{"id":"https://openalex.org/W2087239175","doi":"https://doi.org/10.1117/12.646000","title":"In vivo multiphoton tomography of skin cancer","display_name":"In vivo multiphoton tomography of skin cancer","publication_year":2006,"publication_date":"2006-02-09","ids":{"openalex":"https://openalex.org/W2087239175","doi":"https://doi.org/10.1117/12.646000","mag":"2087239175"},"language":"en","primary_location":{"id":"doi:10.1117/12.646000","doi":"https://doi.org/10.1117/12.646000","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.646000","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111672232","display_name":"Karsten K\u00f6nig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152467","display_name":"Fraunhofer Institute for Biomedical Engineering","ror":"https://ror.org/05tpsgh61","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210152467","https://openalex.org/I4923324"]},{"id":"https://openalex.org/I4923324","display_name":"Fraunhofer-Gesellschaft","ror":"https://ror.org/05hkkdn48","country_code":"DE","type":"government","lineage":["https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karsten K\u00f6nig","raw_affiliation_strings":["Fraunhofer Institute of Biomedical Technology (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fraunhofer Institute of Biomedical Technology (Germany)","institution_ids":["https://openalex.org/I4210152467","https://openalex.org/I4923324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020865150","display_name":"Iris Riemann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152467","display_name":"Fraunhofer Institute for Biomedical Engineering","ror":"https://ror.org/05tpsgh61","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210152467","https://openalex.org/I4923324"]},{"id":"https://openalex.org/I4923324","display_name":"Fraunhofer-Gesellschaft","ror":"https://ror.org/05hkkdn48","country_code":"DE","type":"government","lineage":["https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Iris Riemann","raw_affiliation_strings":["Fraunhofer Institute of Biomedical Technology (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fraunhofer Institute of Biomedical Technology (Germany)","institution_ids":["https://openalex.org/I4210152467","https://openalex.org/I4923324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041045525","display_name":"Alexander Ehlers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152467","display_name":"Fraunhofer Institute for Biomedical Engineering","ror":"https://ror.org/05tpsgh61","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210152467","https://openalex.org/I4923324"]},{"id":"https://openalex.org/I4923324","display_name":"Fraunhofer-Gesellschaft","ror":"https://ror.org/05hkkdn48","country_code":"DE","type":"government","lineage":["https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Ehlers","raw_affiliation_strings":["Fraunhofer Institute of Biomedical Technology (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fraunhofer Institute of Biomedical Technology (Germany)","institution_ids":["https://openalex.org/I4210152467","https://openalex.org/I4923324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109186512","display_name":"Rainer B\u00fcckle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165602","display_name":"JenLab (Germany)","ror":"https://ror.org/056j0ka11","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210165602"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rainer Buckle","raw_affiliation_strings":["JenLab GmbH (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JenLab GmbH (Germany)","institution_ids":["https://openalex.org/I4210165602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042545725","display_name":"Enrico Dimitrow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Enrico Dimitrow","raw_affiliation_strings":["Univ. Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Jena, Germany","institution_ids":["https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090872399","display_name":"Martin Kaatz","orcid":"https://orcid.org/0000-0002-0650-2576","observed_orcids":["https://orcid.org/0000-0002-0650-2576","https://orcid.org/0000-0002-8522-5449"]},"institutions":[{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Kaatz","raw_affiliation_strings":["Univ. Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Jena, Germany","institution_ids":["https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041682292","display_name":"Joachim W. Fluhr","orcid":"https://orcid.org/0000-0003-3610-0698","observed_orcids":["https://orcid.org/0000-0003-3610-0698"]},"institutions":[{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joachim Fluhr","raw_affiliation_strings":["Univ. Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Jena, Germany","institution_ids":["https://openalex.org/I76198965"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034101869","display_name":"Peter Ulrich Elsner","orcid":"https://orcid.org/0000-0001-7696-3274","observed_orcids":["https://orcid.org/0000-0001-7696-3274"]},"institutions":[{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Elsner","raw_affiliation_strings":["Univ. Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Jena, Germany","institution_ids":["https://openalex.org/I76198965"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.6718,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.96613546,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"6089","issue":null,"first_page":"60890R","last_page":"60890R"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.36570000648498535,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.36570000648498535,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.20170000195503235,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.19820000231266022,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiphoton-tomography","display_name":"multiphoton tomography","score":0.9959999918937683},{"id":"https://openalex.org/keywords/skin-cancer","display_name":"skin cancer","score":0.9490000009536743},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.7390000224113464},{"id":"https://openalex.org/keywords/non-invasive-optical-imaging","display_name":"non-invasive optical imaging","score":0.7609999775886536},{"id":"https://openalex.org/keywords/two-photon-autofluorescence","display_name":"two-photon autofluorescence","score":0.9350000023841858},{"id":"https://openalex.org/keywords/second-harmonic-generation","display_name":"second harmonic generation","score":1.0},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.878000020980835},{"id":"https://openalex.org/keywords/melanocytes","display_name":"melanocytes","score":0.6949999928474426},{"id":"https://openalex.org/keywords/near-infrared-femtosecond-laser","display_name":"near-infrared femtosecond laser","score":0.8240000009536743},{"id":"https://openalex.org/keywords/treatment-monitoring","display_name":"treatment monitoring","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C179687394","wikidata":"https://www.wikidata.org/wiki/Q4826281","display_name":"Autofluorescence","level":3,"score":0.7245209217071533},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5785200595855713},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.5388393998146057},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.507476270198822},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5002684593200684},{"id":"https://openalex.org/C167735695","wikidata":"https://www.wikidata.org/wiki/Q1777507","display_name":"Femtosecond","level":3,"score":0.4850460886955261},{"id":"https://openalex.org/C47785574","wikidata":"https://www.wikidata.org/wiki/Q373859","display_name":"Two-photon excitation microscopy","level":3,"score":0.47851288318634033},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42838284373283386},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.42780590057373047},{"id":"https://openalex.org/C2777413408","wikidata":"https://www.wikidata.org/wiki/Q1968843","display_name":"Optical tomography","level":3,"score":0.4132123589515686},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.4005567729473114},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37412434816360474},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37146836519241333},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.33188924193382263},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.31217092275619507},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.20181721448898315},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.1954481303691864},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.13696035742759705},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12435382604598999},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06411883234977722},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1117/12.646000","doi":"https://doi.org/10.1117/12.646000","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.646000","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmh:oai:fraunhofer.de:N-64665","doi":null,"is_oa":false,"landing_page_url":"http://publica.fraunhofer.de/documents/N-64665.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400801","display_name":"Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fraunhofer IBMT","raw_type":"Conference Paper"},{"id":"pmh:oai:publica.fraunhofer.de:publica/352975","doi":null,"is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/352975","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"conference paper"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2041725665","https://openalex.org/W2088706422","https://openalex.org/W4246577767","https://openalex.org/W2077210783","https://openalex.org/W2069467765","https://openalex.org/W2003545747","https://openalex.org/W2071019410","https://openalex.org/W2082280132","https://openalex.org/W2021561979","https://openalex.org/W2058450135"],"abstract_inverted_index":{"The":[0],"multiphoton":[1],"tomograph":[2],"DermaInspect":[3],"was":[4],"used":[5],"to":[6,68,94],"perform":[7],"first":[8],"clinical":[9],"studies":[10],"on":[11,20],"the":[12,73,78],"early":[13,101],"non-invasive":[14,21,92],"detection":[15],"of":[16,24,75,80],"skin":[17,25,70],"cancer":[18,102],"based":[19],"optical":[22,98],"sectioning":[23],"by":[26],"two-photon":[27],"autofluorescence":[28],"and":[29,106],"second":[30],"harmonic":[31],"generation.":[32],"In":[33,72],"particular,":[34],"deep-tissue":[35],"pigmented":[36],"lesions":[37],"-nevi-":[38],"have":[39,58],"been":[40,59,84],"imaged":[41],"with":[42],"intracellular":[43],"resolution":[44],"using":[45],"near":[46],"infrared":[47],"(NIR)":[48],"femtosecond":[49],"laser":[50],"radiation.":[51],"So":[52],"far,":[53],"more":[54],"than":[55],"250":[56],"patients":[57],"investigated.":[60],"Cancerous":[61],"tissues":[62],"showed":[63],"significant":[64],"morphological":[65],"differences":[66],"compared":[67],"normal":[69],"layers.":[71],"case":[74],"malignant":[76],"melanoma,":[77],"occurrence":[79],"luminescent":[81],"melanocytes":[82],"has":[83],"detected.":[85],"Multiphoton":[86],"tomography":[87],"will":[88],"become":[89],"a":[90],"novel":[91],"method":[93],"obtain":[95],"high-resolution":[96],"3D":[97],"biopsies":[99],"for":[100],"detection,":[103],"treatment":[104],"control,":[105],"in":[107],"situ":[108],"drug":[109],"screening.":[110]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
