{"id":"https://openalex.org/W2087040416","doi":"https://doi.org/10.4103/0253-7613.44150","title":"Partial nicotinic acetylcholine (\u03b14\u03b22) agonists as promising new medications for smoking cessation","display_name":"Partial nicotinic acetylcholine (\u03b14\u03b22) agonists as promising new medications for smoking cessation","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2087040416","doi":"https://doi.org/10.4103/0253-7613.44150","mag":"2087040416","pmid":"https://pubmed.ncbi.nlm.nih.gov/20040957","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2792622"},"language":"en","primary_location":{"id":"doi:10.4103/0253-7613.44150","doi":"https://doi.org/10.4103/0253-7613.44150","is_oa":false,"landing_page_url":"https://doi.org/10.4103/0253-7613.44150","pdf_url":null,"source":{"id":"https://openalex.org/S112348374","display_name":"Indian Journal of Pharmacology","issn_l":"0253-7613","issn":["0253-7613","1998-3751"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2792622","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111821095","display_name":"S Budhiraja","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Salil Budhiraja","raw_affiliation_strings":["Department of Pharmacology, Pt. B. D. Sharma PGIMS, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Pt. B. D. Sharma PGIMS, Haryana, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101661396","display_name":"Jarnail Singh","orcid":"https://orcid.org/0000-0002-1781-8250","observed_orcids":["https://orcid.org/0000-0002-1781-8250"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Singh","raw_affiliation_strings":["Department of Pharmacology, Pt. B. D. Sharma PGIMS, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Pt. B. D. Sharma PGIMS, Haryana, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111821095"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0237,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.80454579,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"40","issue":"5","first_page":"191","last_page":"191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/smoking-cessation","display_name":"smoking cessation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/alpha4beta2-nicotinic-acetylcholine-receptor","display_name":"\u03b14\u03b22 nicotinic acetylcholine receptor","score":0.9190000295639038},{"id":"https://openalex.org/keywords/partial-agonists","display_name":"partial agonists","score":0.9010000228881836},{"id":"https://openalex.org/keywords/varenicline","display_name":"varenicline","score":1.0},{"id":"https://openalex.org/keywords/cytisine","display_name":"cytisine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dopamine-release","display_name":"dopamine release","score":0.8619999885559082},{"id":"https://openalex.org/keywords/nicotine-replacement-therapy","display_name":"nicotine replacement therapy","score":0.6639999747276306},{"id":"https://openalex.org/keywords/drug-efficacy-and-safety","display_name":"drug safety and efficacy","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C2777053506","wikidata":"https://www.wikidata.org/wiki/Q411330","display_name":"Varenicline","level":3,"score":0.9888991117477417},{"id":"https://openalex.org/C2777301948","wikidata":"https://www.wikidata.org/wiki/Q417343","display_name":"Cytisine","level":4,"score":0.9487231373786926},{"id":"https://openalex.org/C58732023","wikidata":"https://www.wikidata.org/wiki/Q770260","display_name":"Partial agonist","level":4,"score":0.8782317638397217},{"id":"https://openalex.org/C2777843972","wikidata":"https://www.wikidata.org/wiki/Q2462253","display_name":"Smoking cessation","level":2,"score":0.7815995216369629},{"id":"https://openalex.org/C2779908668","wikidata":"https://www.wikidata.org/wiki/Q834280","display_name":"Bupropion","level":3,"score":0.7294454574584961},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.6595865488052368},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.640950620174408},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.6326676607131958},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6174299716949463},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5805842876434326},{"id":"https://openalex.org/C2779570518","wikidata":"https://www.wikidata.org/wiki/Q412256","display_name":"Nicotinic acetylcholine receptor","level":4,"score":0.48051270842552185},{"id":"https://openalex.org/C2779177420","wikidata":"https://www.wikidata.org/wiki/Q3961638","display_name":"Nicotine withdrawal","level":3,"score":0.41060948371887207},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.278949499130249},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1949751377105713},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.4103/0253-7613.44150","doi":"https://doi.org/10.4103/0253-7613.44150","is_oa":false,"landing_page_url":"https://doi.org/10.4103/0253-7613.44150","pdf_url":null,"source":{"id":"https://openalex.org/S112348374","display_name":"Indian Journal of Pharmacology","issn_l":"0253-7613","issn":["0253-7613","1998-3751"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2792622","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2792622","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian J Pharmacol","raw_type":"Text"},{"id":"pmid:20040957","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20040957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:utoronto.scholaris.ca:1807/59511","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/59511","pdf_url":"https://utoronto.scholaris.ca/bitstreams/1fa4ca8d-9cc4-402b-981c-31327080de8c/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:cria:bioline:ph:ph08059","doi":null,"is_oa":false,"landing_page_url":"http://www.bioline.org.br/abstract?id=ph08059","pdf_url":null,"source":{"id":"https://openalex.org/S4306402188","display_name":"Bioline International (Bioline International)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Indian Journal of Pharmacology (ISSN: 0253-7613) Vol 40 Num 5","raw_type":"SY"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2792622","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2792622","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian J Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2087040416.pdf","grobid_xml":"https://content.openalex.org/works/W2087040416.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W29281053","https://openalex.org/W1571140265","https://openalex.org/W1596946495","https://openalex.org/W1715524310","https://openalex.org/W1721085211","https://openalex.org/W1969169809","https://openalex.org/W1981495315","https://openalex.org/W1987297260","https://openalex.org/W1993112595","https://openalex.org/W1997727963","https://openalex.org/W1998335883","https://openalex.org/W2001109168","https://openalex.org/W2011246896","https://openalex.org/W2021782736","https://openalex.org/W2030671645","https://openalex.org/W2033156615","https://openalex.org/W2034116639","https://openalex.org/W2034708714","https://openalex.org/W2035097524","https://openalex.org/W2040142797","https://openalex.org/W2041003372","https://openalex.org/W2042529247","https://openalex.org/W2044210997","https://openalex.org/W2047492603","https://openalex.org/W2053457282","https://openalex.org/W2066951615","https://openalex.org/W2084624520","https://openalex.org/W2093235629","https://openalex.org/W2099727280","https://openalex.org/W2101520329","https://openalex.org/W2106950438","https://openalex.org/W2107200746","https://openalex.org/W2113308458","https://openalex.org/W2115838882","https://openalex.org/W2117389430","https://openalex.org/W2122502474","https://openalex.org/W2131366415","https://openalex.org/W2133053824","https://openalex.org/W2140401786","https://openalex.org/W2163574850","https://openalex.org/W2164386461","https://openalex.org/W2165398609","https://openalex.org/W2252376906","https://openalex.org/W2417366488","https://openalex.org/W2471173822","https://openalex.org/W4233323187"],"related_works":["https://openalex.org/W1997437727","https://openalex.org/W2101520329","https://openalex.org/W2171420658","https://openalex.org/W1993112595","https://openalex.org/W2106950438","https://openalex.org/W2117449031","https://openalex.org/W2880903124","https://openalex.org/W4230210308","https://openalex.org/W2946623164","https://openalex.org/W2165094621"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"review":[2,22,67],"the":[3,33,55,74,102,134,152,163,182,188,211,246],"pharmacology,":[4],"clinical":[5],"efficacy":[6],"and":[7,21,46,50,66,73,131,173,214],"safety":[8],"of":[9,12,57,136,141,168,176,190,235,242],"partial":[10,38,75,202],"agonists":[11],"alpha4beta2":[13,40,77,158,169,195,205,223],"nicotinic":[14,41,78],"acetylcholine":[15,42,79],"receptor.":[16],"DATA":[17,63,83],"SOURCES:":[18],"Primary":[19],"literature":[20],"articles":[23,68],"were":[24,52,81],"obtained":[25],"via":[26],"a":[27,90,201,228],"PUBMED":[28],"search":[29],"(1988-August":[30],"2006)":[31],"using":[32],"key":[34],"terms":[35],"smoking":[36,112,146,150,218,232,243],"cessation,":[37],"agonist":[39,76,167,203,222],"receptor,":[43],"varenicline,":[44,71,200],"cytisine":[45,72],"SSR591813.":[47],"Additional":[48],"studies":[49],"abstracts":[51],"identified":[53],"from":[54],"bibliographies":[56],"reviewed":[58],"literature.":[59],"STUDY":[60],"SELECTION":[61],"AND":[62],"EXTRACTION:":[64],"Studies":[65],"related":[69],"to":[70,101,110,116,149,226],"receptor":[80],"reviewed.":[82],"SYNTHESIS:":[84],"Smoking":[85,94],"is":[86,179,238],"widely":[87],"recognized":[88],"as":[89],"serious":[91],"health":[92,98],"problem.":[93],"cessation":[95,147,183,244],"has":[96,207],"major":[97],"benefits.":[99],"According":[100],"US":[103],"Public":[104],"Health":[105],"Services,":[106],"all":[107],"patients":[108,142],"attempting":[109],"quit":[111],"should":[113],"be":[114,227],"encouraged":[115],"use":[117],"one":[118],"or":[119],"more":[120],"effective":[121],"pharmacotherapy.":[122,137],"Currently,":[123],"along":[124],"with":[125,194],"nicotine":[126,191],"replacement":[127],"therapy,":[128],"bupropion,":[129],"nortriptyline":[130],"clonidine,":[132],"are":[133],"mainstay":[135],"More":[138],"than":[139],"(3/4)":[140],"receiving":[143],"treatment":[144,241],"for":[145,217,240],"return":[148],"within":[151],"first":[153],"year.":[154],"Nicotine,":[155],"through":[156],"stimulating":[157],"nAChR,":[159,206],"releases":[160],"dopamine":[161],"in":[162,231,248],"reward":[164],"pathway.":[165],"Partial":[166,221],"nAChR":[170,224],"elicits":[171],"moderate":[172],"sustained":[174],"release":[175],"dopamine,":[177],"which":[178],"countered":[180],"during":[181,197],"attempts;":[184],"it":[185],"simultaneously":[186],"blocks":[187],"effects":[189],"by":[192,210,245],"binding":[193],"receptors":[196],"smoking.":[198],"Recently,":[199],"at":[204],"been":[208],"approved":[209,239],"FDA":[212,247],"(Food":[213],"Drug":[215],"Administration)":[216],"cessation.":[219,233],"CONCLUSION:":[220],"appears":[225],"promising":[229],"target":[230],"Varenicline":[234],"this":[236],"group":[237],"May":[249],"2006.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}