{"id":"https://openalex.org/W2087072291","doi":"https://doi.org/10.1016/0014-2999(88)90381-0","title":"Antidepressant-like effects of (+)-oxaprotiline on a behavioral screen","display_name":"Antidepressant-like effects of (+)-oxaprotiline on a behavioral screen","publication_year":1988,"publication_date":"1988-11-01","ids":{"openalex":"https://openalex.org/W2087072291","doi":"https://doi.org/10.1016/0014-2999(88)90381-0","mag":"2087072291","pmid":"https://pubmed.ncbi.nlm.nih.gov/3224637"},"language":"en","primary_location":{"id":"doi:10.1016/0014-2999(88)90381-0","doi":"https://doi.org/10.1016/0014-2999(88)90381-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-2999(88)90381-0","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004332028","display_name":"Gerard J. Marek","orcid":"https://orcid.org/0000-0001-8103-4306","observed_orcids":["https://orcid.org/0000-0001-8103-4306"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerard J. Marek","raw_affiliation_strings":["University of Chicago, Department of Pharmacological and Physiological Sciences, IL 60637","The University of Chicago, Department of Pharmacological and Physiological Sciences, 947, East 58th Street, Chicago, IL 60637, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Department of Pharmacological and Physiological Sciences, IL 60637","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"The University of Chicago, Department of Pharmacological and Physiological Sciences, 947, East 58th Street, Chicago, IL 60637, U.S.A","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078694527","display_name":"Abby Li","orcid":"https://orcid.org/0000-0001-8897-0754","observed_orcids":["https://orcid.org/0000-0001-8897-0754"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abby Li","raw_affiliation_strings":["The University of Chicago, Department of Pharmacological and Physiological Sciences, 947, East 58th Street, Chicago, IL 60637, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Department of Pharmacological and Physiological Sciences, 947, East 58th Street, Chicago, IL 60637, U.S.A","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111691188","display_name":"Lewis S. Seiden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lewis S. Seiden","raw_affiliation_strings":["The University of Chicago, Department of Pharmacological and Physiological Sciences, 947, East 58th Street, Chicago, IL 60637, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Department of Pharmacological and Physiological Sciences, 947, East 58th Street, Chicago, IL 60637, U.S.A","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111691188"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":0.3782,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.60803244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"157","issue":"2-3","first_page":"183","last_page":"188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.6122999787330627,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.6122999787330627,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.37790000438690186,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxaprotiline","display_name":"oxaprotiline","score":0.972000002861023},{"id":"https://openalex.org/keywords/antidepressant-like-effects","display_name":"antidepressant-like effects","score":0.8550000190734863},{"id":"https://openalex.org/keywords/noradrenaline-reuptake-inhibition","display_name":"norepinephrine reuptake inhibition","score":0.9129999876022339},{"id":"https://openalex.org/keywords/stereoselectivity","display_name":"stereoselectivity","score":0.7229999899864197},{"id":"https://openalex.org/keywords/enantiomers","display_name":"enantiomers","score":0.7940000295639038},{"id":"https://openalex.org/keywords/differential-reinforcement-of-low-rates","display_name":"differential reinforcement of low rates","score":0.8140000104904175},{"id":"https://openalex.org/keywords/temporal-discrimination","display_name":"temporal discrimination","score":0.9139999747276306},{"id":"https://openalex.org/keywords/response-rate","display_name":"response rate","score":0.6990000009536743},{"id":"https://openalex.org/keywords/rate-of-reinforcement","display_name":"reinforcement rate","score":0.8119999766349792},{"id":"https://openalex.org/keywords/mood-disorders","display_name":"mood disorders","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C67203356","wikidata":"https://www.wikidata.org/wiki/Q1321905","display_name":"Reinforcement","level":2,"score":0.6358606219291687},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.6332211494445801},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.6071510314941406},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5635932683944702},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5175718069076538},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.4693532884120941},{"id":"https://openalex.org/C2775859304","wikidata":"https://www.wikidata.org/wiki/Q132621","display_name":"Epinephrine","level":2,"score":0.46693697571754456},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.45019179582595825},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3972664177417755},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3844103515148163},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.30606603622436523},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.2883322834968567},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21014022827148438},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.06082737445831299},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000873","descriptor_name":"Anthracenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004193","descriptor_name":"Discrimination Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008376","descriptor_name":"Maprotiline","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D008376","descriptor_name":"Maprotiline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012055","descriptor_name":"Reinforcement Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-2999(88)90381-0","doi":"https://doi.org/10.1016/0014-2999(88)90381-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-2999(88)90381-0","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:3224637","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3224637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2158075542","display_name":null,"funder_award_id":"MH-10562","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2799163916","display_name":"Medical Scientist National Research Service Award","funder_award_id":"T32GM007281","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8602274586","display_name":null,"funder_award_id":"MH 11191-20","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W252298518","https://openalex.org/W305727594","https://openalex.org/W1850609236","https://openalex.org/W1930574664","https://openalex.org/W1977785204","https://openalex.org/W1983704418","https://openalex.org/W1989314580","https://openalex.org/W1993082527","https://openalex.org/W2002946197","https://openalex.org/W2010175057","https://openalex.org/W2029415534","https://openalex.org/W2060048710","https://openalex.org/W2070114687","https://openalex.org/W2089892459","https://openalex.org/W2264924628","https://openalex.org/W2292099303","https://openalex.org/W2314858779","https://openalex.org/W2412217266","https://openalex.org/W6657914782"],"related_works":["https://openalex.org/W1993082527","https://openalex.org/W2010175057","https://openalex.org/W2061419032","https://openalex.org/W2009465256","https://openalex.org/W2481679743","https://openalex.org/W1977045409","https://openalex.org/W2034013592","https://openalex.org/W2472083434","https://openalex.org/W1968974461","https://openalex.org/W1456061279"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}