{"id":"https://openalex.org/W2086701519","doi":"https://doi.org/10.1073/pnas.97.11.5690","title":"In search of \u03b3-secretase: Presenilin at the cutting edge","display_name":"In search of \u03b3-secretase: Presenilin at the cutting edge","publication_year":2000,"publication_date":"2000-05-23","ids":{"openalex":"https://openalex.org/W2086701519","doi":"https://doi.org/10.1073/pnas.97.11.5690","mag":"2086701519","pmid":"https://pubmed.ncbi.nlm.nih.gov/10823929","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/33989"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.97.11.5690","doi":"https://doi.org/10.1073/pnas.97.11.5690","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.97.11.5690","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC33989","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087935119","display_name":"Dennis J. Selkoe","orcid":"https://orcid.org/0000-0001-8846-9767","observed_orcids":["https://orcid.org/0000-0001-8846-9767"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis J. Selkoe","raw_affiliation_strings":["Center for Neurologic Diseases, Harvard Medical School and Brigham\r and Women's Hospital, 77 Avenue Louis Pasteur, HIM 730, Boston, MA\r 02115","Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, 77 Avenue Louis Pasteur, HIM 730, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurologic Diseases, Harvard Medical School and Brigham\r and Women's Hospital, 77 Avenue Louis Pasteur, HIM 730, Boston, MA\r 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, 77 Avenue Louis Pasteur, HIM 730, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070207434","display_name":"Michael S. Wolfe","orcid":"https://orcid.org/0000-0002-5721-9092","observed_orcids":["https://orcid.org/0000-0002-5721-9092"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael S. Wolfe","raw_affiliation_strings":["Center for Neurologic Diseases, Harvard Medical School and Brigham\r and Women's Hospital, 77 Avenue Louis Pasteur, HIM 730, Boston, MA\r 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurologic Diseases, Harvard Medical School and Brigham\r and Women's Hospital, 77 Avenue Louis Pasteur, HIM 730, Boston, MA\r 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.4344,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.98189135,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"97","issue":"11","first_page":"5690","last_page":"5692"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-secretase","display_name":"gamma-secretase","score":0.8370000123977661},{"id":"https://openalex.org/keywords/presenilin","display_name":"presenilin","score":0.9380000233650208},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8579999804496765},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.8769999742507935},{"id":"https://openalex.org/keywords/intramembrane-proteolysis","display_name":"intramembrane proteolysis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/notch-receptor","display_name":"Notch receptor","score":0.652999997138977},{"id":"https://openalex.org/keywords/ire1","display_name":"IRE1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9599999785423279},{"id":"https://openalex.org/keywords/beta-secretase","display_name":"beta-secretase","score":0.9409999847412109},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.367000013589859}],"concepts":[{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.7493484020233154},{"id":"https://openalex.org/C162307627","wikidata":"https://www.wikidata.org/wiki/Q204833","display_name":"Enhanced Data Rates for GSM Evolution","level":2,"score":0.4341681897640228},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42009326815605164},{"id":"https://openalex.org/C36103677","wikidata":"https://www.wikidata.org/wiki/Q4749551","display_name":"Amyloid precursor protein secretase","level":5,"score":0.4134026765823364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3801315724849701},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.372404009103775},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3632029891014099},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.24958333373069763},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.22950267791748047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16048341989517212},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.12276104092597961},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07155799865722656},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002793","descriptor_name":"Cholic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003902","descriptor_name":"Detergents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004722","descriptor_name":"Endoribonucleases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.97.11.5690","doi":"https://doi.org/10.1073/pnas.97.11.5690","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.97.11.5690","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:192301","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC33989","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:33989","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/33989","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:10823929","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10823929","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"mag:2764746919","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/30016229248","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci USA","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:192301","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC33989","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1502820594","https://openalex.org/W1534001036","https://openalex.org/W1644122431","https://openalex.org/W1655404681","https://openalex.org/W1660631781","https://openalex.org/W1675105744","https://openalex.org/W1974130870","https://openalex.org/W1979543098","https://openalex.org/W1979773315","https://openalex.org/W1985325561","https://openalex.org/W1992555577","https://openalex.org/W2004305803","https://openalex.org/W2004465970","https://openalex.org/W2019007505","https://openalex.org/W2022796225","https://openalex.org/W2026053103","https://openalex.org/W2033382511","https://openalex.org/W2040732053","https://openalex.org/W2050030183","https://openalex.org/W2062283435","https://openalex.org/W2067521893","https://openalex.org/W2077674018","https://openalex.org/W2079438371","https://openalex.org/W2081733923","https://openalex.org/W2082669967","https://openalex.org/W2086278983","https://openalex.org/W2098503611","https://openalex.org/W2104636742","https://openalex.org/W2128084592","https://openalex.org/W2133019124","https://openalex.org/W2146955477","https://openalex.org/W2154861644","https://openalex.org/W2162815565","https://openalex.org/W2949745155"],"related_works":["https://openalex.org/W1988923764","https://openalex.org/W2395390038","https://openalex.org/W71170684","https://openalex.org/W7073897381","https://openalex.org/W2136902554","https://openalex.org/W22223414","https://openalex.org/W3019791016","https://openalex.org/W2441087252","https://openalex.org/W2074158251","https://openalex.org/W3002762550"],"abstract_inverted_index":{"The":[0,70,129],"effort":[1],"to":[2,9,16,43,146,171,229],"solve":[3],"Alzheimer's":[4],"disease":[5],"(AD)":[6],"has":[7,31,186],"led":[8],"a":[10,18,40,90,173],"salutary":[11],"intersection":[12],"between":[13],"the":[14,23,35,77,103,116,123,134,162,177,209,224],"desire":[15],"prevent":[17,46],"major":[19],"health":[20],"problem":[21],"and":[22,45,64,115,142,199,205,217],"fundamental":[24],"study":[25],"of":[26,72,106,137,164,192,211,226],"membrane":[27,54],"protein":[28,80,125],"biology.":[29],"It":[30],"become":[32],"apparent":[33],"in":[34,74,122,150,194,208],"last":[36],"few":[37],"years":[38],"that":[39,119,132,167],"compelling":[41],"strategy":[42],"treat":[44,230],"AD":[47,75],"may":[48],"involve":[49],"understanding":[50],"how":[51],"certain":[52],"integral":[53],"proteins":[55,85,118],"undergo":[56],"unusual":[57],"proteolytic":[58,95],"cleavages":[59],"within":[60,97],"their":[61,98],"transmembrane":[62,100],"domains,":[63,101],"then":[65],"inhibiting":[66],"this":[67],"process":[68],"pharmacologically.":[69],"substrate":[71],"interest":[73],"is":[76,144,155,161,201],"\u03b2amyloid":[78],"precursor":[79],"(APP),":[81],"but":[82],"several":[83],"other":[84,182],"apparently":[86],"are":[87,219],"cleaved":[88],"by":[89],"highly":[91],"similar":[92],"or":[93],"identical":[94],"activity":[96],"respective":[99],"including":[102],"Notch":[104,141],"family":[105],"cell-surface":[107],"receptors":[108],"required":[109],"for":[110,223],"cell":[111],"fate":[112],"determination":[113],"(1)":[114],"Ire1":[117],"initiate":[120],"signaling":[121],"unfolded":[124],"response":[126],"pathway":[127],"(2).":[128],"unknown":[130],"protease":[131],"affects":[133],"intramembranous":[135],"cleavage":[136],"APP":[138,170],"(and":[139],"perhaps":[140],"Ire1)":[143],"referred":[145],"as":[147],"\u03b3-secretase":[148],"(reviewed":[149],"ref.":[151],"3).":[152],"Its":[153],"identity":[154],"being":[156],"actively":[157],"sought":[158],"because":[159],"it":[160],"second":[163],"two":[165],"proteases":[166],"sequentially":[168],"cleave":[169],"release":[172],"small":[174],"fragment":[175],"called":[176],"amyloid":[178],"\u03b2-protein":[179],"(A\u03b2).":[180],"[The":[181],"protease,":[183],"\u03b2-secretase,":[184],"recently":[185],"been":[187],"cloned":[188],"(4\u20138).]":[189],"Progressive":[190],"accumulation":[191],"A\u03b2":[193],"brain":[195],"regions":[196],"subserving":[197],"memory":[198],"cognition":[200],"an":[202],"early,":[203],"invariant,":[204],"necessary":[206],"step":[207],"pathogenesis":[210],"AD.":[212,231],"For":[213],"these":[214],"reasons,":[215],"\u03b2-":[216],"\u03b3-secretases":[218],"considered":[220],"important":[221],"targets":[222],"development":[225],"effective":[227],"therapeutics":[228]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
