{"id":"https://openalex.org/W2087041328","doi":"https://doi.org/10.1128/iai.00506-12","title":"Lack of Lipid A Pyrophosphorylation and Functional lptA Reduces Inflammation by Neisseria Commensals","display_name":"Lack of Lipid A Pyrophosphorylation and Functional lptA Reduces Inflammation by Neisseria Commensals","publication_year":2012,"publication_date":"2012-09-05","ids":{"openalex":"https://openalex.org/W2087041328","doi":"https://doi.org/10.1128/iai.00506-12","mag":"2087041328","pmid":"https://pubmed.ncbi.nlm.nih.gov/22949553","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3486066"},"language":"en","primary_location":{"id":"doi:10.1128/iai.00506-12","doi":"https://doi.org/10.1128/iai.00506-12","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.00506-12","pdf_url":"https://iai.asm.org/content/iai/80/11/4014.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://iai.asm.org/content/iai/80/11/4014.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035234881","display_name":"Constance M. John","orcid":"https://orcid.org/0000-0003-4984-6325","observed_orcids":["https://orcid.org/0000-0003-4984-6325"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Constance M. John","raw_affiliation_strings":["Center for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA","institution_ids":["https://openalex.org/I1315708478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085662959","display_name":"Mingfeng Liu","orcid":"https://orcid.org/0000-0003-4962-7691","observed_orcids":["https://orcid.org/0000-0003-4962-7691","https://orcid.org/0009-0007-0502-4078"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingfeng Liu","raw_affiliation_strings":["Center for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA","Department of Laboratory Medicine, University of California, San Francisco, California, USA","aCenter for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA","bDepartment of Laboratory Medicine, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA","institution_ids":["https://openalex.org/I1315708478"]},{"raw_affiliation_string":"Department of Laboratory Medicine, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"aCenter for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA","institution_ids":["https://openalex.org/I1315708478"]},{"raw_affiliation_string":"bDepartment of Laboratory Medicine, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114247345","display_name":"Nancy J. Phillips","orcid":"https://orcid.org/0009-0009-4298-0522","observed_orcids":["https://orcid.org/0009-0009-4298-0522"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy J. Phillips","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California, San Francisco, California, USA","cDepartment of Pharmaceutical Chemistry, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"cDepartment of Pharmaceutical Chemistry, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054594047","display_name":"Zhijie Yang","orcid":"https://orcid.org/0000-0002-0994-6420","observed_orcids":["https://orcid.org/0000-0002-0994-6420"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhijie Yang","raw_affiliation_strings":["Center for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA","aCenter for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA","institution_ids":["https://openalex.org/I1315708478"]},{"raw_affiliation_string":"aCenter for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA","institution_ids":["https://openalex.org/I1315708478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014179122","display_name":"Courtney R. Funk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney R. Funk","raw_affiliation_strings":["Center for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA","aCenter for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA","institution_ids":["https://openalex.org/I1315708478"]},{"raw_affiliation_string":"aCenter for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA","institution_ids":["https://openalex.org/I1315708478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069270814","display_name":"Lindsey I. Zimmerman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsey I. Zimmerman","raw_affiliation_strings":["Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA","dDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA","institution_ids":["https://openalex.org/I66946132"]},{"raw_affiliation_string":"dDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113534323","display_name":"John McLeod Griffiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. McLeod Griffiss","raw_affiliation_strings":["Center for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA","Department of Laboratory Medicine, University of California, San Francisco, California, USA","aCenter for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA","bDepartment of Laboratory Medicine, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA","institution_ids":["https://openalex.org/I1315708478"]},{"raw_affiliation_string":"Department of Laboratory Medicine, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"aCenter for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA","institution_ids":["https://openalex.org/I1315708478"]},{"raw_affiliation_string":"bDepartment of Laboratory Medicine, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079145539","display_name":"Daniel C. Stein","orcid":"https://orcid.org/0000-0003-3397-5720","observed_orcids":["https://orcid.org/0000-0003-3397-5720"]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel C. Stein","raw_affiliation_strings":["Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA","dDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA","institution_ids":["https://openalex.org/I66946132"]},{"raw_affiliation_string":"dDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015010568","display_name":"Gary A. Jarvis","orcid":"https://orcid.org/0000-0002-7576-3702","observed_orcids":["https://orcid.org/0000-0002-7576-3702"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary A. Jarvis","raw_affiliation_strings":["Center for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA","Department of Laboratory Medicine, University of California, San Francisco, California, USA","aCenter for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA","bDepartment of Laboratory Medicine, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA","institution_ids":["https://openalex.org/I1315708478"]},{"raw_affiliation_string":"Department of Laboratory Medicine, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"aCenter for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California, USA","institution_ids":["https://openalex.org/I1315708478"]},{"raw_affiliation_string":"bDepartment of Laboratory Medicine, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.991,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.85462352,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"80","issue":"11","first_page":"4014","last_page":"4026"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.04769999906420708,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lpta","display_name":"LptA","score":0.9169999957084656},{"id":"https://openalex.org/keywords/lipooligosaccharide","display_name":"lipooligosaccharide","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tlr4-signaling","display_name":"TLR4 signaling","score":0.9570000171661377},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/neisseria-lactamica","display_name":"Neisseria lactamica","score":0.9520000219345093},{"id":"https://openalex.org/keywords/neisseria-meningitidis","display_name":"Neisseria meningitidis","score":0.7129999995231628},{"id":"https://openalex.org/keywords/immune-privilege","display_name":"immune privilege","score":0.7590000033378601},{"id":"https://openalex.org/keywords/commensalism","display_name":"commensalism","score":0.7099999785423279},{"id":"https://openalex.org/keywords/thp-1-cells","display_name":"THP-1 cells","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C37193104","wikidata":"https://www.wikidata.org/wiki/Q191934","display_name":"Commensalism","level":3,"score":0.8357435464859009},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8023949861526489},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7897804975509644},{"id":"https://openalex.org/C144464004","wikidata":"https://www.wikidata.org/wiki/Q3077338","display_name":"Lipid A","level":3,"score":0.6876574158668518},{"id":"https://openalex.org/C2777954195","wikidata":"https://www.wikidata.org/wiki/Q132209","display_name":"Neisseria","level":3,"score":0.6832438707351685},{"id":"https://openalex.org/C2776983828","wikidata":"https://www.wikidata.org/wiki/Q1974989","display_name":"Neisseriaceae","level":3,"score":0.588235080242157},{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.4915793836116791},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4720669090747833},{"id":"https://openalex.org/C2778458888","wikidata":"https://www.wikidata.org/wiki/Q154625","display_name":"Neisseria meningitidis","level":3,"score":0.4512275457382202},{"id":"https://openalex.org/C2780183148","wikidata":"https://www.wikidata.org/wiki/Q21099571","display_name":"Lipid II","level":4,"score":0.4406316876411438},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4256017208099365},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.3271762728691101},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3209177255630493},{"id":"https://openalex.org/C2776634448","wikidata":"https://www.wikidata.org/wiki/Q206920","display_name":"Peptidoglycan","level":3,"score":0.26910966634750366},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2623007893562317},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13725438714027405},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.12601032853126526}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008050","descriptor_name":"Lipid A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008050","descriptor_name":"Lipid A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009343","descriptor_name":"Neisseria","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009343","descriptor_name":"Neisseria","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015139","descriptor_name":"Blotting, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/iai.00506-12","doi":"https://doi.org/10.1128/iai.00506-12","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.00506-12","pdf_url":"https://iai.asm.org/content/iai/80/11/4014.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2635640","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3486066","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3486066","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3486066","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:22949553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22949553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt7x5907fc","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7x5907fc","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Infection and Immunity, vol 80, iss 11","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1128/iai.00506-12","doi":"https://doi.org/10.1128/iai.00506-12","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.00506-12","pdf_url":"https://iai.asm.org/content/iai/80/11/4014.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1573360520","display_name":"Bacterial STI and Innate Immunity in HIV Susceptibility","funder_award_id":"R01AI063927","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2220533550","display_name":"Genetic Variation in genes involved in Neisseria gonorrhoeae LOS biosynthesis","funder_award_id":"R01AI073667","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2905007957","display_name":"Southeastern Sexually Transmitted Infections Cooperative Research Center","funder_award_id":"U19AI031496","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3348954569","display_name":"Structural Characterization of Polypeptides, Protein Complexes, Oligosaccharides","funder_award_id":"S10RR029446","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4374873734","display_name":"Risk Factors and Susceptibility in Gonococcal Infection","funder_award_id":"R01AI065605","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5334010142","display_name":"Bio-Organic Biomedical Mass Spectrometry Resource","funder_award_id":"P41RR001614","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6855650707","display_name":"A Meningococcal LOS Vaccine","funder_award_id":"R01AI053728","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7500985589","display_name":"LIPOOLIGOSACCHARIDE BIOSYNTHESIS IN NEISSERIACEAE","funder_award_id":"R01AI024452","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000868711","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA082103","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306202","display_name":"Gordon and Betty Moore Foundation","ror":"https://ror.org/006wxqw41"},{"id":"https://openalex.org/F4320309508","display_name":"Sandler Foundation","ror":"https://ror.org/05f1ftz34"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2087041328.pdf","grobid_xml":"https://content.openalex.org/works/W2087041328.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W88914751","https://openalex.org/W164381428","https://openalex.org/W169886481","https://openalex.org/W1529472446","https://openalex.org/W1550067421","https://openalex.org/W1566509180","https://openalex.org/W1576543020","https://openalex.org/W1646366224","https://openalex.org/W1723840739","https://openalex.org/W1849057723","https://openalex.org/W1886645137","https://openalex.org/W1894792769","https://openalex.org/W1904110251","https://openalex.org/W1910347083","https://openalex.org/W1917501444","https://openalex.org/W1920234020","https://openalex.org/W1967999707","https://openalex.org/W1974897055","https://openalex.org/W1976891658","https://openalex.org/W1978761891","https://openalex.org/W1983307257","https://openalex.org/W1983526490","https://openalex.org/W1989245307","https://openalex.org/W1996874768","https://openalex.org/W1997058721","https://openalex.org/W2011868851","https://openalex.org/W2018581368","https://openalex.org/W2029443025","https://openalex.org/W2034825276","https://openalex.org/W2039217252","https://openalex.org/W2043884503","https://openalex.org/W2045942322","https://openalex.org/W2049451312","https://openalex.org/W2057967701","https://openalex.org/W2060944563","https://openalex.org/W2062353962","https://openalex.org/W2072347337","https://openalex.org/W2084682726","https://openalex.org/W2090957965","https://openalex.org/W2095184706","https://openalex.org/W2095619327","https://openalex.org/W2099195853","https://openalex.org/W2104282603","https://openalex.org/W2109975723","https://openalex.org/W2111401791","https://openalex.org/W2112544586","https://openalex.org/W2112946943","https://openalex.org/W2113458136","https://openalex.org/W2117522399","https://openalex.org/W2123208796","https://openalex.org/W2127109116","https://openalex.org/W2127335580","https://openalex.org/W2128897591","https://openalex.org/W2133410828","https://openalex.org/W2140247005","https://openalex.org/W2144634347","https://openalex.org/W2146128861","https://openalex.org/W2146373443","https://openalex.org/W2151175125","https://openalex.org/W2151276427","https://openalex.org/W2152831268","https://openalex.org/W2154013663","https://openalex.org/W2154191727","https://openalex.org/W2169078527","https://openalex.org/W2314225431","https://openalex.org/W2917693701","https://openalex.org/W3152046499","https://openalex.org/W6759490859"],"related_works":["https://openalex.org/W2126279424","https://openalex.org/W1875336248","https://openalex.org/W3080861706","https://openalex.org/W1976891658","https://openalex.org/W2264086687","https://openalex.org/W2095619327","https://openalex.org/W2137027206","https://openalex.org/W2605860488","https://openalex.org/W2112946943","https://openalex.org/W2109328536"],"abstract_inverted_index":{"The":[0],"interaction":[1],"of":[2,23,67,83,95,104,112,148,156,210,219,227,231,239,249],"the":[3,19,46,102,146,151,208,217,236,246],"immune":[4,237],"system":[5],"with":[6,127,130,145],"Neisseria":[7,74,132,242],"commensals":[8],"remains":[9],"poorly":[10],"understood.":[11],"We":[12],"have":[13],"previously":[14],"shown":[15],"that":[16,61,77,134,184,225],"phosphoethanolamine":[17,39,47],"on":[18],"lipid":[20,43,51,96,110,168,192,211,232],"A":[21,44,97,111,169,193,197,212,233],"portion":[22],"lipooligosaccharide":[24],"(LOS)":[25],"plays":[26],"an":[27],"important":[28],"role":[29],"in":[30,81,90,109,119,216],"Toll-like":[31],"receptor":[32],"4":[33],"(TLR4)":[34],"signaling.":[35],"For":[36],"pathogenic":[37,128],"Neisseria,":[38],"is":[40,54],"added":[41],"to":[42,140,194,235],"by":[45,56,244],"transferase":[48],"specific":[49],"for":[50],"A,":[52],"which":[53],"encoded":[55],"lptA.":[57,116],"Here,":[58],"we":[59],"report":[60],"Southern":[62],"hybridizations":[63],"and":[64,98,107,137,173,175,214,229],"bioinformatics":[65],"analyses":[66],"genomic":[68],"sequences":[69],"from":[70],"all":[71],"eight":[72],"commensal":[73,113,131,160,241],"species":[75,114,186],"confirmed":[76],"lptA":[78,199],"was":[79,88,124,143],"absent":[80],"15":[82],"17":[84],"strains":[85,133,161,243],"examined":[86],"but":[87],"present":[89],"N.":[91,158],"lactamica.":[92],"Mass":[93],"spectrometry":[94],"intact":[99],"LOS":[100],"revealed":[101],"lack":[103,226],"both":[105],"pyrophosphorylation":[106,172,213,228],"phosphoethanolaminylation":[108,174,215,230],"lacking":[115],"Inflammatory":[117],"signaling":[118],"human":[120],"THP-1":[121],"monocytic":[122],"cells":[123],"much":[125],"greater":[126,138],"than":[129,190],"lacked":[135],"lptA,":[136],"sensitivity":[139],"polymyxin":[141],"B":[142],"consistent":[144],"absence":[147],"phosphoethanolamine.":[149],"Unlike":[150],"other":[152,189],"commensals,":[153],"whole":[154],"bacteria":[155],"two":[157],"lactamica":[159],"had":[162,170,202],"low":[163],"inflammatory":[164,178,204,247],"potential,":[165,205],"whereas":[166],"their":[167],"high-level":[171,177],"induced":[176],"signaling,":[179],"supporting":[180],"previous":[181],"studies":[182],"indicating":[183],"this":[185],"uses":[187],"mechanisms":[188],"altering":[191],"support":[195],"commensalism.":[196],"meningococcal":[198],"deletion":[200],"mutant":[201],"reduced":[203],"further":[206],"illustrating":[207],"importance":[209],"bioactivity":[218],"LOS.":[220,250],"Overall,":[221],"our":[222],"results":[223],"indicate":[224],"contributes":[234],"privilege":[238],"most":[240],"reducing":[245],"potential":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}