{"id":"https://openalex.org/W2086882575","doi":"https://doi.org/10.1371/journal.pone.0033389","title":"Common Variants in CDKN2B-AS1 Associated with Optic-Nerve Vulnerability of Glaucoma Identified by Genome-Wide Association Studies in Japanese","display_name":"Common Variants in CDKN2B-AS1 Associated with Optic-Nerve Vulnerability of Glaucoma Identified by Genome-Wide Association Studies in Japanese","publication_year":2012,"publication_date":"2012-03-12","ids":{"openalex":"https://openalex.org/W2086882575","doi":"https://doi.org/10.1371/journal.pone.0033389","mag":"2086882575","pmid":"https://pubmed.ncbi.nlm.nih.gov/22428042","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3299784"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0033389","doi":"https://doi.org/10.1371/journal.pone.0033389","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0033389","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0033389&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0033389&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018608174","display_name":"Masakazu Nakano","orcid":"https://orcid.org/0000-0001-6720-2158","observed_orcids":["https://orcid.org/0000-0001-6720-2158"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masakazu Nakano","raw_affiliation_strings":["Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103089632","display_name":"Yoko Ikeda","orcid":"https://orcid.org/0000-0003-3131-9156","observed_orcids":["https://orcid.org/0000-0003-3131-9156"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Ikeda","raw_affiliation_strings":["Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113571150","display_name":"Yuichi Tokuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuichi Tokuda","raw_affiliation_strings":["Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032129452","display_name":"Masahiro Fuwa","orcid":"https://orcid.org/0000-0002-7958-762X","observed_orcids":["https://orcid.org/0000-0002-7958-762X"]},"institutions":[{"id":"https://openalex.org/I149737975","display_name":"Santen (Japan)","ror":"https://ror.org/032msy923","country_code":"JP","type":"company","lineage":["https://openalex.org/I149737975"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Fuwa","raw_affiliation_strings":["Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan","Research and Development Center, Santen Pharmaceutical Co. Ltd., Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Research and Development Center, Santen Pharmaceutical Co. Ltd., Nara, Japan","institution_ids":["https://openalex.org/I149737975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111385034","display_name":"Natsue Omi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Natsue Omi","raw_affiliation_strings":["Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101890236","display_name":"Morio Ueno","orcid":"https://orcid.org/0000-0002-8137-5730","observed_orcids":["https://orcid.org/0000-0002-8137-5730"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Morio Ueno","raw_affiliation_strings":["Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110467591","display_name":"Kojiro Imai","orcid":"https://orcid.org/0009-0005-4703-5600","observed_orcids":["https://orcid.org/0009-0005-4703-5600"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kojiro Imai","raw_affiliation_strings":["Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102294896","display_name":"Hiroko Adachi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroko Adachi","raw_affiliation_strings":["Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102971991","display_name":"Masaaki Kageyama","orcid":"https://orcid.org/0000-0002-6520-7905","observed_orcids":["https://orcid.org/0000-0002-6520-7905"]},"institutions":[{"id":"https://openalex.org/I149737975","display_name":"Santen (Japan)","ror":"https://ror.org/032msy923","country_code":"JP","type":"company","lineage":["https://openalex.org/I149737975"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Kageyama","raw_affiliation_strings":["Research and Development Center, Santen Pharmaceutical Co. Ltd., Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Center, Santen Pharmaceutical Co. Ltd., Nara, Japan","institution_ids":["https://openalex.org/I149737975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103161927","display_name":"Kazuhiko Mori","orcid":"https://orcid.org/0000-0002-5505-4917","observed_orcids":["https://orcid.org/0000-0002-5505-4917"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiko Mori","raw_affiliation_strings":["Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029687156","display_name":"Shigeru Kinoshita","orcid":"https://orcid.org/0000-0002-6839-251X","observed_orcids":["https://orcid.org/0000-0002-6839-251X"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shigeru Kinoshita","raw_affiliation_strings":["Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070028777","display_name":"Kei Tashiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kei Tashiro","raw_affiliation_strings":["Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029687156","https://openalex.org/A5070028777"],"corresponding_institution_ids":["https://openalex.org/I40677808"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":9.568,"has_fulltext":true,"cited_by_count":98,"citation_normalized_percentile":{"value":0.98396374,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"3","first_page":"e33389","last_page":"e33389"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-open-angle-glaucoma","display_name":"primary open-angle glaucoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cdkn2b-as1","display_name":"CDKN2B-AS1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chromosome-9p21-3","display_name":"chromosome 9p21.3","score":0.9580000042915344},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8640000224113464},{"id":"https://openalex.org/keywords/normal-tension-glaucoma","display_name":"normal-tension glaucoma","score":0.8550000190734863},{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.9449999928474426},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7829999923706055},{"id":"https://openalex.org/keywords/japanese-population","display_name":"Japanese population","score":0.9430000185966492}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7018852829933167},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5821011066436768},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.5327368378639221},{"id":"https://openalex.org/C2780837183","wikidata":"https://www.wikidata.org/wiki/Q186029","display_name":"Optic nerve","level":2,"score":0.531875491142273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.520234227180481},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.46860966086387634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3678857088088989},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.23307573795318604},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2049843966960907},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.16116493940353394},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1142244040966034}],"mesh":[{"descriptor_ui":"D002899","descriptor_name":"Chromosomes, Human, Pair 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009900","descriptor_name":"Optic Nerve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0033389","doi":"https://doi.org/10.1371/journal.pone.0033389","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0033389","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0033389&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3299784","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3299784","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22428042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22428042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.774.3998","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.774.3998","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/2f/a0/pone.0033389.PMC3299784.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:1f44411c63504bb6bb56f3ef07af379a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1f44411c63504bb6bb56f3ef07af379a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 3, p e33389 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/127826","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Common_Variants_in_CDKN2B_AS1_Associated_with_Optic_Nerve_Vulnerability_of_Glaucoma_Identified_by_Genome_Wide_Association_Studies_in_Japanese/127826","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0033389","doi":"https://doi.org/10.1371/journal.pone.0033389","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0033389","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0033389&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1825219094","display_name":"Pioneering Research to Elucidate the Pathogenic Mechanism and Genetic Susceptibility of Stevens Johnson Syndrome/Toxic Epidermal Necrolysis","funder_award_id":"22390325","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3471015263","display_name":"Analyzing glaucoma-associated variants to reveal molecular mechanism of glaucoma pathogenesis","funder_award_id":"22790324","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8896703988","display_name":"Gain more insight, perform the following genome-wide association studies in Japanese, counterargument to the study that need correct re-diagnosis by Europe-an study","funder_award_id":"23659160","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G942868759","display_name":"Candidate gene analysis of well-known genes in primary open-angle glaucoma patients utilizing custom-made gene chip","funder_award_id":"24592636","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320322516","display_name":"Santen","ror":"https://ror.org/032msy923"},{"id":"https://openalex.org/F4320330165","display_name":"Serbian Academy of Sciences and Arts","ror":"https://ror.org/05m1y4204"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2086882575.pdf","grobid_xml":"https://content.openalex.org/works/W2086882575.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W169963234","https://openalex.org/W1499959019","https://openalex.org/W1780762990","https://openalex.org/W1968210590","https://openalex.org/W1975899243","https://openalex.org/W1978215768","https://openalex.org/W1989399186","https://openalex.org/W1990245848","https://openalex.org/W1995006312","https://openalex.org/W1995751421","https://openalex.org/W1998383538","https://openalex.org/W2002404684","https://openalex.org/W2012404345","https://openalex.org/W2036198235","https://openalex.org/W2037179295","https://openalex.org/W2048755332","https://openalex.org/W2050405284","https://openalex.org/W2051417851","https://openalex.org/W2057266151","https://openalex.org/W2059053771","https://openalex.org/W2065235031","https://openalex.org/W2066874799","https://openalex.org/W2075562177","https://openalex.org/W2082122713","https://openalex.org/W2114068481","https://openalex.org/W2114585426","https://openalex.org/W2119279196","https://openalex.org/W2119970640","https://openalex.org/W2120451046","https://openalex.org/W2131840223","https://openalex.org/W2134783591","https://openalex.org/W2144633001","https://openalex.org/W2145192598","https://openalex.org/W2148890166","https://openalex.org/W2150000105","https://openalex.org/W2223920023"],"related_works":["https://openalex.org/W2778590979","https://openalex.org/W2138974073","https://openalex.org/W7046070516","https://openalex.org/W2005725365","https://openalex.org/W3206769561","https://openalex.org/W2015310445","https://openalex.org/W2059907984","https://openalex.org/W3169235882","https://openalex.org/W2559582615","https://openalex.org/W1551577506"],"abstract_inverted_index":{"BACKGROUND:":[0],"To":[1],"date,":[2],"only":[3],"a":[4,42,51,69,91,225],"small":[5],"portion":[6],"of":[7,19,34,44,124,149,180,269,282],"the":[8,16,35,75,95,101,119,125,139,147,170,173,178,194,197,221,236,245,251,260,267,270,280],"genetic":[9],"variation":[10],"for":[11,206,278],"primary":[12],"open-angle":[13],"glaucoma":[14],"(POAG),":[15],"major":[17],"type":[18],"glaucoma,":[20,158,167],"has":[21],"been":[22],"elucidated.":[23],"METHODS":[24],"AND":[25,210],"PRINCIPAL":[26],"FINDINGS:":[27],"We":[28,136],"examined":[29],"our":[30,105],"two":[31,143,174],"data":[32,102,108,175],"sets":[33],"genome-wide":[36],"association":[37,130],"studies":[38],"(GWAS)":[39],"derived":[40,110],"from":[41,111,196],"total":[43],"2,219":[45],"Japanese":[46,183,226],"subjects.":[47],"First,":[48],"we":[49,99,215,240],"performed":[50,169],"GWAS":[52,107,171],"by":[53,118],"analyzing":[54],"653,519":[55],"autosomal":[56],"common":[57],"single-nucleotide":[58],"polymorphisms":[59],"(SNPs)":[60],"in":[61,80,94,182,188,220,253],"833":[62],"POAG":[63,113,132],"patients":[64,114],"and":[65,115,122,160,258],"686":[66],"controls.":[67],"As":[68],"result,":[70],"five":[71],"variants":[72,127,195,219,229,261],"that":[73,161,193,244],"passed":[74],"Bonferroni":[76],"correction":[77],"were":[78,201],"identified":[79,217],"CDKN2B-AS1":[81,199,222],"on":[82,146],"chromosome":[83],"9p21.3,":[84],"which":[85,275],"was":[86],"already":[87],"reported":[88,231],"to":[89,203,250,273],"be":[90,204,248,263],"significant":[92,205],"locus":[93,200,223],"Caucasian":[96,237],"population.":[97,238],"Moreover,":[98],"combined":[100,126],"set":[103,109],"with":[104,131,153,162,235,266],"previous":[106],"411":[112],"289":[116],"controls":[117],"Mantel-Haenszel":[120],"test,":[121],"all":[123],"showed":[128],"stronger":[129],"(P<5.8":[133],"\u00d7":[134],"10(-10)).":[135],"then":[137],"subdivided":[138],"case":[140],"groups":[141],"into":[142],"subtypes":[144],"based":[145],"value":[148],"intraocular":[150],"pressure":[151,157,166],"(IOP)--POAG":[152],"high":[154],"IOP":[155,164],"(high":[156],"HPG)":[159],"normal":[163],"(normal":[165],"NPG)--and":[168],"using":[172,224],"sets,":[176],"as":[177,232],"prevalence":[179],"NPG":[181,207],"is":[184,276],"much":[185],"higher":[186],"than":[187],"Caucasians.":[189],"The":[190],"results":[191],"suggested":[192],"same":[198],"likely":[202],"patients.":[208],"CONCLUSIONS":[209],"SIGNIFICANCE:":[211],"In":[212],"this":[213],"study,":[214],"successfully":[216],"POAG-associated":[218],"population,":[227],"i.e.,":[228],"originally":[230],"being":[233],"associated":[234,264],"Although":[239],"cannot":[241],"rule":[242],"out":[243],"significance":[246],"could":[247,262],"due":[249],"differences":[252],"sample":[254],"size":[255],"between":[256],"HPG":[257],"NPG,":[259],"specifically":[265],"vulnerability":[268],"optic":[271],"nerve":[272],"IOP,":[274],"useful":[277],"investigating":[279],"etiology":[281],"glaucoma.":[283]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}