{"id":"https://openalex.org/W2087147268","doi":"https://doi.org/10.1159/000330355","title":"The Role of Statins in Chronic Kidney Disease","display_name":"The Role of Statins in Chronic Kidney Disease","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2087147268","doi":"https://doi.org/10.1159/000330355","mag":"2087147268","pmid":"https://pubmed.ncbi.nlm.nih.gov/21791915"},"language":"en","primary_location":{"id":"doi:10.1159/000330355","doi":"https://doi.org/10.1159/000330355","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000330355","pdf_url":null,"source":{"id":"https://openalex.org/S106979888","display_name":"American Journal of Nephrology","issn_l":"0250-8095","issn":["0250-8095","1421-9670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Nephrology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032021350","display_name":"Rigas Kalaitzidis","orcid":"https://orcid.org/0000-0002-7773-7575","observed_orcids":["https://orcid.org/0000-0002-7773-7575"]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Rigas G. Kalaitzidis","raw_affiliation_strings":["Department of Internal Medicine, Medical School, University of Ioannina, Greece","Dept. of Internal Medicine, Medical School, University of Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Medical School, University of Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]},{"raw_affiliation_string":"Dept. of Internal Medicine, Medical School, University of Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056379080","display_name":"Moses Elisaf","orcid":"https://orcid.org/0000-0003-0505-078X","observed_orcids":["https://orcid.org/0000-0003-0505-078X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Moses S. Elisaf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9178,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.66814815,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"34","issue":"3","first_page":"195","last_page":"202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.5278000235557556,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.5278000235557556,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.45190000534057617,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":1.0},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":1.0},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9070000052452087},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.7789999842643738},{"id":"https://openalex.org/keywords/dialysis","display_name":"dialysis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/ezetimibe","display_name":"ezetimibe","score":0.8100000023841858},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.7570000290870667},{"id":"https://openalex.org/keywords/kidney-disease-progression","display_name":"kidney disease progression","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.5109999775886536},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.5740000009536743},{"id":"https://openalex.org/keywords/sharp-trial","display_name":"SHARP trial","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9477819204330444},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.8360899686813354},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.6909852027893066},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.655451238155365},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5997326374053955},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5863956212997437},{"id":"https://openalex.org/C2778657065","wikidata":"https://www.wikidata.org/wiki/Q417997","display_name":"Ezetimibe","level":3,"score":0.5515282154083252},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.49912023544311523},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.4984138011932373},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4639875888824463},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45782336592674255},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.44891390204429626},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.431167334318161},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.32568681240081787},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000330355","doi":"https://doi.org/10.1159/000330355","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000330355","pdf_url":null,"source":{"id":"https://openalex.org/S106979888","display_name":"American Journal of Nephrology","issn_l":"0250-8095","issn":["0250-8095","1421-9670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Nephrology","raw_type":"journal-article"},{"id":"pmid:21791915","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21791915","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of nephrology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W38523360","https://openalex.org/W42443949","https://openalex.org/W50513579","https://openalex.org/W1483531931","https://openalex.org/W1502524639","https://openalex.org/W1965113453","https://openalex.org/W1973878234","https://openalex.org/W1979397038","https://openalex.org/W1981155050","https://openalex.org/W1993266652","https://openalex.org/W2015738659","https://openalex.org/W2021586491","https://openalex.org/W2027441714","https://openalex.org/W2029778128","https://openalex.org/W2032160189","https://openalex.org/W2032992532","https://openalex.org/W2039263780","https://openalex.org/W2042318705","https://openalex.org/W2042875425","https://openalex.org/W2043143373","https://openalex.org/W2044334355","https://openalex.org/W2047498248","https://openalex.org/W2059371152","https://openalex.org/W2063826027","https://openalex.org/W2064024971","https://openalex.org/W2064236028","https://openalex.org/W2081650111","https://openalex.org/W2085728170","https://openalex.org/W2089151124","https://openalex.org/W2101967622","https://openalex.org/W2102459463","https://openalex.org/W2103477598","https://openalex.org/W2106530304","https://openalex.org/W2110601215","https://openalex.org/W2113310960","https://openalex.org/W2117248462","https://openalex.org/W2117848894","https://openalex.org/W2117930137","https://openalex.org/W2120300458","https://openalex.org/W2128460332","https://openalex.org/W2132627628","https://openalex.org/W2134777998","https://openalex.org/W2146311281","https://openalex.org/W2149019709","https://openalex.org/W2155019824","https://openalex.org/W2156880046","https://openalex.org/W2162430779","https://openalex.org/W2163914595","https://openalex.org/W2165924268","https://openalex.org/W2166998621","https://openalex.org/W2169745311","https://openalex.org/W4246764494","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2011906273","https://openalex.org/W2052204128","https://openalex.org/W2020750307","https://openalex.org/W2020476431","https://openalex.org/W2162958882","https://openalex.org/W2096006006","https://openalex.org/W2787312030","https://openalex.org/W1965771856","https://openalex.org/W2017897276","https://openalex.org/W2093721755"],"abstract_inverted_index":{"Cardiovascular":[0],"disease":[1,24,101,142],"(CVD)":[2],"is":[3],"the":[4,14,57,69,112,177,181,188],"leading":[5],"cause":[6,169],"of":[7,35,62,71,76,85,114,180,184,190],"morbidity":[8],"and":[9,59,64,116,140],"mortality":[10],"not":[11,106],"only":[12],"amongst":[13],"general":[15],"population,":[16],"but":[17],"also":[18],"in":[19,73,98,130,155,194],"patients":[20,68,102],"with":[21,27,87,124,135,187],"chronic":[22],"kidney":[23,40,185],"(CKD).":[25],"Persons":[26],"CKD":[28,67,195],"are":[29,48],"much":[30],"more":[31],"likely":[32],"to":[33,38,79,91],"die":[34],"CVD":[36,77],"than":[37],"experience":[39],"failure.":[41],"Clinical":[42,133],"trials":[43],"have":[44,144,150,160],"demonstrated":[45],"that":[46,122,162],"statins":[47,72,123,136,163],"gaining":[49],"widespread":[50],"acceptance":[51],"as":[52],"a":[53,88,152],"principal":[54],"therapy":[55],"for":[56],"primary":[58,74],"secondary":[60],"prevention":[61,75],"atherosclerosis":[63],"CVD.":[65],"In":[66],"role":[70],"remains":[78],"be":[80,92,127],"clarified.":[81],"The":[82],"absolute":[83],"benefit":[84],"treatment":[86],"statin":[89],"seems":[90],"greater":[93],"among":[94],"nondialysis-dependent-CKD":[95],"patients.":[96,132,196],"Studies":[97],"end-stage":[99],"renal":[100,141],"on":[103,137],"dialysis":[104,131],"did":[105],"confirm":[107],"these":[108],"results.":[109,147],"Recently,":[110],"however,":[111],"Study":[113],"Heart":[115],"Renal":[117],"Protection":[118],"(SHARP)":[119],"has":[120],"suggested":[121],"ezetimibe":[125],"may":[126,168],"beneficial":[128],"even":[129],"studies":[134,149,159],"proteinuria":[138,170],"reduction":[139,154],"progression":[143],"yielded":[145],"conflicting":[146],"Some":[148],"shown":[151,161],"prominent":[153],"proteinuria,":[156],"while":[157],"other":[158],"had":[164],"no":[165],"effect":[166],"or":[167],"at":[171],"high":[172],"doses.":[173],"This":[174],"review":[175],"examines":[176],"clinical":[178],"evidence":[179],"observed":[182],"benefits":[183],"function":[186],"use":[189],"this":[191],"drug":[192],"category":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
