{"id":"https://openalex.org/W2087147338","doi":"https://doi.org/10.1021/bi801724n","title":"Structural Basis of Substrate Recognition by Hematopoietic Tyrosine Phosphatase,","display_name":"Structural Basis of Substrate Recognition by Hematopoietic Tyrosine Phosphatase,","publication_year":2008,"publication_date":"2008-11-20","ids":{"openalex":"https://openalex.org/W2087147338","doi":"https://doi.org/10.1021/bi801724n","mag":"2087147338","pmid":"https://pubmed.ncbi.nlm.nih.gov/19053285","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2908255"},"language":"en","primary_location":{"id":"doi:10.1021/bi801724n","doi":"https://doi.org/10.1021/bi801724n","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi801724n","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2908255","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016607794","display_name":"David Critton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Critton","raw_affiliation_strings":["Departments of Molecular Biology, Cell Biology, and Biochemistry and of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island 02912"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Biology, Cell Biology, and Biochemistry and of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island 02912","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035877111","display_name":"Antoni Tortajada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antoni Tortajada","raw_affiliation_strings":["Departments of Molecular Biology, Cell Biology, and Biochemistry and of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island 02912"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Biology, Cell Biology, and Biochemistry and of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island 02912","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061576490","display_name":"Geoffrey V. Stetson","orcid":"https://orcid.org/0000-0002-5219-3727","observed_orcids":["https://orcid.org/0000-0002-5219-3727"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey Stetson","raw_affiliation_strings":["Departments of Molecular Biology, Cell Biology, and Biochemistry and of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island 02912"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Biology, Cell Biology, and Biochemistry and of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island 02912","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067107586","display_name":"Wolfgang Peti","orcid":"https://orcid.org/0000-0002-8830-6594","observed_orcids":["https://orcid.org/0000-0002-8830-6594"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wolfgang Peti","raw_affiliation_strings":["Departments of Molecular Biology, Cell Biology, and Biochemistry and of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island 02912"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Biology, Cell Biology, and Biochemistry and of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island 02912","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089446505","display_name":"Rebecca Page","orcid":"https://orcid.org/0000-0002-4645-1232","observed_orcids":["https://orcid.org/0000-0002-4645-1232"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rebecca Page","raw_affiliation_strings":["Departments of Molecular Biology, Cell Biology, and Biochemistry and of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island 02912"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Biology, Cell Biology, and Biochemistry and of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island 02912","institution_ids":["https://openalex.org/I27804330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089446505"],"corresponding_institution_ids":["https://openalex.org/I27804330"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.784,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.67581911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"47","issue":"50","first_page":"13336","last_page":"13345"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/substrate-recognition","display_name":"substrate recognition","score":0.9409999847412109},{"id":"https://openalex.org/keywords/erk2","display_name":"ERK2","score":0.8500000238418579},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.8740000128746033},{"id":"https://openalex.org/keywords/substrate-binding-loop","display_name":"substrate-binding loop","score":0.6010000109672546},{"id":"https://openalex.org/keywords/dephosphorylation","display_name":"dephosphorylation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.48399999737739563},{"id":"https://openalex.org/keywords/step","display_name":"STEP","score":0.3499999940395355},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.6809815764427185},{"id":"https://openalex.org/C2775895851","wikidata":"https://www.wikidata.org/wiki/Q185906","display_name":"Asparagine","level":3,"score":0.6263799667358398},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.5592559576034546},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5577963590621948},{"id":"https://openalex.org/C181912034","wikidata":"https://www.wikidata.org/wiki/Q1101143","display_name":"Dephosphorylation","level":4,"score":0.5275663137435913},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5152469277381897},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4681221544742584},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.4653495252132416},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.4558904767036438},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45302504301071167},{"id":"https://openalex.org/C2781208047","wikidata":"https://www.wikidata.org/wiki/Q178450","display_name":"Aspartic acid","level":3,"score":0.44922250509262085},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4296691417694092},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.42699137330055237},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.42335861921310425},{"id":"https://openalex.org/C117745874","wikidata":"https://www.wikidata.org/wiki/Q901612","display_name":"Sequence motif","level":3,"score":0.4211147129535675},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.24561139941215515},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.24434256553649902},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.08226355910301208}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054558","descriptor_name":"Protein Tyrosine Phosphatases, Non-Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054558","descriptor_name":"Protein Tyrosine Phosphatases, Non-Receptor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D054558","descriptor_name":"Protein Tyrosine Phosphatases, Non-Receptor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/bi801724n","doi":"https://doi.org/10.1021/bi801724n","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi801724n","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:19053285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19053285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Comparative Study"},{"id":"pmh:oai:europepmc.org:2000621","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2908255","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2908255","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2908255","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2000621","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2908255","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3285181043","display_name":"RI Network for Excellence in Biomedical and Behavioral Research","funder_award_id":"P20RR016457","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G357077679","display_name":null,"funder_award_id":"Y01 GM000080","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8146236672","display_name":"An 800 MHz NMR spectrometer for the Boston area","funder_award_id":"S10RR017269","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1504478980","https://openalex.org/W1532900970","https://openalex.org/W1539699466","https://openalex.org/W1539796472","https://openalex.org/W1541248287","https://openalex.org/W1970160140","https://openalex.org/W1979600897","https://openalex.org/W1993653637","https://openalex.org/W1994286350","https://openalex.org/W1994341799","https://openalex.org/W1999863139","https://openalex.org/W2001183750","https://openalex.org/W2007551386","https://openalex.org/W2009930457","https://openalex.org/W2011147958","https://openalex.org/W2016255772","https://openalex.org/W2017334692","https://openalex.org/W2021819516","https://openalex.org/W2026395206","https://openalex.org/W2038679488","https://openalex.org/W2038840577","https://openalex.org/W2043617798","https://openalex.org/W2044529125","https://openalex.org/W2067920491","https://openalex.org/W2069579672","https://openalex.org/W2071006062","https://openalex.org/W2074986801","https://openalex.org/W2080175465","https://openalex.org/W2081359386","https://openalex.org/W2081895178","https://openalex.org/W2081912151","https://openalex.org/W2085530715","https://openalex.org/W2086790663","https://openalex.org/W2091890461","https://openalex.org/W2094186244","https://openalex.org/W2098854471","https://openalex.org/W2114427980","https://openalex.org/W2116372588","https://openalex.org/W2117239890","https://openalex.org/W2132006815","https://openalex.org/W2135028971","https://openalex.org/W2140490890","https://openalex.org/W2142959145","https://openalex.org/W2144081223","https://openalex.org/W2147281292","https://openalex.org/W2154431772","https://openalex.org/W2314948125"],"related_works":["https://openalex.org/W1999863139","https://openalex.org/W2331735788","https://openalex.org/W2330407560","https://openalex.org/W2114427980","https://openalex.org/W2032477833","https://openalex.org/W2326678848","https://openalex.org/W2080285527","https://openalex.org/W2038679488","https://openalex.org/W2095460098","https://openalex.org/W2150603409"],"abstract_inverted_index":{"Hematopoietic":[0],"tyrosine":[1],"phosphatase":[2,15],"(HePTP)":[3,66],"is":[4,53,117,280],"one":[5],"of":[6,9,80,90,111,135,147,176,185,199,231,247,277,292],"three":[7],"members":[8],"the":[10,32,44,91,98,133,144,167,173,181,211,229,232,237,244,266,278,284,289],"kinase":[11],"interaction":[12,51,276,287],"motif":[13],"(KIM)":[14],"family":[16],"which":[17,34,52,210,258],"also":[18,74],"includes":[19],"STEP":[20],"and":[21,48,67],"PCPTP1.":[22],"The":[23,71,223],"KIM-PTPs":[24,72,99,264],"are":[25,73,94,259],"characterized":[26,75],"by":[27,76,150],"a":[28,77,204],"15":[29],"residue":[30,214],"sequence,":[31],"KIM,":[33],"confers":[35],"specific":[36,138,206,213],"high-affinity":[37],"binding":[38,86],"to":[39,58,102,142,157,171,196,218,254,261],"their":[40,56,83],"only":[41,194,255],"known":[42],"substrates,":[43],"MAP":[45],"kinases":[46],"Erk":[47],"p38,":[49],"an":[50,119,219],"critical":[54],"for":[55,282],"ability":[57],"regulate":[59],"processes":[60],"such":[61],"as":[62,100],"T":[63],"cell":[64],"differentiation":[65],"neuronal":[68],"signaling":[69],"(STEP).":[70],"unique":[78],"set":[79],"residues":[81,93,139],"in":[82,115,123,140,209,250],"PTP":[84],"substrate":[85,148],"loops,":[87],"where":[88],"4":[89],"13":[92],"differentially":[95],"conserved":[96],"among":[97],"compared":[101],"more":[103],"than":[104],"30":[105],"other":[106,126],"class":[107],"I":[108],"PTPs.":[109],"One":[110],"these":[112,136,200],"residues,":[113],"T106":[114,215,249],"HePTP,":[116],"either":[118],"aspartate":[120,225],"or":[121],"asparagine":[122],"nearly":[124],"every":[125],"PTP.":[127],"Using":[128],"multiple":[129],"techniques,":[130],"we":[131,153,179,192,272],"investigate":[132],"role":[134,246],"KIM-PTP":[137,205,212],"order":[141],"elucidate":[143],"molecular":[145,174],"basis":[146],"recognition":[149],"HePTP.":[151],"First,":[152],"used":[154],"NMR":[155],"spectroscopy":[156],"show":[158],"that":[159],"Erk2-derived":[160],"peptides":[161],"interact":[162,262],"specifically":[163],"with":[164,263],"HePTP":[165,248,252],"at":[166,288],"active":[168,238,290],"site.":[169],"Next,":[170],"reveal":[172],"details":[175],"this":[177,275],"interaction,":[178],"solved":[180],"high-resolution":[182],"three-dimensional":[183],"structures":[184,242],"two":[186],"distinct":[187],"HePTP-Erk2":[188],"peptide":[189],"complexes.":[190],"Strikingly,":[191],"were":[193],"able":[195,260],"obtain":[197],"crystals":[198],"transient":[201],"complexes":[202],"using":[203],"substrate-trapping":[207],"mutant,":[208],"was":[216],"mutated":[217],"aspartic":[220],"acid":[221],"(T106D).":[222],"introduced":[224],"side":[226],"chain":[227],"facilitates":[228],"coordination":[230],"bound":[233],"peptides,":[234],"thereby":[235],"stabilizing":[236],"dephosphorylation":[239],"complex.":[240],"These":[241],"establish":[243],"essential":[245],"restricting":[251],"specificity":[253],"those":[256],"substrates":[257],"via":[265],"KIM":[267,279],"(e.g.,":[268],"Erk2,":[269],"p38).":[270],"Finally,":[271],"describe":[273],"how":[274],"sufficient":[281],"overcoming":[283],"otherwise":[285],"weak":[286],"site":[291],"KIM-PTPs.":[293]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}