{"id":"https://openalex.org/W2087207463","doi":"https://doi.org/10.1007/s11084-005-9006-1","title":"Intramolecular RNA replicase: Possibly the first self-replicating molecule in the RNA world","display_name":"Intramolecular RNA replicase: Possibly the first self-replicating molecule in the RNA world","publication_year":2006,"publication_date":"2006-08-01","ids":{"openalex":"https://openalex.org/W2087207463","doi":"https://doi.org/10.1007/s11084-005-9006-1","mag":"2087207463","pmid":"https://pubmed.ncbi.nlm.nih.gov/16909330"},"language":"en","primary_location":{"id":"doi:10.1007/s11084-005-9006-1","doi":"https://doi.org/10.1007/s11084-005-9006-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11084-005-9006-1","pdf_url":null,"source":{"id":"https://openalex.org/S126192178","display_name":"Origins of Life and Evolution of Biospheres","issn_l":"0169-6149","issn":["0169-6149","0302-1688","1573-0875","2214-7047"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","norway-1","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Origins of Life and Evolution of Biospheres","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102728538","display_name":"Wentao Ma","orcid":"https://orcid.org/0000-0003-2948-7695","observed_orcids":["https://orcid.org/0000-0003-2948-7695"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wentao Ma","raw_affiliation_strings":["College of Life Sciences, Wuhan University, Wuhan, 430072, PR China. mwt@whu.edu.cn","College of Life Sciences, Wuhan University, Wuhan, 430072, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Wuhan University, Wuhan, 430072, PR China. mwt@whu.edu.cn","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"College of Life Sciences, Wuhan University, Wuhan, 430072, P.R.China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114430010","display_name":"Chunwu Yu","orcid":"https://orcid.org/0009-0009-2610-0919","observed_orcids":["https://orcid.org/0009-0009-2610-0919"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunwu Yu","raw_affiliation_strings":["College of Computer Sciences, Wuhan University, Wuhan, 430072, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Sciences, Wuhan University, Wuhan, 430072, P.R.China","institution_ids":["https://openalex.org/I37461747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102728538"],"corresponding_institution_ids":["https://openalex.org/I37461747"],"apc_list":{"value":1520,"currency":"USD","value_usd":1520},"apc_paid":null,"fwci":0.1186,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.31372549,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"36","issue":"4","first_page":"413","last_page":"420"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-world-hypothesis","display_name":"RNA world","score":0.7110000252723694},{"id":"https://openalex.org/keywords/origin-of-life","display_name":"origin of life","score":0.7649999856948853},{"id":"https://openalex.org/keywords/rna-replicase","display_name":"RNA replicase","score":0.7789999842643738},{"id":"https://openalex.org/keywords/intramolecular-catalysis","display_name":"intramolecular catalysis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/self-replicating-molecules","display_name":"self-replicating molecules","score":0.8410000205039978},{"id":"https://openalex.org/keywords/ribozyme-evolution","display_name":"ribozyme evolution","score":0.6710000038146973},{"id":"https://openalex.org/keywords/rna-self-replication","display_name":"RNA self-replication","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C76346623","wikidata":"https://www.wikidata.org/wiki/Q205858","display_name":"Ribozyme","level":4,"score":0.8729093074798584},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.8384655714035034},{"id":"https://openalex.org/C1342335","wikidata":"https://www.wikidata.org/wiki/Q6545871","display_name":"Ligase ribozyme","level":5,"score":0.8335596323013306},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.7195285558700562},{"id":"https://openalex.org/C41258723","wikidata":"https://www.wikidata.org/wiki/Q2919111","display_name":"RNA-dependent RNA polymerase","level":4,"score":0.705988347530365},{"id":"https://openalex.org/C107745601","wikidata":"https://www.wikidata.org/wiki/Q3934265","display_name":"Hairpin ribozyme","level":5,"score":0.49558961391448975},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.45364049077033997},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43177181482315063},{"id":"https://openalex.org/C21786251","wikidata":"https://www.wikidata.org/wiki/Q14886350","display_name":"RNA editing","level":4,"score":0.42892566323280334},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41637617349624634},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.4144039750099182},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3852267265319824},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3406029939651489},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.24719452857971191},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08764961361885071}],"mesh":[{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012324","descriptor_name":"RNA-Dependent RNA Polymerase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016337","descriptor_name":"RNA, Catalytic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11084-005-9006-1","doi":"https://doi.org/10.1007/s11084-005-9006-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11084-005-9006-1","pdf_url":null,"source":{"id":"https://openalex.org/S126192178","display_name":"Origins of Life and Evolution of Biospheres","issn_l":"0169-6149","issn":["0169-6149","0302-1688","1573-0875","2214-7047"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","norway-1","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Origins of Life and Evolution of Biospheres","raw_type":"journal-article"},{"id":"pmid:16909330","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16909330","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324116","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17"},{"id":"https://openalex.org/F4320326939","display_name":"State Key Laboratory of Software Engineering","ror":"https://ror.org/01z3jn402"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W192589153","https://openalex.org/W613806986","https://openalex.org/W818307174","https://openalex.org/W934317300","https://openalex.org/W1503940664","https://openalex.org/W1548173963","https://openalex.org/W1964583257","https://openalex.org/W1979795987","https://openalex.org/W1980461160","https://openalex.org/W1984195518","https://openalex.org/W1994563829","https://openalex.org/W1996674793","https://openalex.org/W2014232577","https://openalex.org/W2017457582","https://openalex.org/W2037238732","https://openalex.org/W2040539237","https://openalex.org/W2050110866","https://openalex.org/W2050273964","https://openalex.org/W2053143020","https://openalex.org/W2058939722","https://openalex.org/W2063147689","https://openalex.org/W2073775872","https://openalex.org/W2079288581","https://openalex.org/W2084943154","https://openalex.org/W2087501169","https://openalex.org/W2089339672","https://openalex.org/W2092770354","https://openalex.org/W2093975709","https://openalex.org/W2108421490","https://openalex.org/W2124390729","https://openalex.org/W2133830966","https://openalex.org/W2164701497","https://openalex.org/W4213070614","https://openalex.org/W4235033012","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2170154073","https://openalex.org/W2070980680","https://openalex.org/W1975747768","https://openalex.org/W4386903188","https://openalex.org/W7202417439","https://openalex.org/W7172408214","https://openalex.org/W2946468581","https://openalex.org/W2105801230","https://openalex.org/W3082564993","https://openalex.org/W2039424624"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
