{"id":"https://openalex.org/W2087257572","doi":"https://doi.org/10.1016/j.pupt.2004.02.001","title":"Allergen challenge alters lymphocyte phosphodiesterase activity in horses with heaves","display_name":"Allergen challenge alters lymphocyte phosphodiesterase activity in horses with heaves","publication_year":2004,"publication_date":"2004-04-10","ids":{"openalex":"https://openalex.org/W2087257572","doi":"https://doi.org/10.1016/j.pupt.2004.02.001","mag":"2087257572","pmid":"https://pubmed.ncbi.nlm.nih.gov/15123226"},"language":"en","primary_location":{"id":"doi:10.1016/j.pupt.2004.02.001","doi":"https://doi.org/10.1016/j.pupt.2004.02.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pupt.2004.02.001","pdf_url":null,"source":{"id":"https://openalex.org/S102131606","display_name":"Pulmonary Pharmacology & Therapeutics","issn_l":"1094-5539","issn":["1094-5539","1522-9629"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary Pharmacology &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://researchonline.rvc.ac.uk/id/eprint/92/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048076038","display_name":"Karen J. Rickards","orcid":"https://orcid.org/0000-0003-3641-5067","observed_orcids":["https://orcid.org/0000-0003-3641-5067"]},"institutions":[{"id":"https://openalex.org/I133836048","display_name":"Royal Veterinary College","ror":"https://ror.org/01wka8n18","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I133836048"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"K.J Rickards","raw_affiliation_strings":["Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Herts AL9 7TA, UK. karen.rickards@kcl.ac.uk","Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Herts AL9 7TA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Herts AL9 7TA, UK. karen.rickards@kcl.ac.uk","institution_ids":["https://openalex.org/I133836048"]},{"raw_affiliation_string":"Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Herts AL9 7TA, UK","institution_ids":["https://openalex.org/I133836048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085336912","display_name":"Clive Peter Page","orcid":"https://orcid.org/0000-0002-9358-3799","observed_orcids":["https://orcid.org/0000-0002-9358-3799"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C.P Page","raw_affiliation_strings":["Sackler Institute of Pulmonary Pharmacology, Division of Pharmacology and Therapeutics, GKT School of Biomedical Sciences, King's College London, Guy's Campus, London Bridge, London SE1 9RT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sackler Institute of Pulmonary Pharmacology, Division of Pharmacology and Therapeutics, GKT School of Biomedical Sciences, King's College London, Guy's Campus, London Bridge, London SE1 9RT, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007575726","display_name":"Fiona M Cunningham","orcid":"https://orcid.org/0000-0002-7445-2419","observed_orcids":["https://orcid.org/0000-0002-7445-2419"]},"institutions":[{"id":"https://openalex.org/I133836048","display_name":"Royal Veterinary College","ror":"https://ror.org/01wka8n18","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I133836048"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F.M Cunningham","raw_affiliation_strings":["Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Herts AL9 7TA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Herts AL9 7TA, UK","institution_ids":["https://openalex.org/I133836048"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048076038"],"corresponding_institution_ids":["https://openalex.org/I133836048"],"apc_list":{"value":3730,"currency":"USD","value_usd":3730},"apc_paid":null,"fwci":0.5486,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.59690008,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"17","issue":"3","first_page":"163","last_page":"172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.864300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.864300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.1282999962568283,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10872","display_name":"Veterinary Equine Medical Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/3402","display_name":"Equine"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heave","display_name":"heave motion","score":0.9610000252723694},{"id":"https://openalex.org/keywords/allergic-airway-disease","display_name":"allergic airway disease","score":0.8050000071525574},{"id":"https://openalex.org/keywords/horses","display_name":"horses","score":0.9340000152587891},{"id":"https://openalex.org/keywords/phosphodiesterase-activity","display_name":"phosphodiesterase activity","score":0.7879999876022339},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.6460000276565552},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.9739999771118164},{"id":"https://openalex.org/keywords/phosphodiesterase-iii-inhibitors","display_name":"phosphodiesterase III inhibitor","score":0.6930000185966492},{"id":"https://openalex.org/keywords/phosphodiesterase-4-inhibitors","display_name":"phosphodiesterase-4 inhibitors","score":0.9940000176429749},{"id":"https://openalex.org/keywords/phosphodiesterase-5-inhibitors","display_name":"phosphodiesterase-5 inhibitors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rolipram","display_name":"rolipram","score":0.8700000047683716},{"id":"https://openalex.org/keywords/zaprinast","display_name":"zaprinast","score":0.9890000224113464},{"id":"https://openalex.org/keywords/theophylline","display_name":"theophylline","score":0.8220000267028809},{"id":"https://openalex.org/keywords/allergen-challenge","display_name":"allergen challenge","score":0.8709999918937683},{"id":"https://openalex.org/keywords/lymphocyte-proliferation","display_name":"lymphocyte proliferation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/th2-response","display_name":"Th2 immune response","score":0.8709999918937683},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.9409999847412109}],"concepts":[{"id":"https://openalex.org/C2776958096","wikidata":"https://www.wikidata.org/wiki/Q410285","display_name":"Rolipram","level":4,"score":0.8807138800621033},{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.6732096672058105},{"id":"https://openalex.org/C58141971","wikidata":"https://www.wikidata.org/wiki/Q906688","display_name":"Phosphodiesterase 3","level":4,"score":0.6114293336868286},{"id":"https://openalex.org/C2776846068","wikidata":"https://www.wikidata.org/wiki/Q6592076","display_name":"Zaprinast","level":4,"score":0.5967448353767395},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4838787317276001},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4063414931297302},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39770859479904175},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3386771082878113},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21836614608764648},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17091694474220276},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11422023177146912}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001985","descriptor_name":"Bronchial Provocation Tests","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D006734","descriptor_name":"Horse Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006734","descriptor_name":"Horse Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006736","descriptor_name":"Horses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010726","descriptor_name":"Phosphodiesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016084","descriptor_name":"Bronchoconstriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.pupt.2004.02.001","doi":"https://doi.org/10.1016/j.pupt.2004.02.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pupt.2004.02.001","pdf_url":null,"source":{"id":"https://openalex.org/S102131606","display_name":"Pulmonary Pharmacology & Therapeutics","issn_l":"1094-5539","issn":["1094-5539","1522-9629"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary Pharmacology &amp; Therapeutics","raw_type":"journal-article"},{"id":"pmid:15123226","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15123226","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary pharmacology & therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/ab4395da-7c3c-4130-a00e-6b83f4aeedbb","doi":null,"is_oa":false,"landing_page_url":"http://www.scopus.com/inward/record.url?scp=1942486272&partnerID=8YFLogxK","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rickards, K J, Page, C P & Cunningham, F M 2004, 'Allergen challenge alters lymphocyte phosphodiesterase activity in horses with heaves', PULMONARY PHARMACOLOGY AND THERAPEUTICS, vol. 17, no. 3, pp. 163 - 172. https://doi.org/10.1016/j.pupt.2004.02.001","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:researchonline.rvc.ac.uk:92","doi":null,"is_oa":true,"landing_page_url":"http://researchonline.rvc.ac.uk/id/eprint/92/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402069","display_name":"RVC Research Online (Royal Veterinary College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I133836048","host_organization_name":"Royal Veterinary College","host_organization_lineage":["https://openalex.org/I133836048"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:researchonline.rvc.ac.uk:92","doi":null,"is_oa":true,"landing_page_url":"http://researchonline.rvc.ac.uk/id/eprint/92/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402069","display_name":"RVC Research Online (Royal Veterinary College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I133836048","host_organization_name":"Royal Veterinary College","host_organization_lineage":["https://openalex.org/I133836048"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1775749144","https://openalex.org/W1823679757","https://openalex.org/W1967882515","https://openalex.org/W1968226808","https://openalex.org/W1973260205","https://openalex.org/W1973519389","https://openalex.org/W1974536864","https://openalex.org/W1974825502","https://openalex.org/W1976375287","https://openalex.org/W1994248480","https://openalex.org/W1996145424","https://openalex.org/W2011569264","https://openalex.org/W2016018338","https://openalex.org/W2020199042","https://openalex.org/W2022352561","https://openalex.org/W2023430605","https://openalex.org/W2031584475","https://openalex.org/W2033788890","https://openalex.org/W2034179761","https://openalex.org/W2041385557","https://openalex.org/W2047359372","https://openalex.org/W2048497209","https://openalex.org/W2052819862","https://openalex.org/W2057665954","https://openalex.org/W2059822315","https://openalex.org/W2063354518","https://openalex.org/W2070399392","https://openalex.org/W2074834459","https://openalex.org/W2081192590","https://openalex.org/W2085338889","https://openalex.org/W2086187705","https://openalex.org/W2112667627","https://openalex.org/W2117174491","https://openalex.org/W2127790273","https://openalex.org/W2131230648","https://openalex.org/W2140775892","https://openalex.org/W2148081236","https://openalex.org/W2288346340","https://openalex.org/W2439881600","https://openalex.org/W6638391806"],"related_works":["https://openalex.org/W1999295709","https://openalex.org/W1976375287","https://openalex.org/W4391199815","https://openalex.org/W2018190011","https://openalex.org/W2034179761","https://openalex.org/W2056426013","https://openalex.org/W7095888433","https://openalex.org/W2052819862","https://openalex.org/W2038514482","https://openalex.org/W7214157622"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
