{"id":"https://openalex.org/W2087436166","doi":"https://doi.org/10.1210/jcem-30-6-727","title":"Effect of Estrogen Administration on Androgen Production and Plasma Luteinizing Hormone in Hirsute Women1","display_name":"Effect of Estrogen Administration on Androgen Production and Plasma Luteinizing Hormone in Hirsute Women1","publication_year":1970,"publication_date":"1970-06-01","ids":{"openalex":"https://openalex.org/W2087436166","doi":"https://doi.org/10.1210/jcem-30-6-727","mag":"2087436166","pmid":"https://pubmed.ncbi.nlm.nih.gov/5444560"},"language":"en","primary_location":{"id":"doi:10.1210/jcem-30-6-727","doi":"https://doi.org/10.1210/jcem-30-6-727","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-30-6-727","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109094377","display_name":"Marvin A. Kirschner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. A. KIRSCHNER","raw_affiliation_strings":["Endocrinology Branch, National Cancer Institute Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology Branch, National Cancer Institute Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108314749","display_name":"C. Wayne Bardin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. W. BARDIN","raw_affiliation_strings":["Endocrinology Branch, National Cancer Institute Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology Branch, National Cancer Institute Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111418381","display_name":"Wylie C. Hembree","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. C. HEMBREE","raw_affiliation_strings":["Endocrinology Branch, National Cancer Institute Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology Branch, National Cancer Institute Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113549083","display_name":"G. T. ROSS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. T. ROSS","raw_affiliation_strings":["Endocrinology Branch, National Cancer Institute Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology Branch, National Cancer Institute Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210140884"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.9695,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.89738806,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"30","issue":"6","first_page":"727","last_page":"732"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-therapy","display_name":"estrogen therapy","score":0.699999988079071},{"id":"https://openalex.org/keywords/hirsutism","display_name":"hirsutism","score":0.9589999914169312},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.9470000267028809},{"id":"https://openalex.org/keywords/androgen-biosynthesis","display_name":"androgen production","score":0.9509999752044678},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.4180000126361847},{"id":"https://openalex.org/keywords/androstenedione","display_name":"androstenedione","score":0.8700000047683716},{"id":"https://openalex.org/keywords/plasma-testosterone-levels","display_name":"plasma testosterone","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8768736720085144},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8702288866043091},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.8185993432998657},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.7991908192634583},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.7102078199386597},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.6605858206748962},{"id":"https://openalex.org/C2776683971","wikidata":"https://www.wikidata.org/wiki/Q411064","display_name":"Androstenedione","level":4,"score":0.6527895331382751},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.45975637435913086},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3925480842590332},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3347168564796448}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000568","descriptor_name":"Amenorrhea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000731","descriptor_name":"Androstanes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000731","descriptor_name":"Androstanes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002987","descriptor_name":"Clitoris","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004054","descriptor_name":"Diethylstilbestrol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004997","descriptor_name":"Ethinyl Estradiol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006628","descriptor_name":"Hirsutism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006628","descriptor_name":"Hirsutism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009641","descriptor_name":"Norethynodrel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010060","descriptor_name":"Ovulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015068","descriptor_name":"17-Ketosteroids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015068","descriptor_name":"17-Ketosteroids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/jcem-30-6-727","doi":"https://doi.org/10.1210/jcem-30-6-727","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-30-6-727","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:5444560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5444560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1973884112","https://openalex.org/W2017056340","https://openalex.org/W1999638939","https://openalex.org/W1987392256","https://openalex.org/W2417010213","https://openalex.org/W2328151462","https://openalex.org/W1999611386","https://openalex.org/W2026199681","https://openalex.org/W2148302421","https://openalex.org/W2059039276"],"abstract_inverted_index":{"Large":[0],"doses":[1],"of":[2,31,39,53,67,75,98,101,113,133,142,147,158,165],"estrogens":[3],"were":[4,49],"given":[5],"for":[6],"10\u2013200":[7],"days":[8],"to":[9,16,61,152],"11":[10,72],"hirsute":[11,134,166],"women":[12,167],"in":[13,37,70,111,130,162],"an":[14,95],"attempt":[15],"suppress":[17,128],"LH":[18,47,129],"production,":[19],"and":[20,51,93,136],"thus":[21],"androgen":[22,54],"production":[23,55,80],"originating":[24],"from":[25],"the":[26,43,63,99,131,139,163],"ovaries.":[27],"In":[28,42],"only":[29],"2":[30],"7":[32],"patients":[33,73],"did":[34],"estrogen":[35,102,117,123,159],"result":[36],"suppression":[38,160],"plasma":[40,86,148],"LH.":[41],"remaining":[44],"5":[45],"women,":[46,135],"levels":[48],"unchanged,":[50,89],"abnormalities":[52],"persisted.":[56],"Estrogen":[57],"treatment":[58],"was":[59,94,109],"noted":[60,110],"decrease":[62],"metabolic":[64],"clearance":[65],"rates":[66],"testosterone":[68,79,104,143],"(MCRT)":[69],"all":[71],"independent":[74],"its":[76],"effect":[77,100],"on":[78,103],"rate":[81],".":[82],"AS":[83],"a":[84],"result,":[85],"T":[87,149],"remained":[88],"increased":[90],"or":[91],"decreased,":[92],"unreliable":[96],"parameter":[97],"production.":[105],"No":[106],"consistent":[107],"change":[108],"MCR":[112],"androstenedione":[114],"(MCR\u0394)":[115],"after":[116],"treatment.":[118],"These":[119],"studies":[120],"demonstrate":[121],"that":[122,145],"administration":[124],"1)":[125],"does":[126],"not":[127],"majority":[132],"2)":[137],"alters":[138],"peripheral":[140],"metabolism":[141],"such":[144],"measurement":[146],"can":[150],"lead":[151],"erroneous":[153],"conclusions.":[154],"The":[155],"use,":[156],"therefore,":[157],"tests":[161],"evaluation":[164],"must":[168],"be":[169],"interpreted":[170],"with":[171],"caution.":[172]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}