{"id":"https://openalex.org/W2087216612","doi":"https://doi.org/10.1177/0269881104042622","title":"A Double-Blind, Randomized, 26-Week Study Comparing the Cognitive and Psychomotor Effects and Efficacy of 75 mg (37.5 mg b.i.d.) Venlafaxine and 75 mg (25 mg Mane, 50 mg Nocte) Dothiepin in Elderly Patients with Moderate Major Depression Being Treated in General Practice","display_name":"A Double-Blind, Randomized, 26-Week Study Comparing the Cognitive and Psychomotor Effects and Efficacy of 75 mg (37.5 mg b.i.d.) Venlafaxine and 75 mg (25 mg Mane, 50 mg Nocte) Dothiepin in Elderly Patients with Moderate Major Depression Being Treated in General Practice","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W2087216612","doi":"https://doi.org/10.1177/0269881104042622","mag":"2087216612","pmid":"https://pubmed.ncbi.nlm.nih.gov/15260909"},"language":"en","primary_location":{"id":"doi:10.1177/0269881104042622","doi":"https://doi.org/10.1177/0269881104042622","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0269881104042622","pdf_url":null,"source":{"id":"https://openalex.org/S136368880","display_name":"Journal of Psychopharmacology","issn_l":"0269-8811","issn":["0269-8811","1461-7285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://durham-repository.worktribe.com/output/1291306","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016929823","display_name":"Leanne Trick","orcid":"https://orcid.org/0000-0001-6712-3425","observed_orcids":["https://orcid.org/0000-0001-6712-3425"]},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Leanne Trick","raw_affiliation_strings":["HPRU Medical Research Centre, University of Surrey, Egerton Road, Guildford, Surrey, UK.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HPRU Medical Research Centre, University of Surrey, Egerton Road, Guildford, Surrey, UK.,","institution_ids":["https://openalex.org/I28290843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014647371","display_name":"Neil Stanley","orcid":"https://orcid.org/0000-0002-5876-3006","observed_orcids":["https://orcid.org/0000-0002-5876-3006"]},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Neil Stanley","raw_affiliation_strings":["HPRU Medical Research Centre, University of Surrey, Egerton Road, Guildford, Surrey, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HPRU Medical Research Centre, University of Surrey, Egerton Road, Guildford, Surrey, UK","institution_ids":["https://openalex.org/I28290843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033381538","display_name":"Una Rigney","orcid":"https://orcid.org/0009-0000-2305-5109","observed_orcids":["https://orcid.org/0009-0000-2305-5109"]},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Una Rigney","raw_affiliation_strings":["HPRU Medical Research Centre, University of Surrey, Egerton Road, Guildford, Surrey, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HPRU Medical Research Centre, University of Surrey, Egerton Road, Guildford, Surrey, UK","institution_ids":["https://openalex.org/I28290843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108209748","display_name":"Ian Hindmarch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ian Hindmarch","raw_affiliation_strings":["HPRU Medical Research Centre, University of Surrey, Egerton Road, Guildford, Surrey, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HPRU Medical Research Centre, University of Surrey, Egerton Road, Guildford, Surrey, UK","institution_ids":["https://openalex.org/I28290843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016929823"],"corresponding_institution_ids":["https://openalex.org/I28290843"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":1.6949,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.82680458,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"18","issue":"2","first_page":"205","last_page":"214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/venlafaxine","display_name":"venlafaxine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dothiepin","display_name":"dothiepin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/geriatric-depression","display_name":"geriatric depression","score":0.7179999947547913},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.722000002861023},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.7099999785423279},{"id":"https://openalex.org/keywords/psychomotor-function","display_name":"psychomotor performance","score":0.9480000138282776},{"id":"https://openalex.org/keywords/critical-flicker-fusion","display_name":"critical flicker fusion","score":0.8040000200271606},{"id":"https://openalex.org/keywords/sleepiness","display_name":"sleepiness","score":0.6589999794960022},{"id":"https://openalex.org/keywords/sedation","display_name":"sedation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8379999995231628},{"id":"https://openalex.org/keywords/antidepressant-efficacy","display_name":"antidepressant efficacy","score":0.6179999709129333},{"id":"https://openalex.org/keywords/general-practice","display_name":"general practice","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2776466888","wikidata":"https://www.wikidata.org/wiki/Q898407","display_name":"Venlafaxine","level":4,"score":0.5731042623519897},{"id":"https://openalex.org/C164953862","wikidata":"https://www.wikidata.org/wiki/Q7256440","display_name":"Psychomotor learning","level":3,"score":0.5669684410095215},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5490649938583374},{"id":"https://openalex.org/C2776153860","wikidata":"https://www.wikidata.org/wiki/Q394129","display_name":"Psychomotor agitation","level":2,"score":0.47482427954673767},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.4709545075893402},{"id":"https://openalex.org/C2778664715","wikidata":"https://www.wikidata.org/wiki/Q1347756","display_name":"Epworth Sleepiness Scale","level":4,"score":0.4650138020515442},{"id":"https://openalex.org/C2776466505","wikidata":"https://www.wikidata.org/wiki/Q385555","display_name":"Hamilton Rating Scale for Depression","level":4,"score":0.4584142863750458},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.4415467381477356},{"id":"https://openalex.org/C83849319","wikidata":"https://www.wikidata.org/wiki/Q7295720","display_name":"Rating scale","level":2,"score":0.43330246210098267},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4273528456687927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42660221457481384},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.3826673626899719},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.36532068252563477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26818084716796875},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.12401330471038818},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.11435794830322266},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.09107959270477295},{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.09054675698280334},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.0753481388092041},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C2781326671","wikidata":"https://www.wikidata.org/wiki/Q754424","display_name":"Apnea","level":2,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069470","descriptor_name":"Venlafaxine Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003511","descriptor_name":"Cyclohexanols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003511","descriptor_name":"Cyclohexanols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003511","descriptor_name":"Cyclohexanols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004244","descriptor_name":"Dizziness","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D004244","descriptor_name":"Dizziness","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004308","descriptor_name":"Dothiepin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004308","descriptor_name":"Dothiepin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004308","descriptor_name":"Dothiepin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005425","descriptor_name":"Flicker Fusion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006970","descriptor_name":"Disorders of Excessive Somnolence","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009290","descriptor_name":"Narcolepsy","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009290","descriptor_name":"Narcolepsy","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009325","descriptor_name":"Nausea","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009325","descriptor_name":"Nausea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011594","descriptor_name":"Psychometrics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011597","descriptor_name":"Psychomotor Performance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011597","descriptor_name":"Psychomotor Performance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/0269881104042622","doi":"https://doi.org/10.1177/0269881104042622","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0269881104042622","pdf_url":null,"source":{"id":"https://openalex.org/S136368880","display_name":"Journal of Psychopharmacology","issn_l":"0269-8811","issn":["0269-8811","1461-7285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychopharmacology","raw_type":"journal-article"},{"id":"pmid:15260909","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15260909","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of psychopharmacology (Oxford, England)","raw_type":"Clinical Trial"},{"id":"pmh:oai:https://durham-repository.worktribe.com/:1291306","doi":null,"is_oa":true,"landing_page_url":"https://durham-repository.worktribe.com/output/1291306","pdf_url":null,"source":{"id":"https://openalex.org/S4306400188","display_name":"Durham Research Online (Durham University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I190082696","host_organization_name":"Durham University","host_organization_lineage":["https://openalex.org/I190082696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:https://durham-repository.worktribe.com/:1291306","doi":null,"is_oa":true,"landing_page_url":"https://durham-repository.worktribe.com/output/1291306","pdf_url":null,"source":{"id":"https://openalex.org/S4306400188","display_name":"Durham Research Online (Durham University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I190082696","host_organization_name":"Durham University","host_organization_lineage":["https://openalex.org/I190082696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W50948397","https://openalex.org/W70578903","https://openalex.org/W197066864","https://openalex.org/W1493773294","https://openalex.org/W1974946748","https://openalex.org/W1975870015","https://openalex.org/W1980743538","https://openalex.org/W1993538589","https://openalex.org/W1994657866","https://openalex.org/W1995633792","https://openalex.org/W1999581815","https://openalex.org/W2002491425","https://openalex.org/W2005021105","https://openalex.org/W2005987361","https://openalex.org/W2006710130","https://openalex.org/W2008700075","https://openalex.org/W2018582103","https://openalex.org/W2018882862","https://openalex.org/W2019268145","https://openalex.org/W2025917855","https://openalex.org/W2028912602","https://openalex.org/W2029125254","https://openalex.org/W2032149427","https://openalex.org/W2037465712","https://openalex.org/W2048361493","https://openalex.org/W2050589064","https://openalex.org/W2059313976","https://openalex.org/W2067552242","https://openalex.org/W2071765053","https://openalex.org/W2072743331","https://openalex.org/W2082298277","https://openalex.org/W2083991574","https://openalex.org/W2085988895","https://openalex.org/W2088129863","https://openalex.org/W2096278662","https://openalex.org/W2099564543","https://openalex.org/W2101372256","https://openalex.org/W2101374118","https://openalex.org/W2104058480","https://openalex.org/W2104779097","https://openalex.org/W2113750014","https://openalex.org/W2114613490","https://openalex.org/W2131823335","https://openalex.org/W2133593474","https://openalex.org/W2139170222","https://openalex.org/W2141398558","https://openalex.org/W2155891669","https://openalex.org/W2303635956","https://openalex.org/W2409011936","https://openalex.org/W2414631274","https://openalex.org/W2461357239","https://openalex.org/W2977382310","https://openalex.org/W3021835062","https://openalex.org/W4240663152","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2413046948","https://openalex.org/W2048340122","https://openalex.org/W2045775503","https://openalex.org/W2411135518","https://openalex.org/W4367594173","https://openalex.org/W2385449397","https://openalex.org/W2470240400","https://openalex.org/W1971110371","https://openalex.org/W2090180691","https://openalex.org/W1997697588"],"abstract_inverted_index":{"To":[0],"investigate":[1],"the":[2,71,77],"efficacy":[3],"and":[4,6,11,76,94,116,128,165,171,198],"cognitive":[5,88,196],"psychomotor":[7,199],"effects":[8,194],"of":[9,91,97,122,130,168,182],"venlafaxine":[10,45,179],"dothiepin":[12,55],"in":[13,132,173,186],"elderly":[14,187],"patients":[15,32,189],"with":[16,70],"moderate":[17],"major":[18],"depression.":[19],"A":[20,82],"prospective,":[21],"randomized,":[22],"double-blind,":[23],"parallel-group,":[24],"active":[25],"comparator":[26],"controlled":[27],"study":[28],"was":[29,68],"conducted.":[30],"Eighty-eight":[31],"(aged":[33],">":[34],"or":[35,54],"=":[36],"60":[37],"years)":[38],"were":[39,135],"enrolled.":[40],"Each":[41],"patient":[42],"received":[43],"either":[44],"(immediate":[46],"release":[47],"formulation)":[48],"37.5":[49,183],"mg":[50,57,62,184],"twice":[51],"per":[52],"day":[53],"25":[56],"mane":[58],"followed":[59],"by":[60],"50":[61],"nocte":[63],"for":[64],"26":[65],"weeks.":[66],"Efficacy":[67],"assessed":[69],"Montgomery-Asberg":[72],"Depression":[73,79,133],"Rating":[74,80],"Scale":[75],"Hamilton":[78],"Scale.":[81],"psychometric":[83],"test":[84],"battery":[85],"to":[86,147],"assess":[87],"function,":[89],"activities":[90],"daily":[92],"living":[93],"sleep":[95],"consisted":[96],"Critical":[98],"Flicker":[99],"Fusion":[100],"(CFF),":[101],"Short-term":[102],"Memory--Kim's":[103],"Game,":[104],"Cognitive":[105],"Failures":[106],"Questionnaire,":[107,115],"Milford":[108],"Epworth":[109],"Sleepiness":[110],"Scale,":[111],"Leeds":[112],"Sleep":[113],"Evaluation":[114],"an":[117],"Accident":[118],"Scoring":[119],"Questionnaire.":[120],"Quality":[121,129],"Life":[123,131],"Questionnaires":[124],"(Short":[125],"Form":[126],"36":[127],"Scale)":[134],"also":[136],"administered.":[137],"Venlafaxine":[138],"significantly":[139,158],"(p":[140,159],"<":[141,160],"0.05)":[142,161],"raised":[143],"CFF":[144,163],"scores":[145],"compared":[146],"baseline":[148],"but":[149],"had":[150],"no":[151],"effect":[152],"on":[153,195],"any":[154],"other":[155],"measure.":[156],"Dothiepin":[157],"lowered":[162],"threshold,":[164],"increased":[166],"ratings":[167],"both":[169],"sedation":[170],"difficulty":[172],"waking.":[174],"The":[175],"results":[176],"showed":[177],"that":[178],"at":[180],"doses":[181],"b.i.d.":[185],"depressed":[188],"is":[190],"free":[191],"from":[192],"disruptive":[193],"function":[197],"performance.":[200]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
