{"id":"https://openalex.org/W2086575286","doi":"https://doi.org/10.4161/fly.25438","title":"A method for reversible drug delivery to internal tissues of Drosophila embryos","display_name":"A method for reversible drug delivery to internal tissues of Drosophila embryos","publication_year":2013,"publication_date":"2013-07-21","ids":{"openalex":"https://openalex.org/W2086575286","doi":"https://doi.org/10.4161/fly.25438","mag":"2086575286","pmid":"https://pubmed.ncbi.nlm.nih.gov/23846179","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4049853"},"language":"en","primary_location":{"id":"doi:10.4161/fly.25438","doi":"https://doi.org/10.4161/fly.25438","is_oa":true,"landing_page_url":"https://doi.org/10.4161/fly.25438","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/fly.25438?needAccess=true&role=button","source":{"id":"https://openalex.org/S36681318","display_name":"Fly","issn_l":"1933-6934","issn":["1933-6934","1933-6942"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fly","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/fly.25438?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035752051","display_name":"Victoria K. Schulman","orcid":"https://orcid.org/0000-0001-6134-9212","observed_orcids":["https://orcid.org/0000-0001-6134-9212"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria K Schulman","raw_affiliation_strings":["Program in Developmental Biology; Sloan Kettering Institute; Memorial Sloan-Kettering Cancer Center; New York, NY USA; Department of Cell and Developmental Biology; Weill Cornell Graduate School of Medical Sciences; Cornell University; New York, NY USA","Cornell University","Department of Cell and Developmental Biology","Memorial Sloan-Kettering Cancer Center","New York, NY USA","Program in Developmental Biology","Sloan Kettering Institute","Weill Cornell Graduate School of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Developmental Biology; Sloan Kettering Institute; Memorial Sloan-Kettering Cancer Center; New York, NY USA; Department of Cell and Developmental Biology; Weill Cornell Graduate School of Medical Sciences; Cornell University; New York, NY USA","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295"]},{"raw_affiliation_string":"Cornell University","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Cell and Developmental Biology","institution_ids":[]},{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"New York, NY USA","institution_ids":[]},{"raw_affiliation_string":"Program in Developmental Biology","institution_ids":[]},{"raw_affiliation_string":"Sloan Kettering Institute","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Weill Cornell Graduate School of Medical Sciences","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059928223","display_name":"Eric S. Folker","orcid":"https://orcid.org/0000-0003-1619-7330","observed_orcids":["https://orcid.org/0000-0003-1619-7330"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric S Folker","raw_affiliation_strings":["Program in Developmental Biology; Sloan Kettering Institute; Memorial Sloan-Kettering Cancer Center; New York, NY USA","Memorial Sloan-Kettering Cancer Center","New York, NY USA","Program in Developmental Biology","Sloan Kettering Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Developmental Biology; Sloan Kettering Institute; Memorial Sloan-Kettering Cancer Center; New York, NY USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"New York, NY USA","institution_ids":[]},{"raw_affiliation_string":"Program in Developmental Biology","institution_ids":[]},{"raw_affiliation_string":"Sloan Kettering Institute","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079860834","display_name":"Mary K. Baylies","orcid":"https://orcid.org/0000-0002-1626-8138","observed_orcids":["https://orcid.org/0000-0002-1626-8138"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mary K Baylies","raw_affiliation_strings":["Program in Developmental Biology; Sloan Kettering Institute; Memorial Sloan-Kettering Cancer Center; New York, NY USA; Department of Cell and Developmental Biology; Weill Cornell Graduate School of Medical Sciences; Cornell University; New York, NY USA","Cornell University","Department of Cell and Developmental Biology","Memorial Sloan-Kettering Cancer Center","New York, NY USA","Program in Developmental Biology","Sloan Kettering Institute","Weill Cornell Graduate School of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Developmental Biology; Sloan Kettering Institute; Memorial Sloan-Kettering Cancer Center; New York, NY USA; Department of Cell and Developmental Biology; Weill Cornell Graduate School of Medical Sciences; Cornell University; New York, NY USA","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295"]},{"raw_affiliation_string":"Cornell University","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Cell and Developmental Biology","institution_ids":[]},{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"New York, NY USA","institution_ids":[]},{"raw_affiliation_string":"Program in Developmental Biology","institution_ids":[]},{"raw_affiliation_string":"Sloan Kettering Institute","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Weill Cornell Graduate School of Medical Sciences","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079860834"],"corresponding_institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295","https://openalex.org/I4387153466"],"apc_list":{"value":1860,"currency":"USD","value_usd":1860},"apc_paid":null,"fwci":1.194,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.78136697,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"7","issue":"3","first_page":"193","last_page":"203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.6079000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.6079000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.1542000025510788,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.09350000321865082,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drosophila-melanogaster-embryo","display_name":"Drosophila melanogaster embryo","score":0.8690000176429749},{"id":"https://openalex.org/keywords/nocodazole","display_name":"nocodazole","score":0.9739999771118164},{"id":"https://openalex.org/keywords/microtubule-depolymerization","display_name":"microtubule depolymerization","score":0.9769999980926514},{"id":"https://openalex.org/keywords/microtubule-reassembly","display_name":"microtubule reassembly","score":0.871999979019165},{"id":"https://openalex.org/keywords/muscle-cells","display_name":"muscle cells","score":0.5429999828338623},{"id":"https://openalex.org/keywords/embryonic-lethality","display_name":"embryonic lethality","score":0.6919999718666077},{"id":"https://openalex.org/keywords/embryo-viability","display_name":"embryo viability","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2779363559","wikidata":"https://www.wikidata.org/wiki/Q2506092","display_name":"Nocodazole","level":4,"score":0.9106998443603516},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.7689725160598755},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.750061571598053},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7243791222572327},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7051637768745422},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.689312756061554},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.5441468954086304},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.5227420330047607},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.522443950176239},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.521121084690094},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.48223385214805603},{"id":"https://openalex.org/C167290458","wikidata":"https://www.wikidata.org/wiki/Q2035755","display_name":"Drosophila embryogenesis","level":4,"score":0.4788391590118408},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.401555597782135},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39670228958129883},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2996845245361328},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2911713719367981},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.10405763983726501}],"mesh":[{"descriptor_ui":"D000077222","descriptor_name":"Limonene","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006536","descriptor_name":"Heptanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015739","descriptor_name":"Nocodazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053138","descriptor_name":"Cyclohexenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.4161/fly.25438","doi":"https://doi.org/10.4161/fly.25438","is_oa":true,"landing_page_url":"https://doi.org/10.4161/fly.25438","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/fly.25438?needAccess=true&role=button","source":{"id":"https://openalex.org/S36681318","display_name":"Fly","issn_l":"1933-6934","issn":["1933-6934","1933-6942"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fly","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4049853","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4049853","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fly (Austin)","raw_type":"Text"},{"id":"pmid:23846179","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23846179","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fly","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/fly.25438","doi":"https://doi.org/10.4161/fly.25438","is_oa":true,"landing_page_url":"https://doi.org/10.4161/fly.25438","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/fly.25438?needAccess=true&role=button","source":{"id":"https://openalex.org/S36681318","display_name":"Fly","issn_l":"1933-6934","issn":["1933-6934","1933-6942"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fly","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4578961807","display_name":"Mechanisms Regulating Myoblast Fusion in Drosophila","funder_award_id":"R01GM078318","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2086575286.pdf","grobid_xml":"https://content.openalex.org/works/W2086575286.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W147530323","https://openalex.org/W1524737218","https://openalex.org/W1602794655","https://openalex.org/W1947528035","https://openalex.org/W1978705545","https://openalex.org/W1980317616","https://openalex.org/W1987084599","https://openalex.org/W1989705574","https://openalex.org/W2005104689","https://openalex.org/W2012678565","https://openalex.org/W2018365347","https://openalex.org/W2026243014","https://openalex.org/W2030747779","https://openalex.org/W2036040848","https://openalex.org/W2036065234","https://openalex.org/W2036319656","https://openalex.org/W2041330970","https://openalex.org/W2041546356","https://openalex.org/W2051719835","https://openalex.org/W2068231674","https://openalex.org/W2075772461","https://openalex.org/W2080393723","https://openalex.org/W2082451032","https://openalex.org/W2084093855","https://openalex.org/W2109897768","https://openalex.org/W2110643873","https://openalex.org/W2115657143","https://openalex.org/W2150972545","https://openalex.org/W2152844024","https://openalex.org/W2168614708"],"related_works":["https://openalex.org/W2039473312","https://openalex.org/W2052590326","https://openalex.org/W3006597756","https://openalex.org/W2084093855","https://openalex.org/W1999181914","https://openalex.org/W2051719835","https://openalex.org/W4230995554","https://openalex.org/W2006622726","https://openalex.org/W2009601662","https://openalex.org/W2335542123"],"abstract_inverted_index":{"Drosophila":[0,74],"melanogaster":[1],"is":[2,39,135],"a":[3,62,77,169],"powerful":[4],"model":[5],"organism":[6],"to":[7,41,64,68,91,128,171,191],"elucidate":[8],"basic":[9],"cellular":[10],"mechanisms":[11],"of":[12,16,19,45,71,80,87,110,140,145,194],"development.":[13],"Indeed,":[14],"much":[15],"our":[17],"understanding":[18],"genetic":[20,186],"pathways":[21],"comes":[22],"from":[23],"work":[24],"in":[25,29,100,104,165,175],"Drosophila.":[26],"However,":[27],"mutations":[28],"many":[30],"critical":[31],"genes":[32],"cause":[33],"early":[34,51],"embryonic":[35,56],"lethality;":[36],"thus,":[37],"it":[38],"difficult":[40],"study":[42,193],"the":[43,97,111,115,125,138,182,192],"role":[44],"proteins":[46],"that":[47,132,144],"are":[48],"required":[49],"for":[50,119,124],"fundamental":[52],"processes":[53],"during":[54],"later":[55],"stages.":[57],"We":[58],"have":[59],"therefore":[60],"developed":[61],"method":[63],"reversibly":[65],"deliver":[66],"drugs":[67],"internal":[69],"tissues":[70],"stage":[72],"15-16":[73],"embryos":[75,142],"using":[76],"1:1":[78],"combination":[79],"D-limonene":[81],"and":[82,117,148],"heptane":[83],"(LH).":[84],"Specifically,":[85],"delivery":[86,134],"Nocodazole":[88,116],"was":[89,122,154],"shown":[90],"be":[92,129],"effective":[93],"as":[94,188],"evidenced":[95],"by":[96],"significant":[98],"decrease":[99],"microtubule":[101,112,126],"density":[102],"seen":[103],"muscle":[105],"cells.":[106],"Following":[107],"complete":[108],"depolymerization":[109],"cytoskeleton,":[113],"removing":[114],"washing":[118],"10":[120],"min":[121],"sufficient":[123],"network":[127],"re-established,":[130],"indicating":[131],"drug":[133],"reversible.":[136],"Additionally,":[137],"morphology":[139],"LH-treated":[141],"resembled":[143],"untreated":[146],"controls,":[147],"embryo":[149,166],"viability":[150],"post-treatment":[151],"with":[152,158,177,185],"LH":[153],"significantly":[155],"increased":[156],"compared":[157],"previously":[159],"reported":[160],"permeabilization":[161,167],"techniques.":[162],"These":[163],"advances":[164],"provide":[168],"means":[170],"disrupt":[172],"protein":[173],"function":[174],"vivo":[176],"high":[178],"temporally":[179],"specificity,":[180],"bypassing":[181],"complications":[183],"associated":[184],"disruptions":[187],"they":[189],"relate":[190],"late-stage":[195],"developmental":[196],"mechanisms.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}