{"id":"https://openalex.org/W2087153105","doi":"https://doi.org/10.4103/0971-6866.124361","title":"Genetic variants in the cytochrome P450 2D6 gene in the Sri Lankan population","display_name":"Genetic variants in the cytochrome P450 2D6 gene in the Sri Lankan population","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2087153105","doi":"https://doi.org/10.4103/0971-6866.124361","mag":"2087153105","pmid":"https://pubmed.ncbi.nlm.nih.gov/24497701","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3897131"},"language":"en","primary_location":{"id":"doi:10.4103/0971-6866.124361","doi":"https://doi.org/10.4103/0971-6866.124361","is_oa":false,"landing_page_url":"https://doi.org/10.4103/0971-6866.124361","pdf_url":null,"source":{"id":"https://openalex.org/S85334534","display_name":"Indian journal of human genetics","issn_l":"0971-6866","issn":["0971-6866","1998-362X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Human Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3897131","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029872410","display_name":"Vajira H. W. Dissanayake","orcid":"https://orcid.org/0000-0002-3264-6856","observed_orcids":["https://orcid.org/0000-0002-3264-6856"]},"institutions":[{"id":"https://openalex.org/I90678064","display_name":"University of Colombo","ror":"https://ror.org/02phn5242","country_code":"LK","type":"education","lineage":["https://openalex.org/I90678064"]}],"countries":["LK"],"is_corresponding":false,"raw_author_name":"VajiraH. W. Dissanayake","raw_affiliation_strings":["Department of Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo 00800, Sri Lanka"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo 00800, Sri Lanka","institution_ids":["https://openalex.org/I90678064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043104047","display_name":"T. D.Praveen Tharanga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90678064","display_name":"University of Colombo","ror":"https://ror.org/02phn5242","country_code":"LK","type":"education","lineage":["https://openalex.org/I90678064"]}],"countries":["LK"],"is_corresponding":false,"raw_author_name":"T. D.Praveen Tharanga","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, University of Colombo, Colombo 00800, Sri Lanka"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, University of Colombo, Colombo 00800, Sri Lanka","institution_ids":["https://openalex.org/I90678064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075275119","display_name":"C. V. M. Jinadasa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90678064","display_name":"University of Colombo","ror":"https://ror.org/02phn5242","country_code":"LK","type":"education","lineage":["https://openalex.org/I90678064"]}],"countries":["LK"],"is_corresponding":false,"raw_author_name":"C. M. V. Jinadasa","raw_affiliation_strings":["Department of Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo 00800, Sri Lanka"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo 00800, Sri Lanka","institution_ids":["https://openalex.org/I90678064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114865867","display_name":"MF Risama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90678064","display_name":"University of Colombo","ror":"https://ror.org/02phn5242","country_code":"LK","type":"education","lineage":["https://openalex.org/I90678064"]}],"countries":["LK"],"is_corresponding":false,"raw_author_name":"MF Risama","raw_affiliation_strings":["Department of Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo 00800, Sri Lanka"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo 00800, Sri Lanka","institution_ids":["https://openalex.org/I90678064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074809035","display_name":"Raveendra Laal Jayakody","orcid":"https://orcid.org/0000-0002-1912-8843","observed_orcids":["https://orcid.org/0000-0002-1912-8843"]},"institutions":[{"id":"https://openalex.org/I90678064","display_name":"University of Colombo","ror":"https://ror.org/02phn5242","country_code":"LK","type":"education","lineage":["https://openalex.org/I90678064"]}],"countries":["LK"],"is_corresponding":false,"raw_author_name":"RL Jayakody","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, University of Colombo, Colombo 00800, Sri Lanka"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, University of Colombo, Colombo 00800, Sri Lanka","institution_ids":["https://openalex.org/I90678064"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089092128","display_name":"Priyadarshani Galappatthy","orcid":"https://orcid.org/0000-0002-9279-9053","observed_orcids":["https://orcid.org/0000-0002-9279-9053"]},"institutions":[{"id":"https://openalex.org/I90678064","display_name":"University of Colombo","ror":"https://ror.org/02phn5242","country_code":"LK","type":"education","lineage":["https://openalex.org/I90678064"]}],"countries":["LK"],"is_corresponding":false,"raw_author_name":"Priyadarshani Galappatthy","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, University of Colombo, Colombo 00800, Sri Lanka"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, University of Colombo, Colombo 00800, Sri Lanka","institution_ids":["https://openalex.org/I90678064"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I90678064"],"apc_list":null,"apc_paid":null,"fwci":0.6515,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.66482448,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"19","issue":"4","first_page":"392","last_page":"392"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.9950000047683716},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.8420000076293945},{"id":"https://openalex.org/keywords/sri-lankan-population","display_name":"Sri Lankan population","score":0.8370000123977661},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"allele frequency","score":0.6859999895095825},{"id":"https://openalex.org/keywords/sinhalese","display_name":"Sinhalese","score":0.8389999866485596},{"id":"https://openalex.org/keywords/sri-lankan-tamils","display_name":"Sri Lankan Tamils","score":0.9399999976158142},{"id":"https://openalex.org/keywords/moors","display_name":"Moors","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.6940000057220459},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.6710000038146973},{"id":"https://openalex.org/keywords/loss-of-function-variants","display_name":"loss-of-function mutations","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.832095742225647},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.576429009437561},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5722683072090149},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5402413010597229},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5118328928947449},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3130636215209961},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2797670066356659},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22337260842323303},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4103/0971-6866.124361","doi":"https://doi.org/10.4103/0971-6866.124361","is_oa":false,"landing_page_url":"https://doi.org/10.4103/0971-6866.124361","pdf_url":null,"source":{"id":"https://openalex.org/S85334534","display_name":"Indian journal of human genetics","issn_l":"0971-6866","issn":["0971-6866","1998-362X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Human Genetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2898112","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3897131","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3897131","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3897131","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian J Hum Genet","raw_type":"Text"},{"id":"pmid:24497701","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24497701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of human genetics","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2898112","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3897131","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320337408","display_name":"Division of Undergraduate Education","ror":"https://ror.org/02kd4km72"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1596190251","https://openalex.org/W1964271051","https://openalex.org/W1967670851","https://openalex.org/W1972859881","https://openalex.org/W1984131408","https://openalex.org/W2006294394","https://openalex.org/W2015488487","https://openalex.org/W2015555489","https://openalex.org/W2018974735","https://openalex.org/W2027148131","https://openalex.org/W2048334324","https://openalex.org/W2052733258","https://openalex.org/W2056459858","https://openalex.org/W2060099946","https://openalex.org/W2061306683","https://openalex.org/W2087944254","https://openalex.org/W2150274550","https://openalex.org/W2152797524"],"related_works":["https://openalex.org/W2071928984","https://openalex.org/W2947176627","https://openalex.org/W2010245350","https://openalex.org/W2018974735","https://openalex.org/W2157049444","https://openalex.org/W2781613448","https://openalex.org/W4414162261","https://openalex.org/W1974316701","https://openalex.org/W2051056188","https://openalex.org/W3138815228"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Cytochrome":[1],"P450":[2],"2D6":[3],"(CYP2D6)":[4],"enzymes":[5],"are":[6,226],"involved":[7],"in":[8,65,99,104,178,238,241,256],"the":[9,34,59,87,100,105,134,175],"metabolism":[10],"of":[11,15,36,61,81,89,114,139,142,174,232],"a":[12,130,154,250],"large":[13],"number":[14],"commonly":[16],"prescribed":[17],"drugs":[18],"such":[19],"as":[20],"antidepressants":[21],"and":[22,29,41,48,96,125,183,191,197,203,209,213,222],"cardiovascular":[23],"drugs.":[24,77],"The":[25,79,172],"CYP2D6":[26,39,49,90,176,187,193,199,205,211,233],"*3,":[27,92],"*4":[28,221],"*14":[30,95,212],"variants":[31,43,98,177,215],"associated":[32,227],"with":[33,44,52,75,228],"loss":[35,231],"enzyme":[37,46,56,234],"function;":[38,47],"*10":[40,223],"*17":[42,97,214],"reduced":[45,229],"*2":[50],"variant":[51,63,252],"no":[53],"effect":[54],"on":[55],"function.":[57],"Establishing":[58],"frequency":[60],"these":[62],"alleles":[64],"Sri":[66,106,180],"Lankan":[67,107,181],"population":[68,150,156,240],"would":[69],"be":[70,249],"useful":[71],"for":[72,149],"optimizing":[73],"pharmacotherapy":[74],"CYP2D6-substrate":[76],"OBJECTIVE:":[78],"objective":[80],"this":[82],"study":[83],"was":[84,160,253],"to":[85,248],"determine":[86],"prevalence":[88,173],"*2,":[91],"*4,":[93],"*10,":[94],"main":[101],"ethnic":[102,259],"groups":[103],"population.":[108],"MATERIALS":[109],"AND":[110],"METHODS:":[111],"A":[112],"total":[113],"90":[115],"deoxyribonucleic":[116],"acid":[117],"(DNA)":[118],"samples":[119],"(30":[120],"each":[121],"from":[122,129,153],"Sinhalese,":[123,179],"Tamils":[124,182],"Moors)":[126],"were":[127,186,216,236],"selected":[128],"DNA":[131],"resource":[132],"at":[133],"Human":[135],"Genetic":[136],"Unit,":[137],"Faculty":[138],"Medicine,":[140],"University":[141],"Colombo.":[143],"This":[144],"collection":[145],"had":[146],"been":[147],"made":[148],"genetic":[151],"studies":[152],"random":[155],"based":[157],"volunteers.":[158],"Genotyping":[159],"performed":[161],"using":[162],"published":[163],"polymerase":[164],"chain":[165],"reaction/restriction":[166],"fragment":[167],"length":[168],"polymorphism":[169],"methods.":[170],"RESULTS:":[171],"Moors":[184],"respectively":[185],"*2:":[188],"37%,":[189],"41.6%":[190],"37.9%;":[192],"*3:":[194],"60.3%,":[195],"45%":[196],"30%;":[198],"*4:":[200],"21.6%,":[201],"6.6%":[202],"8.3%;":[204],"*10:":[206],"40%,":[207],"35%":[208],"44%.":[210],"not":[217],"identified.":[218],"CONCLUSION:":[219],"CYP2D6*3,":[220],"variants,":[224],"which":[225,245],"or":[230],"function":[235],"found":[237,255],"our":[239],"significant":[242],"frequencies.":[243],"CYP2D6*4,":[244],"is":[246],"reported":[247],"Caucasian":[251],"also":[254],"all":[257],"three":[258],"groups.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
