{"id":"https://openalex.org/W2086776463","doi":"https://doi.org/10.1523/jneurosci.4403-10.2010","title":"CX3CR1 in Microglia Regulates Brain Amyloid Deposition through Selective Protofibrillar Amyloid-\u03b2 Phagocytosis","display_name":"CX3CR1 in Microglia Regulates Brain Amyloid Deposition through Selective Protofibrillar Amyloid-\u03b2 Phagocytosis","publication_year":2010,"publication_date":"2010-12-15","ids":{"openalex":"https://openalex.org/W2086776463","doi":"https://doi.org/10.1523/jneurosci.4403-10.2010","mag":"2086776463","pmid":"https://pubmed.ncbi.nlm.nih.gov/21159979","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3077120"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.4403-10.2010","doi":"https://doi.org/10.1523/jneurosci.4403-10.2010","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4403-10.2010","pdf_url":"https://www.jneurosci.org/content/jneuro/30/50/17091.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/30/50/17091.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100415103","display_name":"Zhiqiang Liu","orcid":"https://orcid.org/0000-0002-7579-6280","observed_orcids":["https://orcid.org/0000-0002-7579-6280"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiqiang Liu","raw_affiliation_strings":["Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091904954","display_name":"Carlo Condello","orcid":"https://orcid.org/0000-0002-8454-5360","observed_orcids":["https://orcid.org/0000-0002-8454-5360"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlo Condello","raw_affiliation_strings":["Departments of Neurology and Physiology, North-western University Feinberg School of Medicine, 303 East Chicago Avenue, Ward 10-132, Chicago, IL 60611","Departments of 1 Neurology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Physiology, North-western University Feinberg School of Medicine, 303 East Chicago Avenue, Ward 10-132, Chicago, IL 60611","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Departments of 1 Neurology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046530889","display_name":"Aaron J. Schain","orcid":"https://orcid.org/0000-0001-7707-3556","observed_orcids":["https://orcid.org/0000-0001-7707-3556"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Schain","raw_affiliation_strings":["Departments of Neurology and Physiology, North-western University Feinberg School of Medicine, 303 East Chicago Avenue, Ward 10-132, Chicago, IL 60611","Departments of 1 Neurology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Physiology, North-western University Feinberg School of Medicine, 303 East Chicago Avenue, Ward 10-132, Chicago, IL 60611","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Departments of 1 Neurology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014608956","display_name":"Roa Harb","orcid":"https://orcid.org/0000-0001-8709-4318","observed_orcids":["https://orcid.org/0000-0001-8709-4318"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roa Harb","raw_affiliation_strings":["Departments of Neurology and Physiology, North-western University Feinberg School of Medicine, 303 East Chicago Avenue, Ward 10-132, Chicago, IL 60611","Departments of 1 Neurology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Physiology, North-western University Feinberg School of Medicine, 303 East Chicago Avenue, Ward 10-132, Chicago, IL 60611","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Departments of 1 Neurology and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022037048","display_name":"Jaime Grutzendler","orcid":"https://orcid.org/0000-0002-5000-243X","observed_orcids":["https://orcid.org/0000-0002-5000-243X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaime Grutzendler","raw_affiliation_strings":["Departments of 1 Neurology and Physiology , Northwestern University Feinberg School of Medicine , Chicago , Illinois 60611","Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1 Neurology and Physiology , Northwestern University Feinberg School of Medicine , Chicago , Illinois 60611","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":8.6299,"has_fulltext":true,"cited_by_count":275,"citation_normalized_percentile":{"value":0.98413921,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"30","issue":"50","first_page":"17091","last_page":"17101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.6699000000953674,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.6699000000953674,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.3285999894142151,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cx3cr1","display_name":"CX3CR1","score":1.0},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8970000147819519},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8159999847412109},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.9020000100135803},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.7139999866485596},{"id":"https://openalex.org/keywords/microglial-proliferation","display_name":"microglial proliferation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/phagolysosomes","display_name":"phagolysosomes","score":0.8519999980926514},{"id":"https://openalex.org/keywords/chemokine-receptor-signaling","display_name":"chemokine receptor signaling","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.9794435501098633},{"id":"https://openalex.org/C31179232","wikidata":"https://www.wikidata.org/wiki/Q14911549","display_name":"CX3CR1","level":5,"score":0.9492714405059814},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.7516043186187744},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5241549015045166},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.5003476142883301},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4682406485080719},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44274285435676575},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4382108449935913},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4157079756259918},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36308541893959045},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3207274079322815},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.30695515871047974},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2783091068267822},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.2584155201911926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21627214550971985},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0793752670288086}],"mesh":[{"descriptor_ui":"D000073883","descriptor_name":"CX3C Chemokine Receptor 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.4403-10.2010","doi":"https://doi.org/10.1523/jneurosci.4403-10.2010","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4403-10.2010","pdf_url":"https://www.jneurosci.org/content/jneuro/30/50/17091.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3077120","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3077120","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:21159979","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21159979","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.4403-10.2010","doi":"https://doi.org/10.1523/jneurosci.4403-10.2010","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4403-10.2010","pdf_url":"https://www.jneurosci.org/content/jneuro/30/50/17091.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5121017662","display_name":"Vascular Mechanisms of Neuronal Circuit Disruption in Dementia","funder_award_id":"R01AG027855","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306135","display_name":"Ellison Medical Foundation","ror":"https://ror.org/01pqy3846"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2086776463.pdf","grobid_xml":"https://content.openalex.org/works/W2086776463.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W109402025","https://openalex.org/W274427711","https://openalex.org/W1528113046","https://openalex.org/W1607135210","https://openalex.org/W1899752912","https://openalex.org/W1973353696","https://openalex.org/W1974966491","https://openalex.org/W1987595364","https://openalex.org/W1993909442","https://openalex.org/W1998079087","https://openalex.org/W1999419270","https://openalex.org/W2003674452","https://openalex.org/W2004349171","https://openalex.org/W2008669330","https://openalex.org/W2026927834","https://openalex.org/W2029906813","https://openalex.org/W2038421461","https://openalex.org/W2043679754","https://openalex.org/W2045720033","https://openalex.org/W2047964142","https://openalex.org/W2052652421","https://openalex.org/W2056305549","https://openalex.org/W2058614488","https://openalex.org/W2066165659","https://openalex.org/W2073516240","https://openalex.org/W2075481535","https://openalex.org/W2080351494","https://openalex.org/W2088542086","https://openalex.org/W2096601751","https://openalex.org/W2097867538","https://openalex.org/W2113107925","https://openalex.org/W2122828560","https://openalex.org/W2130145174","https://openalex.org/W2140139281","https://openalex.org/W2153747061","https://openalex.org/W2155965284","https://openalex.org/W2156193029","https://openalex.org/W2160031422","https://openalex.org/W2161057248","https://openalex.org/W2163487275","https://openalex.org/W2165021720","https://openalex.org/W2166548070"],"related_works":["https://openalex.org/W2115855931","https://openalex.org/W2988505515","https://openalex.org/W4283643624","https://openalex.org/W2117478398","https://openalex.org/W2044269404","https://openalex.org/W4312087379","https://openalex.org/W2139649416","https://openalex.org/W2148721608","https://openalex.org/W2169708427","https://openalex.org/W576141130"],"abstract_inverted_index":{"In":[0],"Alzheimer's":[1,61],"disease":[2,21],"(AD),":[3],"amyloid-\u03b2":[4],"(A\u03b2)":[5],"deposits":[6],"are":[7],"frequently":[8],"surrounded":[9],"by":[10,202],"activated":[11],"microglia":[12,33,47,87,142,176,182,198],"but":[13,108],"the":[14,43,60,103,165],"precise":[15],"role":[16],"of":[17,46,75,84,105,111,113,141,147,167,197],"these":[18,97],"cells":[19,98],"in":[20,32,52,92],"progression":[22],"remains":[23],"unclear.":[24],"The":[25],"chemokine":[26],"receptor":[27],"CX3CR1":[28,58,117,160,203],"is":[29,35],"selectively":[30],"expressed":[31],"and":[34,77,79,88,188,200],"thought":[36],"to":[37,127,154],"modulate":[38],"their":[39],"activity.":[40],"To":[41],"study":[42],"specific":[44],"effects":[45],"activation":[48],"on":[49],"amyloid":[50,81,107,129],"pathology":[51],"vivo,":[53],"we":[54,66],"crossbred":[55],"mice":[56,70,94,136],"lacking":[57],"with":[59,121],"mouse":[62],"model":[63],"CRND8.":[64],"Surprisingly,":[65],"found":[67],"that":[68,96,181],"CX3CR1-deficient":[69,135],"had":[71,137],"lower":[72],"brain":[73,185],"levels":[74,187],"A\u03b240":[76],"A\u03b242":[78],"reduced":[80],"deposits.":[82],"Quantification":[83],"A\u03b2":[85,186,194],"within":[86,131],"time-lapse":[89],"two-photon":[90],"microscopy":[91],"live":[93],"revealed":[95],"were":[99,109],"highly":[100],"effective":[101],"at":[102],"uptake":[104],"protofibrillar":[106,193],"incapable":[110],"phagocytosis":[112],"fibrillar":[114],"congophilic":[115],"A\u03b2.":[116],"deletion":[118,161],"was":[119],"associated":[120],"increased":[122,139,175],"phagocytic":[123,158],"ability,":[124],"which":[125,151],"led":[126],"greater":[128,157],"content":[130],"microglial":[132],"phagolysosomes.":[133],"Furthermore,":[134],"an":[138,155],"number":[140],"around":[143,172],"individual":[144],"plaques":[145,173],"because":[146],"higher":[148],"proliferative":[149],"rates,":[150],"likely":[152],"contributed":[153],"overall":[156],"capacity.":[159],"did":[162],"not":[163],"affect":[164],"degree":[166],"neuronal":[168],"or":[169],"synaptic":[170],"damage":[171],"despite":[174],"density.":[177],"Our":[178],"results":[179],"demonstrate":[180],"can":[183],"regulate":[184],"plaque":[189],"deposition":[190],"via":[191],"selective":[192],"phagocytosis.":[195],"Modulation":[196],"activity":[199],"proliferation":[201],"signaling":[204],"may":[205],"represent":[206],"a":[207],"therapeutic":[208],"strategy":[209],"for":[210],"AD.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":27},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":25},{"year":2014,"cited_by_count":24},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}