{"id":"https://openalex.org/W208651091","doi":"https://doi.org/10.21236/ada593281","title":"AKT in Differential miRNA Processing in Prostate Carcinoma","display_name":"AKT in Differential miRNA Processing in Prostate Carcinoma","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W208651091","doi":"https://doi.org/10.21236/ada593281","mag":"208651091"},"language":"en","primary_location":{"id":"doi:10.21236/ada593281","doi":"https://doi.org/10.21236/ada593281","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada593281","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113139311","display_name":"Mohammed M. Shareef","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammed M. Shareef","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071586257","display_name":"Biju Isaac","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Biju Isaac","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050102682","display_name":"Sakhi Philip","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sakhi Philip","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111144763","display_name":"Thirupandiyur S. Udayakumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thirupandiyur Udayakumar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063389942","display_name":"Alan S Pollack","orcid":"https://orcid.org/0000-0002-1801-2865","observed_orcids":["https://orcid.org/0000-0002-1801-2865"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan Pollack","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.906000018119812},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.871999979019165},{"id":"https://openalex.org/keywords/microrna-processing","display_name":"microRNA processing","score":0.7829999923706055},{"id":"https://openalex.org/keywords/rna-induced-silencing-complex","display_name":"RNA-induced silencing complex","score":0.9919999837875366},{"id":"https://openalex.org/keywords/argonaute-proteins","display_name":"Argonaute proteins","score":0.8029999732971191},{"id":"https://openalex.org/keywords/triciribine","display_name":"triciribine","score":0.8600000143051147},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8759999871253967},{"id":"https://openalex.org/keywords/mirna-mrna-correlation","display_name":"miRNA-mRNA correlation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9350000023841858},{"id":"https://openalex.org/keywords/smad","display_name":"Smad","score":0.8989999890327454},{"id":"https://openalex.org/keywords/ksrp","display_name":"KSRP","score":0.8569999933242798},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2993388676","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate carcinoma","level":4,"score":0.8674032688140869},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.705177903175354},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6456212997436523},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6001982092857361},{"id":"https://openalex.org/C93226319","wikidata":"https://www.wikidata.org/wiki/Q193137","display_name":"Differential (mechanical device)","level":2,"score":0.48498961329460144},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3681982457637787},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3602652847766876},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3451199531555176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2723219096660614},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27068936824798584},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10784298181533813},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.10283350944519043},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09014099836349487},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08562642335891724},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.08305889368057251},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06858015060424805},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21236/ada593281","doi":"https://doi.org/10.21236/ada593281","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada593281","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2568145770","https://openalex.org/W2890302563","https://openalex.org/W6927102915","https://openalex.org/W4386444461","https://openalex.org/W2168401797","https://openalex.org/W6892201427","https://openalex.org/W7095235972","https://openalex.org/W2018596602","https://openalex.org/W4220983950","https://openalex.org/W2619255479"],"abstract_inverted_index":{"Abstract":[0],":":[1],"Our":[2],"original":[3],"hypothesis":[4,29,273],"was":[5,125,138,241,249],"AKT":[6,40,55,74,120,156,175,275],"regulates":[7,41,61,276],"the":[8,15,28,42,62,93,143,162,208,233,244,260,272,277,284],"RNA-induced":[9,278],"silencing":[10,279],"Complex":[11,280],"(RISC)":[12,281],"activity":[13,63,282],"through":[14,283],"phosphorylation":[16,57,76,285],"of":[17,58,64,73,77,95,109,216,246,286],"AGO":[18,59,78,238],"proteins":[19,60,79],"in":[20,46,133,150,169,229,289],"Prostate":[21,290],"carcinoma":[22,48,82,114,135,291],"cells":[23,83,115,136,153,172,292],".":[24,293],"Objectives:":[25],"To":[26,37,52,69],"test":[27,271],"following":[30],"specific":[31,237],"aims":[32],"were":[33,179],"proposed.":[34],"Aim":[35,50,67,87],"1:":[36],"show":[38,53,70],"that":[39,54,71,274],"miRNA":[43,128,187,192,198,204,234,247],"expression":[44,131],"profile":[45],"prostate":[47,81,113,134],"cells.":[49],"2:":[51],"mediated":[56,75],"RISC":[65],"complex.":[66],"3:":[68],"abrogation":[72],"sensitizes":[80],"to":[84,141,152,171,231],"chemotherapy.":[85],"For":[86,226],"1,":[88],"we":[89,211,251,268],"initially":[90],"tried":[91],"studying":[92],"interaction":[94,103],"Ago":[96],"(pan)":[97],"with":[98,117,155,174,236],"14-3-3.":[99,110],"We":[100,111,159],"could":[101,252,269],"see":[102],"between":[104],"Ago(pan)":[105],"and":[106,127,129,199,205],"(tau)":[107],"isoform":[108],"treated":[112,154,173],"(PC3)":[116,137],"40":[118],"M":[119],"inhibitor":[121,157,176],"V,":[122],"Triciribine.Total":[123],"RNA":[124],"isolated":[126,248],"mRNA":[130,189,194,200,206],"analysis":[132,210],"carried":[139,242],"out":[140],"identify":[142,232],"miRNA-mRNA":[144,163,261],"correlation":[145,164],"matrices":[146,165,178],"using":[147,166],"Pearson":[148,167],"Correlation":[149,168],"response":[151,170],"(Triciribine).":[158],"also":[160],"identified":[161,212],"(Triciribine)These":[177],"further":[180,255],"classified":[181],"into":[182],"four":[183],"groups":[184],"viz.,":[185],"I.":[186],"up":[188],"down.":[190],"II":[191],"down":[193],"up.":[195,201],"III.":[196],"Both":[197,203],"IV.":[202],"down..Using":[207],"GeneGo":[209],"TGF-":[213],"dependent":[214],"induction":[215],"Epithelial":[217],"Mesenchymal":[218],"Transition":[219],"(EMT)":[220],"via":[221],"SMADs":[222],"as":[223],"its":[224],"target.":[225],"aim":[227],"2,":[228],"order":[230],"associated":[235],"proteins,":[239],"Immunoprecipitation":[240],"out.Since,":[243],"quality":[245],"poor,":[250],"not":[253],"proceed":[254],"on":[256],"this":[257],"aim.":[258],"Once":[259],"pair":[262],"regulated":[263],"by":[264],"PI3K/AKT/14-3-3":[265],"is":[266],"identified,":[267],"then":[270],"KSRP":[287],"protein":[288]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}