{"id":"https://openalex.org/W2086914764","doi":"https://doi.org/10.1016/s0168-9525(02)02591-x","title":"Regulatory context is a crucial part of gene function","display_name":"Regulatory context is a crucial part of gene function","publication_year":2002,"publication_date":"2002-02-01","ids":{"openalex":"https://openalex.org/W2086914764","doi":"https://doi.org/10.1016/s0168-9525(02)02591-x","mag":"2086914764","pmid":"https://pubmed.ncbi.nlm.nih.gov/11818130"},"language":"en","primary_location":{"id":"doi:10.1016/s0168-9525(02)02591-x","doi":"https://doi.org/10.1016/s0168-9525(02)02591-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-9525(02)02591-x","pdf_url":null,"source":{"id":"https://openalex.org/S139283865","display_name":"Trends in Genetics","issn_l":"0168-9525","issn":["0168-9525","1362-4555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Genetics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048565038","display_name":"Sabine Fessele","orcid":"https://orcid.org/0000-0002-5399-3574","observed_orcids":["https://orcid.org/0000-0002-5399-3574"]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Fessele","raw_affiliation_strings":["Medizinische Poliklinik der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Schillerstr. 42, D-80336, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Poliklinik der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Schillerstr. 42, D-80336, Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102774380","display_name":"Holger Maier","orcid":"https://orcid.org/0000-0003-2514-8290","observed_orcids":["https://orcid.org/0000-0003-2514-8290"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Holger Maier","raw_affiliation_strings":["GSF-National Research Center for Environment and Health, Institute of Experimental Genetics, Ingolst\u00e4dter Landstr. 1, D-85764, Neuherberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GSF-National Research Center for Environment and Health, Institute of Experimental Genetics, Ingolst\u00e4dter Landstr. 1, D-85764, Neuherberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060890276","display_name":"Christian Zischek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Zischek","raw_affiliation_strings":["Medizinische Poliklinik der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Schillerstr. 42, D-80336, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Poliklinik der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Schillerstr. 42, D-80336, Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014518109","display_name":"Peter Jon Nelson","orcid":"https://orcid.org/0000-0002-2434-740X","observed_orcids":["https://orcid.org/0000-0002-2434-740X"]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter J Nelson","raw_affiliation_strings":["Medizinische Poliklinik der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Schillerstr. 42, D-80336, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Poliklinik der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Schillerstr. 42, D-80336, Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003191047","display_name":"Thomas Werner","orcid":"https://orcid.org/0000-0002-8865-365X","observed_orcids":["https://orcid.org/0000-0002-8865-365X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Thomas Werner","raw_affiliation_strings":["Genomatix Software GmbH, Landsberger Str. 6, D-80339 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomatix Software GmbH, Landsberger Str. 6, D-80339 Munich, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5003191047"],"corresponding_institution_ids":[],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":0.8996,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.6643377,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"18","issue":"2","first_page":"60","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/promoter-organization","display_name":"promoter organization","score":0.6359999775886536},{"id":"https://openalex.org/keywords/ccl5-rantes","display_name":"CCL5/RANTES","score":0.8019999861717224},{"id":"https://openalex.org/keywords/transcription-start-site","display_name":"transcription start sites","score":0.5070000290870667},{"id":"https://openalex.org/keywords/spatiotemporal-gene-expression","display_name":"spatiotemporal gene expression","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8306845426559448},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.7098487615585327},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6174968481063843},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5981180667877197},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.578956663608551},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5719400644302368},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5138654708862305},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49959325790405273},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.477140873670578},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.45442038774490356},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4517766833305359},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.449749231338501},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4316120147705078},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002630","descriptor_name":"Chemotactic Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018946","descriptor_name":"Chemokine CCL5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019743","descriptor_name":"Chemokines, CXC","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054360","descriptor_name":"Chemokine CXCL1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054426","descriptor_name":"Chemokine CXCL2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0168-9525(02)02591-x","doi":"https://doi.org/10.1016/s0168-9525(02)02591-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-9525(02)02591-x","pdf_url":null,"source":{"id":"https://openalex.org/S139283865","display_name":"Trends in Genetics","issn_l":"0168-9525","issn":["0168-9525","1362-4555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Genetics","raw_type":"journal-article"},{"id":"pmid:11818130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11818130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in genetics : TIG","raw_type":"Journal Article"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:9833","doi":null,"is_oa":false,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=9833","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Trends Genet. 18, 60-63 (2002)","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W207055555","https://openalex.org/W1512809401","https://openalex.org/W1536291417","https://openalex.org/W1602000691","https://openalex.org/W1817256155","https://openalex.org/W1970175473","https://openalex.org/W1971068712","https://openalex.org/W1972596521","https://openalex.org/W1979103216","https://openalex.org/W1980809845","https://openalex.org/W2001785106","https://openalex.org/W2006077118","https://openalex.org/W2008900336","https://openalex.org/W2018834244","https://openalex.org/W2026829049","https://openalex.org/W2027960051","https://openalex.org/W2053360677","https://openalex.org/W2068011423","https://openalex.org/W2082736011","https://openalex.org/W2089629517","https://openalex.org/W2101690350","https://openalex.org/W2106607972","https://openalex.org/W2110041134","https://openalex.org/W2111365614","https://openalex.org/W2121298930","https://openalex.org/W2121923215","https://openalex.org/W2125046431","https://openalex.org/W2125508747","https://openalex.org/W2133029085","https://openalex.org/W2145759855","https://openalex.org/W2149769193","https://openalex.org/W2149966579","https://openalex.org/W2153800196","https://openalex.org/W2154514071","https://openalex.org/W2159543436","https://openalex.org/W4232298325","https://openalex.org/W4242043490","https://openalex.org/W4313379046","https://openalex.org/W4406623080"],"related_works":["https://openalex.org/W4249570476","https://openalex.org/W2146202528","https://openalex.org/W5833750","https://openalex.org/W112485314","https://openalex.org/W2141581386","https://openalex.org/W7101098662","https://openalex.org/W2072666874","https://openalex.org/W7204548005","https://openalex.org/W2887116946","https://openalex.org/W4225166158"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}