{"id":"https://openalex.org/W2086678772","doi":"https://doi.org/10.1097/00000539-199807000-00036","title":"Tramadol Reduces the Sweating, Vasoconstriction, and Shivering Thresholds","display_name":"Tramadol Reduces the Sweating, Vasoconstriction, and Shivering Thresholds","publication_year":1998,"publication_date":"1998-07-01","ids":{"openalex":"https://openalex.org/W2086678772","doi":"https://doi.org/10.1097/00000539-199807000-00036","mag":"2086678772","pmid":"https://pubmed.ncbi.nlm.nih.gov/9661569"},"language":"en","primary_location":{"id":"doi:10.1097/00000539-199807000-00036","doi":"https://doi.org/10.1097/00000539-199807000-00036","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000539-199807000-00036","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013030217","display_name":"Jan L. De Witte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["AT","AU","US"],"is_corresponding":false,"raw_author_name":"Jan L. De Witte","raw_affiliation_strings":["Department of Anesthesia, University of California-San Francisco 94143-0648, USA","(Bjorksten) Department of Anaesthesia, Royal Melbourne Hospital, Parkville, Victoria, Australia","(De Witte, Kim, Sessler, Bastanmehr) Department of Anesthesia, University of California-San Francisco, San Francisco, California","(Sessler) Ludwig Boltzmann Institute for Clinical Anesthesia and Intensive Care and Outcomes Research[trade mark sign] Laboratory, Department of Anesthesia and General Intensive Care, University of Vienna, Vienna, Austria","Daniel I. Sessler, MD, Department of Anesthesia, University of California, San Francisco, CA 94143-0648. Address e-mail to [email\u00a0protected]","Major corporate funding for the Outcomes Research[trade mark sign] Laboratory is provided by Augustine Medical, Inc","Mallinckrodt Anesthesiology Products, Inc. (St. Louis, MO) donated the thermocouples we used","The authors do not consult for, accept honoraria from, or own stock or stock options in any anesthesia-related company"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, University of California-San Francisco 94143-0648, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"(Bjorksten) Department of Anaesthesia, Royal Melbourne Hospital, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"(De Witte, Kim, Sessler, Bastanmehr) Department of Anesthesia, University of California-San Francisco, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"(Sessler) Ludwig Boltzmann Institute for Clinical Anesthesia and Intensive Care and Outcomes Research[trade mark sign] Laboratory, Department of Anesthesia and General Intensive Care, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Daniel I. Sessler, MD, Department of Anesthesia, University of California, San Francisco, CA 94143-0648. Address e-mail to [email\u00a0protected]","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Major corporate funding for the Outcomes Research[trade mark sign] Laboratory is provided by Augustine Medical, Inc","institution_ids":[]},{"raw_affiliation_string":"Mallinckrodt Anesthesiology Products, Inc. (St. Louis, MO) donated the thermocouples we used","institution_ids":[]},{"raw_affiliation_string":"The authors do not consult for, accept honoraria from, or own stock or stock options in any anesthesia-related company","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100390262","display_name":"Jin Soo Kim","orcid":"https://orcid.org/0000-0002-3362-574X","observed_orcids":["https://orcid.org/0000-0002-3362-574X"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["AT","AU","US"],"is_corresponding":false,"raw_author_name":"Jin-Soo Kim","raw_affiliation_strings":["(Bjorksten) Department of Anaesthesia, Royal Melbourne Hospital, Parkville, Victoria, Australia","(De Witte, Kim, Sessler, Bastanmehr) Department of Anesthesia, University of California-San Francisco, San Francisco, California","(Sessler) Ludwig Boltzmann Institute for Clinical Anesthesia and Intensive Care and Outcomes Research[trade mark sign] Laboratory, Department of Anesthesia and General Intensive Care, University of Vienna, Vienna, Austria","Daniel I. Sessler, MD, Department of Anesthesia, University of California, San Francisco, CA 94143-0648. Address e-mail to [email\u00a0protected]","Major corporate funding for the Outcomes Research[trade mark sign] Laboratory is provided by Augustine Medical, Inc","Mallinckrodt Anesthesiology Products, Inc. (St. Louis, MO) donated the thermocouples we used","The authors do not consult for, accept honoraria from, or own stock or stock options in any anesthesia-related company"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Bjorksten) Department of Anaesthesia, Royal Melbourne Hospital, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"(De Witte, Kim, Sessler, Bastanmehr) Department of Anesthesia, University of California-San Francisco, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"(Sessler) Ludwig Boltzmann Institute for Clinical Anesthesia and Intensive Care and Outcomes Research[trade mark sign] Laboratory, Department of Anesthesia and General Intensive Care, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Daniel I. Sessler, MD, Department of Anesthesia, University of California, San Francisco, CA 94143-0648. Address e-mail to [email\u00a0protected]","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Major corporate funding for the Outcomes Research[trade mark sign] Laboratory is provided by Augustine Medical, Inc","institution_ids":[]},{"raw_affiliation_string":"Mallinckrodt Anesthesiology Products, Inc. (St. Louis, MO) donated the thermocouples we used","institution_ids":[]},{"raw_affiliation_string":"The authors do not consult for, accept honoraria from, or own stock or stock options in any anesthesia-related company","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042996287","display_name":"Daniel I. Sessler","orcid":"https://orcid.org/0000-0001-9932-3077","observed_orcids":["https://orcid.org/0000-0001-9932-3077"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["AT","AU","US"],"is_corresponding":true,"raw_author_name":"Daniel I. Sessler","raw_affiliation_strings":["(Bjorksten) Department of Anaesthesia, Royal Melbourne Hospital, Parkville, Victoria, Australia","(De Witte, Kim, Sessler, Bastanmehr) Department of Anesthesia, University of California-San Francisco, San Francisco, California","(Sessler) Ludwig Boltzmann Institute for Clinical Anesthesia and Intensive Care and Outcomes Research[trade mark sign] Laboratory, Department of Anesthesia and General Intensive Care, University of Vienna, Vienna, Austria","Daniel I. Sessler, MD, Department of Anesthesia, University of California, San Francisco, CA 94143-0648. Address e-mail to [email\u00a0protected]","Major corporate funding for the Outcomes Research[trade mark sign] Laboratory is provided by Augustine Medical, Inc","Mallinckrodt Anesthesiology Products, Inc. (St. Louis, MO) donated the thermocouples we used","The authors do not consult for, accept honoraria from, or own stock or stock options in any anesthesia-related company"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Bjorksten) Department of Anaesthesia, Royal Melbourne Hospital, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"(De Witte, Kim, Sessler, Bastanmehr) Department of Anesthesia, University of California-San Francisco, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"(Sessler) Ludwig Boltzmann Institute for Clinical Anesthesia and Intensive Care and Outcomes Research[trade mark sign] Laboratory, Department of Anesthesia and General Intensive Care, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Daniel I. Sessler, MD, Department of Anesthesia, University of California, San Francisco, CA 94143-0648. Address e-mail to [email\u00a0protected]","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Major corporate funding for the Outcomes Research[trade mark sign] Laboratory is provided by Augustine Medical, Inc","institution_ids":[]},{"raw_affiliation_string":"Mallinckrodt Anesthesiology Products, Inc. (St. Louis, MO) donated the thermocouples we used","institution_ids":[]},{"raw_affiliation_string":"The authors do not consult for, accept honoraria from, or own stock or stock options in any anesthesia-related company","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044377488","display_name":"Hiva Bastanmehr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["AT","AU","US"],"is_corresponding":false,"raw_author_name":"Hiva Bastanmehr","raw_affiliation_strings":["(Bjorksten) Department of Anaesthesia, Royal Melbourne Hospital, Parkville, Victoria, Australia","(De Witte, Kim, Sessler, Bastanmehr) Department of Anesthesia, University of California-San Francisco, San Francisco, California","(Sessler) Ludwig Boltzmann Institute for Clinical Anesthesia and Intensive Care and Outcomes Research[trade mark sign] Laboratory, Department of Anesthesia and General Intensive Care, University of Vienna, Vienna, Austria","Daniel I. Sessler, MD, Department of Anesthesia, University of California, San Francisco, CA 94143-0648. Address e-mail to [email\u00a0protected]","Major corporate funding for the Outcomes Research[trade mark sign] Laboratory is provided by Augustine Medical, Inc","Mallinckrodt Anesthesiology Products, Inc. (St. Louis, MO) donated the thermocouples we used","The authors do not consult for, accept honoraria from, or own stock or stock options in any anesthesia-related company"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Bjorksten) Department of Anaesthesia, Royal Melbourne Hospital, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"(De Witte, Kim, Sessler, Bastanmehr) Department of Anesthesia, University of California-San Francisco, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"(Sessler) Ludwig Boltzmann Institute for Clinical Anesthesia and Intensive Care and Outcomes Research[trade mark sign] Laboratory, Department of Anesthesia and General Intensive Care, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Daniel I. Sessler, MD, Department of Anesthesia, University of California, San Francisco, CA 94143-0648. Address e-mail to [email\u00a0protected]","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Major corporate funding for the Outcomes Research[trade mark sign] Laboratory is provided by Augustine Medical, Inc","institution_ids":[]},{"raw_affiliation_string":"Mallinckrodt Anesthesiology Products, Inc. (St. Louis, MO) donated the thermocouples we used","institution_ids":[]},{"raw_affiliation_string":"The authors do not consult for, accept honoraria from, or own stock or stock options in any anesthesia-related company","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108468010","display_name":"Andrew R. Bjorksten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["AT","AU","US"],"is_corresponding":false,"raw_author_name":"Andrew R. Bjorksten","raw_affiliation_strings":["(Bjorksten) Department of Anaesthesia, Royal Melbourne Hospital, Parkville, Victoria, Australia","(De Witte, Kim, Sessler, Bastanmehr) Department of Anesthesia, University of California-San Francisco, San Francisco, California","(Sessler) Ludwig Boltzmann Institute for Clinical Anesthesia and Intensive Care and Outcomes Research[trade mark sign] Laboratory, Department of Anesthesia and General Intensive Care, University of Vienna, Vienna, Austria","Daniel I. Sessler, MD, Department of Anesthesia, University of California, San Francisco, CA 94143-0648. Address e-mail to [email\u00a0protected]","Major corporate funding for the Outcomes Research[trade mark sign] Laboratory is provided by Augustine Medical, Inc","Mallinckrodt Anesthesiology Products, Inc. (St. Louis, MO) donated the thermocouples we used","The authors do not consult for, accept honoraria from, or own stock or stock options in any anesthesia-related company"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Bjorksten) Department of Anaesthesia, Royal Melbourne Hospital, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"(De Witte, Kim, Sessler, Bastanmehr) Department of Anesthesia, University of California-San Francisco, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"(Sessler) Ludwig Boltzmann Institute for Clinical Anesthesia and Intensive Care and Outcomes Research[trade mark sign] Laboratory, Department of Anesthesia and General Intensive Care, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Daniel I. Sessler, MD, Department of Anesthesia, University of California, San Francisco, CA 94143-0648. Address e-mail to [email\u00a0protected]","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Major corporate funding for the Outcomes Research[trade mark sign] Laboratory is provided by Augustine Medical, Inc","institution_ids":[]},{"raw_affiliation_string":"Mallinckrodt Anesthesiology Products, Inc. (St. Louis, MO) donated the thermocouples we used","institution_ids":[]},{"raw_affiliation_string":"The authors do not consult for, accept honoraria from, or own stock or stock options in any anesthesia-related company","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5042996287"],"corresponding_institution_ids":["https://openalex.org/I129774422","https://openalex.org/I1320473756","https://openalex.org/I180670191"],"apc_list":null,"apc_paid":null,"fwci":3.0728,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.91409631,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"87","issue":"1","first_page":"173","last_page":"179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.10779999941587448,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tramadol","display_name":"tramadol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thermoregulation","display_name":"thermoregulation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/sweating-threshold","display_name":"sweating threshold","score":0.8180000185966492},{"id":"https://openalex.org/keywords/shivering-threshold","display_name":"shivering threshold","score":0.9929999709129333},{"id":"https://openalex.org/keywords/naloxone","display_name":"naloxone","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.8309999704360962},{"id":"https://openalex.org/keywords/norepinephrine-uptake","display_name":"norepinephrine uptake","score":0.8529999852180481},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.5329999923706055},{"id":"https://openalex.org/keywords/hypothermia","display_name":"hypothermia","score":0.7149999737739563},{"id":"https://openalex.org/keywords/fever","display_name":"fever","score":0.9430000185966492},{"id":"https://openalex.org/keywords/analgesic-adverse-effects","display_name":"analgesic side effects","score":0.6309999823570251},{"id":"https://openalex.org/keywords/skin-temperature","display_name":"skin temperature","score":0.5889999866485596},{"id":"https://openalex.org/keywords/core-body-temperature","display_name":"core body temperature","score":0.9409999847412109}],"concepts":[{"id":"https://openalex.org/C2779777798","wikidata":"https://www.wikidata.org/wiki/Q407592","display_name":"Tramadol","level":3,"score":0.9612109661102295},{"id":"https://openalex.org/C2781258859","wikidata":"https://www.wikidata.org/wiki/Q1060890","display_name":"Shivering","level":2,"score":0.8626962900161743},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.7592339515686035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7042551040649414},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.6734815835952759},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6725279092788696},{"id":"https://openalex.org/C100564792","wikidata":"https://www.wikidata.org/wiki/Q190259","display_name":"Thermoregulation","level":2,"score":0.5022027492523193},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.3819345235824585},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.3674886226654053},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30118757486343384},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06280356645584106}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009292","descriptor_name":"Narcotic Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011957","descriptor_name":"Receptors, Opioid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011957","descriptor_name":"Receptors, Opioid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012684","descriptor_name":"Sensory Thresholds","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012768","descriptor_name":"Shivering","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013546","descriptor_name":"Sweating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/00000539-199807000-00036","doi":"https://doi.org/10.1097/00000539-199807000-00036","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000539-199807000-00036","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},{"id":"doi:10.1213/00000539-199807000-00036","doi":"https://doi.org/10.1213/00000539-199807000-00036","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-199807000-00036","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},{"id":"pmid:9661569","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9661569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G322282307","display_name":"PERIANESTHETIC THERMOREGULATION AND HEAT BALANCE","funder_award_id":"R01GM049670","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W49271446","https://openalex.org/W136788106","https://openalex.org/W1495713016","https://openalex.org/W1749436095","https://openalex.org/W1782095941","https://openalex.org/W1968960226","https://openalex.org/W1969296208","https://openalex.org/W1971352655","https://openalex.org/W1975303253","https://openalex.org/W1985697512","https://openalex.org/W1993251735","https://openalex.org/W1994367077","https://openalex.org/W1999450232","https://openalex.org/W2003431622","https://openalex.org/W2014489798","https://openalex.org/W2025203122","https://openalex.org/W2039702370","https://openalex.org/W2039979982","https://openalex.org/W2041320351","https://openalex.org/W2044558604","https://openalex.org/W2060795452","https://openalex.org/W2077083535","https://openalex.org/W2080425581","https://openalex.org/W2085479803","https://openalex.org/W2088753465","https://openalex.org/W2094565333","https://openalex.org/W2102869868","https://openalex.org/W2110193433","https://openalex.org/W2114840163","https://openalex.org/W2155102101","https://openalex.org/W2173037079","https://openalex.org/W2190494528","https://openalex.org/W2337702294","https://openalex.org/W2405887519","https://openalex.org/W4406969490","https://openalex.org/W6687387438"],"related_works":["https://openalex.org/W1525626036","https://openalex.org/W2039979982","https://openalex.org/W2043979256","https://openalex.org/W2003431622","https://openalex.org/W2080425581","https://openalex.org/W1969296208","https://openalex.org/W4205130355","https://openalex.org/W1514105100","https://openalex.org/W2163076934","https://openalex.org/W2153117055"],"abstract_inverted_index":{"UNLABELLED:":[0],"The":[1,86,145,174,186,259],"analgesic":[2,266],"tramadol":[3,35,53,56,60,170,190,229,244,267],"inhibits":[4,36],"the":[5,32,97,115,131,166,181,202,217,232,247,256,262,265,269],"neuronal":[6],"reuptake":[7],"of":[8,20,168,176,184,189,195,225,249,264],"norepinephrine":[9],"and":[10,15,59,67,77,82,130,276],"5-hydroxytryptamine,":[11],"facilitates":[12],"5-hydroxytryptamine":[13],"release,":[14],"activates":[16],"mu-opioid":[17],"receptors.":[18],"Each":[19],"these":[21],"actions":[22],"is":[23,286],"likely":[24],"to":[25,147,159,254,289,293],"influence":[26],"thermoregulatory":[27,37,182,187,209,226,250,272,282],"control.":[28,38,227],"We":[29],"therefore":[30],"tested":[31],"hypothesis":[33],"that":[34,199,243],"Eight":[39],"volunteers":[40],"were":[41,70,84],"evaluated":[42,261],"on":[43,47,268],"four":[44],"study":[45],"days,":[46],"which":[48],"they":[49],"received":[50],"no":[51],"drugs,":[52],"125":[54],"mg,":[55,58],"250":[57,61],"mg":[62],"with":[63],"naloxone,":[64],"respectively.":[65],"Skin":[66],"core":[68,87],"temperatures":[69],"gradually":[71],"increased":[72],"until":[73,80],"sweating":[74,98,146],"was":[75],"observed":[76],"then":[78],"decreased":[79,96,114],"vasoconstriction":[81,116,148],"shivering":[83,132],"detected.":[85],"temperature":[88],"triggering":[89,204],"each":[90],"response":[91],"defined":[92],"its":[93],"threshold.":[94],"Tramadol":[95,112,278],"threshold":[99,117,133],"by":[100,118,134],"-1.03":[101],"+/-":[102,110,120,128,136,143,155,161],"0.67":[103],"degrees":[104,122,138],"C":[105,123,139,158,164],"microgram-1.mL":[106,124],"(r2":[107,125],"=":[108,126,141,172],"0.90":[109],"0.12).":[111],"also":[113],"-3.0":[119],"4.0":[121,137],"0.94":[127],"0.98)":[129],"-4.2":[135],"microgram-1.mL(r2":[140],"0.98":[142],"0.98).":[144],"interthreshold":[149,233],"range":[150,234],"nearly":[151,230],"doubled":[152,231],"from":[153],"0.3":[154],"0.4":[156],"degree":[157,163],"0.7":[160],"0.6":[162],"during":[165],"administration":[167],"large-dose":[169],"(P":[171],"0.04).":[173],"addition":[175,253],"naloxone":[177],"only":[178,280],"partially":[179],"reversed":[180],"effects":[183,188,263],"tramadol.":[185],"thus":[191,287],"most":[192],"resemble":[193],"those":[194],"midazolam,":[196],"another":[197],"drug":[198],"slightly":[200,245],"decreases":[201,246],"thresholds":[203],"all":[205],"three":[206,270],"major":[207,271],"autonomic":[208],"defenses.":[210],"In":[211],"this":[212],"respect,":[213],"both":[214],"drugs":[215],"reduce":[216],"\"setpoint\"":[218],"rather":[219],"than":[220],"produce":[221],"a":[222,236],"generalized":[223],"impairment":[224],"Nonetheless,":[228],"at":[235],"concentration":[237],"near":[238],"200":[239],"ng/mL.":[240],"This":[241],"indicates":[242],"precision":[248],"control":[251],"in":[252],"reducing":[255],"setpoint.":[257],"IMPLICATIONS:":[258],"authors":[260],"responses:":[273],"sweating,":[274],"vasoconstriction,":[275],"shivering.":[277],"had":[279],"slight":[281],"effects.":[283],"Its":[284],"use":[285],"unlikely":[288],"provoke":[290],"hypothermia":[291],"or":[292],"facilitate":[294],"fever.":[295]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
