{"id":"https://openalex.org/W2086530747","doi":"https://doi.org/10.1074/jbc.m511039200","title":"Heparin Potentiates the in Vivo Ectopic Bone Formation Induced by Bone Morphogenetic Protein-2","display_name":"Heparin Potentiates the in Vivo Ectopic Bone Formation Induced by Bone Morphogenetic Protein-2","publication_year":2006,"publication_date":"2006-06-06","ids":{"openalex":"https://openalex.org/W2086530747","doi":"https://doi.org/10.1074/jbc.m511039200","mag":"2086530747","pmid":"https://pubmed.ncbi.nlm.nih.gov/16754660"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m511039200","doi":"https://doi.org/10.1074/jbc.m511039200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m511039200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m511039200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075501638","display_name":"Baohong Zhao","orcid":"https://orcid.org/0000-0002-1286-0919","observed_orcids":["https://orcid.org/0000-0002-1286-0919"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Baohong Zhao","raw_affiliation_strings":["Departments of Biochemistry and Periodontology, School of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Periodontology, School of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016126494","display_name":"Takenobu Katagiri","orcid":"https://orcid.org/0000-0001-9304-2098","observed_orcids":["https://orcid.org/0000-0001-9304-2098"]},"institutions":[{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takenobu Katagiri","raw_affiliation_strings":["Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama 350-1241"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama 350-1241","institution_ids":["https://openalex.org/I8588240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020163990","display_name":"Hiromitsu Toyoda","orcid":"https://orcid.org/0000-0002-3126-0046","observed_orcids":["https://orcid.org/0000-0002-3126-0046"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromitsu Toyoda","raw_affiliation_strings":["Department of Orthopaedic Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abenoku, Osaka 545-8585"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abenoku, Osaka 545-8585","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044006043","display_name":"Takatora Takada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takatora Takada","raw_affiliation_strings":["Department of Periodontology, School of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, School of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103784393","display_name":"Takako Yanai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takako Yanai","raw_affiliation_strings":["Department of Biochemistry, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111678150","display_name":"Toru Fukuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Fukuda","raw_affiliation_strings":["Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama 350-1241"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama 350-1241","institution_ids":["https://openalex.org/I8588240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048462960","display_name":"Ung\u2010il Chung","orcid":"https://orcid.org/0000-0002-4691-6394","observed_orcids":["https://orcid.org/0000-0002-4691-6394"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ung-il Chung","raw_affiliation_strings":["Division of Tissue Engineering, Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo, Tokyo 113-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Tissue Engineering, Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo, Tokyo 113-8655, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074923100","display_name":"Tatsuya Koike","orcid":"https://orcid.org/0000-0002-1522-8740","observed_orcids":["https://orcid.org/0000-0002-1522-8740"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuya Koike","raw_affiliation_strings":["Department of Orthopaedic Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abenoku, Osaka 545-8585"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abenoku, Osaka 545-8585","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110030667","display_name":"Kunio Takaoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunio Takaoka","raw_affiliation_strings":["Department of Orthopaedic Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abenoku, Osaka 545-8585"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abenoku, Osaka 545-8585","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039533514","display_name":"Ryutaro Kamijo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryutaro Kamijo","raw_affiliation_strings":["Department of Biochemistry, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555","institution_ids":["https://openalex.org/I119182057"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5016126494"],"corresponding_institution_ids":["https://openalex.org/I8588240"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":5.2772,"has_fulltext":false,"cited_by_count":284,"citation_normalized_percentile":{"value":0.97192732,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"281","issue":"32","first_page":"23246","last_page":"23253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.7002000212669373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.7002000212669373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.11400000005960464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12960","display_name":"Heterotopic Ossification and Related Conditions","score":0.039400000125169754,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":1.0},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/heterotopic-bone-formation","display_name":"ectopic bone formation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/smad1-5-8-phosphorylation","display_name":"Smad1/5/8 phosphorylation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/noggin","display_name":"noggin","score":0.7350000143051147},{"id":"https://openalex.org/keywords/heparitinase","display_name":"heparitinase","score":0.8640000224113464},{"id":"https://openalex.org/keywords/bmp-antagonists","display_name":"BMP antagonists","score":0.7570000290870667},{"id":"https://openalex.org/keywords/c2c12-myoblasts","display_name":"C2C12 myoblasts","score":0.8709999918937683},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7272011637687683},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.6857832074165344},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.6762514710426331},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.6650180816650391},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.5784028172492981},{"id":"https://openalex.org/C125349252","wikidata":"https://www.wikidata.org/wiki/Q14903102","display_name":"Bone morphogenetic protein 7","level":4,"score":0.4546544551849365},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44379156827926636},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.400520384311676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3435882031917572},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.29523253440856934},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24955224990844727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21501818299293518},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09641525149345398},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07203248143196106},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06981885433197021}],"mesh":[{"descriptor_ui":"D000099176","descriptor_name":"Noggin Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001846","descriptor_name":"Bone Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055396","descriptor_name":"Bone Morphogenetic Protein 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m511039200","doi":"https://doi.org/10.1074/jbc.m511039200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m511039200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:16754660","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16754660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"mag:3144974423","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/500000494779","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1074/jbc.m511039200","doi":"https://doi.org/10.1074/jbc.m511039200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m511039200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1935346479","https://openalex.org/W1968822620","https://openalex.org/W1974873948","https://openalex.org/W1975828859","https://openalex.org/W1976154397","https://openalex.org/W1979518793","https://openalex.org/W1980308012","https://openalex.org/W1984086000","https://openalex.org/W1986469118","https://openalex.org/W1988176449","https://openalex.org/W1989251966","https://openalex.org/W2011088037","https://openalex.org/W2015272152","https://openalex.org/W2015574865","https://openalex.org/W2036760454","https://openalex.org/W2058079332","https://openalex.org/W2070226860","https://openalex.org/W2073378176","https://openalex.org/W2084503148","https://openalex.org/W2087472570","https://openalex.org/W2093820637","https://openalex.org/W2101785627","https://openalex.org/W2110149781","https://openalex.org/W2122367477","https://openalex.org/W2131350538","https://openalex.org/W2134132415","https://openalex.org/W2142344672","https://openalex.org/W2154601080","https://openalex.org/W2154983834","https://openalex.org/W2163788818","https://openalex.org/W2325981820"],"related_works":["https://openalex.org/W4237900957","https://openalex.org/W2081773669","https://openalex.org/W1973428054","https://openalex.org/W1888200745","https://openalex.org/W2039234206","https://openalex.org/W2492756281","https://openalex.org/W128314757","https://openalex.org/W2016500999","https://openalex.org/W2015574865","https://openalex.org/W2259443360"],"abstract_inverted_index":{"Although":[0,142],"bone":[1,9,18,66,184],"morphogenetic":[2],"proteins":[3],"(BMPs)":[4],"are":[5,13],"clinically":[6],"useful":[7],"for":[8],"regeneration,":[10],"large":[11],"amounts":[12,181],"required":[14],"to":[15,75,116,160],"induce":[16],"new":[17],"formation":[19,67],"in":[20,32,71,133,164,176,202,206,217,220],"monkeys":[21],"and":[22,48,73,94,100,128,174,219,227],"humans.":[23],"We":[24],"found":[25],"recently":[26],"that":[27,194,211],"heparin":[28,64,82,175,195,212],"stimulates":[29,83],"BMP":[30,84,230],"activity":[31,85,163],"vitro":[33,203,218],"(Takada,":[34],"T.,":[35,37],"Katagiri,":[36],"Ifuku,":[38],"M.,":[39,43],"Morimura,":[40],"N.,":[41],"Kobayashi,":[42],"Hasegawa,":[44],"K.,":[45],"Ogamo,":[46],"A.,":[47],"Kamijo,":[49],"R.":[50],"(2003)":[51],"J.":[52],"Biol.":[53],"Chem.":[54],"278,":[55],"43229-43235).":[56],"In":[57,118],"the":[58,77,112,119,129,134,154,165],"present":[59],"study,":[60],"we":[61],"examined":[62],"whether":[63],"enhances":[65,196,213],"induced":[68,146,179],"by":[69,80,139,147,222,229],"BMPs":[70,224],"vivo":[72,177,221],"attempted":[74],"determine":[76],"molecular":[78],"mechanism":[79],"which":[81],"using":[86],"C2C12":[87],"myoblasts.":[88],"Heparin":[89],"enhanced":[90],"BMP-2-induced":[91],"gene":[92],"expression":[93],"Smad1/5/8":[95],"phosphorylation":[96],"at":[97],"24":[98],"h":[99,151],"thereafter,":[101],"although":[102],"not":[103,110,200],"within":[104,149],"12":[105],"h.":[106],"Heparitinase":[107],"treatment":[108],"did":[109],"affect":[111],"response":[113],"of":[114,121,124,131,153,156,167,172,182],"cells":[115],"BMP-2.":[117],"presence":[120,155,166],"heparin,":[122,157],"degradation":[123,226],"BMP-2":[125,132,148,162,173,188],"was":[126,137,145],"blocked,":[127],"half-life":[130],"culture":[135],"medium":[136],"prolonged":[138],"nearly":[140],"20-fold.":[141],"noggin":[143,158],"mRNA":[144],"1":[150],"regardless":[152],"failed":[159],"inhibit":[161],"heparin.":[168],"Furthermore,":[169],"simultaneous":[170],"administration":[171],"dose-dependently":[178],"larger":[180],"mineralized":[183],"tissue":[185],"compared":[186],"with":[187],"alone.":[189],"These":[190],"findings":[191],"clearly":[192],"indicate":[193],"BMP-induced":[197,214],"osteoblast":[198,215],"differentiation":[199,216],"only":[201],"but":[204],"also":[205],"vivo.":[207],"This":[208],"study":[209],"indicates":[210],"protecting":[223],"from":[225],"inhibition":[228],"antagonists.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}