{"id":"https://openalex.org/W2086798367","doi":"https://doi.org/10.1002/art.27437","title":"Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line","display_name":"Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line","publication_year":2010,"publication_date":"2010-03-03","ids":{"openalex":"https://openalex.org/W2086798367","doi":"https://doi.org/10.1002/art.27437","mag":"2086798367","pmid":"https://pubmed.ncbi.nlm.nih.gov/20201078"},"language":"en","primary_location":{"id":"doi:10.1002/art.27437","doi":"https://doi.org/10.1002/art.27437","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.27437","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108444345","display_name":"Anna Iacono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096311","display_name":"Complejo Hospitalario Universitario de Santiago","ror":"https://ror.org/00mpdg388","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096311"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["ES","IT"],"is_corresponding":false,"raw_author_name":"Anna Iacono","raw_affiliation_strings":["Santiago University Clinical Hospital, Santiago de Compostela, Spain","University of Naples Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santiago University Clinical Hospital, Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I4210096311"]},{"raw_affiliation_string":"University of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014810154","display_name":"Rodolfo G\u00f3mez","orcid":"https://orcid.org/0000-0002-1309-1023","observed_orcids":["https://orcid.org/0000-0002-1309-1023"]},"institutions":[{"id":"https://openalex.org/I4210096311","display_name":"Complejo Hospitalario Universitario de Santiago","ror":"https://ror.org/00mpdg388","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096311"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rodolfo G\u00f3mez","raw_affiliation_strings":["Santiago University Clinical Hospital, Santiago de Compostela, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santiago University Clinical Hospital, Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I4210096311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005218140","display_name":"Jeffrey B. Sperry","orcid":"https://orcid.org/0000-0003-0365-5646","observed_orcids":["https://orcid.org/0000-0003-0365-5646"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Sperry","raw_affiliation_strings":["University of Pennsylvania , Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania , Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011112502","display_name":"Javier Conde","orcid":"https://orcid.org/0000-0002-2187-479X","observed_orcids":["https://orcid.org/0000-0002-2187-479X"]},"institutions":[{"id":"https://openalex.org/I4210096311","display_name":"Complejo Hospitalario Universitario de Santiago","ror":"https://ror.org/00mpdg388","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096311"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Conde","raw_affiliation_strings":["Santiago University Clinical Hospital, Santiago de Compostela, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santiago University Clinical Hospital, Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I4210096311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087346741","display_name":"Giuseppe Bianco","orcid":"https://orcid.org/0000-0001-7451-4002","observed_orcids":["https://orcid.org/0000-0001-7451-4002","https://orcid.org/0009-0009-0840-9058"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I4210096311","display_name":"Complejo Hospitalario Universitario de Santiago","ror":"https://ror.org/00mpdg388","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096311"]}],"countries":["ES","IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Bianco","raw_affiliation_strings":["Santiago University Clinical Hospital, Santiago de Compostela, Spain","University of Salerno, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santiago University Clinical Hospital, Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I4210096311"]},{"raw_affiliation_string":"University of Salerno, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033436256","display_name":"Rosaria Meli","orcid":"https://orcid.org/0000-0002-6246-6813","observed_orcids":["https://orcid.org/0000-0002-6246-6813"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosaria Meli","raw_affiliation_strings":["University of Naples \u2018Federico II\u2019Naples Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Naples \u2018Federico II\u2019Naples Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071926023","display_name":"Juan Jes\u00fas G\u00f3mez-Reino","orcid":"https://orcid.org/0000-0001-5229-6294","observed_orcids":["https://orcid.org/0000-0001-5229-6294"]},"institutions":[{"id":"https://openalex.org/I4210096311","display_name":"Complejo Hospitalario Universitario de Santiago","ror":"https://ror.org/00mpdg388","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096311"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan J. G\u00f3mez\u2010Reino","raw_affiliation_strings":["Santiago University Clinical Hospital, Santiago de Compostela, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santiago University Clinical Hospital, Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I4210096311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066527875","display_name":"Amos B. Smith","orcid":"https://orcid.org/0000-0002-1712-8567","observed_orcids":["https://orcid.org/0000-0002-1712-8567"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amos B. Smith","raw_affiliation_strings":["University of Pennsylvania , Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania , Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041596182","display_name":"Oreste Gualillo","orcid":"https://orcid.org/0000-0002-7154-1328","observed_orcids":["https://orcid.org/0000-0002-7154-1328"]},"institutions":[{"id":"https://openalex.org/I4210096311","display_name":"Complejo Hospitalario Universitario de Santiago","ror":"https://ror.org/00mpdg388","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096311"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Oreste Gualillo","raw_affiliation_strings":["Santiago University Clinical Hospital, Santiago de Compostela, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santiago University Clinical Hospital, Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I4210096311"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3256,"has_fulltext":false,"cited_by_count":105,"citation_normalized_percentile":{"value":0.91819547,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"62","issue":"6","first_page":"1675","last_page":"1682"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oleocanthal","display_name":"oleocanthal","score":1.0},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7260000109672546},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9729999899864197},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.9129999876022339},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8360000252723694},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cartilage-degeneration","display_name":"cartilage degeneration","score":0.7419999837875366},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.7139999866485596},{"id":"https://openalex.org/keywords/extra-virgin-olive-oil","display_name":"extra virgin olive oil","score":0.9480000138282776},{"id":"https://openalex.org/keywords/nitrite-accumulation","display_name":"nitrite accumulation","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.7421489357948303},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6332806944847107},{"id":"https://openalex.org/C2779944601","wikidata":"https://www.wikidata.org/wiki/Q186969","display_name":"Ibuprofen","level":2,"score":0.6098874807357788},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.6065746545791626},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.5756043195724487},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5552433133125305},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5219137668609619},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5048790574073792},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4957331120967865},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4911291301250458},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4784524440765381},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.342783123254776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32225388288497925},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3078070878982544},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25036343932151794},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22661864757537842},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18048423528671265},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16461580991744995},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12175676226615906},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08491119742393494},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000081004","descriptor_name":"Cyclopentane Monoterpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/art.27437","doi":"https://doi.org/10.1002/art.27437","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.27437","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},{"id":"pmid:20201078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20201078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis and rheumatism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W40928199","https://openalex.org/W73392286","https://openalex.org/W1492086662","https://openalex.org/W1494688418","https://openalex.org/W1519147845","https://openalex.org/W1899997617","https://openalex.org/W1927941125","https://openalex.org/W1964106067","https://openalex.org/W1973018387","https://openalex.org/W1981069044","https://openalex.org/W1991040567","https://openalex.org/W2001358890","https://openalex.org/W2005464684","https://openalex.org/W2009590767","https://openalex.org/W2009789674","https://openalex.org/W2011867519","https://openalex.org/W2014668871","https://openalex.org/W2017670199","https://openalex.org/W2025297807","https://openalex.org/W2032962802","https://openalex.org/W2033088300","https://openalex.org/W2033496106","https://openalex.org/W2056013998","https://openalex.org/W2063444278","https://openalex.org/W2067328495","https://openalex.org/W2068359337","https://openalex.org/W2079810675","https://openalex.org/W2081577257","https://openalex.org/W2082137621","https://openalex.org/W2085623998","https://openalex.org/W2092174616","https://openalex.org/W2103166031","https://openalex.org/W2104361594","https://openalex.org/W2114471642","https://openalex.org/W2114918609","https://openalex.org/W2123348322","https://openalex.org/W2135794174","https://openalex.org/W2136628975","https://openalex.org/W2137244891","https://openalex.org/W2137838799","https://openalex.org/W2142328693","https://openalex.org/W2150882549","https://openalex.org/W2152732334","https://openalex.org/W2153831122","https://openalex.org/W2163293935","https://openalex.org/W2164082697","https://openalex.org/W2168647880","https://openalex.org/W2184578345","https://openalex.org/W2416915265","https://openalex.org/W3146550976","https://openalex.org/W4360790438"],"related_works":["https://openalex.org/W2077723599","https://openalex.org/W2893327675","https://openalex.org/W4285593902","https://openalex.org/W2041085246","https://openalex.org/W1988983157","https://openalex.org/W2124480246","https://openalex.org/W2511117452","https://openalex.org/W195122929","https://openalex.org/W4214571878","https://openalex.org/W2781312912"],"abstract_inverted_index":{"OBJECTIVE:":[0],"In":[1,25],"joint":[2,111,241],"diseases,":[3],"cartilage":[4,55,61],"homeostasis":[5],"is":[6,42,74],"disrupted":[7],"by":[8,13,44],"mechanisms":[9],"that":[10,18,99],"are":[11],"driven":[12],"combinations":[14],"of":[15,33,60,69,100,110,122,130,144,218,227,238],"biologic":[16],"factors":[17],"vary":[19],"according":[20],"to":[21,91,98,118],"the":[22,58,67,107,120,128,154,165,200,207,236],"disease":[23],"process.":[24],"osteoarthritis":[26],"(OA),":[27],"biomechanical":[28],"stimuli":[29],"predominate,":[30],"with":[31,54,141],"up-regulation":[32],"both":[34],"catabolic":[35],"and":[36,124,146,182],"anabolic":[37],"factors.":[38],"Likewise,":[39],"OA":[40],"progression":[41],"characterized":[43],"increased":[45],"nitric":[46],"oxide":[47],"(NO)":[48],"production,":[49],"which":[50],"has":[51],"been":[52],"associated":[53],"degradation.":[56],"Given":[57],"relevance":[59],"degenerative":[62,240],"diseases":[63],"in":[64,106,133,161,189],"our":[65],"society,":[66],"development":[68],"a":[70,75,102,232],"novel":[71],"pharmacologic":[72],"intervention":[73],"critically":[76],"important":[77],"public":[78],"health":[79],"goal.":[80],"Recently,":[81],"oleocanthal":[82,123,145],"isolated":[83],"from":[84],"extra":[85],"virgin":[86],"olive":[87],"oil":[88],"was":[89,151,159,174,206,216],"found":[90],"display":[92],"nonsteroidal":[93],"antiinflammatory":[94],"drug":[95,103],"activity":[96],"similar":[97],"ibuprofen,":[101],"widely":[104],"used":[105],"therapeutic":[108,233],"management":[109],"inflammatory":[112,239],"diseases.":[113,242],"We":[114],"undertook":[115],"this":[116],"study":[117],"evaluate":[119],"effect":[121,213],"its":[125,147,183,211],"derivatives":[126,184,201],"on":[127,214],"modulation":[129],"NO":[131,169],"production":[132],"chondrocytes.":[134],"METHODS:":[135],"Cultured":[136],"ATDC-5":[137],"chondrocytes":[138,190],"were":[139],"tested":[140],"different":[142],"doses":[143],"derivatives.":[148],"Cell":[149],"viability":[150,195],"evaluated":[152],"using":[153,164,176],"MTT":[155],"assay.":[156],"Nitrite":[157],"accumulation":[158],"determined":[160],"culture":[162],"supernatant":[163],"Griess":[166],"reaction.":[167],"Inducible":[168],"synthase":[170],"(NOS2)":[171],"protein":[172],"expression":[173],"examined":[175],"Western":[177],"blotting":[178],"analysis.":[179],"RESULTS:":[180],"Oleocanthal":[181],"decreased":[185],"lipopolysaccharide-induced":[186],"NOS2":[187,215],"synthesis":[188],"without":[191],"significantly":[192],"affecting":[193],"cell":[194],"at":[196,221],"lower":[197],"concentrations.":[198,223],"Among":[199],"we":[202],"examined,":[203],"derivative":[204],"231":[205],"most":[208],"interesting,":[209],"since":[210],"inhibitory":[212],"devoid":[217],"cytotoxicity":[219],"even":[220],"higher":[222],"CONCLUSION:":[224],"This":[225],"class":[226],"molecules":[228],"shows":[229],"potential":[230],"as":[231],"weapon":[234],"for":[235],"treatment":[237]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
