{"id":"https://openalex.org/W2086923544","doi":"https://doi.org/10.1159/000289224","title":"Inability of Plasma and Urine F2A-Isoprostane Levels to Differentiate Mild Cognitive Impairment from Alzheimer\u2019s Disease","display_name":"Inability of Plasma and Urine F2A-Isoprostane Levels to Differentiate Mild Cognitive Impairment from Alzheimer\u2019s Disease","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2086923544","doi":"https://doi.org/10.1159/000289224","mag":"2086923544","pmid":"https://pubmed.ncbi.nlm.nih.gov/20197693","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3221250"},"language":"en","primary_location":{"id":"doi:10.1159/000289224","doi":"https://doi.org/10.1159/000289224","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000289224","pdf_url":null,"source":{"id":"https://openalex.org/S101887095","display_name":"Neurodegenerative Diseases","issn_l":"1660-2854","issn":["1660-2854","1660-2862"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurodegenerative Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3221250","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072527270","display_name":"Elliott Jay Mufson","orcid":"https://orcid.org/0000-0003-4438-7334","observed_orcids":["https://orcid.org/0000-0003-4438-7334"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elliott J. Mufson","raw_affiliation_strings":["Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA. emufson@rush.edu","Department of Neurological Sciences, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA. emufson@rush.edu","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Department of Neurological Sciences, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070294274","display_name":"Sue E. Leurgans","orcid":"https://orcid.org/0000-0003-2536-1665","observed_orcids":["https://orcid.org/0000-0003-2536-1665"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sue Leurgans","raw_affiliation_strings":["Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Ill., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Ill., USA","institution_ids":["https://openalex.org/I1285301757"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1285301757"],"apc_list":null,"apc_paid":null,"fwci":2.3283,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.87241756,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"7","issue":"1-3","first_page":"139","last_page":"142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/f2-isoprostanes","display_name":"F2-isoprostanes","score":0.9890000224113464},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8989999890327454},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9409999847412109},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":1.0},{"id":"https://openalex.org/keywords/dementia-biomarkers","display_name":"dementia biomarkers","score":0.6510000228881836},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.9039999842643738},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.906000018119812},{"id":"https://openalex.org/keywords/religious-orders-study","display_name":"Religious Orders Study","score":0.8009999990463257},{"id":"https://openalex.org/keywords/postmortem-neuropathology","display_name":"postmortem neuropathology","score":0.8190000057220459},{"id":"https://openalex.org/keywords/diagnostic-sensitivity","display_name":"diagnostic sensitivity","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.7279646396636963},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7087536454200745},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.663202166557312},{"id":"https://openalex.org/C2780340399","wikidata":"https://www.wikidata.org/wiki/Q4198767","display_name":"Isoprostane","level":4,"score":0.6483145952224731},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5733497142791748},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5658779740333557},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5334193110466003},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.4993424415588379},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.47944608330726624},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.415262371301651},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.412703275680542},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.377741277217865},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3599892556667328},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.12446635961532593},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06772351264953613}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028441","descriptor_name":"F2-Isoprostanes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D028441","descriptor_name":"F2-Isoprostanes","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1159/000289224","doi":"https://doi.org/10.1159/000289224","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000289224","pdf_url":null,"source":{"id":"https://openalex.org/S101887095","display_name":"Neurodegenerative Diseases","issn_l":"1660-2854","issn":["1660-2854","1660-2862"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurodegenerative Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2237242","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3221250","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3221250","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3221250","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurodegener Dis","raw_type":"Text"},{"id":"pmid:20197693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20197693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-degenerative diseases","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2237242","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3221250","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2675502447","display_name":null,"funder_award_id":"P50AG10161","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3711302076","display_name":"Neurobiology of Mild Cognitive Impairment in the Elderly","funder_award_id":"P01AG014449","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5029820101","display_name":"Rush Alzheimer's Disease Core Center","funder_award_id":"P30AG010161","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6770541748","display_name":"Cellular and Molecular Medial Temporal Lobe Pathology in Elderly PreMCI subjects","funder_award_id":"R01AG043375","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7478080448","display_name":"Anatomic, Physiologic, and Cognitive Pathology of AD","funder_award_id":"P01AG009466","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1936038923","https://openalex.org/W1964550496","https://openalex.org/W1984153538","https://openalex.org/W1993474946","https://openalex.org/W2013553668","https://openalex.org/W2014670147","https://openalex.org/W2052742260","https://openalex.org/W2055021833","https://openalex.org/W2067820958","https://openalex.org/W2069099293","https://openalex.org/W2075464796","https://openalex.org/W2077549929","https://openalex.org/W2087572120","https://openalex.org/W2103163836","https://openalex.org/W2146729934","https://openalex.org/W2165441361","https://openalex.org/W2725718031","https://openalex.org/W4235851084"],"related_works":["https://openalex.org/W2087572120","https://openalex.org/W2167291917","https://openalex.org/W2103163836","https://openalex.org/W2082828310","https://openalex.org/W2004993283","https://openalex.org/W2038879645","https://openalex.org/W2055021833","https://openalex.org/W2208873116","https://openalex.org/W7042076043","https://openalex.org/W2154489853"],"abstract_inverted_index":{"BACKGROUND:":[0],"Oxidative":[1],"stress":[2],"has":[3,32],"been":[4,33],"implicated":[5],"in":[6,61],"the":[7,22,40,110,122,125],"pathogenesis":[8],"of":[9,80,89,117,124,158],"Alzheimer's":[10],"disease":[11],"(AD).":[12],"The":[13,26],"pathobiological":[14],"changes":[15],"related":[16],"to":[17,38,47,150],"AD":[18,86],"occur":[19],"long":[20],"before":[21],"overt":[23],"clinical":[24,78,112,156],"symptoms.":[25],"plasma":[27,53,134,141],"lipid":[28],"peroxidation":[29],"enzyme":[30],"F2-isoprostane":[31,56,104,135],"suggested":[34],"as":[35],"a":[36,77,155],"biomarker":[37],"detect":[39],"progression":[41],"from":[42,70],"mild":[43],"cognitive":[44,82,160],"impairment":[45],"(MCI)":[46],"AD.":[48,164],"OBJECTIVE:":[49],"To":[50],"test":[51],"whether":[52],"and":[54,66,102],"urine":[55,67,103,143],"was":[57,127],"diagnostic":[58],"for":[59],"dementia":[60],"living":[62,139],"people.":[63],"METHODS:":[64],"Plasma":[65,101],"were":[68,94,146],"collected":[69],"222":[71],"Religious":[72],"Orders":[73],"Study":[74],"participants":[75],"with":[76,130,154],"diagnosis":[79,116,157],"no":[81,159],"impairment,":[83,161],"MCI":[84,162],"or":[85,133,142,163],"at":[87],"time":[88],"fluid":[90],"collection.":[91],"Isoprostane":[92],"levels":[93,105,145],"determined":[95],"using":[96],"gas":[97],"chromatography/mass":[98],"spectroscopy.":[99],"RESULTS:":[100],"did":[106],"not":[107,128,147],"differ":[108],"between":[109,152],"three":[111],"groups.":[113],"Postmortem":[114],"neuropathologic":[115],"subjects":[118],"who":[119],"died":[120],"during":[121],"course":[123],"study":[126],"associated":[129],"baseline":[131],"blood":[132],"levels.":[136],"CONCLUSIONS:":[137],"In":[138],"people,":[140],"isoprostane":[144],"sensitive":[148],"enough":[149],"discriminate":[151],"individuals":[153]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}