{"id":"https://openalex.org/W2086563965","doi":"https://doi.org/10.1097/01.bcr.0000216512.30415.78","title":"Closed-Loop Resuscitation of Burn Shock","display_name":"Closed-Loop Resuscitation of Burn Shock","publication_year":2006,"publication_date":"2006-05-01","ids":{"openalex":"https://openalex.org/W2086563965","doi":"https://doi.org/10.1097/01.bcr.0000216512.30415.78","mag":"2086563965","pmid":"https://pubmed.ncbi.nlm.nih.gov/16679909"},"language":"en","primary_location":{"id":"doi:10.1097/01.bcr.0000216512.30415.78","doi":"https://doi.org/10.1097/01.bcr.0000216512.30415.78","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.bcr.0000216512.30415.78","pdf_url":null,"source":{"id":"https://openalex.org/S57131103","display_name":"Journal of Burn Care & Research","issn_l":"1559-047X","issn":["1559-047X","1559-0488"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Burn Care & Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014109992","display_name":"Stephen L. Hoskins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen L. Hoskins","raw_affiliation_strings":["Resuscitation Research Laboratory, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555-0801, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Resuscitation Research Laboratory, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555-0801, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000214423","display_name":"Geir Ivar Elgjo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geir Ivar Elgjo","raw_affiliation_strings":["Resuscitation Research Laboratory, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas","University of Texas Medical Branch at Galveston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Resuscitation Research Laboratory, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"University of Texas Medical Branch at Galveston","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020566809","display_name":"Jialung Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jialung Lu","raw_affiliation_strings":["Resuscitation Research Laboratory, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas","University of Texas Medical Branch at Galveston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Resuscitation Research Laboratory, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"University of Texas Medical Branch at Galveston","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082640513","display_name":"Hao Ying","orcid":"https://orcid.org/0000-0002-4891-6785","observed_orcids":["https://orcid.org/0000-0002-4891-6785"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Ying","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Wayne State University, Detroit, Michigan","Wayne State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Wayne State University, Detroit, Michigan","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Wayne State University","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084984818","display_name":"James J. Grady","orcid":"https://orcid.org/0000-0003-4783-5964","observed_orcids":["https://orcid.org/0000-0003-4783-5964"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James J. Grady","raw_affiliation_strings":["Resuscitation Research Laboratory, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas","University of Texas Medical Branch at Galveston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Resuscitation Research Laboratory, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"University of Texas Medical Branch at Galveston","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014429489","display_name":"David Newcomb Herndon","orcid":"https://orcid.org/0000-0002-3861-6463","observed_orcids":["https://orcid.org/0000-0002-3861-6463","https://orcid.org/0000-0003-0396-9442"]},"institutions":[{"id":"https://openalex.org/I2801713311","display_name":"Shriners Hospitals for Children - Galveston","ror":"https://ror.org/01v95tx09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801713311","https://openalex.org/I4210144267"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David N. Herndon","raw_affiliation_strings":["Shriners Burns Hospital, Galveston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shriners Burns Hospital, Galveston, Texas","institution_ids":["https://openalex.org/I2801713311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054232363","display_name":"George C. Kramer","orcid":"https://orcid.org/0000-0001-6146-2944","observed_orcids":["https://orcid.org/0000-0001-6146-2944"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"George C. Kramer","raw_affiliation_strings":["Resuscitation Research Laboratory, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Resuscitation Research Laboratory, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054232363"],"corresponding_institution_ids":["https://openalex.org/I55302922"],"apc_list":{"value":3698,"currency":"USD","value_usd":3698},"apc_paid":null,"fwci":5.8051,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.95893753,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"27","issue":"3","first_page":"377","last_page":"385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14189","display_name":"Intravenous Infusion Technology and Safety","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/burn-shock","display_name":"burn shock","score":0.9139999747276306},{"id":"https://openalex.org/keywords/fluid-resuscitation","display_name":"fluid resuscitation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/feedback-control","display_name":"feedback control","score":0.843999981880188},{"id":"https://openalex.org/keywords/urine-output","display_name":"urine output","score":0.8299999833106995},{"id":"https://openalex.org/keywords/infusion-rate","display_name":"infusion rate","score":0.5419999957084656},{"id":"https://openalex.org/keywords/sheep-model","display_name":"sheep model","score":0.7239999771118164},{"id":"https://openalex.org/keywords/full-thickness-burns","display_name":"third-degree burns","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.637503445148468},{"id":"https://openalex.org/C67101536","wikidata":"https://www.wikidata.org/wiki/Q5535910","display_name":"George (robot)","level":2,"score":0.6341084241867065},{"id":"https://openalex.org/C2779526319","wikidata":"https://www.wikidata.org/wiki/Q615057","display_name":"Anesthesiology","level":2,"score":0.5017423629760742},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.45277953147888184},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.4181225597858429},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.35410648584365845},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.25660526752471924},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.16195985674858093},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.13098028302192688},{"id":"https://openalex.org/C52119013","wikidata":"https://www.wikidata.org/wiki/Q50637","display_name":"Art history","level":1,"score":0.09627196192741394},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002056","descriptor_name":"Burns","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003422","descriptor_name":"Critical Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004360","descriptor_name":"Drug Therapy, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005440","descriptor_name":"Fluid Therapy","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D005440","descriptor_name":"Fluid Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007260","descriptor_name":"Infusion Pumps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014556","descriptor_name":"Urine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.bcr.0000216512.30415.78","doi":"https://doi.org/10.1097/01.bcr.0000216512.30415.78","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.bcr.0000216512.30415.78","pdf_url":null,"source":{"id":"https://openalex.org/S57131103","display_name":"Journal of Burn Care & Research","issn_l":"1559-047X","issn":["1559-047X","1559-0488"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Burn Care & Research","raw_type":"journal-article"},{"id":"pmid:16679909","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16679909","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of burn care & research : official publication of the American Burn Association","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W319003747","https://openalex.org/W1996599613","https://openalex.org/W2004736650","https://openalex.org/W2007254392","https://openalex.org/W2009668006","https://openalex.org/W2009931247","https://openalex.org/W2011751065","https://openalex.org/W2017837895","https://openalex.org/W2038613832","https://openalex.org/W2039612689","https://openalex.org/W2040060245","https://openalex.org/W2055233649","https://openalex.org/W2066683976","https://openalex.org/W2071215036","https://openalex.org/W2132127582","https://openalex.org/W2314029956","https://openalex.org/W2323554824","https://openalex.org/W2407419311"],"related_works":["https://openalex.org/W1990541830","https://openalex.org/W2505184582","https://openalex.org/W1996599613","https://openalex.org/W1549315653","https://openalex.org/W2043563338","https://openalex.org/W2071582480","https://openalex.org/W7097296669","https://openalex.org/W1996424184","https://openalex.org/W2052238594","https://openalex.org/W2053493489"],"abstract_inverted_index":{"Fluid":[0],"therapy":[1],"for":[2,18,39,144,155,176,201],"burn":[3,40,237],"shock":[4],"is":[5,101],"adjusted":[6,108],"to":[7,28,55,69,221],"establish":[8],"a":[9,44,64,104],"target":[10,65,131,243,251],"level":[11],"of":[12,32,67,77,90,126,192,233],"urinary":[13,61,118,121,178,209,240],"output.":[14,119],"However,":[15],"the":[16,30,75,124,145,156,193,202,212,224],"means":[17],"adjusting":[19],"infusion":[20,91,109,160,181,234],"rate":[21,92,110,182],"are":[22],"not":[23],"defined.":[24],"Our":[25],"objective":[26],"was":[27,215],"compare":[29],"performance":[31],"automated":[33,97],"computer-controlled":[34],"resuscitation":[35,82,99,258,265],"with":[36,43,199,223,245],"manual":[37,87,254],"control":[38,232],"resuscitation.":[41],"Sheep":[42],"40%":[45],"TBSA":[46],"full-thickness":[47],"burn,":[48],"administered":[49],"under":[50,250],"halothane":[51],"anesthesia,":[52],"were":[53,129,134,166,188],"resuscitated":[54],"restore":[56],"and":[57,115,133,148,162,180,248],"maintain":[58],"normal":[59],"sheep":[60],"outputs":[62,122,241],"in":[63,117,130,190,195,211,242],"range":[66,132],"1":[68],"2":[70],"ml/kg":[71,141,152],"per":[72,142,153],"hour":[73,143,154],"over":[74,123,263],"course":[76,125],"48":[78,127],"hours":[79,128],"using":[80],"closed-loop":[81,98,146,169,203,225,231],"(n":[83,93],"=":[84,94,206,228],"10)":[85],"or":[86],"hourly":[88,174,184,255],"adjustment":[89],"11).":[95],"The":[96,168],"system":[100],"based":[102,111],"on":[103,112],"proportional-integral-derivative":[105],"algorithm,":[106],"which":[107],"continuous":[113],"monitoring":[114],"changes":[116],"Mean":[120,159],"virtually":[135],"identical":[136],"at":[137],"1.9":[138],"+/-":[139,150],"0.5":[140],"group":[147,170,197,204,214,226],"2.0":[149],"0.7":[151],"technician":[157,196,213],"group.":[158],"rates":[161,235],"infused":[163],"volumes":[164],"also":[165],"similar.":[167],"exhibited":[171],"significantly":[172],"lower":[173],"variation":[175,247],"both":[177],"output":[179,210],"compared":[183,198],"control.":[185],"Hourly":[186,208],"targets":[187],"achieved":[189],"41%":[191],"measurements":[194],"48%":[200],"(P":[205,227],".23).":[207],"undertarget":[216],"by":[217],"25%":[218],"as":[219],"opposed":[220],"16%":[222],".02).":[229],"Automated":[230],"after":[236],"injury":[238],"produced":[239],"ranges":[244],"less":[246,249],"values":[252],"than":[253],"adjustments.":[256],"Closed-loop":[257],"may":[259],"provide":[260],"an":[261],"improvement":[262],"current":[264],"regimens.":[266]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}