{"id":"https://openalex.org/W2086989516","doi":"https://doi.org/10.1097/00004850-199409000-00009","title":"The effect of fluoxetine on sleep","display_name":"The effect of fluoxetine on sleep","publication_year":1994,"publication_date":"1994-09-01","ids":{"openalex":"https://openalex.org/W2086989516","doi":"https://doi.org/10.1097/00004850-199409000-00009","mag":"2086989516","pmid":"https://pubmed.ncbi.nlm.nih.gov/7814830"},"language":"en","primary_location":{"id":"doi:10.1097/00004850-199409000-00009","doi":"https://doi.org/10.1097/00004850-199409000-00009","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004850-199409000-00009","pdf_url":null,"source":{"id":"https://openalex.org/S149156103","display_name":"International Clinical Psychopharmacology","issn_l":"0268-1315","issn":["0268-1315","1473-5857"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Clinical Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066751874","display_name":"Veiko Vasar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"V. Vasar","raw_affiliation_strings":["Department of Psychiatry, University of Tartu, Finland","Department of Psychiatry, University of Tartu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Tartu, Finland","institution_ids":["https://openalex.org/I56085075"]},{"raw_affiliation_string":"Department of Psychiatry, University of Tartu","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035546828","display_name":"Bj\u00f6rn Appelberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"B. Appelberg","raw_affiliation_strings":["Department of Psychiatry, University of Helsinki, Lapinlahdentie, SF-00180 Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Helsinki, Lapinlahdentie, SF-00180 Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091205749","display_name":"Ranan Rim\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"R. Rim\u00f3n","raw_affiliation_strings":["Department of Psychiatry, University of Helsinki, Lapinlahdentie, SF-00180 Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Helsinki, Lapinlahdentie, SF-00180 Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5096839384","display_name":"J. Selvaratnam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"J. Selvaratnam","raw_affiliation_strings":["Department of Psychiatry, University of Helsinki, Lapinlahdentie, SF-00180 Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Helsinki, Lapinlahdentie, SF-00180 Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3832,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.52972534,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"9","issue":"3","first_page":"203","last_page":"206"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.6664999723434448,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.6664999723434448,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.30320000648498535,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluoxetine","display_name":"fluoxetine","score":1.0},{"id":"https://openalex.org/keywords/sleep","display_name":"sleep","score":0.7850000262260437},{"id":"https://openalex.org/keywords/rem-sleep","display_name":"REM sleep","score":0.9150000214576721},{"id":"https://openalex.org/keywords/sleep-onset-latency","display_name":"sleep latency","score":0.5659999847412109},{"id":"https://openalex.org/keywords/rem-latency","display_name":"REM latency","score":0.7789999842643738},{"id":"https://openalex.org/keywords/sleep-stages","display_name":"sleep stages","score":0.6570000052452087},{"id":"https://openalex.org/keywords/slow-wave-sleep","display_name":"slow-wave sleep","score":0.843999981880188},{"id":"https://openalex.org/keywords/nrem-sleep","display_name":"NREM sleep","score":0.6060000061988831},{"id":"https://openalex.org/keywords/antidepressant-side-effects","display_name":"antidepressant side effects","score":0.7329999804496765},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.859000027179718},{"id":"https://openalex.org/keywords/subjective-sleep-quality","display_name":"subjective sleep quality","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2776134451","wikidata":"https://www.wikidata.org/wiki/Q422244","display_name":"Fluoxetine","level":4,"score":0.9599943161010742},{"id":"https://openalex.org/C20566671","wikidata":"https://www.wikidata.org/wiki/Q1752878","display_name":"Non-rapid eye movement sleep","level":3,"score":0.780358612537384},{"id":"https://openalex.org/C110539466","wikidata":"https://www.wikidata.org/wiki/Q3964845","display_name":"Slow-wave sleep","level":3,"score":0.6121656894683838},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.6064707040786743},{"id":"https://openalex.org/C153050134","wikidata":"https://www.wikidata.org/wiki/Q760256","display_name":"Eye movement","level":2,"score":0.5886298418045044},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5704776048660278},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5371392965316772},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5321919918060303},{"id":"https://openalex.org/C2779213384","wikidata":"https://www.wikidata.org/wiki/Q211402","display_name":"Rapid eye movement sleep","level":3,"score":0.5195510983467102},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.4482033848762512},{"id":"https://openalex.org/C63759246","wikidata":"https://www.wikidata.org/wiki/Q7539762","display_name":"Sleep onset","level":3,"score":0.4116798937320709},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37626564502716064},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27819857001304626},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2238250970840454},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.21761423349380493},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.11004546284675598},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.09137383103370667},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005473","descriptor_name":"Fluoxetine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012894","descriptor_name":"Sleep Stages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012895","descriptor_name":"Sleep, REM","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014851","descriptor_name":"Wakefulness","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017286","descriptor_name":"Polysomnography","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00004850-199409000-00009","doi":"https://doi.org/10.1097/00004850-199409000-00009","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004850-199409000-00009","pdf_url":null,"source":{"id":"https://openalex.org/S149156103","display_name":"International Clinical Psychopharmacology","issn_l":"0268-1315","issn":["0268-1315","1473-5857"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Clinical Psychopharmacology","raw_type":"journal-article"},{"id":"pmid:7814830","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7814830","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International clinical psychopharmacology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2416477247","https://openalex.org/W2060071097","https://openalex.org/W1965043512","https://openalex.org/W2468943027","https://openalex.org/W2135729576","https://openalex.org/W2084800079","https://openalex.org/W2077731351","https://openalex.org/W2017747690","https://openalex.org/W2088068894","https://openalex.org/W2084065055"],"abstract_inverted_index":{"Fluoxetine,":[0],"a":[1,13,135],"selective":[2],"inhibitor":[3],"of":[4,36,46,69,76,96,116,122,139,147,155],"serotonin":[5],"(5-HT)":[6],"uptake,":[7],"was":[8,62,87],"compared":[9],"with":[10,91],"placebo":[11],"in":[12,18,66,112,127,149],"randomized":[14],"double-blind":[15],"longitudinal":[16],"trial":[17],"12":[19],"healthy":[20],"volunteers.":[21],"Sleep":[22],"polygraphic":[23],"recordings":[24],"were":[25,58],"performed":[26],"at":[27],"home":[28],"twice":[29],"before":[30],"and":[31,55,79,125],"once":[32],"after":[33,82],"6":[34,39],"days":[35,40],"medication.":[37],"After":[38],"fluoxetine":[41,83,129,140],"significantly":[42],"decreased":[43],"the":[44,67,117,128,144],"amount":[45,68,95],"rapid":[47],"eye":[48,104,108],"movement":[49,109],"(REM)":[50],"sleep.":[51,98],"The":[52,73],"sleep-onset":[53],"latency":[54,57],"REM":[56,150],"increased,":[59],"but":[60],"there":[61,86],"no":[63,88],"significant":[64,89],"increase":[65],"awakenings":[70],"during":[71,106],"night.":[72],"relative":[74],"proportion":[75],"stages":[77],"2":[78],"3":[80],"increased":[81],"administration,":[84],"although":[85],"change":[90],"regard":[92],"to":[93],"total":[94],"slow-wave":[97],"Fluoxetine":[99],"did":[100],"not":[101],"induce":[102],"prominent":[103],"movements":[105],"non-rapid":[107],"(NREM)":[110],"sleep":[111,124,151],"this":[113],"study.":[114],"Results":[115],"subjective":[118],"assessment":[119],"revealed":[120],"tendencies":[121],"improved":[123],"well-being":[126],"group.":[130],"It":[131],"is":[132],"concluded":[133],"that":[134],"comparatively":[136],"small":[137],"dose":[138],"(20":[141],"mg/day)":[142],"causes":[143],"same":[145],"type":[146],"changes":[148],"which":[152],"are":[153],"characteristic":[154],"most":[156],"antidepressive":[157],"drugs.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}