation":[185],"phenotype,":[188],"indicated":[189],"predicts":[193],"some":[194],"aspects":[195],"biological":[199],"behavior.":[200]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}