{"id":"https://openalex.org/W2086865035","doi":"https://doi.org/10.1038/newbio231115a0","title":"Insulin activates Pyruvate Dehydrogenase in Rat Epididymal Adipose Tissue","display_name":"Insulin activates Pyruvate Dehydrogenase in Rat Epididymal Adipose Tissue","publication_year":1971,"publication_date":"1971-05-01","ids":{"openalex":"https://openalex.org/W2086865035","doi":"https://doi.org/10.1038/newbio231115a0","mag":"2086865035","pmid":"https://pubmed.ncbi.nlm.nih.gov/5281187"},"language":"en","primary_location":{"id":"doi:10.1038/newbio231115a0","doi":"https://doi.org/10.1038/newbio231115a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/newbio231115a0","pdf_url":null,"source":{"id":"https://openalex.org/S4210210546","display_name":"Nature New Biology","issn_l":"0090-0028","issn":["0090-0028","2058-1092"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature New Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082178856","display_name":"Richard M. Denton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. M. DENTON","raw_affiliation_strings":["Department of Biochemistry, University of Bristol,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Bristol,","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112158847","display_name":"Haldane G. Coore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"H. G. COORE","raw_affiliation_strings":["Department of Biochemistry, University of Bristol,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Bristol,","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B. R. MARTIN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B. R. MARTIN","raw_affiliation_strings":["Department of Biochemistry, University of Bristol,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Bristol,","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109535549","display_name":"P J Randle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. J. RANDLE","raw_affiliation_strings":["Department of Biochemistry, University of Bristol,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Bristol,","institution_ids":["https://openalex.org/I36234482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36234482"],"apc_list":null,"apc_paid":null,"fwci":4.093,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.94861301,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"231","issue":"21","first_page":"115","last_page":"116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.10610000044107437,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.04439999908208847,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pyruvate-dehydrogenase","display_name":"pyruvate dehydrogenase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/epididymal-white-adipose-tissue","display_name":"epididymal adipose tissue","score":0.9769999980926514},{"id":"https://openalex.org/keywords/fatty-acid-synthesis","display_name":"fatty acid synthesis","score":0.859000027179718},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.5879999995231628},{"id":"https://openalex.org/keywords/pyruvate-carboxylase","display_name":"pyruvate carboxylase","score":0.9039999842643738},{"id":"https://openalex.org/keywords/acetyl-coa","display_name":"acetyl-CoA","score":0.6159999966621399},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.6299999952316284},{"id":"https://openalex.org/keywords/fructose","display_name":"fructose","score":0.6340000033378601},{"id":"https://openalex.org/keywords/glucose-transport","display_name":"glucose transport","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C88099638","wikidata":"https://www.wikidata.org/wiki/Q412856","display_name":"Pyruvate dehydrogenase complex","level":3,"score":0.7654961347579956},{"id":"https://openalex.org/C140137476","wikidata":"https://www.wikidata.org/wiki/Q21114968","display_name":"Pyruvate carboxylase","level":3,"score":0.7532598972320557},{"id":"https://openalex.org/C101972281","wikidata":"https://www.wikidata.org/wiki/Q899965","display_name":"Pyruvate decarboxylation","level":4,"score":0.7022756338119507},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6187853813171387},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6009215712547302},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5904127955436707},{"id":"https://openalex.org/C2776941171","wikidata":"https://www.wikidata.org/wiki/Q900209","display_name":"Fatty acid synthesis","level":3,"score":0.5883665084838867},{"id":"https://openalex.org/C9506865","wikidata":"https://www.wikidata.org/wiki/Q6321025","display_name":"Pyruvate dehydrogenase kinase","level":4,"score":0.5722669363021851},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5603731870651245},{"id":"https://openalex.org/C190098323","wikidata":"https://www.wikidata.org/wiki/Q14912712","display_name":"Pyruvate dehydrogenase phosphatase","level":4,"score":0.5401121973991394},{"id":"https://openalex.org/C2776970464","wikidata":"https://www.wikidata.org/wiki/Q122043","display_name":"Fructose","level":2,"score":0.4995582103729248},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4536449909210205},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43943628668785095},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.4351932406425476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3788454830646515},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1997489333152771},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08496233820915222}],"mesh":[{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001391","descriptor_name":"Azo Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004822","descriptor_name":"Epididymis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010856","descriptor_name":"Columbidae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011773","descriptor_name":"Pyruvates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/newbio231115a0","doi":"https://doi.org/10.1038/newbio231115a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/newbio231115a0","pdf_url":null,"source":{"id":"https://openalex.org/S4210210546","display_name":"Nature New Biology","issn_l":"0090-0028","issn":["0090-0028","2058-1092"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature New Biology","raw_type":"journal-article"},{"id":"pmid:5281187","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5281187","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature: New biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W8024089","https://openalex.org/W79184038","https://openalex.org/W128185823","https://openalex.org/W163803792","https://openalex.org/W1531420956","https://openalex.org/W1538699852","https://openalex.org/W1835557351","https://openalex.org/W1988238572","https://openalex.org/W2028746287","https://openalex.org/W2061202598","https://openalex.org/W2082520757","https://openalex.org/W2163033308","https://openalex.org/W2432195370"],"related_works":["https://openalex.org/W1254243414","https://openalex.org/W1979106096","https://openalex.org/W1979481443","https://openalex.org/W1764261190","https://openalex.org/W1695034058","https://openalex.org/W1493348989","https://openalex.org/W2028746287","https://openalex.org/W2088572314","https://openalex.org/W2404891622","https://openalex.org/W2046114634"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
