{"id":"https://openalex.org/W2086604757","doi":"https://doi.org/10.1161/01.atv.15.8.1161","title":"Mibefradil Prevents Neointima Formation After Vascular Injury in Rats","display_name":"Mibefradil Prevents Neointima Formation After Vascular Injury in Rats","publication_year":1995,"publication_date":"1995-08-01","ids":{"openalex":"https://openalex.org/W2086604757","doi":"https://doi.org/10.1161/01.atv.15.8.1161","mag":"2086604757","pmid":"https://pubmed.ncbi.nlm.nih.gov/7627710"},"language":"en","primary_location":{"id":"doi:10.1161/01.atv.15.8.1161","doi":"https://doi.org/10.1161/01.atv.15.8.1161","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.atv.15.8.1161","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048110759","display_name":"R Schmitt","orcid":"https://orcid.org/0009-0000-7419-7633","observed_orcids":["https://orcid.org/0009-0000-7419-7633"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"R. Schmitt","raw_affiliation_strings":["From the Pharma Division, Preclinical Research, Clinical Research and Development (R.S., F.R.B.), F. Hoffmann\u2013La Roche Ltd, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Pharma Division, Preclinical Research, Clinical Research and Development (R.S., F.R.B.), F. Hoffmann\u2013La Roche Ltd, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113773460","display_name":"Jean\u2010Paul Clozel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J.-P. Clozel","raw_affiliation_strings":["From the Pharma Division, Preclinical Research, Clinical Research and Development (R.S., F.R.B.), F. Hoffmann\u2013La Roche Ltd, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Pharma Division, Preclinical Research, Clinical Research and Development (R.S., F.R.B.), F. Hoffmann\u2013La Roche Ltd, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016179025","display_name":"Niggi Iberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"N. Iberg","raw_affiliation_strings":["From the Pharma Division, Preclinical Research, Clinical Research and Development (R.S., F.R.B.), F. Hoffmann\u2013La Roche Ltd, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Pharma Division, Preclinical Research, Clinical Research and Development (R.S., F.R.B.), F. Hoffmann\u2013La Roche Ltd, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109938371","display_name":"Fritz Rolf B\u00fchler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"F. R. Bu\u0308hler","raw_affiliation_strings":["From the Pharma Division, Preclinical Research, Clinical Research and Development (R.S., F.R.B.), F. Hoffmann\u2013La Roche Ltd, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Pharma Division, Preclinical Research, Clinical Research and Development (R.S., F.R.B.), F. Hoffmann\u2013La Roche Ltd, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I118019719"],"apc_list":null,"apc_paid":null,"fwci":3.6312,"has_fulltext":false,"cited_by_count":115,"citation_normalized_percentile":{"value":0.94446251,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"15","issue":"8","first_page":"1161","last_page":"1165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.03359999880194664,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mibefradil","display_name":"mibefradil","score":1.0},{"id":"https://openalex.org/keywords/neointima-formation","display_name":"neointima formation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/vascular-injury","display_name":"vascular injury","score":0.9259999990463257},{"id":"https://openalex.org/keywords/t-type-calcium-channels","display_name":"T-type calcium channels","score":0.8809999823570251},{"id":"https://openalex.org/keywords/l-type-calcium-channel-blockade","display_name":"L-type calcium channel blockade","score":0.6970000267028809},{"id":"https://openalex.org/keywords/smooth-muscle-cell-proliferation","display_name":"smooth muscle cell proliferation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/amlodipine","display_name":"amlodipine","score":0.8209999799728394},{"id":"https://openalex.org/keywords/verapamil","display_name":"verapamil","score":1.0},{"id":"https://openalex.org/keywords/balloon-injury","display_name":"balloon injury","score":0.8109999895095825},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8009999990463257},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2778673320","wikidata":"https://www.wikidata.org/wiki/Q6827783","display_name":"Mibefradil","level":4,"score":0.9962998628616333},{"id":"https://openalex.org/C2777339539","wikidata":"https://www.wikidata.org/wiki/Q6993039","display_name":"Neointima","level":4,"score":0.831795871257782},{"id":"https://openalex.org/C2777022698","wikidata":"https://www.wikidata.org/wiki/Q410291","display_name":"Verapamil","level":3,"score":0.7566839456558228},{"id":"https://openalex.org/C30979828","wikidata":"https://www.wikidata.org/wiki/Q2487620","display_name":"T-type calcium channel","level":4,"score":0.7200009822845459},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.677558183670044},{"id":"https://openalex.org/C117499352","wikidata":"https://www.wikidata.org/wiki/Q2600696","display_name":"L-type calcium channel","level":4,"score":0.5989526510238647},{"id":"https://openalex.org/C2779646130","wikidata":"https://www.wikidata.org/wiki/Q411347","display_name":"Amlodipine","level":3,"score":0.5738973617553711},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5676183104515076},{"id":"https://openalex.org/C18699975","wikidata":"https://www.wikidata.org/wiki/Q14905735","display_name":"Voltage-dependent calcium channel","level":3,"score":0.5313140749931335},{"id":"https://openalex.org/C85520022","wikidata":"https://www.wikidata.org/wiki/Q15322916","display_name":"Calcium channel","level":3,"score":0.5161803364753723},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5070629119873047},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.49550187587738037},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4895380437374115},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4178903102874756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2861897349357605},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.13381025195121765},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.09141352772712708},{"id":"https://openalex.org/C2778583881","wikidata":"https://www.wikidata.org/wiki/Q1325542","display_name":"Stent","level":2,"score":0.0},{"id":"https://openalex.org/C2778283817","wikidata":"https://www.wikidata.org/wiki/Q6590597","display_name":"Restenosis","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013764","descriptor_name":"Tetrahydronaphthalenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014700","descriptor_name":"Verapamil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017311","descriptor_name":"Amlodipine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017539","descriptor_name":"Tunica Intima","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017539","descriptor_name":"Tunica Intima","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020212","descriptor_name":"Carotid Artery Injuries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020748","descriptor_name":"Mibefradil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.atv.15.8.1161","doi":"https://doi.org/10.1161/01.atv.15.8.1161","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.atv.15.8.1161","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},{"id":"pmid:7627710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7627710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, thrombosis, and vascular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W95791577","https://openalex.org/W153662504","https://openalex.org/W1815855529","https://openalex.org/W1968598458","https://openalex.org/W1971836552","https://openalex.org/W1980794949","https://openalex.org/W1987416588","https://openalex.org/W1989810511","https://openalex.org/W2000023960","https://openalex.org/W2034877370","https://openalex.org/W2042789806","https://openalex.org/W2045673068","https://openalex.org/W2046725590","https://openalex.org/W2058749515","https://openalex.org/W2068617048","https://openalex.org/W2083681760","https://openalex.org/W2084951845","https://openalex.org/W2087375731","https://openalex.org/W2092643356","https://openalex.org/W2103819453","https://openalex.org/W2118309627","https://openalex.org/W2126757874","https://openalex.org/W2165627388","https://openalex.org/W2170364275","https://openalex.org/W2397462681","https://openalex.org/W2406065508","https://openalex.org/W2412427424","https://openalex.org/W2415053638","https://openalex.org/W2416895886"],"related_works":["https://openalex.org/W2022766670","https://openalex.org/W1556374401","https://openalex.org/W1986498390","https://openalex.org/W2194251361","https://openalex.org/W2144573443","https://openalex.org/W2886113429","https://openalex.org/W2048922444","https://openalex.org/W2078659551","https://openalex.org/W2115883993","https://openalex.org/W2033601338"],"abstract_inverted_index":{"Mibefradil":[0,114],"is":[1,7],"a":[2,143,208],"novel":[3],"calcium":[4,13,22,36],"antagonist":[5],"that":[6,49,63,151,203],"selective":[8],"for":[9],"the":[10,17,32,50,57,79,118],"T-type":[11,21,88],"voltage-operated":[12,227],"channel":[14],"rather":[15],"than":[16],"L":[18],"type.":[19],"Because":[20],"channels":[23,54],"are":[24],"present":[25],"on":[26,90,212],"rapidly":[27],"proliferating":[28],"cells":[29,188,215],"and":[30,87,96,107],"mediate":[31],"increase":[33],"of":[34,52,81,102,105,120,152,158,164,178,226],"intracellular":[35],"induced":[37],"by":[38,128,171,190],"some":[39],"growth":[40,45],"factors,":[41],"such":[42,67],"as":[43,68,169],"platelet-derived":[44],"factor,":[46],"we":[47,75,97],"hypothesized":[48],"blockade":[51,225],"T":[53,228],"could":[55],"prevent":[56],"excessive":[58],"smooth":[59,165,186,213],"muscle":[60,166,187,214],"cell":[61,167],"proliferation":[62],"occurs":[64],"in":[65,77,155,183,185,204],"conditions":[66],"vascular":[69,94,217],"injury.":[70,218],"To":[71],"test":[72],"this":[73,195],"hypothesis,":[74],"evaluated":[76],"rats":[78,205],"effects":[80],"mibefradil":[82,159,179,206],"(which":[83,109],"blocks":[84],"both":[85],"L-":[86],"channels)":[89],"neointima":[91,121],"formation":[92],"after":[93,125,216],"injury,":[95],"compared":[98],"them":[99],"with":[100],"those":[101],"equihypotensive":[103],"doses":[104],"amlodipine":[106,138],"verapamil":[108,136,198],"block":[110],"only":[111],"L-type":[112],"channels).":[113],"(30":[115],"mg/kg)":[116],"decreased":[117],"area":[119],"formed":[122],"14":[123],"days":[124],"balloon":[126],"injury":[127],"54%":[129],"(P":[130],"<":[131],".001).":[132],"In":[133,194],"contrast,":[134],"neither":[135],"nor":[137],"had":[139],"an":[140,162],"effect":[141,157,177,211,220],"despite":[142],"blood":[144],"pressure":[145],"reduction":[146],"at":[147],"least":[148],"equal":[149],"to":[150,224],"mibefradil.":[153],"The":[154],"vivo":[156],"was":[160,180,199],"indeed":[161],"inhibition":[163],"proliferation,":[168],"shown":[170],"thymidine":[172],"incorporation":[173],"experiments.":[174],"This":[175,219],"antiproliferative":[176,210],"also":[181],"observed":[182],"vitro":[184],"stimulated":[189],"fetal":[191],"calf":[192],"serum.":[193],"condition":[196],"also,":[197],"ineffective.":[200],"We":[201],"conclude":[202],"has":[207],"potent":[209],"might":[221],"be":[222],"due":[223],"channels.":[229]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}