{"id":"https://openalex.org/W2087424536","doi":"https://doi.org/10.1002/(sici)1099-1077(199605)11:3<225::aid-hup791>3.0.co;2-2","title":"Rebound insomnia after abrupt discontinuation of hypnotic treatment: double-blind randomized comparison of zolpidem versus triazolam","display_name":"Rebound insomnia after abrupt discontinuation of hypnotic treatment: double-blind randomized comparison of zolpidem versus triazolam","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W2087424536","doi":"https://doi.org/10.1002/(sici)1099-1077(199605)11:3<225::aid-hup791>3.0.co;2-2","mag":"2087424536"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1099-1077(199605)11:3<225::aid-hup791>3.0.co;2-2","doi":"https://doi.org/10.1002/(sici)1099-1077(199605)11:3<225::aid-hup791>3.0.co;2-2","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1099-1077(199605)11:3<225::aid-hup791>3.0.co;2-2","pdf_url":null,"source":{"id":"https://openalex.org/S154207414","display_name":"Human Psychopharmacology Clinical and Experimental","issn_l":"0885-6222","issn":["0885-6222","1099-1077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Psychopharmacology: Clinical and Experimental","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023350824","display_name":"Rosalia Silvestri","orcid":"https://orcid.org/0000-0002-1800-032X","observed_orcids":["https://orcid.org/0000-0002-1800-032X"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R. Silvestri","raw_affiliation_strings":["Clinica Neurologica I, Universita\u0300 di Messina, Italy","Clinica Neurologica I, Universit\u00e0 di Messina, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Neurologica I, Universita\u0300 di Messina, Italy","institution_ids":["https://openalex.org/I112862951"]},{"raw_affiliation_string":"Clinica Neurologica I, Universit\u00e0 di Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014835886","display_name":"Franco Ferrillo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Ferrillo","raw_affiliation_strings":["Cattedra di Neurofisiopatologia, Universita\u0300 di Genova, Italy","Cattedra di Neurofisiopatologia, Universit\u00e0 di Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra di Neurofisiopatologia, Universita\u0300 di Genova, Italy","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"Cattedra di Neurofisiopatologia, Universit\u00e0 di Genova, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004603683","display_name":"Luigi Murri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Murri","raw_affiliation_strings":["Unita\u0300 di Neurofisiopatologia, Ospedale S. Chiara Pisa, Italy","Unit\u00e0 di Neurofisiopatologia, Ospedale S. Chiara Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unita\u0300 di Neurofisiopatologia, Ospedale S. Chiara Pisa, Italy","institution_ids":[]},{"raw_affiliation_string":"Unit\u00e0 di Neurofisiopatologia, Ospedale S. Chiara Pisa, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023498300","display_name":"R. Massetani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Massetani","raw_affiliation_strings":["Unita\u0300 di Neurofisiopatologia, Ospedale S. Chiara Pisa, Italy","Unit\u00e0 di Neurofisiopatologia, Ospedale S. Chiara Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unita\u0300 di Neurofisiopatologia, Ospedale S. Chiara Pisa, Italy","institution_ids":[]},{"raw_affiliation_string":"Unit\u00e0 di Neurofisiopatologia, Ospedale S. Chiara Pisa, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019963060","display_name":"R. Di Perri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R. Di Perri","raw_affiliation_strings":["Clinica Neurologica I, Universita\u0300 di Messina, Italy","Clinica Neurologica I, Universit\u00e0 di Messina, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Neurologica I, Universita\u0300 di Messina, Italy","institution_ids":["https://openalex.org/I112862951"]},{"raw_affiliation_string":"Clinica Neurologica I, Universit\u00e0 di Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044651024","display_name":"Guido Rosadini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Rosadini","raw_affiliation_strings":["Cattedra di Neurofisiopatologia, Universita\u0300 di Genova, Italy","Cattedra di Neurofisiopatologia, Universit\u00e0 di Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra di Neurofisiopatologia, Universita\u0300 di Genova, Italy","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"Cattedra di Neurofisiopatologia, Universit\u00e0 di Genova, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Montesano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Montesano","raw_affiliation_strings":["Synthe\u0301labo Recherche Milan, Italy","Synth\u00e9labo Recherche Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthe\u0301labo Recherche Milan, Italy","institution_ids":[]},{"raw_affiliation_string":"Synth\u00e9labo Recherche Milan, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109316722","display_name":"C. Borghi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Borghi","raw_affiliation_strings":["Synthe\u0301labo Recherche Milan, Italy","Synth\u00e9labo Recherche Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthe\u0301labo Recherche Milan, Italy","institution_ids":[]},{"raw_affiliation_string":"Synth\u00e9labo Recherche Milan, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067456218","display_name":"B. De La Giclais","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"B. De La Giclais","raw_affiliation_strings":["Synthe\u0301labo Recherche Paris, 23\u2013 25, Avenue Morane Saulnier, 92367 Meudon-La-Foret Cedex, France","Synth\u00e9labo Recherche Paris, 23\u2013 25, Avenue Morane Saulnier, 92367 Meudon\u2010La\u2010Foret Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthe\u0301labo Recherche Paris, 23\u2013 25, Avenue Morane Saulnier, 92367 Meudon-La-Foret Cedex, France","institution_ids":[]},{"raw_affiliation_string":"Synth\u00e9labo Recherche Paris, 23\u2013 25, Avenue Morane Saulnier, 92367 Meudon\u2010La\u2010Foret Cedex, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067456218"],"corresponding_institution_ids":[],"apc_list":{"value":4030,"currency":"USD","value_usd":4030},"apc_paid":null,"fwci":4.3654,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.94152255,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"11","issue":"3","first_page":"225","last_page":"233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rebound-insomnia","display_name":"rebound insomnia","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hypnotic-withdrawal","display_name":"hypnotic withdrawal","score":0.7570000290870667},{"id":"https://openalex.org/keywords/zolpidem","display_name":"zolpidem","score":0.9559999704360962},{"id":"https://openalex.org/keywords/triazolam","display_name":"triazolam","score":1.0},{"id":"https://openalex.org/keywords/benzodiazepine-discontinuation","display_name":"benzodiazepine discontinuation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.6169999837875366},{"id":"https://openalex.org/keywords/imidazopyridines","display_name":"imidazopyridines","score":0.8730000257492065},{"id":"https://openalex.org/keywords/sleep-efficiency","display_name":"sleep efficiency","score":0.5699999928474426},{"id":"https://openalex.org/keywords/total-sleep-time","display_name":"total sleep time","score":0.875},{"id":"https://openalex.org/keywords/wake-after-sleep-onset","display_name":"wake after sleep onset","score":0.8999999761581421},{"id":"https://openalex.org/keywords/sleep-onset-latency","display_name":"sleep latency","score":0.5920000076293945},{"id":"https://openalex.org/keywords/insomnia-treatment","display_name":"insomnia treatment","score":0.46299999952316284},{"id":"https://openalex.org/keywords/poor-sleepers","display_name":"poor sleepers","score":0.9369999766349792}],"concepts":[{"id":"https://openalex.org/C2777123777","wikidata":"https://www.wikidata.org/wiki/Q218842","display_name":"Zolpidem","level":3,"score":0.9781964421272278},{"id":"https://openalex.org/C2779738154","wikidata":"https://www.wikidata.org/wiki/Q412143","display_name":"Triazolam","level":4,"score":0.950421154499054},{"id":"https://openalex.org/C2780930544","wikidata":"https://www.wikidata.org/wiki/Q62962","display_name":"Hypnotic","level":2,"score":0.8200289011001587},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.7866878509521484},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.7130641341209412},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.532454788684845},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5190544724464417},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5008552074432373},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.40765875577926636},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.26905113458633423},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.24125415086746216},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13603180646896362},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/(sici)1099-1077(199605)11:3<225::aid-hup791>3.0.co;2-2","doi":"https://doi.org/10.1002/(sici)1099-1077(199605)11:3<225::aid-hup791>3.0.co;2-2","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1099-1077(199605)11:3<225::aid-hup791>3.0.co;2-2","pdf_url":null,"source":{"id":"https://openalex.org/S154207414","display_name":"Human Psychopharmacology Clinical and Experimental","issn_l":"0885-6222","issn":["0885-6222","1099-1077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Psychopharmacology: Clinical and Experimental","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W108154029","https://openalex.org/W184955306","https://openalex.org/W1967895907","https://openalex.org/W1971485642","https://openalex.org/W1999589177","https://openalex.org/W2030875572","https://openalex.org/W2035250490","https://openalex.org/W2038344171","https://openalex.org/W2049309469","https://openalex.org/W2050783298","https://openalex.org/W2056572339","https://openalex.org/W2061378977","https://openalex.org/W2064238127","https://openalex.org/W2065444825","https://openalex.org/W2071220073","https://openalex.org/W2076160481","https://openalex.org/W2076440924","https://openalex.org/W2079328435","https://openalex.org/W2082111758","https://openalex.org/W2093617247","https://openalex.org/W2094595978","https://openalex.org/W2134932140","https://openalex.org/W2136277022","https://openalex.org/W2146289490","https://openalex.org/W2160070901","https://openalex.org/W2160743614","https://openalex.org/W2402149294","https://openalex.org/W2418992167","https://openalex.org/W2525537354","https://openalex.org/W3022302886","https://openalex.org/W4236038590","https://openalex.org/W4247019676","https://openalex.org/W4256355487"],"related_works":["https://openalex.org/W2083942987","https://openalex.org/W2043451114","https://openalex.org/W2079328435","https://openalex.org/W3032253714","https://openalex.org/W2138006666","https://openalex.org/W2025723031","https://openalex.org/W2086252261","https://openalex.org/W2167835306","https://openalex.org/W2442226093","https://openalex.org/W2035250490"],"abstract_inverted_index":{"Rebound":[0],"insomnia":[1,100,316],"is":[2,32,324],"a":[3,49,145,151,165,219,251,286,322,339],"transient":[4,126],"intense":[5],"worsening":[6],"of":[7,18,28,52,61,67,98,103,114,142,228,237,307,313,333,346],"sleep":[8,62,68,78],"usually":[9],"appearing":[10],"within":[11,41],"3":[12],"days":[13],"from":[14,124],"the":[15,42,59,65,96,198,244,260,278,308,311,330],"abrupt":[16,331],"discontinuation":[17,102,332],"benzodiazepines":[19],"(mainly":[20],"short-acting),":[21],"following":[22],"long":[23],"term":[24],"use":[25],"and":[26,54,63,80,183,194,218,234,299,342],"abuse":[27],"these":[29],"hypnotics.":[30],"Zolpidem":[31],"an":[33,235],"imidazopyridine,":[34],"that":[35],"binds":[36],"selectively":[37],"at":[38,94],"\u03c91-receptor":[39],"subtypes":[40],"GABAA":[43],"receptor":[44],"supramolecular":[45],"complex.":[46],"It":[47],"has":[48],"rapid":[50],"onset":[51],"action":[53],"short-elimination":[55],"half-life;":[56],"it":[57],"reduces":[58],"latency":[60],"prolongs":[64],"duration":[66,116],"in":[69,120],"patients":[70,122,134,196],"with":[71,149,169,285,326],"insomnia,":[72,127,132],"without":[73,335,343],"any":[74,336,344],"major":[75],"effects":[76,82],"on":[77,224],"stages":[79],"rebound":[81,99,315],"upon":[83],"discontinuation.":[84],"The":[85,139,305],"present":[86],"multicentre":[87],"trial":[88,113,140],"(three":[89],"Italian":[90],"centres)":[91],"was":[92,117,222],"aimed":[93],"assessing":[95],"symptoms/signs":[97],"after":[101,209,216,232,241,266,273,295,301,317],"either":[104,125],"zolpidem":[105,267,302,334],"or":[106,128,133,160],"triazolam.":[107],"A":[108],"double-blind,":[109],"randomized,":[110],"parallel":[111],"group":[112],"20-day":[115],"carried":[118],"out":[119],"22":[121],"suffering":[123],"short-term":[129],"(situational":[130],"stress)":[131],"who":[135],"were":[136,172],"poor":[137],"sleepers.":[138],"consisted":[141],"three":[143],"periods:":[144],"3-day":[146,166],"run-in":[147],"period":[148,155,168],"placebo,":[150],"14-day":[152],"active":[153],"treatment":[154],"(zolpidem":[156],"10":[157],"mg":[158,163],"od":[159],"triazolam":[161,210,233,274,296,318],"0.25":[162],"od),":[164],"withdrawal":[167,200,262],"placebo.":[170],"There":[171],"statistically":[173,252,287],"significant":[174,288],"[p":[175],"=":[176,185,255,291],"0.0064":[177],"for":[178,187,338],"Total":[179],"Sleep":[180,188,247],"Time":[181],"(TST)":[182],"p":[184],"0.0051":[186],"Efficiency":[189],"(SE%)]":[190],"differences":[191],"between":[192],"triazolam-":[193],"zolpidem-treated":[195],"during":[197,259],"first":[199,261],"night":[201],"versus":[202],"baseline:":[203],"TST":[204],"decreased":[205,265,300],"to":[206,213,281],"34.5":[207],"min":[208,215],"but":[211,270],"increased":[212,294],"43.8":[214],"zolpidem,":[217],"similar":[220],"evolution":[221],"shown":[223],"SE%":[225],"(a":[226],"decrease":[227],"6.3":[229],"per":[230,239],"cent":[231,240],"increase":[236],"9.9":[238],"zolpidem).":[242],"Also":[243,277],"Wake-time":[245],"After":[246],"Onset":[248],"(WASO)":[249],"showed":[250],"significantly":[253],"(p":[254,290],"0.0083)":[256],"different":[257],"pattern,":[258],"night,":[263],"remaining":[264],"(37.5":[268],"min)":[269,298],"suddenly":[271],"increasing":[272],"(17.3":[275],"min).":[276,304],"subjective":[279],"time":[280],"fall":[282],"asleep":[283],"changed":[284],"difference":[289],"0.042),":[292],"being":[293],"(8.6":[297],"(20.8":[303],"results":[306],"study":[309],"demonstrate":[310],"presence":[312],"clear":[314],"discontinuation,":[319],"whereas":[320],"such":[321],"drawback":[323],"absent":[325],"zolpidem.":[327],"This":[328],"allows":[329],"need":[337],"tapering":[340],"procedure":[341],"risk":[345],"pharmacological":[347],"dependence.":[348]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}