{"id":"https://openalex.org/W2086862033","doi":"https://doi.org/10.1021/la701850p","title":"Characterization of Insulin Adsorption in the Presence of Albumin by Time-of-Flight Secondary Ion Mass Spectrometry and X-ray Photoelectron Spectroscopy","display_name":"Characterization of Insulin Adsorption in the Presence of Albumin by Time-of-Flight Secondary Ion Mass Spectrometry and X-ray Photoelectron Spectroscopy","publication_year":2007,"publication_date":"2007-12-12","ids":{"openalex":"https://openalex.org/W2086862033","doi":"https://doi.org/10.1021/la701850p","mag":"2086862033","pmid":"https://pubmed.ncbi.nlm.nih.gov/18072791"},"language":"en","primary_location":{"id":"doi:10.1021/la701850p","doi":"https://doi.org/10.1021/la701850p","is_oa":false,"landing_page_url":"https://doi.org/10.1021/la701850p","pdf_url":null,"source":{"id":"https://openalex.org/S75741262","display_name":"Langmuir","issn_l":"0743-7463","issn":["0743-7463","1520-5827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langmuir","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040261333","display_name":"Mathieu Henry","orcid":"https://orcid.org/0000-0003-1889-6135","observed_orcids":["https://orcid.org/0000-0003-1889-6135"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"M. Henry","raw_affiliation_strings":["Unit\u00e9 de Physico-Chimie et de Physique des Mat\u00e9riaux, Universit\u00e9 catholique de Louvain, 1 Croix du Sud, 1348 Louvain-la-Neuve, Belgium, and Unit\u00e9 de Chimie des Interfaces, Universit\u00e9 catholique de Louvain, 2/18 Croix du Sud, 1348 Louvain-La-Neuve, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Physico-Chimie et de Physique des Mat\u00e9riaux, Universit\u00e9 catholique de Louvain, 1 Croix du Sud, 1348 Louvain-la-Neuve, Belgium, and Unit\u00e9 de Chimie des Interfaces, Universit\u00e9 catholique de Louvain, 2/18 Croix du Sud, 1348 Louvain-La-Neuve, Belgium","institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110074546","display_name":"Ch. C. Dupont-Gillain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"C. Dupont-Gillain","raw_affiliation_strings":["Unit\u00e9 de Physico-Chimie et de Physique des Mat\u00e9riaux, Universit\u00e9 catholique de Louvain, 1 Croix du Sud, 1348 Louvain-la-Neuve, Belgium, and Unit\u00e9 de Chimie des Interfaces, Universit\u00e9 catholique de Louvain, 2/18 Croix du Sud, 1348 Louvain-La-Neuve, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Physico-Chimie et de Physique des Mat\u00e9riaux, Universit\u00e9 catholique de Louvain, 1 Croix du Sud, 1348 Louvain-la-Neuve, Belgium, and Unit\u00e9 de Chimie des Interfaces, Universit\u00e9 catholique de Louvain, 2/18 Croix du Sud, 1348 Louvain-La-Neuve, Belgium","institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112233423","display_name":"Patrick Bertrand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"P. Bertrand","raw_affiliation_strings":["Unit\u00e9 de Physico-Chimie et de Physique des Mat\u00e9riaux, Universit\u00e9 catholique de Louvain, 1 Croix du Sud, 1348 Louvain-la-Neuve, Belgium, and Unit\u00e9 de Chimie des Interfaces, Universit\u00e9 catholique de Louvain, 2/18 Croix du Sud, 1348 Louvain-La-Neuve, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Physico-Chimie et de Physique des Mat\u00e9riaux, Universit\u00e9 catholique de Louvain, 1 Croix du Sud, 1348 Louvain-la-Neuve, Belgium, and Unit\u00e9 de Chimie des Interfaces, Universit\u00e9 catholique de Louvain, 2/18 Croix du Sud, 1348 Louvain-La-Neuve, Belgium","institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040261333"],"corresponding_institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.4237,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.77454066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"24","issue":"2","first_page":"458","last_page":"464"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.3422999978065491,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.3422999978065491,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12166","display_name":"Ion-surface interactions and analysis","score":0.2856000065803528,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12039","display_name":"Electron and X-Ray Spectroscopy Techniques","score":0.2476000040769577,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-adsorption","display_name":"insulin adsorption","score":0.9919999837875366},{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-adsorption","display_name":"protein adsorption","score":0.6790000200271606},{"id":"https://openalex.org/keywords/polycarbonate-membranes","display_name":"polycarbonate membranes","score":0.9160000085830688},{"id":"https://openalex.org/keywords/bioartificial-pancreas","display_name":"bioartificial pancreas","score":0.9559999704360962},{"id":"https://openalex.org/keywords/adsorption-isotherms","display_name":"adsorption isotherms","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.805131733417511},{"id":"https://openalex.org/C175708663","wikidata":"https://www.wikidata.org/wiki/Q899559","display_name":"X-ray photoelectron spectroscopy","level":2,"score":0.725756049156189},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6735482215881348},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.6370532512664795},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.5781132578849792},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.5564539432525635},{"id":"https://openalex.org/C77671233","wikidata":"https://www.wikidata.org/wiki/Q556046","display_name":"Secondary ion mass spectrometry","level":3,"score":0.5143636465072632},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.4657121002674103},{"id":"https://openalex.org/C2779328170","wikidata":"https://www.wikidata.org/wiki/Q34777","display_name":"X-ray","level":2,"score":0.451376348733902},{"id":"https://openalex.org/C98960154","wikidata":"https://www.wikidata.org/wiki/Q3983322","display_name":"Time of flight","level":2,"score":0.42444974184036255},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.34582918882369995},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.22847512364387512},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.13940736651420593},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1323210597038269},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.09765210747718811},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09093692898750305},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.05226889252662659},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000327","descriptor_name":"Adsorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001187","descriptor_name":"Artificial Organs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018629","descriptor_name":"Spectrometry, Mass, Secondary Ion","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/la701850p","doi":"https://doi.org/10.1021/la701850p","is_oa":false,"landing_page_url":"https://doi.org/10.1021/la701850p","pdf_url":null,"source":{"id":"https://openalex.org/S75741262","display_name":"Langmuir","issn_l":"0743-7463","issn":["0743-7463","1520-5827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langmuir","raw_type":"journal-article"},{"id":"pmid:18072791","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18072791","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langmuir : the ACS journal of surfaces and colloids","raw_type":"Journal Article"},{"id":"pmh:oai:dial.uclouvain.be:boreal:11220","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2078.1/11220","pdf_url":null,"source":{"id":"https://openalex.org/S4306400166","display_name":"Digital Access to Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800384882","host_organization_name":"Harris County Public Library","host_organization_lineage":["https://openalex.org/I2800384882"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Langmuir : the A C S journal of surfaces and colloids, Vol. 24, no. 2, p. 458-464 (2008)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1524961740","https://openalex.org/W1606810029","https://openalex.org/W1977451826","https://openalex.org/W1985691647","https://openalex.org/W2009928511","https://openalex.org/W2014948964","https://openalex.org/W2015562860","https://openalex.org/W2018413191","https://openalex.org/W2020995700","https://openalex.org/W2022322089","https://openalex.org/W2028041669","https://openalex.org/W2039323273","https://openalex.org/W2053093355","https://openalex.org/W2078041550","https://openalex.org/W2092793590","https://openalex.org/W2169586329","https://openalex.org/W2492660732"],"related_works":["https://openalex.org/W2166605222","https://openalex.org/W1981211088","https://openalex.org/W2009928511","https://openalex.org/W2092742346","https://openalex.org/W2000471284","https://openalex.org/W1965304129","https://openalex.org/W2283079606","https://openalex.org/W7095235849","https://openalex.org/W2266922295","https://openalex.org/W1982218634"],"abstract_inverted_index":{"With":[0],"a":[1,9,40],"view":[2],"to":[3,32,187,215],"develop":[4],"an":[5,49,161],"encapsulation":[6],"membrane":[7,42],"for":[8,77,99,171],"bioartificial":[10],"pancreas,":[11],"we":[12],"have":[13],"studied":[14],"the":[15,34,45,57,61,100,106,111,119,123,130,144,152,164,182,191,206,216],"adsorption":[16,84,150],"of":[17,28,36,47,56,63,110,143,151,163,181],"insulin":[18,37,78,138,157,165,172,202,213],"and":[19,70,79,114,129,169],"human":[20],"serum":[21],"albumin":[22],"(HSA)":[23],"on":[24,39],"it.":[25],"The":[26,53,125,140,195],"aim":[27],"this":[29,82],"study":[30],"was":[31],"determine":[33],"possibility":[35],"detection":[38],"polycarbonate":[41],"surface":[43],"in":[44,60,86,122,147,167,204,212],"presence":[46],"HSA,":[48],"abundant":[50],"blood":[51],"protein.":[52],"first":[54],"step":[55,142],"work":[58,145],"consisted":[59,146],"identification":[62],"time-of-flight":[64],"secondary":[65],"ion":[66],"mass":[67],"spectrometry":[68],"(ToF-SIMS)":[69],"X-ray":[71],"photoelectron":[72],"spectroscopy":[73],"(XPS)":[74],"specific":[75],"signals":[76],"albumin.":[80],"For":[81],"purpose,":[83],"isotherms":[85],"physiological":[87],"conditions":[88],"(pH":[89],"=":[90,93],"7.2,":[91],"T":[92],"37":[94],"degrees":[95],")":[96],"were":[97,134],"established":[98],"two":[101,153],"proteins":[102,154],"by":[103],"looking":[104],"at":[105,199],"SIMS":[107],"intensity":[108],"variations":[109],"characteristic":[112],"protein":[113,120,192],"substrate":[115],"fragments":[116],"when":[117],"increasing":[118,156],"concentration":[121,173,203],"solution.":[124,217],"CHS+":[126],"ToF-SIMS":[127,168,183],"fragment":[128],"S2p":[131],"XPS":[132,170],"peak":[133],"identified":[135],"as":[136],"representative":[137],"signals.":[139],"second":[141],"performing":[148],"simultaneous":[149],"with":[155],"concentration.":[158],"We":[159],"observed":[160],"increase":[162],"signal":[166],"beyond":[174],"5":[175],"microg/mL.":[176],"Principal":[177],"component":[178],"analysis":[179],"(PCA)":[180],"results":[184,196],"permits":[185],"us":[186],"obtain":[188],"information":[189],"about":[190],"layer":[193],"composition.":[194],"show":[197],"that":[198],"low":[200],"relative":[201],"solution,":[205],"mixed":[207],"adsorbed":[208],"layers":[209],"are":[210],"enriched":[211],"compared":[214]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
